Decoding Longevity

Raghav Sehgal
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A podcast dedicated to unraveling the mysteries of aging through the lens of cutting-edge science. Each episode breaks down the latest research papers in the field of geroscience, offering clear, insightful discussions on longevity, biological aging, and the quest for extending healthspan. Perfect for scientists, enthusiasts, and anyone curious about the science behind living longer and healthier lives.

  1. Redesigning Aging: Ethics, Economics, and the Narrative of Longevity — A Conversation with Raiany Romanni-Klein, Ph.D.

    29 ABR

    Redesigning Aging: Ethics, Economics, and the Narrative of Longevity — A Conversation with Raiany Romanni-Klein, Ph.D.

    What if the biggest barrier to healthy longevity isn’t scientific—but philosophical, economic, and ethical? In this episode of Decoding Longevity, Raghav Sehgal and Macsue Jacques are joined by Dr. Raiany Romanni-Klein to explore how our beliefs about aging, death, and human value shape the future of longevity science. From the idea that “natural is good” to the economic incentives holding the field back, this conversation challenges how we think about aging—and what it will take to change it. 🔗 Resources & Links: Silver Linings : https://silverlinings.bio/Raiany’s TEDx Talk: https://www.youtube.com/watch?v=kB1IFGYaYXo

    20 min
  2. The First Cellular Rejuvenation Therapy in Clinical Trials with Michael Ringel, Ph.D., J.D.

    15 ABR

    The First Cellular Rejuvenation Therapy in Clinical Trials with Michael Ringel, Ph.D., J.D.

    Aging might not be inevitable. In this episode of Decoding Longevity, Dr. Michael Ringel (COO, Life Biosciences) explains how scientists are learning to “reset” the biological age of cells—without changing what they are. From reversing vision loss in preclinical models to launching one of the first human trials, this conversation explores a future where we don’t just treat diseases of aging—we target aging itself. 🔗 Show notes: Life Biosciences: https://www.lifebiosciences.com/ Clinical pipeline: https://www.lifebiosciences.com/pipeline/ Michael Ringel talks: https://www.youtube.com/watch?v=XC31N9KbOEs / https://www.youtube.com/watch?v=OycGR-03S8A / https://www.youtube.com/watch?v=EZUBjXv5wIw

    28 min
  3. Mobility, Metabolism, and Resilience: Translating Geroscience into Function — A Conversation with Steve Kritchevsky

    1 ABR

    Mobility, Metabolism, and Resilience: Translating Geroscience into Function — A Conversation with Steve Kritchevsky

    What if aging isn’t defined by disease — but by how much function we preserve over time? In this episode of Decoding Longevity, Raghav Sehgal and Macsue Jacques sit down with Stephen Kritchevsky to explore how mobility, metabolism, and physiological resilience shape the aging process. From walking speed as a powerful integrative biomarker… to why muscle quality may matter more than muscle mass… to what long-term trials like Look AHEAD reveal about bending aging trajectories — this conversation reframes longevity around function, not just lifespan. We also dive into the trade-offs of weight loss in older adults, the connection between brain and physical aging, and what it will take to measure — and truly slow — aging in humans.

    45 min
  4. From Science to Strategy: How Policy Will Shape the Future of Longevity — A Conversation with Dylan Livingston

    18 MAR

    From Science to Strategy: How Policy Will Shape the Future of Longevity — A Conversation with Dylan Livingston

    What if the biggest barrier to extending healthy human lifespan isn’t the science — but policy? In this episode of Decoding Longevity, hosts Raghav Sehgal and Macsue Jacques speak with Dylan Livingston, founder of the Alliance for Longevity Initiatives. Together, they explore why public policy may be one of the most important — and overlooked — drivers of progress in longevity science. From building support for aging research funding to launching the Congressional Longevity Science Caucus and expanding access to investigational therapies, Dylan shares how advocacy and legislation could shape the future of preventative medicine and healthy aging. Learn more: Alliance for Longevity Initiatives (A4LI) → https://a4li.org/ LongeviPAC → https://www.longevipac.org/

    31 min
  5. Turning Biology of Aging into Medicines: A Conversation with James Peyer, Ph.D.

    5 MAR

    Turning Biology of Aging into Medicines: A Conversation with James Peyer, Ph.D.

    What if the future of medicine is preventing aging-related disease before it begins? In this episode of Decoding Longevity, Raghav Sehgal and Macsue Jacques speak with James Peyer, CEO of Cambrian Biopharma, about turning aging biology into real therapeutics. We explore exercise-mimetic drugs, metabolism reset therapies, mTOR inhibition, and the path to the first approved gerotherapeutics.

    39 min
  6. Inflammaging, the Immune System, and the Hidden Biology of Aging — A Conversation with Alan Landay, Ph.D.

    18 FEB

    Inflammaging, the Immune System, and the Hidden Biology of Aging — A Conversation with Alan Landay, Ph.D.

    In this episode of Decoding Longevity, host Raghav Sehgal and co-host Macsue Jacques explore one of the most powerful — and often overlooked — drivers of aging: the immune system. Joined by immunologist Alan Landay, the conversation uncovers how chronic inflammation — often described as inflammaging — shapes biological aging at the cellular level. Drawing on decades of HIV research, Dr. Landay explains how persistent immune activation, gut barrier dysfunction, and microbiome imbalance contribute to age-related diseases long before symptoms appear. The episode dives into: • Why aging is a biological process — not just the passage of time • How immune dysregulation accelerates cardiovascular and metabolic disease • The role of gut health and microbial metabolites in systemic inflammation • Biological aging clocks and emerging biomarkers • Promising interventions — from lifestyle strategies to immune-targeted therapies This conversation reframes aging as an immune-driven process and highlights how understanding inflammation may be key to extending healthspan.

    24 min
  7. Behind the Biotech Boom: Investing in the Age of Rejuvenation — A Conversation with Karl Pfleger, Ph.D

    4 FEB

    Behind the Biotech Boom: Investing in the Age of Rejuvenation — A Conversation with Karl Pfleger, Ph.D

    In this episode of Decoding Longevity, hosts Raghav Sehgal and Macsue Jacques are joined by Dr. Karl Pfleger — angel investor, longevity industry analyst, and creator of AgingBiotech.info. We explore the rapidly growing aging biotech ecosystem, including: Repairing aging vs. slowing aging Rejuvenation biotech and combination therapies Longevity investing, biomarkers, and regulation Why ecosystems matter in aging research A big-picture conversation on longevity science, rejuvenation, and the future of aging as a biological problem.

    29 min
  8. Cities, Communities and Clinics: The New Testbeds for Longevity Research — A Conversation with Tina Woods

    03/12/2025

    Cities, Communities and Clinics: The New Testbeds for Longevity Research — A Conversation with Tina Woods

    What if healthy longevity depends not only on your DNA, but on the city you live in, the air you breathe, and the communities you’re part of? In this episode, Raghav Sehgal and Macsue Jacques talk with Tina Woods — CEO of Collider Health and leading voice of the Human Exposome Project — about how environmental, social and lifestyle exposures shape aging. You’ll learn: What the human exposome is and why it drives most health outcomes How cities, neighborhoods & clinics can become “living labs” for aging research How exposome data links with methylation, inflammation & aging biomarkers Why future longevity breakthroughs rely on policy, environment & community design The role of trust, data governance & public engagement in healthy longevity 👇 Links Collider Health: https://www.colliderhealth.com/ Human Exposome Project paper: https://www.nature.com/articles/s41591-025-03519-8 🎙️ Hosts: Raghav Sehgal & Macsue Jacques Follow for more conversations on aging, healthspan & prevention.

    25 min
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A podcast dedicated to unraveling the mysteries of aging through the lens of cutting-edge science. Each episode breaks down the latest research papers in the field of geroscience, offering clear, insightful discussions on longevity, biological aging, and the quest for extending healthspan. Perfect for scientists, enthusiasts, and anyone curious about the science behind living longer and healthier lives.

Información

  • Creador
    Raghav Sehgal
  • Años de actividad
    2 k
  • Episodios
    25
  • Clasificación
    Apto
  • Copyright
    © Raghav Sehgal
  • Mostrar sitio web
    Decoding Longevity

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