Gut Instinct: GI Research Update is a podcast that brings you the latest research in gastroenterology, hepatology, and nutrition direct to your headphones. Hosts Tamsin Cargill and Michael FitzPatrick, gastroenterology doctors and researchers at the University of Oxford, talk you through recent clinical and translational research papers that have caught their eye, with clear explanations, critical appraisal, and (hopefully) a sense of humour.
Twitter (@GIUpdate): https://twitter.com/GIUpdate
Gut Instinct Ep. 6 - Cell-free DNA diagnostics for biliary strictures, diet and weight loss, and minimum unit price strategies for alcohol
Another fun-filled episode from your favourite GI podcasters. From hepatobiliary disease to alcohol policy, luminal gastro to nutrition, we have something for everyone this episode. Enjoy!
Gut Instinct Ep. 5 - Transplants for alcoholic hepatitis, Single-cell in ulcerative colitis, and haemopray
This month Fitz and Tamsin discuss outcomes from early liver transplant for alcoholic hepatitis, a single-cell study of UC plasma cells, whether haemospray really is the answer in GI bleeds, coeliac epidemiology, and more!
Gut Instinct Ep. 4 - C. difficile therapeutics, liver spatial genomics, and paediatric hepatitis
What a week! We discuss some cracking papers, including a new microbiome therapeutic for C. diff, spatial transcriptomics in the liver, and the recent epidemic of paediatric hepatitis.
Gut Instinct Ep. 3 - Keto vs Carbs and Livers vs Albumin
We review a few interesting papers from the world of nutrition science and hepatology, plus the usual assortment of bits and bobs from the gastro literature.
Gut Instinct Ep. 2 - Long-term drains for ascites, the developing gut, and drugs for obesity
A smorgasbord of research for you this week; we discuss quantitative and qualitative data about long-term drains for ascites, an incredible atlas of the developing gut, drugs for obesity, fibrates for itch, and pharmacokinetics in pregnancy.
Gut Instinct Ep.1 - COVID and cancer, ACLF, and the downfall of biomarkers
The first episode! We talk through the impact of COVID-19 on colorectal cancer, transcriptomics in ACLF, the pitfalls of biomarker studies in IBD, microscopic colitis and cancer risk, HBV and PBC treatment, and more... Gut Instinct Ep.1 - COVID and cancer, ACLF, and the downfall of biomarkers
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Episode recap - what have we learnt?
- COVID-19 pandemic has had major impacts on CRC pathways in the NHS, with huge reductions in referrals and procedures in the first wave, leading to a 22% reduction in diagnoses, 3,500 fewer patients diagnosed than expected.
Morris E, et al. Impact of the COVID-19 pandemic on the detection and management of colorectal cancer in England: a population-based study. Lancet Gastro Hep (2021). https://doi.org/10.1016/S2468-1253(21)00005-4
- Acute on chronic liver failure is associated with changes in gene expression in immune cell populations, particularly associated with immunometabolism, which may help us develop new biomarkers and potentially treatments.
Li J, et al. PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF. Gut (2021). https://doi.org/10.1136/gutjnl-2020-323395
- Disappointingly, a previously reported gene expression biomarker of IBD progression could not be validated in two further cohorts. We need to be cautious, even sceptical, about novel transcriptional biomarkers for disease and prognosis, and seek out multiple independent validation studies.
Gasparetto M, et al. Transcription and DNA Methylation Patterns of Blood-Derived CD8+ T Cells Are Associated With Age and Inflammatory Bowel Disease But Do Not Predict Prognosis. Gastroenterology (2021). https://doi.org/10.1053/j.gastro.2020.08.017
- Microscopic colitis is associated with a small increased risk of lung cancer and lymphoma at diagnosis, but a lower risk of CRC over time.
Bergman D, et al. Microscopic Colitis and Risk Of Cancer—A Population-Based Cohort Study. Journal of Crohn's and Colitis (2021). https://doi.org/10.1093/ecco-jcc/jjaa156
- In the real world setting, vedolizumab for IBD shows decent performance in terms of clinical remission, even in patients several years post-diagnosis, and who have been previously exposed to multiple anti-TNF agents.
Mühl L, et al. Clinical experiences and predictors of success of treatment with vedolizumab in IBD patients: a cohort study. BMC Gastroenterol (2021). https://doi.org/10.1186/s12876-021-01604-z
- Treatment of patients with minimally raised ALT and high viral load in CHB reduces the risk of fibrosis progression
Hsu Y-C, et al. Once-daily tenofovir disoproxil fumarate in treatment-naive Taiwanese patients with chronic hepatitis B and minimally raised alanine aminotransferase (TORCH-B): a multicentre, double-blind, placebo-controlled, parallel-group, randomised trial. Lancet Inf Dis (2021). https://doi.org/10.1016/S1473-3099(20)30692-7
- Treatment of individuals with PBC resistant to UDCA with add on budesonide does not improve liver histology, but may improve biochemical outcome measures. More trials and novel therapeutics for AI liver diseases are urgently required! This study also underlines the problem of evidence-based medicine in rare diseases.
Hirschfield G, et al. A placebo-controlled randomised trial of budesonide for PBC following an insufficient response to UDCA. Journal of Hepatology (2021). https://doi.org/10.1016/j.jhep.2020.09.011
Thanks for listening to Gut Instinct!