Analytically Speaking

LCGC & Spectroscopy
  • 4.8 (4)
  • Science
  • Updated Monthly

Analytically Speaking, the podcast from LCGC and Spectroscopy magazines, addresses important issues in separation science and analytical spectroscopy. Topics include new analytical techniques, methods, and approaches; the latest trends; advances in instrument and software technology; practical solutions for specific applications; recent papers in the scientific literature and their applicability; challenges and solutions for data analysis and interpretation; analytical chemistry theory and fundamentals (from advanced research to tutorials and troubleshooting); and more. Our regular hosts are Dwight Stoll, PhD, a professor of chemistry at Gustavus Adolphus College in St. Peter, Minnesota, and Jerry Workman, PhD, a spectroscopist, noted author, and currently the Senior Technical Editor of Spectroscopy and LCGC. Dwight covers separation science and Jerry addresses spectroscopy related topics.

  1. 3d ago

    Ep. 48: From Fortran to Field Flow Fractionation

    Welcome to “Analytically Speaking,” the podcast from LCGC International and Spectroscopy. In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Mark Schure, who has worked in separation science for over 35 years in both industry and academia. Over a 28-year period, he worked for Digital Equipment Corporation, the Rohm and Haas Company, and the Dow Chemical Company. Since then, he has served as Chief Technology Officer for Kroungold Analytical, and he has been an adjunct professor in the Department of Chemical and Biomolecular Engineering at the University of Delaware for over 20 years. Dr. Schure is a widely recognized expert in separation science who has published more than 110 papers, holds numerous patents, and edited the book Multidimensional Liquid Chromatography. His scientific interests encompass the fundamental separation science of complex molecules, polymers, and colloids, alongside 2D chromatography, retention mechanisms, and field flow fractionation. He has received numerous accolades, including the Eastern Analytical Symposium Award in Separation Science and the Uwe Neue Award from the HPLC conference. In a wide ranging conversation recorded live at the HPLC 2026 conference in Indianapolis following a memorial session for Prof. Peter Carr, we explore Mark’s unique entry into separation science, which benefited from prior experiences building amplifiers and electronics before transitioning to write Fortran software as a consultant for chemists at Northeastern University. We then discuss Mark’s foundational simulation work in field flow fractionation (FFF), including his approaches to modeling Coriolis effects and sedimentation. We also spend some time talking about Mark’s pioneering theoretical contributions to 2D chromatography on topics including sampling rate and detection limits. Finally, Mark shares his perspective on the intense inter-diffusion of information between his modeling group and Pete Carr and Ilja Siepmann at the University of Minnesota, the future of analytical chemistry, the need for improved analytical strategies for complex matrices like exosomes, and the potential for artificial intelligence to help identify unknown compounds in complex mixtures.

    Ep. 48: From Fortran to Field Flow Fractionation

  2. Aug 7

    Ep 47: The Other Half of Beer’s Law

    Welcome to “Analytically Speaking,” the podcast from LCGC International and Spectroscopy. Here in Episode #47, podcast host Dr. Jerry Workman speaks with Dr. Thomas Mayerhöfer from the Leibniz Institute of Photonic Technology (Leibniz IPHT) in Jena, Germany, and Friedrich Schiller University Jena, about “the other half” of the Beer–Lambert law: dispersion theory, the concentration law of the refractive index, and refractive-index and complex-valued chemometrics. Dr. Mayerhöfer, who first joined the podcast for Episode #29 on the history and theory of infrared spectroscopy, returns to explain how Beer’s law falls out of dispersion theory as a limiting case, why the refractive index obeys a concentration law of its own that was mainstream physical chemistry before about 1920 (and helped confirm the Kekulé structure of benzene), and how new refractive-index and complex-valued chemometric methods — in combination with PLS — can outperform conventional absorbance-based calibration by up to an order of magnitude.

    Ep 47: The Other Half of Beer’s Law

  3. Jul 7

    Ep. 46: Live from Pittcon with Award Winners Bob Pirok and Justin Godinho

    In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with two recent award winners live from the Pittcon conference in San Antonio, Texas: Dr. Bob Pirok and Dr. Justin Godinho. Dr. Bob Pirok is an Associate Professor at the University of Amsterdam in the Netherlands, where he also completed his Ph.D. under the direction of Professor Peter Schoenmakers. He is an expert in multi-dimensional chromatography and the application of machine learning within the field. At Pittcon we celebrated his receipt of the Emerging Leader in Chromatography Award, presented by LCGC International Magazine. Dr. Justin Godinho is a Senior Principal Scientist at GlaxoSmithKline (GSK) in Upper Providence, Pennsylvania. He completed his undergraduate work at Davidson College and his Ph.D. under the direction of Professor Jim Jorgenson at the University of North Carolina at Chapel Hill. Before joining GSK, he worked in the column manufacturing business with Advanced Materials Technology. He is a recognized expert in column technology at both capillary and analytical scales, as well as the analysis of small and biotherapeutic molecules. At this year's conference, he received the Young Investigator in Separation Science Award, sponsored by the ACS Division of Analytical Chemistry. In the conversation, we discuss the recent award sessions for both guests and the evolution of their respective careers. We explore Justin’s transition from fundamental column packing research to biopharmaceutical applications at GSK, touching on the ongoing need for protein-suitable columns, capillary-scale techniques, and the Hydrophobic Subtraction Model column database. We then shift to Bob’s research on automated method development discussed at the meeting. This includes a deep dive into data-driven chromatography, the complexities involved in establishing effective Chromatographic Response Functions (CRFs), and why setting realistic expectations for artificial intelligence and automated method development is critical to avoiding a future "AI winter."

    Ep. 46: Live from Pittcon with Award Winners Bob Pirok and Justin Godinho

  4. May 15

    Ep 45: Overfitting in Chemometrics: Designing Models That Truly Work

    Ep 45: Overfitting in Chemometrics: Designing Models That Truly Work by LCGC & Spectroscopy

    Ep 45: Overfitting in Chemometrics: Designing Models That Truly Work

  5. Mar 20

    Ep. 44: Be a Nice Person

    In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Pierre-Hugues (PH) Stefanuto who is an Associate Professor and Lead Scientist in the Molecular System Research Unit at University of Liège in Liège, Belgium. He previously received both his M.S. and Ph.D. degrees from the same institution. Following his graduate work in Liege he was a postdoctoral research fellow at Dartmouth College. He is a recognized world expert in multidimensional gas chromatography, where he focuses on profiling volatile organic compound mixtures in various life science samples. Currently, he is focused on developing multi-omics screening approaches to tackle biomedical challenges at the molecular level. He has received a number of accolades to date, including the John Phillips Award and Richard Sacks Award, which are two of the highest honors in the field of multidimensional gas chromatography. He is also one of the co-chairs of the ongoing Multidimensional Chromatography Workshop symposium series. In the conversation we talk about PH’s early experiences as a kid scientist, both experimenting in the kitchen at home, and as a laureate of the Chemistry Olympiad in Belgium. We then move on to discuss the Multidimensional Chromatography Workshop - the early days, the alignment with PH’s professional interests, the 17th annual workshop in Williamsburg, VA, and the upcoming 18th workshop in Liège in early 2027. We also talk about the “Century Mix” Project, which was discussed at the Williamsburg with guidance from PH and Dr. John Dimandjia, and has aims to democratize the characterization of GCxGC systems, and provide open datasets for anyone in the community to use. Later in the conversation we briefly discuss two of PH’s recent papers in the GCxGC field, both focused on aspects of data analysis. Finally, we finish with some quick hits, where PH has great advice for young scientists.

    Ep. 44: Be a Nice Person

  6. Feb 2

    EP 43: An Introduction to Optical Photothermal Infrared (O-PTIR) Spectroscopy

    Here in Episode #43, podcast host Dr. Jerry Workman speaks with Dr. Mustafa Kansiz, who is currently the Director of Product Management at Photothermal Spectroscopy Corporation in Santa Barbara, California. They will be discussing an introduction to optical photothermal infrared (O-PTIR) spectroscopy; the technique, its applications and the newest innovations in O-PTIR and even Photothermal Stimulated Raman Scattering (PT-SRS).

    EP 43: An Introduction to Optical Photothermal Infrared (O-PTIR) Spectroscopy

  7. Jan 6

    Ep. 42: Did You Look at the Raw Data?

    In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Professor Kelly Hines. Dr. Hines is an associate professor in the Department of Chemistry at the University of Georgia in Athens. She received her B.S. degree in Chemistry from the University of Florida, and then completed the Ph.D. in Chemistry at Vanderbilt University. Her doctoral studies focused on monitoring biomolecular signatures of disease via ion mobility and mass spectrometry techniques, and then she moved on to post-doctoral experiences at two different institutions. The first stop was at the metabolomics resource core at the Mayo Clinic, and the second stop was in the Department of Medicinal Chemistry at the University of Washington School of Pharmacy. Kelly has won several awards in the field of chemical analysis, including recognition as a Female Role Model in Analytical Chemistry by Analytical and Bioanalytical Chemistry, as an Emerging Investigator by the Journal of the American Society for Mass Spectrometry, an ASMS Research Award (which is one of the top honors that young investigators in MS can receive), and very recently was named as the Chemist of the Year by the Northeast Georgia Section of the American Chemical Society. In a wide-ranging conversation, we discuss the early origins of Kelly’s interest in science rooted in her opportunity to explore the plant nursery managed by her father, and then her turn from civil engineering to analytical chemistry inspired by an early undergraduate course “Chemistry for Engineers”. We discuss Hines’ recent and ongoing work involving the use of ion mobility mass spectrometry (IMS-MS), with pre-separation using chromatography when appropriate, for multi-omics studies, aimed at deeper understanding of the biochemistry of organisms at the metabolite level. We also discuss Kelly’s positive experiences developing peer networks through regular attendance at conferences, particularly the American Society for Mass Spectrometry (ASMS) annual meeting, experiences in her second post-doctoral position that inspired her to pursue an academic position, and her approach to mentoring graduate students who show up in her laboratory with diverse backgrounds, interests, and abilities.

    Ep. 42: Did You Look at the Raw Data?

  8. 11/21/2025

    Ep 41: The Story of the Michelson Exhibit at the Angels Camp Museum

    Here in Episode #41, podcast host Dr. Jerry Workman speaks with Sunil Mehrotra and Doug Modlin, who are the project leaders of the Albert Michelson Exhibit at the Angels Camp Museum located in Angels Camp, California. They will be discussing the life and times of Albert Michelson and the creation of the Albert Michelson Angels Camp Museum Exhibit. Albert A. Michelson was the first Nobel Laureate in the sciences from the United States and the first physicist to accurately measure the speed of light, the size of stars, and more. References and Further Information for Albert A. Michelson’s Life and Angels Camp Museum Exhibit Life and Scientific Contributions (1) The Albert Michelson website landing page. https://albertmichelson.com/ (accessed 2025-09-30). (2) Michelson live interview film YouTube link: https://youtu.be/gQoNnu0n2lk (accessed 2025-09-30). (3) Workman, J., Jr. Albert A. Michelson: A Pioneer of Interferometry and Precision Optical Spectroscopy. Spectroscopy 2025, 40 (6), 22–26. https://doi.org/10.56530/spectroscopy.tz5770i4. (4) National Academy of Sciences (USA) Biographical Memoir of Albert Abraham Michelson PDF document. Available at: https://drive.google.com/file/d/1jd-yeTdj8y0kQVENLZkCXe8uoF3RX84E/view?usp=sharing (accessed 2025-09-30). (5) Albert A. Michelson, Recent advances in spectroscopy, Nobel Lecture, December 12, 1907. Available at: https://drive.google.com/file/d/1GeXXxuCoLbWVIfG8wS1XJ-kpY0ajBXEz/view?usp=sharing (accessed 2025-09-30). (6) Michelson featured in US Navy (USN) history video, YouTube link: https://youtu.be/-CbrVa9SrCI (accessed 2025-09-30). (7) Edna and Albert Michelson Family History. Available at: https://docs.google.com/document/d/1Kk_HpxnKjKbtHx9SPozM-jDbVFKc9L-_/edit?usp=sharing&ouid=100533588463446467177&rtpof=true&sd=true (accessed 2025-09-30). Albert Michelson exhibit at Angels Camp Museum (8) Albert Michelson exhibit unveiled at Angels Camp Museum article. Available at: https://drive.google.com/file/d/1VMjhYta7qfJbq95lKW2ftqPglJqCdhDO/view?usp=sharing (accessed 2025-09-30). (9) Albert Michelson Exhibit Inspires Young Minds at Angels Camp Museum Link: https://new.thepinetree.net/?p=179327 (accessed 2025-09-30). (10) Mark Twain Elementary Students Tour the Albert Michelson Exhibit YouTube link: https://youtu.be/hwpe-wkHtOo (accessed 2025-09-30). (11) A teacher and a student touring Albert Michelson exhibit at the Angels Camp Museum YouTube link: https://youtu.be/vdVJDkretU4 (accessed 2025-09-30). (12) Albert Michelson Exhibit at the Angels Camp Museum-spectrometer description YouTube link: https://youtu.be/Ed_-JSq_4pg (accessed 2025-09-30). (13). Virtual tour of the Albert Michelson Exhibit at the Angels Camp Museum link: https://tourmkr.com/F1SYh8VcsS/43684268p&273.03h&90t (14). The Albert Michelson Education Project supports the Learning Center at the Albert Michelson Exhibit and the Albert Michelson Science Fair Awards. Be sure to indicate that your donation is intended for the Albert Michelson Education Project and use the following link: https://www.m-otm.org/contribute (15). The Michelson STEAM Scholarship supports local high school students in Calaveras County pursue their education in STEAM related disciplines. Be sure to indicate that your donation is intended for the Michelon STEAM Scholarship and use the following link: https://calaverascommunityfoundation.org/ways-to-give/

    Ep 41: The Story of the Michelson Exhibit at the Angels Camp Museum
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About

Analytically Speaking, the podcast from LCGC and Spectroscopy magazines, addresses important issues in separation science and analytical spectroscopy. Topics include new analytical techniques, methods, and approaches; the latest trends; advances in instrument and software technology; practical solutions for specific applications; recent papers in the scientific literature and their applicability; challenges and solutions for data analysis and interpretation; analytical chemistry theory and fundamentals (from advanced research to tutorials and troubleshooting); and more. Our regular hosts are Dwight Stoll, PhD, a professor of chemistry at Gustavus Adolphus College in St. Peter, Minnesota, and Jerry Workman, PhD, a spectroscopist, noted author, and currently the Senior Technical Editor of Spectroscopy and LCGC. Dwight covers separation science and Jerry addresses spectroscopy related topics.

Information

  • Creator
    LCGC & Spectroscopy
  • Years Active
    2022 - 2026
  • Episodes
    49
  • Rating
    Clean
  • Copyright
    © All rights reserved
  • Show Website
    Analytically Speaking

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