Beyond Longevity

Daphna Stern
  • 5,0 (1)
  • MÉDECINE

Beyond Longevity is a deep-dive podcast exploring the cutting edge of longevity science. Through conversations with leading researchers, clinicians, and innovators who are redefining health and longevity, the show unpacks the evidence behind living longer and healthier. Each episode translates complex research into clear, thoughtful discussions, decoding the future of ageing one conversation at a time.

  1. -6 J

    From Lab to Life: Translating Ageing Science into Real-world Solutions with Professor Lorna Harries

    Professor Lorna Harries has spent more than two decades studying why cells age and what might be done about it. In this episode, she explains one of the most overlooked mechanisms in ageing biology, RNA splicing. When cells lose control of this process, they become stressed, dysfunctional and can tip into senescence, a state that contributes to ageing across almost every organ system. She explains what senescent cells actually do, how the signals they release can spread damage from one tissue to another, and why calling them “zombie cells” does not come close to telling the full story. We talk about the possibility of intervening before cells reach an irreversible state, why targeting the biology of ageing itself may matter more than tackling diseases one at a time, and what meaningful rejuvenation should really look like. Prof Lorna also discusses the challenge of turning lab science into therapies through her spin-out SENISCA, her work with L’Oréal, and why conditions such as IPF are an important place to begin. Along the way, she addresses the tougher questions too, including how longevity science moves from promise to treatment, where the field risks drifting into hype, and whether these advances will be available to the many or only the few. Links: http://www.senisca/ http://www.iscarna.com/ https://teamrna.wixsite.com/harrieslab https://experts.exeter.ac.uk/1873-lorna-harries Innovate UK ICURe Programme https://iuk-business-connect.org.uk/programme/icure/ 00:00 Podcast Intro Guest Setup 01:50 Meet Professor Harris Basics 02:16 DNA RNA Explained 03:38 RNA Splicing And Ageing 05:48 What Senescent Cells Do 07:38 Reversing Senescence Window 09:01 Fat Tissue And Faster Ageing 11:01 Splicing As Central Hallmark 12:11 Rejuvenation Discovery Story 13:52 From Lab To Spinout Company 16:41 Translating Science To Products 19:17 Therapy Targets IPF And Beyond 21:45 Why Translation Often Fails 23:19 Defining Real Rejuvenation 25:14 Avoiding Hype In Longevity 27:17 Who Is Lagging Behind 27:37 Regulatory Mindset Shift 28:47 Trials Built for Ageing 29:28 Scepticism and Overhype 31:25 Is Ageing a Disease 32:49 Policy and Demographic Timebomb 33:48 Advocacy and Communication 35:24 Personal Ageing Habits 36:24 Key Unasked Questions 39:15 Longevity for the Rich 41:43 Access via NHS and Patents 45:06 Rapid Fire and Myths 49:05 Closing Reflections

    51 min

  2. 10 AVR. ·  BONUS

    ViVE Bonus: Marc Zemel on Real-Time Hemodynamic Monitoring and Early Deterioration Detection in Critical Care

    Recorded at the 2026 VIVE conference in Los Angeles, this Beyond Longevity mini-series episode features Mark Zemel, co-founder and CEO of Retia Medical, discussing the company’s hemodynamic monitoring technology that turns continuous bedside physiological signals into real-time clinical insights for high-risk surgery and critical care. Marc explains Retia’s aim to detect early deterioration, guide diagnosis and therapy, and avoid the unreliability, invasiveness and complexity of older tools, noting deployment in 75 US hospitals and distribution via Medtronic, plus presence in 18 countries. He highlights FDA clearance for Argos Infinity enterprise software, which extends insights across the hospital and to clinicians’ phones and laptops, and shares a case where rapid detection of falling stroke volume revealed bleeding during AAA repair. The conversation covers workflow-first design, interoperability, cybersecurity, regulatory strategy, and a future path from ICU to broader wards and ultimately wearables for earlier intervention and preventative care. 00:00 Beyond Longevity Intro 00:44 Meet Mark Zeel 01:40 Rata Medical Mission 02:54 Argos Infinity Launch 03:58 Clinicians Want Real Time 05:19 Surgery Near Miss Story 07:20 Why Accuracy Matters 08:42 Why Algorithms Are Hard 10:08 From ICU To Wearables 12:20 Scaling Distribution Globally 13:22 Plug And Play Integration 15:22 Wearables And Data Overload 18:31 Alerts And Clinical Judgment 20:16 AI As Decision Support 21:56 US Versus Europe Markets 23:09 Wearables Beyond EMRs 23:57 Regulation And Cybersecurity 25:07 FDA And AI Pathways 26:50 Clinician Workflow Design 29:39 Bad Data From Friction 31:58 Open Ecosystems Future 33:25 Prevention And Longevity 35:46 Personal Why Wearables Matter 39:24 From ICU To Early Detection 41:44 Rapid Fire And Wrap

    45 min

  3. 6 AVR.

    Why Longer lives Are Changing Work, Business and Society, with Avivah Wittenberg-Cox

    This week’s guest is Avivah Wittenberg-Cox. Avivah advises leaders on gender and generational balance, the future of work, and the longevity economy. She hosts the podcast 4-Quarter Lives, publishes the Substack Elderberries, and writes regularly for Forbes and Harvard Business Review. She is Visiting Faculty at Oxford’s Saïd Business School, co-directs the Longevity Leadership Programme at Católica Lisbon, and has given three TED Talks. In this episode, Avivah and Daphna explore how longer lives are reshaping work, business, and society. Avivah argues that longevity is not just a health story but a structural shift that is forcing organisations to rethink how they are built, how careers unfold, and how different generations work together. She explains why the old pyramid model of the workforce is giving way to a more square demographic reality, with far more balance between younger and older generations than most institutions were designed for. That shift brings real pressure, from pensions to healthcare, but also major opportunities for businesses willing to adapt. The conversation looks at why older workers are still too often overlooked, what businesses lose when they fail to value experience, and why age-inclusive thinking is becoming a strategic advantage rather than a social add-on. More broadly, the episode challenges outdated assumptions about ageing and asks what it would mean to build a society that treats longer lives as a source of possibility, not decline. This episode is a reminder that longevity is not only changing how long we live, but how we work, lead, learn, and contribute across the course of our lives. https://www.avivahwittenbergcox.com/ https://elderberries.substack.com https://elderberries.substack.com/podcast https://www.ted.com/search?q=Avivah+Wittenberg+Cox https://20-first.com/ https://www.forbes.com/sites/avivahwittenbergcox/#61c5a38ebf19 00:00 Longevity Meets Work 02:06 Longevity Mega Trend 03:09 Institutions Lag Behind 05:37 From Gender To Age 07:39 Women And Longer Lives 10:08 Multi Stage Careers 11:26 Rethinking Education Midlife 15:29 Rebranding Old Age 17:54 Opportunity And Ageism 21:24 Fear Of Ageing And Happiness 25:37 Goldman Sachs And AI 27:17 Company First Mover Advantage 28:43 Who Is Leading The Way 29:52 Brands Embrace Pro Ageing 30:21 Longevity In Hospitality 31:12 Retirees As Consultants 31:56 Why Leaders Miss Demographics 35:29 Government Levers And Limits 38:34 The Square Society Shift 40:43 Measuring Longevity Readiness 43:25 Advice Four Quarter Lives 47:54 Designing A Four Quarter Life 53:22 Ageing Better Than Expected 54:46 Rapid Fire And Wrap Up

    58 min

  4. 30 MARS

    NAD, Precision Health & the Science of Living Better for Longer with Dr Jin-Xiong She

    In this episode, Dr Jin-Xiong She, a scientist with more than 400 publications, over 20,000 citations, and more than $100 million in research funding, explains why he left the top tier of academic medicine to pursue something more urgent: finding better ways to detect decline early and protect healthspan before disease takes hold. He shares what nearly 100,000 NAD tests have uncovered and why he believes biomarker baselines could change the way we think about prevention. https://www.jinfiniti.com/ https://www.youtube.com/@ProfJinShe In this episode: 00:00 Welcome and Guest Intro 01:47 From Genomics to Longevity 04:18 T1D TEDDY Study Breakthroughs 06:07 Leaving Academia for Impact 07:37 Healthspan Over Lifespan 10:09 TAO Test Act Optimise 13:20 Choosing Actionable Biomarkers 17:02 Why NAD Tops the List 21:45 NAD Decline and Key Drivers 25:21 Raising NAD Lifestyle vs Supplements 27:51 Athletes' Inflammation and Low NAD 31:54 Optimal NAD Range and Niacin Risks 37:28 SubQ Injections vs Oral NMN Data 41:42 Dosing and Cutting Useless Supplements 43:52 Access Economics and Policy Ideas 46:50 Industry Adoption and Big Names 47:59 Supplement Market Problems 50:17 Rapid Fire and Closing Takeaways 52:04 Final Summary and Goodbye

    53 min

  5. 23 MARS

    Why Governments Still Ignore Ageing, and What Must Change with Dr Ilia Stambler

    What does it take to turn longevity science into real-world policy? In this episode, Daphna speaks with Dr Ilia Stambler, historian of longevity, published author, Chair of the International Longevity Alliance (ILA), and Chief Science Officer and Chairman of Vetek (Seniority) Association, about why advocacy and ecosystem-building may be just as important as the science itself. Dr Stambler shares how the ILA has grown into a global network connecting 76 nonprofits across 66 countries, organising international conferences, and running the annual Longevity Day (1st October) and Longevity Month (October) campaigns. He points to concrete wins, including efforts to support the inclusion of ageing-related conditions in the ICD and the WHO's work programme. The conversation gets honest about the real barriers to progress. Dr Stambler argues the problem isn't convincing governments that ageing matters, it's getting them to treat it with urgency. Despite ageing representing one of the largest disease burdens globally, it remains chronically underfunded and deprioritised, in part because the research timelines required don't fit neatly into political cycles. He also reflects on the deeper intellectual questions underpinning the field: how to balance holism and reductionism, why historical perspective is essential for longevity researchers, and how the same patterns of enthusiasm, scepticism, and neglect have repeated across centuries of rejuvenation science. Looking ahead to 2030, Dr Stambler highlights the need for better public education, evidence-based criteria for evaluating interventions, and growing grassroots motivation, because ultimately, he believes, a longer and healthier life begins with wanting one. In This Episode: How the ILA operates across 66 countries and what it's achievedWhy governments acknowledge ageing but still fail to act on itThe long funding timelines longevity research demands — and why that's a political problemWhich countries are currently leading on longevity policyWhy solo science isn't enough and advocacy changes outcomesThe "Death Valley of ideas" and how to get research across itBalancing holism and reductionism in longevity scienceWhy the history of rejuvenation science keeps repeating itselfWhat meaningful success in this field actually looks like. Ilia Stambler, PhD Chairman and CSO. Vetek (Seniority) Association – The Movement for Longevity and Quality of Life, Israel http://www.longevityisrael.org/ Chairman. International Longevity Alliance (ILA) http://www.longevityalliance.org/ Fellow. Department of Science, Technology and Society, Bar-Ilan University, Israel https://sts.biu.ac.il/ Author. A History of Life-Extensionism in the Twentieth Century; Longevity Promotion: Multidisciplinary Perspectives; Healthy Longevity: Policies and Practices http://longevityhistory.com https://www.longevityhistory.com/about-the-author/ 00:00 Welcome and Guest Intro 01:28 Staler Background and Mission 03:18 What the ILA Does 04:04 Key Wins and Campaigns 05:25 Public Misconceptions 07:27 Getting Governments to Act 09:14 Funding Research Long Term 10:49 Education and Conferences 12:05 Which Countries Lead 15:22 Why Advocacy Beats Solo Science 17:38 Advocacy Success Stories 20:48 Breaking Longevity Silos 21:23 Holism vs Reductionism 22:28 Why History Matters 24:17 Death Valley of Ideas 25:49 Rejuvenation Patterns Repeat 27:42 Misunderstood Longevity History 29:22 Balance and Modesty 31:23 Measuring Real Success 34:59 Making Longevity Policy 36:09 Rapid Fire Takeaways 38:58 Final Wrap Up

    40 min

  6. 16 MARS

    AI, Biomarkers and the Future of Longevity Medicine, with Elio Verhoef, Co-Founder of LongevAI

    In this episode, Daphna sits down with Elio, co-founder of LongevAI, a platform using artificial intelligence to help longevity clinics analyse biomarker data, streamline documentation, and build personalised client plans. With a background in computer science and a lifelong passion for health optimisation, Elio offers a grounded, honest perspective on what AI in longevity medicine can do today, and where the limits still lie. ______________ What We Cover • How LongevAI was founded and what problem it solves for longevity clinics • What it means to automate clinical documentation without removing the clinician from the process • How AI interprets biomarker data, and why speed and accuracy both play a role • The hallucination problem: what it is, why it happens, and how it is being managed • Data privacy, GDPR compliance, and anonymisation in clinical AI tools • The importance of human oversight, why the clinician must always approve before anything reaches the client • How AI and clinicians can learn from each other in a feedback loop • Wearable integration and the role of continuous vs snapshot data • Where AI in longevity is heading in two to five years, including gene therapy modelling and whole-cell simulation • Why younger people are beginning to engage with longevity, and what still holds them back About the Guest Elio is the co-founder of LongevAI, a software platform built for longevity clinics. He holds a double bachelor's degree in Computer Science and Information Science, and has been focused on health optimisation and AI since his teens. He co-founded LongevAI in December 2024 alongside Cosmina Druica, whom he met through a longevity meetup community in the Netherlands. 🔗 longevai.com Enjoyed this episode? Please subscribe, leave a review on Apple Podcasts or Spotify, and share with anyone curious about the future of longevity medicine. Beyond Longevity is hosted by Daphna Stern · beyond-longevity.co.uk In this episode: 00:00 Welcome and Guest Intro 01:52 Elio Background and Origins 04:01 What Lev AI Does 05:06 Automating Clinic Workflows 07:52 Speed vs Accuracy 11:45 Oversight and Patient Trust 12:57 Privacy and GDPR Security 13:56 How the Model Improves 15:06 Limits Data and Hallucinations 21:37 Training and Integrations 23:45 Personal Biomarker Walkthrough 28:34 Explaining LLMs to non-tech people 33:38 Future of AI and Longevity 35:32 Young People and Longevity 39:56 Rapid Fire Questions 43:45 Wrap Up and Key Takeaways

    45 min

  7. 9 MARS

    Why Do We Age? Dr Bradley Elliott on Biomarkers, Muscle, and What Longevity Science Still Doesn’t Know

    Dr Bradley Elliott — physiologist, university lecturer, and a trustee and Communications Lead at the British Society for Research on Ageing — joins host Daphna for a refreshingly honest conversation about what longevity science actually knows and what we still cannot explain. This episode cuts through the certainty. We talk about biomarkers and biological age, why many measurements may be tracking effects rather than causes, we discuss extracellular vesicles and the surprising limit of science. Dr Bradley discusses some of his papers and related research, and our conversation challenges much of the conventional wisdom in the longevity space. What we cover: -Why we still do not know what fundamentally causes ageing — and why every “root cause” often leads to something deeper -What biomarkers really measure, what they can and cannot tell you, and which markers are most worth tracking right now -Biological age vs chronological age: where the concept is useful, and where it gets overclaimed -Why muscle is one of the most underrated “health organs” in ageing — and what it supports beyond strength -Exercise for longevity: the evidence-based basics, plus what matters most for consistency and adherence -“It is not too late”: what studies in very old adults suggest about strength gains later in life -Extracellular vesicles: the hidden communication system between cells, and why it is getting so much attention -Wearables: why they can still be useful even when the numbers are not perfectly accurate This is a fascinating episode with someone who knows how to communicate science and make it relatable Links to Dr Bradley Elliot: - https://www.westminster.ac.uk/about-us/our-people/directory/elliott-bradley - https://bsra.org.uk/bradley-elliott-2/ - https://www.bradelliott.online/ Papers & Research Referenced• Perri et al. (2025) — Delphi review identifying 14 biomarkers of ageing for use in human research (co-authored by Dr Elliott) ' https://pubmed.ncbi.nlm.nih.gov/39708300/ • Lady V Barrios-Silva et al. — Activin subfamily peptides and prediction of age and physical function (undergraduate-led research, University of Westminster) https://pubmed.ncbi.nlm.nih.gov/30178598/ • Dr Yvoni Kyriakidou (PhD) — Exercise-induced muscle damage in young and old men; extracellular vesicle characterisation post-exercise https://pubmed.ncbi.nlm.nih.gov/34650440/ • Dr Niharika Duggal (University of Birmingham) — Masters athletes and immune function; older athletes vs. age-matched non-athletes https://pubmed.ncbi.nlm.nih.gov/29517845/ • Stephen Harridge (King's College London) — Resistance training in 90+ year olds; gains in muscle strength and mass in the oldest old https://pubmed.ncbi.nlm.nih.gov/10398199/ • Science paper on genetic contribution to longevity — updated estimate shifting genetic contribution to ~50% (noted with editorial by Dr Elliott) https://www.science.org/doi/10.1126/science.adz1187 https://theconversation.com/what-new-twins-study-reveals-about-genes-environment-and-longevity-274763 https://www.ukbiobank.ac.uk/ If you enjoyed this episode, we'd love it if you took 60 seconds to leave us a review on Apple Podcasts or Spotify. It genuinely helps more people find the show and means we can keep bringing you honest, science-backed conversations like this one. Thank you https://beyond-longevity.co.uk/ Chapters: 00:00 Why We Age 01:52 Meet Bradley Elliot 03:07 From Sports Science 05:32 Defining Ageing 07:03 Mechanisms And Theories 09:29 Biomarkers Explained 13:02 Delphi Biomarker List 16:59 Myostatin Study Story 21:25 Actionable Biomarkers 26:07 Wearables And Accuracy 27:38 Endocrine Fingerprints 30:11 Muscle And Healthy Ageing 33:21 Athletes And Immunity 34:26 Muscle Mass And Healthspan 36:36 Exercise Dose Guidelines 39:42 Resistance Training Plateau 40:42 Lifestyle Versus Genetics 42:42 Muscle Damage Study 44:44 Extracellular Vesicles Explained 46:49 Young Blood Controversy 50:08 Dream Research With Omics 56:55 What People Misjudge 58:43 It’s Never Too Late 01:02:41 Rapid Fire And Wrap 01:04:31 Final Takeaways

    1 h 6 min

  8. 2 MARS

    Dr Brendan Khong on Inflammaging, Regenerative Aesthetics and Skin Health

    In this episode, I sit down with Dr Brendan Khong, a London-based aesthetic physician and regenerative medicine advocate, for a practical conversation about what it really means to age well, starting with the skin, but quickly expanding into whole-body biology. The central theme is a shift now reshaping aesthetic medicine: moving away from surface-level fixes and toward addressing the underlying drivers of visible ageing. A key driver, Dr Brendan explains, is inflammaging, a chronic, low-grade inflammation that builds over time and accelerates both skin ageing and broader physiological decline. He breaks down why some conventional aesthetic approaches can backfire, particularly repeated high-heat energy treatments, which may contribute to fibrosis, uneven pigmentation, and a dull, “waxy” skin texture over time. His approach favours smarter, gentler interventions, including an anti-inflammatory 1064nm Nd:YAG laser, targeted resurfacing that can be safer across a wider range of skin types, and calming injectables such as Meso-Wharton (a peptide product derived from Wharton’s jelly) used in practice to support skin quality, texture and fine lines. But this is not just a conversation about devices and injectables. Dr Brendan argues that better results start with better assessment and the need to factor in gut health, supplement use, stress load, and cortisol patterns before reaching for a needle or a laser. He is also candid about timelines: collagen remodelling takes time, and unrealistic expectations are one of the biggest problems in aesthetics. For day-to-day longevity habits that support skin health, he highlights fundamentals that are often overlooked: exercise, stress management, avoiding very hot showers, and finding a retinoid your skin can consistently tolerate. Dr Brendan Khong | London's Most Sought-after Aesthetic Doctor Dr Brendan Khong (@drbrendankhong) • Instagram profile 00:00 Welcome and Guest Intro 02:06 Brandon’s Medical Journey 03:36 Skin as an Inflammation Mirror 07:19 Supplements and Gut Health 10:15 Overtreatment and Inflammaging 14:47 Anti-Inflammatory Laser Approach 17:39 Regenerative Injectables Peptides 21:36 Personalised Protocols and Expectations 25:18 Why Glanine Stands Out 25:57 Microspheres Not Clumps 26:55 Anti-Inflammatory Collagen 27:47 Safety Profile Focus 28:45 Building Patient Protocols 30:25 Longevity Over Quick Fixes 32:17 Future Of Aesthetics 33:41 Gentler Treatment Philosophy 34:49 Quantum Magnetic Resonance 36:18 Healthy Beauty Trends 37:25 Daily Longevity Skin Tips 40:10 Rapid Fire Longevity Qs 45:14 Final Takeaways And Wrap

    47 min
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Beyond Longevity is a deep-dive podcast exploring the cutting edge of longevity science. Through conversations with leading researchers, clinicians, and innovators who are redefining health and longevity, the show unpacks the evidence behind living longer and healthier. Each episode translates complex research into clear, thoughtful discussions, decoding the future of ageing one conversation at a time.

Informations

  • Création
    Daphna Stern
  • Années d’activité
    2 k
  • Épisodes
    13
  • Classification
    Tous publics
  • Copyright
    © Copyright 2026 Daphna Stern
  • Site web de l’émission
    Beyond Longevity

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