Cardio Pod: Heart of the Matter

Heart Failure Collaboratory
  • 5.0 (3)
  • MEDICINE

Introducing Heart of the Matter Cardio Pod. High-level conversations to foster conversation, collaboration, and communication around the ecosystem of cardiovascular research.

  1. Social Drivers of Health

    FEB 4

    Social Drivers of Health

    In this episode, Christopher O’Connor, MD, sits down with Melvin Echols, MD; JoAnn Lindenfeld, MD; Minnow Walsh, MD; and Wayne Batchelor, MD to explore the role of social drivers of health in heart failure clinical trials. This discussion stems from an initiative of the Heart Failure Collaboratory (HFC) that led to a publication in JACC: Heart Failure titled “Social Drivers of Health in Heart Failure Trials: An Analysis from the Heart Failure Collaboratory.

    26 min
  2. Best Practices for Site-Based Research (Part 2)

    JAN 14

    Best Practices for Site-Based Research (Part 2)

    This episode discusses further the challenges of site-based research. What goes into those barriers, obstacles, and opportunities to be a successful site-based researcher.

    24 min
  3. Models of Success in Site-Based Research

    12/03/2025

    Models of Success in Site-Based Research

    In this episode, Host Dr. Christopher O’Connor is joined by Dr. Melvin Echols, Dr. Anu Lala-Trindade, Dr. Maria Rosa Costanzo, Dr. Lars Kober, and Dr. Norman Stockbridge to explore key models of success in site-based research. The discussion covers operational efficiency, dedicated research infrastructure, sustainable funding and business models, collaborative partnerships, diversity and patient access, and excellence in quality and compliance.

    31 min
  4. Why is Site-Based Research Broken in the United States?

    11/12/2025

    Why is Site-Based Research Broken in the United States?

    Hosted by Christopher O’Connor, MD, this episode dives into why site-based research is “broken” — fragmented, inefficient, and weighed down by administrative and regulatory burdens. Many clinical research sites — especially community hospitals and smaller practices — face inconsistent funding, delayed contract approvals, and limited infrastructure for study coordination and data management. Join Dr. O’Connor and expert guests Melvin Echols, MD; Anu Lala-Trindade, MD; Maria Rosa Costanzo, MD; Dalane Kitzman, MD, Marat Fudim, MD; and Sumeet Mitter, MD as they unpack the systemic challenges and explore how to create a more efficient, equitable research ecosystem. #HeartFailureCollaboratory #ClinicalResearch #heartfailure

    29 min
  5. Representation vs. Diversity in Clinical Trials

    10/01/2025

    Representation vs. Diversity in Clinical Trials

    In this episode, host Dr. Christopher O’Connor is joined by Dr. Christian Guilliod, Dr. Wayne Batchelor, Dr. Mona Fiuzat, and Dr. Orly Vardeny to discuss the need for clinical trials to reflect the populations most affected by disease, emphasizing culturally and demographically aligned recruitment. They advocate for targeted, site-based strategies and raise concerns about interpreting results from unrepresentative samples.

    20 min
  6. Should Investigators Have Access to Trial Data?

    09/17/2025

    Should Investigators Have Access to Trial Data?

    In this episode, Host Christopher O’Connor, MD, is joined by Robert Califf, MD; Michael Bristow, MD; Scott Solomon, MD; Marvin Konstam, MD; and Mona Fiuzat, PharmD, to discuss who should have access to clinical trial data amid growing collaboration between academia and industry. The conversation highlights the importance of transparency, trust, and responsible data interpretation to maintain scientific integrity.

    24 min
  7. How Can AI Enhance Recruitment in Clinical Trials?

    09/03/2025

    How Can AI Enhance Recruitment in Clinical Trials?

    In this episode, experts Jonathan Cunningham, MD; Ankeet Bhatt, MD; Trejeeve Martyn, MD; Anu Lala-Trindade, MD; Sneha Shah Jain, MD; Elise Shalowitz, MS; and Mitchell Psotka, MD join host Christopher O’Connor, MD to explore AI’s role in transforming clinical trials by reducing workload, improving recruitment, and enhancing protocols. Together, they discuss AI’s use in clinical workflows, continuous evaluation, and inclusive recruitment, stressing the need for healthcare support to maximize success.

    25 min
  8. Standardized Definitions of Changes in Kidney Function in Trials of Heart Failure

    03/13/2025

    Standardized Definitions of Changes in Kidney Function in Trials of Heart Failure

    Only with cardiology with nephrology working together can the field of acute decompensated heart failure move forward with respect to kidney related entry criteria & endpoints. We call for standardization to allow for real progress. Host Chris O'Connor invites authors of the HFC, newly published JACC Expert Panel, Anuradha Lala, Maria Rosa Costanzo, Muthu Vaduganathan, Jason Feinman, Mona Fiuzat, and Steven Coca to discuss this HF-ARC initiative.

    39 min
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Ratings & Reviews

5
out of 5
3 Ratings

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Introducing Heart of the Matter Cardio Pod. High-level conversations to foster conversation, collaboration, and communication around the ecosystem of cardiovascular research.

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