CReATe Podcast

CReATe Consortium
  • 5.0(4개의 평가)
  • 건강 및 피트니스
  • 매월 업데이트

CReATe Connect podcasts are short recorded interviews on topics we hope will be of interest to patients with ALS and other motor neuron diseases.

  1. 7월 1일

    CReATe Author Series Ep. 19 - Dr. Paul Lingor on Fasudil as a Potential Therapeutic for ALS

    Paul Lingor, MD, is Professor for Neurology, Group Leader and Head of the Outpatient Clinics for Motoneuron Disorders and Co-head of the Outpatient Clinics for Movement Disorders and at the Department of Neurology of the TUM Klinikum Rechts der Isar in Munich, Germany.  Here he discusses the recent publication "Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial."

    41분

  2. 6월 3일

    ALS Untangled Series Ep. 66 - PoNS

    Portable Neuromodulation Stimulator (PoNS) is a type of electrical stimulation that can theoretically increase rewiring in the brain (neuroplasticity).  Small trials suggest that it can improve walking in MS but thus far there are no data in people living with ALS.  Here we further discuss the mechanism, studies in other conditions, and potential risks.

    10분

  3. 5월 15일

    ALS Untangled Series Ep. 65 - ISRIB

    ISRIB stands for “integrated stress response inhibitor).  As we discuss here, it is an oral medication that inhibits an intracellular pathway called the integrative stress response pathway.  It is not FDA approved for any condition but is available in Spain without a prescription.  There are theoretical ways that inhibiting this pathway could help a person with ALS, and there is promising data from preclinical ALS models.  However, it is not clear that ISRIB is soluble enough to get into motor neurons in the brain and spinal cord, and 2 of 3 trials of agents targeting the same pathway failed to show any benefits in people with ALS.  The risks of this product in ALS are not known.

    11분

  4. 4월 9일

    CReATe Author Series Ep. 18 - Dr. Michael Benatar on MMI as a prodromal stage of ALS

    Dr. Michael Benatar is a Professor of Neurology and Chief of the Neuromuscular Division and Executive Director of the ALS Center at the University of Miami. Here he discusses the recent publication “Proposed Research Criteria for Mild Motor Impairment as a Prodromal Syndrome in Amyotrophic Lateral Sclerosis."

    31분

  5. 1월 8일

    CReATe Author Series Ep. 17 - (AI generated) Podcast on C9orf72 Disease Prevention Trials

    Here we have a podcast produced by artificial intelligence discussing the recent publication “Design considerations for C9orf72 disease prevention trials”.

    26분

  6. 2025. 12. 10.

    ALS Untangled Series Ep. 64 - Wahls Protocol

    The Wahls Protocol is a diet that may reduce inflammation, oxidative stress, and mitochondrial dysfunction.  Although these are plausible mechanisms for slowing ALS progression, we discuss the fact that there are no actual data to support this hypothesis, and there are risks which are especially important to consider in people living with ALS.

    17분

  7. 2025. 11. 17.

    ALS Untangled Series Ep. 63 - Psilocybin

    Psilocybin is a psychedelic chemical derived from mushrooms.  It is under study for mood problems in people with ALS.  Here we review its plausible mechanisms for slowing ALS progression.  But there are no data from preclinical models, trials or case reports that currently support this benefit.  And there can be serious risks to using this chemical.

    10분

  8. 2025. 10. 20.

    ALS Untangled Series Ep. 62 - Ashwagandha

    Here we review ashwagandha a nutritional supplement that has plausible mechanisms for slowing ALS, promising pre-clinical evidence, and a reasonable safety profile.  There is one person with ALS who experienced a reversal of symptoms on a cocktail of treatments that included ashwagandha.  Cases like this are difficult to interpret as there can be multiple explanations for a person experiencing an ALS reversal.  We have not found any other cases suggesting improvement on this product.  We hope to see the data from the completed phase 2 trial soon.

    17분
모두 보기(86개)

평가 및 리뷰

5
최고 5점
4개의 평가

소개

CReATe Connect podcasts are short recorded interviews on topics we hope will be of interest to patients with ALS and other motor neuron diseases.

정보

  • 제작진
    CReATe Consortium
  • 방송 연도
    2018년 - 2026년
  • 에피소드
    86
  • 등급
    전체 연령 사용가
  • 저작권
    © Copyright CReATe Consortium
  • 웹사이트 보기
    CReATe Podcast