Episode 4 of the monthly podcast CellOut, where your favorite pair of biology nerds, Derek DeVries and Ford Fishman, summarize and discuss a sample of articles from the April 2022 issue of PLoS biology. Issue Link: https://journals.plos.org/plosbiology/issue?id=10.1371/issue.pbio.v20.i04 Keywords: biology, life science, open access, scientific journals, science, PLoS, transmissible vaccines, evolution SHOW NOTES Podcast Art - Credit Caroline DeVries Episode Cover Art - April 2022 PLoS Biology Cover. Image Credit: Muthugapatti Kandasamy, Adam Sateriale, and Boris Striepen Cutting Edge (0:57) Cheng L, Mishra H (2022) Why did only one genus of insects, Halobates, take to the high seas? PLoS Biol 20(4): e3001570. https://doi.org/10.1371/journal.pbio.3001570 Jargon Jungle (11:12) Thanks to Josh for coming on the show! You can find him on twitter @PippettuaJones Reply the Episode 4 announcement by @CellOutPodcast with the keyword "Macrolide" if you want to prove you can handle the Jargon Jungle next episode! Journal Club (20:15) Griffiths ME, Broos A, Bergner LM, Meza DK, Suarez NM, da Silva Filipe A, et al. (2022) Longitudinal deep sequencing informs vector selection and future deployment strategies for transmissible vaccines. PLoS Biol 20(4): e3001580. https://doi.org/10.1371/journal.pbio.3001580 Cell Culture (36:56) Elden Ring - https://en.bandainamcoent.eu/elden-ring/elden-ring Benkarim O, Paquola C, Park B-y, Kebets V, Hong S-J, Vos de Wael R, et al. (2022) Population heterogeneity in clinical cohorts affects the predictive accuracy of brain imaging. PLoS Biol 20(4): e3001627. https://doi.org/10.1371/journal.pbio.3001627 Bite-Size Discoveries (42:21) Ciesielski HM, Nishida H, Takano T, Fukuhara A, Otani T, Ikegawa Y, et al. (2022) Erebosis, a new cell death mechanism during homeostatic turnover of gut enterocytes. PLoS Biol 20(4): e3001586. https://doi.org/10.1371/journal.pbio.3001586 Derosiere G, Thura D, Cisek P, Duque J (2022) Hasty sensorimotor decisions rely on an overlap of broad and selective changes in motor activity. PLoS Biol 20(4): e3001598. https://doi.org/10.1371/journal.pbio.3001598 Simonetti B, Guo Q, Giménez-Andrés M, Chen K-E, Moody ERR, Evans AJ, et al. (2022) SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling. PLoS Biol 20(4): e3001601. https://doi.org/10.1371/journal.pbio.3001601 English ED, Guérin A, Tandel J, Striepen B (2022) Live imaging of the Cryptosporidium parvum life cycle reveals direct development of male and female gametes from type I meronts. PLoS Biol 20(4): e3001604. https://doi.org/10.1371/journal.pbio.3001604