CannMed Coffee Talk

Medicinal Genomics
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Conversations with the leading minds in cannabis science, medicine, cultivation, and safety testing.

  1. The National Cannabis Study with Ryan Vandrey, PhD & Johannes Thrul, PhD

    12/03/2025

    The National Cannabis Study with Ryan Vandrey, PhD & Johannes Thrul, PhD

    Dr. Ryan Vandrey is a professor of Psychiatry and Behavioral Sciences at Johns Hopkins. Dr. Johannes Thrul is an Associate Professor at Johns Hopkins. They both work for the Cannabis Health & Research Initiative, which is a collaboration between two organizations with years of experience in medicinal cannabis research: Johns Hopkins University and Realm of Caring. Simply put, CHRI is a platform of data collection and dissemination focused on the health outcomes of medicinal cannabis at the patient level, and they have created a number of valuable resources to help cannabis medicine researchers, including: A data repository that contains de-identified data collected through CHRI Research Library that contains more than 3000 published scientific articles related to the health effects of cannabis A set of validated questionnares that clinicians can use when speaking to patients about cannabis – and more The CHRI is also currently recruiting participants for their National Cannabis Study, which is a collection of firsthand experiences with medicinal cannabis among individuals with various health conditions. Specifically, they are looking for participants who plan to use cannabis but have not yet started cannabis use. So if that’s you or someone you know, we highly suggest you consider participating in the study because the research has the potential to impact best practices in healthcare and the cannabis industry. During our conversation, Ryan and Johannes shared more details about the CHRI and the National Cannabis Study, and I think you will agree that their mission aligns perfectly with the CannMed Community. Thanks to This Episode’s Sponsor: Realm of Caring Founded in 2013, Realm of Caring (RoC) serves anyone in need of more information about cannabinoid therapies. Through revolutionary CBD and Cannabis research, innovative education, and life-changing grants, RoC seeks to facilitate and encourage the mainstream acceptance of transformative, plant powered therapies to benefit individuals and families and serve healthcare providers as well as the hemp and cannabis industries. Learn more at realmofcaring.org Additional Resources Cannabis Health Research Initiative website – cannabisandhealth.org

  2. Analyzing California’s Medical Cannabis Patients with Bonni Goldstein, MD

    11/19/2025

    Analyzing California’s Medical Cannabis Patients with Bonni Goldstein, MD

    Dr. Bonni Goldstein is the Medical Director of Canna-Centers Wellness & Education, a leading cannabis medicine specialty practice, and the CEO of GoldsteinWellness.com, an educational platform dedicated to helping licensed healthcare professionals incorporate medical cannabis into their practices. Bonni has evaluated thousands of patients for medical cannabis treatment, with a special focus on treating children with intractable epilepsy, autism, and cancer. She authored the book Cannabis is Medicine: How Medical Cannabis and CBD are Healing Everything from Anxiety to Chronic Pain, and serves on the board of the International Alliance for Cannabinoid Medicine and Autism Safe Haven. Bonni has also been the medical director for the CannMed Medical Practicum since 2022. During our conversation, we discussed: Exciting updates to the CannMed Medical Practicum, including new topics (sports and recovery, cannabinoids and pregnacy, Pharmacokinetics and Product Formulation, and more) Findings from a California medical cannabis study showing diverse patients, high efficacy, and research gaps The importance of medical guidance when using cannabinoid therapies for complex conditions Safety issues with synthetic or semi-synthetic cannabinoids, and the importance of natural compounds and dosing education Goldstein Wellness as a resource for clinicians and patients, providing education, patient-clinician connections, and vetted product access Thanks to This Episode’s Sponsor: The Society of Cannabis Clinicians  The Society of Cannabis Clinicians is a nonprofit professional association of physicians and other healthcare providers. It provides continuing education—for clinicians, patients, and all concerned about the medical use of cannabis and best practices in clinical care. SCC physicians have been monitoring cannabis use by patients for 20 years and have compiled a wealth of clinical evidence and treatment strategies that will be validated by clinical trials in the years ahead. To learn more about SCC and to join visit cannabisclinicians.org. Additional Resources GoldsteinWellness.com CannMed Medical Practicum

  3. 11/13/2025

    CannMed Coffee Talk Returns Next Week

    No episode this week. We had to call a last-minute audible. You may have heard that the bill to restart the federal government contained language that would ban hemp products containing THC, which has sent the entire hemp industry, including many CannMed supporters and contributors into chaos. As a result, the guest we had scheduled for this week’s episode asked to reschedule, which we were happy to oblige. But don’t worry, we will be back with a new episode next week featuring the always wonderful Bonni Goldstein. She has some exciting details to share about the CannMed 26 Medical Practicum, which is going to feature tons of new topics. So please tune in for that one. In the meantime, I’d like to remind everyone that we are accepting abstracts for the CannMed 26 Summit through the end of the week. The deadline is this Saturday, November 15th. Submit at cannmedevents.com/apply If you have done any novel research in the areas of cannabis science, medicine, cultivation, or safety and testing, we encourage you to submit an abstract for consideration. If selected, not only will you have the opportunity to present your work to the industry leaders in attendance at CannMed 26, but a recording of the presentation will be added to the CannMed Archive and Medicinal Genomics YouTube page for additional exposure after the event. You will also get an invitation from me to appear on the CannMed Coffee Talk podcast, if that’s something you’re interested in. See you next week!

    2 min
  4. The Emerging Science of Cannabinoid Acids with Hemant Kumar Bid, PhD

    10/29/2025

    The Emerging Science of Cannabinoid Acids with Hemant Kumar Bid, PhD

    Dr. Hemant Kumar Bid is a top educator in the field of Biotechnology and Medical Cannabis, where he uses his extensive background in biotechnology research and cannabinoid research to educate cannabis and biotechnology professionals and infuse the industry with science-backed legitimacy. In addition to serving as a Program Director for the Morehouse School of Medicine and teaching graduate students, Hemant also serves as a Scientific Advisor for Essentia Scientific, a company that delivers an array of cannabinoid product solutions, including acidic cannabinoids, with their patented water-as-solvent extraction technology. During our conversation, we discuss:  What are cannabinoid acids and how do they differ from the neutral cannabinoids  Why have cannabinoid acids been traditionally overlooked in research and consumer products  How THCA produces different effects than THC  Why CBDA is more bioavailable and more potent than CBD  How new extraction and stabilization techniques are helping make cannabinoids acids more accessible  and more  Thanks to This Episode’s Sponsor: CANN Since 2015, CANN has been building a strong network of scientists in the cannabis space to promote scientific innovation, safety, and development through education, research, and the empowerment of the scientific community. To learn more about what CANN has to offer please visit their website at www.cann-acs.org. Additional Resources Essentia Scientific Website Email Hemant – Hibid@msm.edu Submit Your Abstract for CannMed 26 Meet the CannMed 26 Advisory Board

    57 min
  5. Potential Cannabinoid-Based Treatment for Endometriosis with Caitlyn Krebs

    10/15/2025

    Potential Cannabinoid-Based Treatment for Endometriosis with Caitlyn Krebs

    Caitlyn Krebs is a biotech executive with over 20 years of experience advancing therapeutics, diagnostics, and digital health innovations. She is the Co-Founder and CEO of Nalu Bio, where she leads the development of next-generation cannabinoid-inspired therapeutics with pharmaceutical-grade quality and scalability. Over her career, Caitlyn has completed more than 50 strategic partnerships and product launches across biopharma, diagnostics, and digital health. Nalu Bio recently announced positive results for a cannabinoid-based therapeutic for endometriosis, a condition that affects 200 million women worldwide. During our conversation, we discussed: Understanding Endometriosis – symptoms, diagnosis, and current treatment options How Millions of women with endometriosis are using CBD or THC to self-treat symptoms What makes the endocannabinoid system a prime target for for endometriosis How Nalu Bio uses an AI platform to accelerate the development of novel, consistent, and non-addictive cannabinoid molecules The potential for broader applications for cannabinoid-based therapeutics, similar to GLP-1 therapies The timeline for future clinical trials and potential FDA-approval Thanks to This Episode’s Sponsor: The Society of Cannabis Clinicians The Society of Cannabis Clinicians’ Med Cann conference offers a rare opportunity for clinicians to dive deep into the clinical realities and therapeutic potential of medical cannabis and psychedelics. Designed with healthcare providers in mind, their sessions focus on case-based learning, emerging protocols, and real-world challenges—offering practical insights that can be immediately applied in your practice. Learn more at cannabisclinicians.org and use code “CP15” to receive 15% Off Your Registration Additional Resources NaluBio.com Big Data Begins to Crack the Case of Endometriosis (UCSF) CannMed Call for Abstracts

    25 min
  6. Mapping Cannabis Diversity with the Pangenome – Todd Michael, PhD

    09/10/2025

    Mapping Cannabis Diversity with the Pangenome – Todd Michael, PhD

    Dr. Todd Michael is a leading researcher specializing in genome sequencing and analysis, currently serving as a Research Professor at the Salk Institute for Biological Studies and an Adjunct Professor at the University of California, San Diego.  His research has made significant contributions to understanding plant genome architecture, particularly through the study of unique and specialized plants that offer insights into adaptive strategies. His innovative work on pangenome tools and long-read sequencing technologies has advanced the understanding of how plant genomes are organized and how they adapt to specific environmental conditions. At CannMed 25, Todd presented “Cannabis Pangenome Exposes Minor Cannabinoid Pathway Potential”, which described how his team integrated 193 cannabis genomes to identify extensive genetic and structural diversity and highlight potential breeding bottlenecks. During our conversation, we discussed: What is a pangenome and why has it replaced single reference genomes Why cannabis is the most interesting plant genome Todd has worked with What has caused cannabis to be one of the world’s most diverse plants How transposable elements AKA “jumping genes” contribute to cannabinoid synthase The potential risks of excluding males plants from breeding and more Thanks to This Episode’s Sponsor: Advanced Nutrients Founded in 1999, Advanced Nutrients was the first to develop a complete nutrient system that unlocks the true genetic potential of the cannabis plant. Since its inception, the brand has introduced more than 50 innovations to the cultivation community and continues to revolutionize the space through proprietary scientific discoveries.  Learn more at AdvancedNutrients.com Additional Resources Michael Lab Website CannMed Video Archive CannMed 25 Photo Gallery

    49 min
  7. Recruitment Challenges for Cannabis Clinical Trials – Emily Lindley, PhD & Rachael Rzasa Lynn, MD

    08/20/2025

    Recruitment Challenges for Cannabis Clinical Trials – Emily Lindley, PhD & Rachael Rzasa Lynn, MD

    Dr. Emily Lindley is Assistant Professor of Orthopedics and Director of the Colorado Cannabis Research Consortium. Her team’s research aims to identify non-opioid alternatives for the treatment of chronic musculoskeletal pain. One such alternative that has gained increased recognition in recent years is medical cannabis, and her lab is currently studying the health effects of cannabis and cannabinoids for chronic musculoskeletal pain. Dr. Rachael Rzasa Lynn is a board certified in pain medicine physician and is an Associate Professor in the Department of Anesthesiology at the University of Colorado, where she is the Associate Program Director for the Pain Medicine Fellowship. Her research includes investigations in opioid pharmacology and the use of cannabis for chronic pain. Emily and Rachael co-authored a poster presented at the most recent ICRS conference titled, Recruitment Challenges in Clinical Studies of Cannabis During our conversation, we discussed: How recruitment for cannabis clinical trials differs from traditional clinical trials Why prior experience with cannabis is considered a negative for patient recruitment How legal concerns and stigma can deter cannabis-naive patients from enrolling Why the particiapnt drop out rate is higher in cannabis trials How rescheduling may affect patient recruitment future trials Thanks to This Episode’s Sponsor: The Society of Cannabis Clinicians The Society of Cannabis Clinicians’ Med Cann conference offers a rare opportunity for clinicians to dive deep into the clinical realities and therapeutic potential of medical cannabis and psychedelics. Designed with healthcare providers in mind, their sessions focus on case-based learning, emerging protocols, and real-world challenges—offering practical insights that can be immediately applied in your practice. Learn more at cannabisclinicians.org and use code “CP15” to receive 15% Off Your Registration Additional Resources Recruitment Challenges in Clinical Studies of Cannabis [Poster] Lindley Lab at the University of Colorado

    38 min
  8. Cannabis Crop Steering Techniques with Jose Leme, PhD

    07/23/2025

    Cannabis Crop Steering Techniques with Jose Leme, PhD

    Dr. Jose Lime is a Professor at Southern Illinois University and the principal investigator in the Cannabis Biology and Cultivation Systems lab. He and his team focus on determining how to leverage environmental controls (light intensity, duration, quality, temperature, and CO2), plant nutrition, biostimulants, and hormones to improve plant production. Moreover, the research group is developing techniques to optimize plant yields and quality based on key crop steering traits that increase sustainability and efficiency via plant physiological, biochemical, and agricultural approaches. During our conversation, we discussed several recent studies that Jose and his team have published, including: Using mechanical stimulation and high stress training to increase production of secondary metabolites Applying plant hormones to increase trichome density Assessing how drought stress affects plant yield and potency Standardizing cloning methods for plant propagation Developing standards for measuring trichome density Thanks to This Episode’s Sponsor: Advanced Nutrients Founded in 1999, Advanced Nutrients was the first to develop a complete nutrient system that unlocks the true genetic potential of the cannabis plant. Since its inception, the brand has introduced more than 50 innovations to the cultivation community and continues to revolutionize the space through proprietary scientific discoveries.  Learn more at AdvancedNutrients.com Additional Resources DrLeme.com Methyl Jasmonate and Ammonium Bicarbonate: Distinct and Synergistic Impacts on Indoor Cannabis Production Dynamics The Role of Jasmonates in Modulating Growth, Trichome Density, and Cannabinoid Accumulation in Cannabis sativa L. The Effects of Water-Deficit Stress on Cannabis sativa L. Development and Production of Secondary Metabolites: A Review From Bracts to Buds: Developing Reliable Methods for Trichome Density Assessment in Cannabis sativa L. Accumulation of Trigonelline in the Leaves of Cannabis sativa L. in Response to Water-Deficit Stress Implementation of a Standardized Cloning and Propagation Protocol for Optimizing Cannabis sativa L. Cultivation

    55 min
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About

Conversations with the leading minds in cannabis science, medicine, cultivation, and safety testing.

Information

  • Creator
    Medicinal Genomics
  • Years Active
    2020 - 2025
  • Episodes
    136
  • Rating
    Clean
  • Show Website
    CannMed Coffee Talk

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