Genetics

Oxford University

We are all products of our genes, and Genetics is a major focus of NDM research. Our podcasts on genetics look at a variety of projects, including the study of some common and less-common inherited afflictions, as well as the effects our genes can have on disease susceptibility and the efficacy of treatment. Moreover, NDM researchers lead in studying the genetic variation within and between human populations, to understand the similarities and differences between us all.

  1. 2016/11/30 · 影片

    Gastrointestinal cancers

    Dr Claire Palles studies whole genome sequencing data and targeted analyses with the aim of discovering genetic variants that affect susceptibility to colorectal cancer and Barrett’s oesophagus. The gastrointestinal track is responsible for more cancers than any other system. A condition called Barrett's oesophagus, characterised by a change in the cells lining the oesophagus, can lead to oesophageal adenocarcinoma. Only few people with Barrett's oesophagus will go on to develop cancer, and genome sequencing studies aim to identify genetic risk factors and therefore better target high-risk patients.

    5 分鐘

  2. 2016/02/04 · 影片

    Rare neurological disorders

    Chorea-Acanthocytosis: ChAc is a rare progressive neurological disorder caused by mutations in a very complex gene. Dr Antonio Velayos-Baeza is interested in two main projects: Chorea-acanthocytosis (ChAc), a rare autosomal-recessive disorder that is characterised by progressive neurodegeneration and red cell acanthocytosis (spiky red blood cells), and Developmental dyslexia, the most common of the childhood learning disorders.

    9 分鐘

  3. 2016/01/07 · 影片

    Computation and genetics

    Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the right drug. BIOINFORMATICS & PATHOGEN GENOMICS Dr Zamin Iqbal studies the DNA of bacteria and parasites, and compares the genomes of individual pathogens to track the spread of antibiotic resistance. Pathogens accumulate small genetic changes over time, and by tracking these changes, it is possible to map the spread of an infection. This enables better surveillance of pathogen evolution, within a host, within a hospital and across the world.

    4 分鐘

  4. 2015/12/02 · 影片

    The Evolution of the Genome

    Computational and stastistical methods help us understand evolution as well as genetic disease. Professor Gerton Lunter is interested in investigating the processes of evolution and biology using computational methods. His focus is on sequencing data; Professor Lunter develops methods to investigate evolutionary questions in population genetics.

    6 分鐘

  5. 2014/12/10 · 影片

    DNA replication and Cancer

    DNA replication and Cancer The process of DNA replication is complex, and mistakes can lead to genome instability. Surveillance systems are not always successful which results in mutations that have the potential to inactivate genes or change their activity. This can lead to cancer, and many chemotherapeutic drugs are designed to disrupt DNA replication. A better understanding of these mechanisms can help us develop new drugs with reduced side effects.

    7 分鐘

  6. 2014/12/10 · 影片

    Big Data

    Over the past decade, data-driven science has produced enormous sets of data. The convergence of statistics and computer science, in the field known as machine learning, provide the means to understand these large datasets. Ultimately, machine learning algorithms will be develop into clinical decision making support systems.

    6 分鐘

  7. 2013/07/09 · 影片

    Human Genetics

    Professor Peter Donnelly tells us how genetics helps us to understand common diseases and develop new drugs. Understanding which variations in our DNA affect susceptibility to diseases can provide new insights into the disease process and lead to new treatments. Professor Peter Donnelly leads large collaborative human genetic studies, and his group develops and applies statistical methods to extract maximal information from the large datasets generated by genomic studies.

    6 分鐘

  8. 2013/05/21 · 影片

    Psychiatric Genetics

    Every psychiatric disorder has a genetic contribution. Although anxiety and depression are very common diseases, current treatments are not very good. A better understanding of the contribution of genetic variants might help us better diagnose as well as develop new therapies.

    4 分鐘
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簡介

We are all products of our genes, and Genetics is a major focus of NDM research. Our podcasts on genetics look at a variety of projects, including the study of some common and less-common inherited afflictions, as well as the effects our genes can have on disease susceptibility and the efficacy of treatment. Moreover, NDM researchers lead in studying the genetic variation within and between human populations, to understand the similarities and differences between us all.

資訊

  • 創作者
    Oxford University
  • 活躍年代
    2013年 - 2016年
  • 集數
    15
  • 年齡分級
    兒少適宜
  • 版權
    © Oxford University
  • 節目網站
    Genetics

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