27 episodes

Host: Samir Kakodkar, MD - specialist in Crohn's disease and ulcerative colitis
Medical School: Northwestern Feinberg School of Medicine
Internal Medicine Residency: Rush University Medical Center
Fellowship in Gastroenterology and Hepatology: Advocate Lutheran General Hospital

Advanced Fellowship in Inflammatory Bowel Disease (Crohn's and Colitis): Northwestern Memorial Hospital

Practice Location
7900 N Milwaukee Ave Suite 19, Niles, IL 60714
For appointments: 847-318-9595
Contact: samir3@gmail.com

YouTube channel: https://www.youtube.com/channel/UCSzuuqUFGgtcwpAbtL5b0xw

Twitter: @KakodkarSamir

Against the Grain Samir Kakodkar

    • Medicine
    • 4.8, 36 Ratings

Host: Samir Kakodkar, MD - specialist in Crohn's disease and ulcerative colitis
Medical School: Northwestern Feinberg School of Medicine
Internal Medicine Residency: Rush University Medical Center
Fellowship in Gastroenterology and Hepatology: Advocate Lutheran General Hospital

Advanced Fellowship in Inflammatory Bowel Disease (Crohn's and Colitis): Northwestern Memorial Hospital

Practice Location
7900 N Milwaukee Ave Suite 19, Niles, IL 60714
For appointments: 847-318-9595
Contact: samir3@gmail.com

YouTube channel: https://www.youtube.com/channel/UCSzuuqUFGgtcwpAbtL5b0xw

Twitter: @KakodkarSamir

    Against the Grain Theme Song (Version #1)

    Against the Grain Theme Song (Version #1)

    For all the mega Against the Grain fans out there, here is the full theme song, version #1 in all its glory. The part you are familiar with is in the middle of the track.

    Produced and Written by Samir Kakodkar. Borrowed some parts from theme from the ABC reality TV show The Mole (that nobody watched).
    Circa 2003 at Northwestern University, Foster Walker Complex, on a microKorg and Garage Band.

    • 5 min
    Against the Grain Theme Song (Version #2)

    Against the Grain Theme Song (Version #2)

    For all the mega Against the Grain fans out there, here is the full theme song, version #2 in all its glory.

    Produced and Written by Samir Kakodkar
    Circa 2003 at Northwestern University, Foster Walker Complex, on a microKorg and Garage Band.

    • 3 min
    Does Mycobacterium Avium Paratuberculosis (MAP) Cause Crohn's Disease?

    Does Mycobacterium Avium Paratuberculosis (MAP) Cause Crohn's Disease?

    There are many theories out there regarding what causes Crohn’s disease. Though ultimately most physicians and scientists acknowledge that we don’t know the cause, there is a small subgroup that believe Crohn’s disease is caused by a specific bacteria called mycobacterium avium paratuberculosis which we will abbreviate as MAP. MAP mainly comes from infected cattle but is now ubiquitous in our environment and all of us are likely exposed to it on a regular basis.
    The treatment paradigm for Crohn’s has mainly been the use of immunosuppressive medications which target a dysregulated immune system thought to be central to the pathophysiology of the disease. However, there are some that treat Crohn’s by targeting MAP with the use of antibiotics, fecal transplants and hyperbaric oxygen. There is even an anti-MAP vaccine in development. In my opinion, this is the biggest controversy in the IBD field right now. In fact, the Crohn’s Disease guidelines published by the American College of Gastroenterology in 2018 explicitly state that anti-MAP therapy has not been shown to be effective for induction or maintenance of remission or mucosal healing in patients with Crohn’s disease and should not be used as primary therapy. This led to subsequent letters being published in the American Journal of Gastroenterology both criticising and defending this statement.

    Today I interviewed gastroenterologist Gaurav Agrawal and microbiologist John Aitken who are MAP experts and will give us a comprehensive overview of this topic.
    As a disclaimer, I am not formally endorsing this therapy for Crohn’s disease as it has not been FDA approved for this purpose in the US. This podcast should not be interpreted as medical advice. This is an open discussion in order to encourage more research and awareness of this topic.

    ACG Clinical Guideline: Management of Crohn’s Disease in Adults:
    https://pubmed.ncbi.nlm.nih.gov/29610508/

    Comment on 2018 ACG Clinical Guideline: Antibiotics in Crohn's Disease:
    https://pubmed.ncbi.nlm.nih.gov/30333546/

    Response to Chamberlin and Borody
    https://pubmed.ncbi.nlm.nih.gov/30633034/

    Two-year Combination Antibiotic Therapy With Clarithromycin, Rifabutin, and Clofazimine for Crohn's Disease:
    https://pubmed.ncbi.nlm.nih.gov/17570206/

    Targeted Combination Antibiotic Therapy Induces Remission in Treatment-Naïve Crohn's Disease: A Case Series:
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142403/

    Combining infliximab, anti-MAP and hyperbaric oxygen therapy for resistant fistulizing Crohn's disease
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137971/

    Profound Remission in Crohn's Disease Requiring No Further Treatment for 3-23 Years: A Case Series
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144342/

    Website regarding Crohn’s Disease Vaccine:
    http://www.crohnsmapvaccine.com

    John Aitken’s
    Website:
    https://otakaropathways.co.nz/about.php

    Email:
    info@otakaropathways.co.nz

    • 2 hr 41 min
    Top 10 Ready to Eat Foods for Crohn's and Colitis Diets

    Top 10 Ready to Eat Foods for Crohn's and Colitis Diets

    This is a show on some of my favorite ready-made food items. These would be considered processed foods to some degree, but definitely less processed than the types of things you would find at The Dollar Store or even a regular grocery store chain. Sometimes it’s nice to have food on hand that you don’t always have to prepare. I understand there are diet purists out there that don’t eat anything unless it is made from scratch. However, for those who are not able to dedicate a lot of time to cooking, these types of food products can help to reduce the time burden. Most of the products I mention would be compatible with the various diets used for inflammatory bowel disease including the Specific Carbohydrate Diet though there may be exceptions depending on the particular diet or stage you are in. Why are thes foods ok for IBD? Because they don’t have the food additives, refined flours or sweeteners that may be detrimental (though I understand even making that statement is controversial). I don’t receive any money or sponsorship from the companies that make these products so these are my unbiased opinions.

    I’m happy to announce that my clinic is now equipped for video and telephone visits. For those who would like more personalized attention, you can schedule an appointment with me. I only treat adults - those 18 years old or over. You can email me at samir3@gmail.com for more information about a virtual appointment if you are interested.

    • 19 min
    How Does Stress Affect Crohn's and Colitis? A Review of the Literature and Case Study of a Healed Colon

    How Does Stress Affect Crohn's and Colitis? A Review of the Literature and Case Study of a Healed Colon

    This show will focus on the effect of stress on Crohn’s disease and ulcerative colitis. I will define stress as the feeling of being challenged by a threatening event of evolving situation. Everyone experiences some degree of stress in life, but when it becomes chronic and perceived as severe, it can have adverse health effects. Many patients attribute their initial diagnosis and subsequent flares to stressful life events. But does stress actually make the inflammation of inflammatory bowel disease worse? I review what the literature says and also present a case of a patient with Crohn's colitis who subsequently had a normal colonoscopy with normal biopsies after decreasing stress in his life. As a disclaimer, this is just an anecdote and does not constitute evidence. I am not recommending stress reduction as a primary treatment modality for IBD without adjunctive appropriate medical therapy.

    References:
    The Brain-Gut Axis and Stress in IBD by Bernstein: https://www.ncbi.nlm.nih.gov/pubmed/29173525

    Manitoba Registry showing stress not associated with intestinal inflammation:
    https://www.ncbi.nlm.nih.gov/pubmed/26077178

    UC patients with more inflammation with more stress:
    https://www.ncbi.nlm.nih.gov/pubmed/?term=10811330

    Mindfulness Based Interventions in IBD by Hood et al : https://www.ncbi.nlm.nih.gov/pubmed/29173527

    Wim Hof Method Paper: https://www.wimhofmethod.com/uploads/kcfinder/files/PNAS.pdf

    • 1 hr 25 min
    Coronavirus in Gastroenterology, Hepatology and Inflammatory Bowel Disease

    Coronavirus in Gastroenterology, Hepatology and Inflammatory Bowel Disease

    Today we are going to tackle Coronavirus, specifically SARS-CoV-2 which causes the disease COVID 19 in relation to gastrointestinal symptoms and disease. I will be interviewing Dr Kaushal Majmudar who is one of our great GI fellows at Advocate Lutheran General Hospital. He recently did a Grand Rounds for our GI department on this very topic and went over all the recent data regarding pathogenesis, treatment and also recommendations from various GI societies for specific clinical scenarios regarding liver disease, endoscopy and inflammatory bowel disease. This will be valuable information for clinicians in all specialties and definitely for those working in GI. Though at times this does become technical at certain points, it will be valuable information for the non-physician audience too. At the end I will give my own thoughts about COVID 19 and IBD with comments on the relevance of the hygiene hypothesis, infusion centers and specific risks of medications. As a disclaimer, we are not the CDC or members of committees creating the guidelines that will be discussed. Opinions are our own. This is an open discussion and should not be interpreted as medical advice.

    • 1 hr 49 min

Customer Reviews

4.8 out of 5
36 Ratings

36 Ratings

Doc Denver ,

Astute, compassionate, helpful

As a family doc and father of a son with “indeterminate IBD”, I find these podcasts incredibly helpful. you radiate light and hope upon a difficult path.
Keep up the amazing work!

samantha021 ,

Thank you!!

Thank you so much for starting this. It’s so interesting to hear about non traditional IBD treatments that have worked for people and so refreshing to have a doctor who is open enough to listen and provide medical insights on these alternative therapies. It’s brought me a lot of hope and even prompted my to switch GI doctors. Every IBD patient needs to know about this podcast!

Sharknet ,

Life changing

Thank you so much for doing what you do! I have learned so much from these podcasts which has helped me with my crohns. I am so grateful!

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