Works in Progress

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Канал • Подкастов: 2

Технологии

Технологии

-2 дн.
Наука

Наука

16 сент.

26 СЕНТ.

How traffic modernism ruined cities with Nicholas Boys Smith

Nicholas Boys Smith joins Ben and Sam to explain how to plan spaces that people like; dense, sociable and, above all else, beautiful. He says people don't like new buildings because they don't trust what planners and architects are going to do to the places that matter to them. As an alternative he presents his playbook for how YIMBYs can win over the public. If you liked this episode, you'll enjoy our first episode on The Great Downzoning: https://www.youtube.com/watch?v=LAcEfeLlqLo For more from Works in Progress: worksinprogress.co/print

26 сент.

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1 ч. 13 мин.
-2 ДН.

Hacking proteins with AI

Nature didn’t evolve all the proteins we need, but maybe artificial intelligence can help. Jacob and Saloni explore how tools like AlphaFold and ProteinMPNN are helping researchers re-engineer proteins, to make them safer, more stable, and more effective. They talk about how new technologies could help make a long-sought vaccine against Strep A, which causes scarlet fever and rheumatic heart disease, and how similar tools have already led to breakthroughs against COVID and RSV. Hard Drugs is a new podcast from Works in Progress and Open Philanthropy about medical innovation presented by Saloni Dattani and Jacob Trefethen. Saloni’s substack newsletter: https://www.scientificdiscovery.dev/ Jacob’s blog: https://blog.jacobtrefethen.com/ Courses: EMBL-EBI. AlphaFold: A practical guide https://www.ebi.ac.uk/training/online/courses/alphafold/ Articles: Monica Jain et al. (2022) Exosite binding modulates the specificity of the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease. https://pmc.ncbi.nlm.nih.gov/articles/PMC9464890/ Jakki Cooney et al. (2008) Crystal structure of C5a peptidase https://www.rcsb.org/structure/3EIF Hui Li et al. (2017) Mutagenesis and immunological evaluation of group A streptococcal C5a peptidase as an antigen for vaccine development and as a carrier protein for glycoconjugate vaccine design https://pubs.rsc.org/en/content/articlelanding/2017/ra/c7ra07923k Lectures: Rosetta Commons (2024) AlphaFold – ML for protein structure prediction https://www.youtube.com/watch?v=SVrn8_8aKO8 Rosetta Commons (2024) MPNN – ML for protein sequence design https://www.youtube.com/watch?v=6z4XmUAwdNA Acknowledgements: Aria Babu, editor at Works in ProgressGraham Bessellieu, video editorRachel Shu, on-site editorAnna Magpie, fact-checkingAbhishaike Mahajan, cover artAtalanta Arden-Miller, art directionDavid Hackett, composer Works in Progress & Open Philanthropy Subscribe to the Works in Progress print magazine: https://worksinprogress.co/print/

-2 дн.

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55 мин.
-2 ДН.

Hacking proteins with AI

Nature didn’t evolve all the proteins we need, but maybe artificial intelligence can help. Jacob and Saloni explore how tools like AlphaFold and ProteinMPNN are helping researchers re-engineer proteins, to make them safer, more stable, and more effective. They talk about how new technologies could help make a long-sought vaccine against Strep A, which causes scarlet fever and rheumatic heart disease, and how similar tools have already led to breakthroughs against COVID and RSV. Hard Drugs is a new podcast from Works in Progress and Open Philanthropy about medical innovation presented by Saloni Dattani and Jacob Trefethen. Saloni’s substack newsletter: https://www.scientificdiscovery.dev/ Jacob’s blog: https://blog.jacobtrefethen.com/ Courses: EMBL-EBI. AlphaFold: A practical guide https://www.ebi.ac.uk/training/online/courses/alphafold/ Articles: Monica Jain et al. (2022) Exosite binding modulates the specificity of the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease. https://pmc.ncbi.nlm.nih.gov/articles/PMC9464890/ Jakki Cooney et al. (2008) Crystal structure of C5a peptidase https://www.rcsb.org/structure/3EIF Hui Li et al. (2017) Mutagenesis and immunological evaluation of group A streptococcal C5a peptidase as an antigen for vaccine development and as a carrier protein for glycoconjugate vaccine design https://pubs.rsc.org/en/content/articlelanding/2017/ra/c7ra07923k Lectures: Rosetta Commons (2024) AlphaFold – ML for protein structure prediction https://www.youtube.com/watch?v=SVrn8_8aKO8 Rosetta Commons (2024) MPNN – ML for protein sequence design https://www.youtube.com/watch?v=6z4XmUAwdNA Acknowledgements: Aria Babu, editor at Works in ProgressGraham Bessellieu, video editorRachel Su, on-site editorAnna Magpie, fact-checkingAbhishaike Mahajan, cover artAtalanta Arden-Miller, art directionDavid Hackett, composer Works in Progress & Open Philanthropy Subscribe to the Works in Progress print magazine: https://worksinprogress.co/print/

-2 дн.

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55 мин.
16 СЕНТ.

100 years of insulin in 15 minutes

A hundred years ago, insulin was scraped from pig pancreases. Today, it’s made by bacteria in giant tanks. In the second part of a mini series on proteins, drug development and AI, Saloni tells the story of how insulin went from a crude animal extract to the first genetically-engineered drug, kickstarting the biotech industry along the way. Hard Drugs is a new podcast from Works in Progress and Open Philanthropy about medical innovation presented by Saloni Dattani and Jacob Trefethen. Saloni’s substack newsletter: https://www.scientificdiscovery.dev/ Jacob’s blog: https://blog.jacobtrefethen.com/ Books: Genentech: The beginnings of biotech by Sally Smith Hughes Articles: FDA (2007). Celebrating a Milestone: FDA's Approval of First Genetically-Engineered Product https://fda.report/media/110447/Celebrating-a-Milestone--FDA%27s-Approval-of-the-First-Genetircally-Engineered-Product.pdf Genentech (2016). Cloning Insulin https://www.gene.com/stories/cloning-insulin Arthur Riggs (2020). Making, Cloning, and the Expression of Human Insulin Genes in Bacteria: The Path to Humulin https://academic.oup.com/edrv/article/42/3/374/6042201 Podcasts: Novo Nordisk (Ozempic) by the Acquired podcast https://www.acquired.fm/episodes/novo-nordisk-ozempic Acknowledgements: Aria Babu, editor at Works in ProgressAdrian Bradley, on-site producerAnna Magpie, fact-checkingAbhishaike Mahajan, cover artAtalanta Arden-Miller, art directionDavid Hackett, composerWorks in Progress & Open Philanthropy

16 сент.

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18 мин.
10 СЕНТ.

Why feminism worked best in the West with Alice Evans

Social scientist Alice Evans talks about why, despite a superficially similar feminist movement in East Asia, Western feminism has been much successful. Alice, Sam and Aria talk about dating markets, drinking culture at work, top-down media control, and what tax policy is best for motivating people to have more children. For more of Alice's work, check out her Substack. Go to worksinprogress.co to read more from Works in Progress. References Flowers of Fire: The Inside Story of South Korea's Feminist Movement and What It Means for Women' s Rights Worldwide Paperback by Hawon JungThe clan and the corporation: Sustaining cooperation in China and Europe by Avner Greif and Guido TabelliniThe Swedish Theory of Love: Individualism and Social Trust in Modern Sweden by Henrik Berggren and Lars TrägårdhDrunk: How We Sipped, Danced, and Stumbled Our Way to Civilization Hardcover by Edward Slingerland

10 сент.

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1 ч. 17 мин.
15 АВГ.

The underrated economics of land with Mike Bird

Why is Chinese housing so expensive despite being oversupplied? How did land reforms in Russia lead to the Bolshevik revolution? What killed Georgism? The Economist’s Wall Street Editor, Mike Bird, discusses the underrated economics of land. You can preorder Mike's book here and read more about land readjustment in Works in Progress Issue 19.

15 авг.

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1 ч. 16 мин.
27 АВГ.

How to become President of China with Dan Wang

Is it better to be run by engineers, lawyers or regulators? Can you build an economy on luxury handbags or do you need advanced manufacturing? Dan Wang, author of Breakneck: China's Quest to Engineer the Future discusses why China outbuilds America, how the young and ambitious succeed in China, and the secret to finding the best Chinese restaurants. You can order his new book here, read his annual letters on China here, and check out London's best Suzhou noodles here.If you want more from Works in Progress you can read the magazine here or listen to our episode about land in East Asia here.

27 авг.

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1 ч. 19 мин.
29 ИЮЛ.

How Henry VIII accidentally started the Industrial Revolution, with Anton Howes

Historian Anton Howes discusses how Henry VIII turned Britain into an economic backwater – making it the unlikeliest place for the Industrial Revolution to happen. But, he explains it only took a small cabal of people who understood the problems of the time to turn the fate of the country (and thus, the world) around. You can learn more about the history of the Industrial Revolution on Anton's Substack, Age of Invention. And you can learn more about progress at Works in Progress.

29 июл.

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1 ч. 12 мин.
3 СЕНТ.

Proteins: Weird blobs that do important things

This episode kicks off a mini-series on proteins, drug development and AI. Saloni and Jacob explore the world of proteins, including how proteins fold into complex shapes, why that complexity matters and how crowded and dynamic the inside of a cell really is; and they exchange surprising statistics about proteins. Hard Drugs is a new podcast from Works in Progress and Open Philanthropy about medical innovation presented by Saloni Dattani and Jacob Trefethen. You can watch or listen on YouTube, Spotify, or Apple Podcasts. Saloni’s substack newsletter: https://www.scientificdiscovery.dev/ Jacob’s blog: https://blog.jacobtrefethen.com/ Books: Ron Milo and Rob Phillips. Biology by the numbers https://book.bionumbers.org/ Carl Ivar Branden and John Tooze (1999) Introduction to protein structure https://www.taylorfrancis.com/books/mono/10.1201/9781136969898/introduction-protein-structure-john-tooze-carl-ivar-branden Articles: Niko McCarty (2023). Biology is a burrito. https://www.asimov.press/p/burrito-biology Rhiannon Morris, Katrina Black, and Elliott Stollar (2022) Uncovering protein function: from classification to complexes. https://pmc.ncbi.nlm.nih.gov/articles/PMC9400073/ Victor Muñoz and Michele Cerminara (2016) When fast is better: protein folding fundamentals and mechanisms from ultrafast approaches https://portlandpress.com/biochemj/article/473/17/2545/49248/When-fast-is-better-protein-folding-fundamentals Image credits: Chang et al. (2012) Egg white in organic electronics. https://spie.org/news/4149-egg-white-in-organic-electronics [diagram of egg white denaturing and cross-linking]John Kendrew’s model of myoglobin’s structure; via Carl Ivar Branden and John Tooze (1999) Introduction to protein structure.Carl Ivar Branden and John Tooze (1999) Introduction to protein structure. [diagram of amino acids and protein structure]Ron Milo and Rob Phillips. Which is bigger, mRNA or the protein it codes for? https://book.bionumbers.org/which-is-bigger-mrna-or-the-protein-it-codes-for/ [diagram of myoglobin mRNA vs protein]Scitable (2014). Microtubules and Filaments. https://www.nature.com/scitable/topicpage/microtubules-and-filaments-14052932/ [diagram of microtubules] Subscribe to the Works in Progress print magazine: https://worksinprogress.co/print/

3 сент.

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20 мин.
16 СЕНТ.

100 years of insulin in 15 minutes

A hundred years ago, insulin was scraped from pig pancreases. Today, it’s made by bacteria in giant tanks. In the second part of a mini series on proteins, drug development and AI, Saloni tells the story of how insulin went from a crude animal extract to the first genetically-engineered drug, kickstarting the biotech industry along the way. Hard Drugs is a new podcast from Works in Progress and Open Philanthropy about medical innovation presented by Saloni Dattani and Jacob Trefethen. Saloni’s substack newsletter: https://www.scientificdiscovery.dev/ Jacob’s blog: https://blog.jacobtrefethen.com/ Books: Genentech: The beginnings of biotech by Sally Smith Hughes Articles: FDA (2007). Celebrating a Milestone: FDA's Approval of First Genetically-Engineered Product https://fda.report/media/110447/Celebrating-a-Milestone--FDA%27s-Approval-of-the-First-Genetircally-Engineered-Product.pdf Genentech (2016). Cloning Insulin https://www.gene.com/stories/cloning-insulin Arthur Riggs (2020). Making, Cloning, and the Expression of Human Insulin Genes in Bacteria: The Path to Humulin https://academic.oup.com/edrv/article/42/3/374/6042201 Podcasts: Novo Nordisk (Ozempic) by the Acquired podcast https://www.acquired.fm/episodes/novo-nordisk-ozempic Acknowledgements: Aria Babu, editor at Works in ProgressAdrian Bradley, on-site producerAnna Magpie, fact-checkingAbhishaike Mahajan, cover artAtalanta Arden-Miller, art directionDavid Hackett, composerWorks in Progress & Open Philanthropy

16 сент.

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18 мин.

Works in Progress is an online magazine devoted to new and underrated ideas about economic growth, scientific progress, and technology. Subscribe to listen to Hard Drugs by Saloni Dattani and Jacob Trefethen and the Works in Progress podcast by the whole team.

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Works in Progress

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How traffic modernism ruined cities with Nicholas Boys Smith

Hacking proteins with AI

Hacking proteins with AI

100 years of insulin in 15 minutes

Why feminism worked best in the West with Alice Evans

The underrated economics of land with Mike Bird

How to become President of China with Dan Wang

How Henry VIII accidentally started the Industrial Revolution, with Anton Howes

Proteins: Weird blobs that do important things

100 years of insulin in 15 minutes

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Works in Progress

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