21 episodes

Monthly discussion of recent publications from the research literature on Alexander Disease, hosted by Albee Messing from the University of Wisconsin-Madison.

Alexander Disease Research Update Albee Messing

    • Health & Fitness
    • 4.0 • 1 Rating

Monthly discussion of recent publications from the research literature on Alexander Disease, hosted by Albee Messing from the University of Wisconsin-Madison.

    Alexander Disease Research Update - Episode #21: 1) Blood levels of GFAP, neurofilaments, and tau, and 2) planning for in-person conference in Philadelphia this summer.

    Alexander Disease Research Update - Episode #21: 1) Blood levels of GFAP, neurofilaments, and tau, and 2) planning for in-person conference in Philadelphia this summer.

    Albee Messing, Jenny Pearson, Natasha Snider, and Amy Waldman discuss the following recent publication and the conference planned for this summer in Philadelphia: [02:02] Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease Neurological Sciences (2024) [full text][04:16] Discussion about Philadelphia Conference, August 2-4, 2024 Sen...

    • 15 min
    Alexander Disease Research Update - Episode #20: 3D bioprinting method for co-culture of neurons and astrocytes reveals new features of Alexander disease

    Alexander Disease Research Update - Episode #20: 3D bioprinting method for co-culture of neurons and astrocytes reveals new features of Alexander disease

    Albee Messing and Linghai Kong discuss the following recent publication: [01:52] 3D bioprinting of human neural tissues with functional connectivity. Cell Stem Cell 31:260-274.e7 (2024) [full text]Send your questions and feedback to: amessing@wisc.eduHelp support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: https://alexander-disease.waisman.wisc.edu/donate/ &n...

    • 15 min
    Alexander Disease Research Update - Episode #19: Giant Axonal Neuropathy and Alexander Disease

    Alexander Disease Research Update - Episode #19: Giant Axonal Neuropathy and Alexander Disease

    Albee Messing, Rachel Battaglia, and Natasha Snider discuss the following publication: [00:59] Intermediate filament dysregulation in astrocytes in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN)Molecular Biology of the Cell (in press)[full text - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846626/]Send your questions and feedback to: amessing@wisc.eduHelp support research on Alexander Disease at the University of Wiscon...

    • 18 min
    Alexander Disease Research Update - Episode #18: 1) Quantitative MRI in rat model, and 2) Developmental milestones in cerebral form of AxD

    Alexander Disease Research Update - Episode #18: 1) Quantitative MRI in rat model, and 2) Developmental milestones in cerebral form of AxD

    Albee Messing, Nick Stowe, JP Yu, and Amy Waldman discuss the following recent publications: [4:30] Stowe NA, Singh AP, Barnett BR, Yi SY, Frautschi PC, Messing A, et al. Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease. Magnetic Resonance in Medicine (2023) in press[15:11] Acquisition and Loss of Developmental Milestones and Time to Disease-Related Outcomes in Cerebral Alexand...

    • 28 min
    Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation

    Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation

    Albee Messing, Rachel Battaglia, and Tracy Hagemann discuss the following recent publications: [01:45] A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells Stem Cell Reports 18, 1701-1720 (2023)[includes new iPS cell line from an individual with Alexander disease] [full text][05:39] Isolation of Intermediate Filament Proteins from M...

    • 24 min
    Alexander Disease Research Update - Episode #16: Webinar - Guangping Gao lab

    Alexander Disease Research Update - Episode #16: Webinar - Guangping Gao lab

    Webinar on the strategy and preliminary results for “AAV-mediated Gene Silencing for the Treatment of Alexander Disease” presented by Drs. Guangping Gao, Jun Xie, and Dominic Gessler from the University of Massachusetts Medical School. This version is audio only - the full video version will be made available later at a site that is not yet determined.

    • 1 hr 8 min

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