ACCEL Lite: Featured ACCEL Interviews on Exciting CV Research

American College of Cardiology
  • 3.8 (54)
  • MEDICINE
  • UPDATED DAILY

The American College of Cardiology offers select interviews and summaries of cardiology’s most interesting research areas from ACCEL’s renowned library, hosted by ACCEL Editor-in-Chief Alison L. Bailey, MD, FACC, FAACPVR.

  1. 2D AGO

    DAN-RSV: RSVpreF Vaccine for Preventing Cardiorespiratory Hospitalizations

    The DAN-RSV trial is one of the largest individually randomized studies ever conducted, enrolling over 131,000 participants aged 60 and older to evaluate the effectiveness of the RSVpreF vaccine. Using a pragmatic design with electronic consent and national health registry data, the trial successfully met its primary objective of reducing RSV-related respiratory tract disease hospitalizations. It also achieved all key secondary endpoints, showing favorable outcomes for RSV-related and all-cause respiratory and cardiorespiratory hospitalizations. These results demonstrate the vaccine’s potential to significantly impact public health and inform future RSV vaccine policy. In this interview, Drs. Richard A. Chazal and Tor Biering-Sørensen discuss “DAN-RSV: RSVpreF Vaccine for Preventing Cardiorespiratory Hospitalizations.”   Suggested Materials:   Tor Biering-Sørensen (2025). Vaccine Effectiveness of a Bivalent RSV Prefusion F Protein-Based Vaccine for Preventing RSV Hospitalizations in Older Adults (DAN-RSV) (ClinicalTrials.gov Identifier NCT06684743). Retrieved from https://clinicaltrials.gov/study/NCT06684743.     Subscribe on Apple Podcasts | Subscribe to ACCEL

    10 min

  2. SEP 23

    The Role of Prevention During and After Reproduction

    Adverse pregnancy outcomes (APOs), affecting up to 20% of pregnancies, serve as early indicators of a woman’s future cardiovascular risk and should be treated as critical markers in preventive care. Pregnancy offers a unique opportunity—a “window”—to identify and address cardiovascular vulnerabilities, making routine screening for heart health essential at every clinical encounter. Long-term monitoring beyond the postpartum period is vital, as cardiovascular risks persist and evolve over time. Improving women’s heart health requires a collaborative, lifelong approach across specialties, integrating cardiology with obstetrics and primary care. This comprehensive strategy ensures that prevention remains central during and after reproduction.    In this interview, Drs. Alison L. Bailey, MD, FACC and Ijeoma Isiadinso, MD, FACC discuss “The Role of Prevention During & After Reproduction”.   Subscribe on Apple Podcasts | Subscribe to ACCEL

    13 min

  3. SEP 16

    The Role of Imaging in Cardiovascular Prevention

    Cohort studies have provided robust data on cardiovascular risk factors, forming the basis for predictive models like the Pooled Cohort Equations and PREVENT. Clinical trials confirm that treating these risk factors effectively reduces cardiovascular events. Over the past 50 years, age-adjusted mortality from acute myocardial infarction has dropped by 89%, reflecting major progress. To advance further, we must consider integrating imaging to identify those at highest risk, using risk factors to guide treatment decisions. This dual approach could enhance precision and improve outcomes in cardiovascular prevention.   In this interview, Drs. Alison L. Bailey and David J. Maron discuss “The Role of Imaging in Cardiovascular Prevention”.   Subscribe to ACCEL

    11 min

  4. SEP 9

    Improving Cardiovascular Clinical Competencies Menopausal Transition

    The menopause transition marks a pivotal period of cardiometabolic change that significantly elevates cardiovascular (CV) risk in women. Despite its clinical importance, this phase remains underrecognized in CV risk assessment, contributing to a profound knowledge gap. Enhancing clinician education and fostering multidisciplinary collaboration are essential to delivering individualized care that addresses both symptom burden and long-term CV outcomes. By prioritizing this life stage, we can improve prevention strategies and reduce the overall burden of cardiovascular disease in women.  In this interview, Drs. Alison L. Bailey and Lily Dastmalchi discuss “Improving Cardiovascular Clinical Competencies for Menopausal Transition”.    Subscribe on Apple Podcasts | Subscribe to ACCEL

    13 min

  5. SEP 2

    Behind the 2025 ACC/AHA Acute Coronary Syndrome Guideline

    The 2025 ACC/AHA Acute Coronary Syndrome guideline is the first major update since 2013, incorporating a decade of new evidence and clinical insights. The writing committee stayed on track and on time, reaching consensus on key recommendations, including checklist-based Class I and II interventions before discharge. They thoughtfully addressed legacy practices and controversial studies to ensure clarity and relevance. While some emerging data didn’t meet the threshold for formal inclusion, areas like discharge antiplatelet therapy, coronary imaging, and mechanical support devices were flagged as important for clinicians to monitor. The result is a practical, evidence-based tool to guide bedside decision-making.    In this interview, Drs. Roxana Mehran and Sunil V. Rao take listeners “Behind the 2025 Acute Coronary Syndrome Guidelines.”   Subscribe on Apple Podcasts | Subscribe to ACCEL

    11 min

  6. AUG 26

    Top Takeaways From the 2025 ACC/AHA Acute Coronary Syndrome Guideline

    The 2025 ACC/AHA Acute Coronary Syndrome (ACS) Guideline clarifies diagnostic distinctions using electrocardiogram changes, troponin levels, and imaging tools such as coronary CT angiography and echocardiography in the emergency setting. Updates in lipid-lowering strategies and antiplatelet therapy reflect a more personalized approach to risk reduction and long-term care. These recommendations aim to streamline acute decision-making and improve outcomes across the ACS spectrum.    In this interview, Drs. Sidney C. Smith Jr. and Michelle L. O'Donoghue discuss “Top Takeaways From the 2025 ACC/AHA Acute Coronary Syndrome Guideline.”    Subscribe on Apple Podcasts | Subscribe on Google Play | Subscribe to ACCEL

    18 min

  7. AUG 19

    Risk vs. Benefit in Chronic Total Occlusion Revascularization

    Chronic Total Occlusion Percutaneous Coronary Intervention (CTO PCI) is a procedure used to open coronary arteries that have been completely blocked for an extended period. It offers benefits like reduced angina and improved quality of life but carries risks such as vessel injury, heart attack, and procedural failure. Before considering CTO PCI, physicians typically optimize patients on anti-anginal medications—such as beta-blockers, nitrates, and calcium channel blockers—to manage symptoms and evaluate the need for intervention.  In this interview, Drs. Anthony N. DeMaria and Lindsey Cilia examine “Risk versus Benefit in Chronic Total Occlusion Revascularization.”  Subscribe on Apple Podcasts | Subscribe to ACCEL

    12 min

  8. AUG 12

    LAAO vs. DOAC for Stroke Prevention in AFib

    While blood thinners like warfarin and direct oral anticoagulants (DOACs) remain the standard for stroke prophylaxis, left atrial appendage occlusion (LAAO) devices offer a non-pharmacologic alternative for patients at high bleeding risk. Recent trials have shown that LAAO can be as effective as anticoagulants in preventing stroke and may be a viable option, especially for patients who cannot tolerate long-term anticoagulation.    In this interview, Drs. Anthony N. DeMaria and Dhanunjaya Lakkireddy explore the evolving landscape of stroke prevention in patients with atrial fibrillation, focusing on the comparison between traditional blood thinners and LAAO.    Subscribe on Apple Podcasts | Subscribe to ACCEL

    15 min
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The American College of Cardiology offers select interviews and summaries of cardiology’s most interesting research areas from ACCEL’s renowned library, hosted by ACCEL Editor-in-Chief Alison L. Bailey, MD, FACC, FAACPVR.

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