22 episodes
Alexander Disease Research Update Albee Messing
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- Health & Fitness
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4.0 • 1 Rating
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Monthly discussion of recent publications from the research literature on Alexander Disease, hosted by Albee Messing from the University of Wisconsin-Madison.
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Alexander Disease Research Update - Episode #22: 1) anesthesia and AxD, and 2) GFAP cross-linking to itself
Albee Messing, Amy Waldman, and Natasha Snider discuss the following recent publications: [02:07] A retrospective observational cohort study of the anesthetic management and outcomes of pediatric patients with Alexander disease undergoing lumbar puncture or magnetic resonance imaging Paediatric Anesthessia (in press) [11:11] Glial fibrillary acidic protein is pathologica...
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Alexander Disease Research Update - Episode #21: 1) Blood levels of GFAP, neurofilaments, and tau, and 2) planning for in-person conference in Philadelphia this summer.
Albee Messing, Jenny Pearson, Natasha Snider, and Amy Waldman discuss the following recent publication and the conference planned for this summer in Philadelphia: [02:02] Plasma concentrations of glial fibrillary acidic protein, neurofilament light, and tau in Alexander disease Neurological Sciences (2024) [full text][04:16] Discussion about Philadelphia Conference, August 2-4, 2024 Sen...
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Alexander Disease Research Update - Episode #20: 3D bioprinting method for co-culture of neurons and astrocytes reveals new features of Alexander disease
Albee Messing and Linghai Kong discuss the following recent publication: [01:52] 3D bioprinting of human neural tissues with functional connectivity. Cell Stem Cell 31:260-274.e7 (2024) [full text]Send your questions and feedback to: amessing@wisc.eduHelp support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center: https://alexander-disease.waisman.wisc.edu/donate/ &n...
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Alexander Disease Research Update - Episode #19: Giant Axonal Neuropathy and Alexander Disease
Albee Messing, Rachel Battaglia, and Natasha Snider discuss the following publication: [00:59] Intermediate filament dysregulation in astrocytes in the human disease model of KLHL16 mutation in giant axonal neuropathy (GAN)Molecular Biology of the Cell (in press)[full text - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846626/]Send your questions and feedback to: amessing@wisc.eduHelp support research on Alexander Disease at the University of Wiscon...
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Alexander Disease Research Update - Episode #18: 1) Quantitative MRI in rat model, and 2) Developmental milestones in cerebral form of AxD
Albee Messing, Nick Stowe, JP Yu, and Amy Waldman discuss the following recent publications: [4:30] Stowe NA, Singh AP, Barnett BR, Yi SY, Frautschi PC, Messing A, et al. Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease. Magnetic Resonance in Medicine (2023) in press[15:11] Acquisition and Loss of Developmental Milestones and Time to Disease-Related Outcomes in Cerebral Alexand...
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Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation
Albee Messing, Rachel Battaglia, and Tracy Hagemann discuss the following recent publications: [01:45] A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells Stem Cell Reports 18, 1701-1720 (2023)[includes new iPS cell line from an individual with Alexander disease] [full text][05:39] Isolation of Intermediate Filament Proteins from M...