Business Trip

Greg Kubin & Matias Serebrinsky
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Business Trip explores the frontiers of brain and mental health through conversations with founders, investors, and researchers at the intersection of neuroscience and technology.

  1. How Gilgamesh Landed a $1.2B AbbVie Deal in Psychedelics

    -5 ДН.

    How Gilgamesh Landed a $1.2B AbbVie Deal in Psychedelics

    Jonathan Sporn (CEO + Founder of Gilgamesh Pharma) joins for a deep dive into next-gen psychedelic medicines, why duration matters for real-world clinical use, and what it takes to build these therapies the way large pharma would—culminating in a partnership with AbbVie worth up to $1.2B. In this episode, we discuss:  • Why Gilgamesh is building psychedelic medicines the way large pharma would  • The thesis behind short-acting psychedelics and why long-duration trips are impractical for real-world psychiatry  • How Gilgamesh designs molecules backwards from clinical needs  • Effective approaches to the challenges of trial designs for psychedelics   • What AbbVie’s deal and Spravato’s trajectory mean for psychedelics  • How psychedelic medicines could reshape mental health Credits: Created by Greg Kubin and Matias Serebrinsky Host: Matias and Greg Produced by Nico V. Rey  Find us at businesstrip.fm and psymed.ventures Follow us on Instagram and Twitter! Theme music by Dorian Love Additional Music: Distant Daze by Zack Frank

    26 мин.
  2. Inside Philanthropy’s Role in Mental & Brain Health

    27 ЯНВ.

    Inside Philanthropy’s Role in Mental & Brain Health

    Greg speaks with three leaders in mental health philanthropy: Alyson Nieman from Mindful Philanthropy, Sabrina Gracias from Ortus Foundation, and Christena Huntsman Durham from Huntsman Mental Health Foundation, each offering a distinct perspective on how funding decisions get made and where the biggest gaps remain. In this episode we discuss: Trends in mental health philanthropy, and the 10-year challenge: how the field moves from roughly $2B to $35B in annual funding.Funding the clinic of the future: a $150M philanthropic gift behind the Huntsman Mental Health Institute’s crisis care centerYouth mental health: how the Ortus Foundation is addressing regional gaps in the US Intermountain WestCredits: Created by Greg Kubin and Matias Serebrinsky Host: Greg Kubin Produced by Caitlin Ner & Nico V. Rey  Find us at businesstrip.fm and psymed.ventures Follow us on Instagram and Twitter! Theme music by Dorian Love Additional Music: Distant Daze by Zack Frank

    42 мин.
  3. Rick Perry on paving the way for Ibogaine in America

    19.12.2025

    Rick Perry on paving the way for Ibogaine in America

    Greg interviews Rick Perry, the former Governor of Texas and former U.S. Secretary of Energy and leading advocate for ibogaine, live at the Real Summit. In this episode, we discuss: How a former Texas governor moved from strict opposition to drugs to becoming a leading advocate for ibogaine after firsthand experience and veteran outcomes.Ibogaine’s impact on PTSD, opioid addiction, and traumatic brain injury, including Stanford-linked brain imaging data showing functional and structural improvement.How veterans are the proving ground that enabled Texas to commit $50M in public funding for ibogaine clinical trials.Why ibogaine requires intensive medical supervision and why rigorous trials are essential for legitimacy and scale.A vision where ibogaine reshapes addiction treatment, veteran care, and eventually criminal justice and homelessness policy.Credits: Created by Greg Kubin and Matias Serebrinsky Host: Greg Kubin Produced by Caitlin Ner & Nico V. Rey  Find us at businesstrip.fm and psymed.ventures Follow us on Instagram and Twitter! Theme music by Dorian Love Additional Music: Distant Daze by Zack Frank

    40 мин.
  4. Brain Shuttles: A New Path Into the Brain with James Gorman of the Wyss Institute

    24.11.2025

    Brain Shuttles: A New Path Into the Brain with James Gorman of the Wyss Institute

    Matias interviews James (Jim) Gorman MD PhD from the Wyss Institute. Jim is Principal Investigator on the Wyss Institute Brain Targeting Program (BTP). Jim leads a team developing new approaches to transport drugs through the blood brain barrier (BBB) into the CNS. In this episode, we discuss: Why the BBB blocks most modern drugs from entering the brain, creating the biggest bottleneck in neuroHow brain shuttles hijack natural transport pathways like the transferrin receptor to move drugs across the BBBHow new modalities that reach the brain can potentially treat diseases like Alzheimer’s, Parkinson’s, ALS, and lysosomal disorders Why delivery route of shuttles enable IV or subcutaneous dosing instead of invasive intrathecal injectionsHow early data shows that shuttle-enabled antibodies clear amyloid faster, at lower doses, and with fewer side effectsHow the field is accelerating through a pre-competitive consortium model that lets multiple companies share shuttle platformsCredits: Created by Greg Kubin and Matias Serebrinsky Host: Matias Serebrinsky Produced by Caitlin Ner & Nico V. Rey  Find us at businesstrip.fm and psymed.ventures Follow us on Instagram and Twitter! Theme music by Dorian Love Additional Music: Distant Daze by Zack Frank

    49 мин.
  5. AI and the future of therapy with Luis Voloch of Jimini Health

    16.10.2025

    AI and the future of therapy with Luis Voloch of Jimini Health

    Greg and Matias interview Luis Voloch, CEO and Co-Founder of Jimini Health, an AI behavioral health company. He previously co-founded and served as CTO of Immunai, where he applied machine learning to immunology and drug discovery.  In this episode, we discuss:  How LLMs expand the scope of machine learning from rule-based tasks to open-ended reasoning and dialogueWhy healthcare adoption is tiered, beginning with clinician-facing AI scribes and moving toward patient-facing companies with human-in-the-loop to enhance quality of careWhy human oversight is essential and how AI can augment complex clinical work instead of replacing itThe competitive advantage from workflows, data, and trust via purpose built AI systemsThe path toward precision psychiatry, where continuous, language-based interactions can generate rich behavioral data to inform diagnostics, treatment, and drug discoveryCredits: Created by Greg Kubin and Matias Serebrinsky Host: Matias Serebrinsky Produced by Caitlin Ner & Nico V. Rey  Find us at businesstrip.fm and psymed.ventures Follow us on Instagram and Twitter! Theme music by Dorian Love Additional Music: Distant Daze by Zack Frank

    38 мин.
  6. Startups, philanthropy, billionaires, academia, neuromodulation, psychedelics, AI and new therapies in bipolar, autism, and Parkinson’s with Rob Malenka

    23.09.2025

    Startups, philanthropy, billionaires, academia, neuromodulation, psychedelics, AI and new therapies in bipolar, autism, and Parkinson’s with Rob Malenka

    Matias interviews Rob Malenka. In this episode, we discuss: Why progress in psychiatry is slow because the brain is the most complex organ and many disorders are highly heterogeneousThe bottlenecks including weak replicability in research, academic politics, perverse incentives, and pharma’s avoidance of neuropsychiatryHow breakthroughs require early detection, rigorous science, and bridging academia with biotech through venture philanthropyHow success depends on mission-driven, ethical people who align science, capital, and patient impact.The opportunities in neuromodulation, data-driven precision medicine, and combination therapies.Credits: Created by Greg Kubin and Matias Serebrinsky Host: Matias Serebrinsky Produced by Caitlin Ner & Nico V. Rey  Find us at businesstrip.fm and psymed.ventures Follow us on Instagram and Twitter! Theme music by Dorian Love Additional Music: Distant Daze by Zack Frank

    1 ч. 33 мин.
  7. Transforming Skin Cells into Neurons to Treat Alzheimer’s with Brendon Boot of Skin2Neuron

    21.08.2025

    Transforming Skin Cells into Neurons to Treat Alzheimer’s with Brendon Boot of Skin2Neuron

    Greg and Matias interview Brendon Boot of Skin2Neuron. Brendon is a neurologist at Harvard and Mayo Clinic with prior experience as Medical Director at Biogen overseeing their Phase 1b Alzheimer’s trials. In this episode, we discuss: How skin-derived cells can be turned into neurons to repair the brain.Why replacing lost neurons may succeed where drugs have failed in Alzheimer’s.What makes autologous (self-derived) cell therapy safer and more effective.How testing in dogs brought stronger proof than traditional mouse models.Why this approach could shift Alzheimer’s treatment from slowing decline to restoring memory.Credits: Created by Greg Kubin and Matias Serebrinsky Host: Matias Serebrinsky & Greg Kubin Produced by Caitlin Ner & Nico V. Rey  Find us at businesstrip.fm and psymed.ventures Follow us on Instagram and Twitter! Theme music by Dorian Love Additional Music: Distant Daze by Zack Frank

    54 мин.
  8. Mitochondria and the Future of Health with Natalie Yivgi-Ohana of Minovia

    22.07.2025

    Mitochondria and the Future of Health with Natalie Yivgi-Ohana of Minovia

    Greg and Matias interview Natalie Yivgi-Ohana of Minovia. Natalie is a life science entrepreneur with twenty years’ experience in mitochondrial research and received her PhD in Biochemistry at The Hebrew University in 2007, after which she performed her postdoctoral fellowship at the Weizmann Institute of Science until 2010.  In this episode, we discuss: How mitochondria impacts health by not just regulating energy, but also hormones, cell survival, and overall cellular functionWhy mitochondrial dysfunction is a root cause of many conditions, from rare genetic disorders to aging and mental health issues.What mitochondrial therapy does by restoring function and improving cellular healthWhat makes mitochondrial therapies distinct from gene therapiesHow to scale mitochondrial therapies for clinical adoptionCredits: Created by Greg Kubin and Matias Serebrinsky Host: Matias Serebrinsky & Greg Kubin Produced by Caitlin Ner & Nico V. Rey  Find us at businesstrip.fm and psymed.ventures Follow us on Instagram and Twitter! Theme music by Dorian Love Additional Music: Distant Daze by Zack Frank

    52 мин.
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Business Trip explores the frontiers of brain and mental health through conversations with founders, investors, and researchers at the intersection of neuroscience and technology.

Информация

  • Автор
    Greg Kubin & Matias Serebrinsky
  • Годы выхода
    2020 - 2026
  • Выпуски
    66
  • Ограничения
    Без ненормативной лексики
  • Авторские права
    © 2026 Business Trip
  • Сайт подкаста
    Business Trip

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