Each month, join Kashef Qaadri, a biologist turned bioinformatician, as he interviews guests exploring real-world research informatics challenges through use-cases, providing insights and strategies for integrating and analyzing complex data that are driving BioPharma R&D.
Episode 15: Optimizing Drug Target Identification through Artificial Intelligence
Traditionally, drug targets are found by scouring scientific publications for insights into molecular pathways or known causative genetic variants, linked to disease. The failure rate of drug candidates in the clinic, even in relatively late-stage clinical trials, is quite high and is extremely costly. Fundamentally, finding better targets will lead to development of better medicines. In this episode, we discuss how artificial intelligence (AI) and the increasing availability of complex biological datasets can be leveraged to identify molecular targets. Machine learning models trained on large amounts of data allow researchers to differentiate between states or conditions more specifically to predict disease-relevant targets.Guest: Avantika Lal, PhD, Senior Genomic Data Scientist, insitroCopyright © 2022 Bio-Rad Laboratories, Inc.All rights reserved.
Episode 14: The Rise of Digital Therapeutics
Digital therapeutics are software-driven, evidence-based products used to prevent, manage, or treat a medical disease or disorder. Digital therapeutics enable patients to be more aware of and play a more active role in managing their health and can improve access for patients for whom visiting a clinician is challenging. This significantly improves health outcomes and reduces healthcare demands as compared to more traditional interventions alone. Digital therapeutics are expected to grow dramatically over the next few years, but significant challenges around regulation and adoption remain. Listen in as we discuss the current state of the industry and where this technology may take us in the future.Guest: Emily Lewis, MS, CCRP, Global Digital Transformation Lead, Neurology, UCBCopyright © 2022 Bio-Rad Laboratories, Inc. All rights reserved
Episode 13: The Realities of Personalized Medicine
Personalized medicine is critical to the future of our healthcare and wellness. Using vast sets of clinical, genomic, proteomic, and other patient data, potentially lifechanging treatments can be discovered and delivered to patients. However, implementation of personalized medicine faces unique challenges, partly because it is focused on individuals, each with their own unique genetics and history, whereas clinical trials tend to average across populations. What changes are needed for personalized medicine to truly become a reality? In this episode, we discuss some of the biggest obstacles and what is needed to catalyze advances in personalized medicine.Guest: Rong Chen, PhD, Assistant Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount SinaiCopyright © 2022 Bio-Rad Laboratories, Inc. All rights reserved.
Episode 12: The Future of Data Management
High-throughput technologies have triggered a surge in scientific data generation and consumption, but managing these volumes of data is challenging. Listen as we discuss data fabric, an emerging solution that connects data sources in one environment.
Episode 11: The Synthetic Biology Revolution
Synthetic biology is the design, testing, and construction of new, standardized biological parts and devices, and programming them to do something productive. Significant medical breakthroughs are already happening as a result of advances in synthetic biology. From antiviral treatment and immune cell engineering to biomonitoring, the applications of synthetic biology are endless, creating new opportunities for innovative informatics. In this episode, we discuss revolutionary applications of synthetic biology in biopharma.
Guest: Mark Charbonneau, PhD, Director and Head of Quantitative Biology, Synlogic
Episode 10: Next-Generation Therapeutic Antibody Discovery
Over the past three decades, since the first monoclonal antibody was approved for clinical use in the U.S., antibody techniques and technologies have advanced radically. However, the supporting informatics have evolved at a much slower pace. There are significant informatic challenges throughout the research process, from concept to regulatory submission. How can a holistic informatics strategy support gaining clearer insights into scientific operations, make smarter decisions about their campaigns, and ultimately bring therapeutics to the clinic faster?
Guest: Colby Souders, PhD, Chief Scientific Officer, Abveris
Informative. Interesting. Engaging.
Great podcast. Brilliant topics. Thank you!
Engaging and riveting, one of a kind podcast. A must listen, don’t miss out.
Best podcast out there