AudioHelicase, the podcast of Whitehead Institute: Unwinding the science and the people behind some of the Institute’s most exciting discoveries.
Whitehead Institute is a world-renowned non-profit research institution dedicated to improving human health through basic biomedical research. By cultivating a deeply collaborative culture and enabling the pursuit of bold, creative inquiry, Whitehead fosters paradigm-shifting scientific achievement. For more than 30 years, Whitehead faculty have delivered breakthroughs that have transformed our understanding of biology and accelerated development of therapies for such diseases as Alzheimer’s, Parkinson’s, diabetes, and certain cancers.
Whitehead Institute’s Silvi Rouskin on solving the structure of the coronavirus genome
In this episode of AudioHelicase Podcast, Whitehead Fellow Silvi Rouskin discusses her research on solving the structure of the novel coronavirus’s RNA genome, with the goal of revealing weak points in the virus’s gene regulation that new drugs could potentially target. Music: “Versailles” by Pierce Murphy (CC-BY 4.0). Produced by Conor Gearin.
Whitehead Institute’s Olivia Corradin on a New Way to Probe Disease Genetics
On this episode of AudioHelicase podcast, Whitehead Fellow Olivia Corradin talked about investigating the genetic underpinnings of diseases through a new technique she developed, the outside variant approach. Applying the method to study the autoimmune disease multiple sclerosis (MS), Corradin and colleagues identified a role for a cell type in the brain in MS, offering a new way of understanding the disease. She also discussed running a lab during the COVID-19 pandemic, and evaluating scientific information in a time of uncertainty.
Music: “Versailles” by Pierce Murphy (CC-BY 4.0). Produced by Conor Gearin.
Whitehead’s Jing-Ke Weng on COVID-19 treatments taking root in plant science
Plants have been used as medicine for thousands of years; could they contribute to a solution to the COVID-19 pandemic? This is what Whitehead Institute Member Jing-Ke-Weng set out to address in a new paper, published May 20 in the journal Molecular Plant. We talked to Weng about an herbal treatment being used to treat … Continue reading Whitehead’s Jing-Ke Weng on COVID-19 treatments taking root in plant science →
AudioHelicase Special: The Conductors of the Cell’s Symphony
In this special episode of AudioHelicase podcast, we’re taking a look at how our researchers are identifying the key players that help conduct the cell’s symphony — the proteins and molecules that direct many other parts of the cell on when and how to do their jobs. The episode features highlights from interviews with Whitehead … Continue reading AudioHelicase Special: The Conductors of the Cell’s Symphony →
Whitehead Institute’s Pulin Li on creating multicellular patterns in a Petri dish
In this episode of AudioHelicase, Whitehead Institute Member Pulin Li talks about how her lab engineers cells in Petri dishes to communicate with each other and form patterns, recreating processes seen in embryo development—and how this work could eventually inform efforts to grow tissues in the lab. Produced by Conor Gearin Music: Pierce Murphy, … Continue reading Whitehead Institute’s Pulin Li on creating multicellular patterns in a Petri dish →
Whitehead Institute’s Ankur Jain on RNA clumps and the neurodegenerative diseases they are associated with
In this episode of AudioHelicase, Whitehead Institute Member Ankur Jain discusses how RNA can clump in cells and the diseases, such as Huntington’s and amyotrophic lateral sclerosis (ALS), that are associated with these aggregations.