Empowered Patient Podcast

Karen Jagoda
  • 4.9 (16)
  • MEDICINE
  • UPDATED DAILY
Empowered Patient Podcast

Empowered Patient Podcast with Karen Jagoda is a window into the latest innovations in digital health, the changing dynamic between doctors and patients, and the emergence of precision medicine. The show covers such topics as aging in place, innovative uses for wearables and sensors, advances in clinical research, applied genetics, drug development, and challenges for connected health entrepreneurs.

  1. 3 DAYS AGO

    Developing Combination Therapies Targeting Hallmarks of Aging to Address Multiple Age-Related Diseases with Dr. Ann Beliën Rejuvenate TRANSCRIPT

    Dr. Ann Beliën, Chief Executive Officer and Founder at Rejuvenate Biomed, is addressing the underlying biology of aging including mechanisms like mitochondrial health, cell-cell communication and inflammation in order to promote healthy aging. Taking a combination therapy approach, Rejuvenate is using AI-enable drug discovery to address multiple pathways that are involved in aging. Their lead drug candidate is a treatment for sarcopenia with plans to assess impact on other age-related biomarkers. Ann explains, "The biology of aging indeed is being defined by 12 hallmarks. These 12 hallmarks are pathways where you see that the functioning is deteriorating. One of them is mitochondrial health. So, the mitochondria are there to create energy in your cells to make sure that they work to an optimal base. That’s a very important element that we need to address." "Another very important one for us is cell-cell communication. So, for instance, in sarcopenia, one of the diseases we study, it’s very important that your muscle continues to be strong and that you don’t lose too much strength during aging. Now, for the muscle to be able to do that, it’s not only important that the muscle has enough energy but that there is also a crosstalk between the neurons that signal to your muscle that it has to contract. So, that cell-cell communication is also very important." "Within Rejuvenate Biomed, when we develop medication for age-related diseases, we start from the hallmarks of aging. We have an AI-enabled in silico system that can map compounds that have existed for quite a while, for which we have checked if they’re safe for an older population and also for chronic application. That information about these compounds, how they exactly work, goes into our system. The system sees if now these compounds theoretically have the ability to have an impact on the hallmarks of aging. If this is the case, the system will predict a combination that can allow you to impact as many different elements as possible. With that combination, we then check in worms, little worms, so C. elegans, to check on health span."   #DrugDiscovery #Aging #AgeRelatedDiseases #AI #ArtificialIntelligence #HealthyAging #Longevity rejuvenatebiomed.com Listen to the podcast here

  2. 3 DAYS AGO

    Developing Combination Therapies Targeting Hallmarks of Aging to Address Multiple Age-Related Diseases with Dr. Ann Beliën Rejuvenate

    Dr. Ann Beliën, Chief Executive Officer and Founder at Rejuvenate Biomed, is addressing the underlying biology of aging including mechanisms like mitochondrial health, cell-cell communication and inflammation in order to promote healthy aging. Taking a combination therapy approach, Rejuvenate is using AI-enable drug discovery to address multiple pathways that are involved in aging. Their lead drug candidate is a treatment for sarcopenia with plans to assess impact on other age-related biomarkers. Ann explains, "The biology of aging indeed is being defined by 12 hallmarks. These 12 hallmarks are pathways where you see that the functioning is deteriorating. One of them is mitochondrial health. So, the mitochondria are there to create energy in your cells to make sure that they work to an optimal base. That’s a very important element that we need to address." "Another very important one for us is cell-cell communication. So, for instance, in sarcopenia, one of the diseases we study, it’s very important that your muscle continues to be strong and that you don’t lose too much strength during aging. Now, for the muscle to be able to do that, it’s not only important that the muscle has enough energy but that there is also a crosstalk between the neurons that signal to your muscle that it has to contract. So, that cell-cell communication is also very important." "Within Rejuvenate Biomed, when we develop medication for age-related diseases, we start from the hallmarks of aging. We have an AI-enabled in silico system that can map compounds that have existed for quite a while, for which we have checked if they’re safe for an older population and also for chronic application. That information about these compounds, how they exactly work, goes into our system. The system sees if now these compounds theoretically have the ability to have an impact on the hallmarks of aging. If this is the case, the system will predict a combination that can allow you to impact as many different elements as possible. With that combination, we then check in worms, little worms, so C. elegans, to check on health span."   #DrugDiscovery #Aging #AgeRelatedDiseases #AI #ArtificialIntelligence #HealthyAging #Longevity rejuvenatebiomed.com Download the transcript here

    19 min

  3. 4 DAYS AGO

    Reimagining Blood Testing with Micro-Sampling and More Access for Collection with Eric Olson BetterWay by Babson Diagnostics TRANSCRIPT

    Eric Olson, COO and Founder of BetterWay™ by Babson Diagnostics™, reports that traditional blood testing is often seen as inconvenient and unpleasant, causing 40% of people to avoid needed blood tests. Babson has developed a more patient-friendly approach to blood collection using a device that fits on the finger and requires a minimum amount of blood. The BetterWay service allows patients or doctors to order tests where blood is drawn at a local pharmacy and samples analyzed at a central lab, providing a quick turnaround with understandable test results.  Eric explains, "Blood testing is something that most people are very familiar with. It’s a routine part of medical care. Every time you go in for your annual visit or if you’re monitoring a disease, maybe a chronic disease, you might get tested more frequently than once a year. The experience is something that a lot of people go through, which consists of having an appointment, going into some sort of patient service center, and getting blood drawn by a professional phlebotomist. They put a needle in your vein and use tubes to pull the blood out of the vein. They fill up multiple tubes of blood that get sent to a high-throughput laboratory that looks a bit like a factory for testing." "If you go to BetterWay.com, you can see the full menu and the prices of all the tests on that menu, so there are no surprise bills. Insurance, FSA, and HSA are accepted. However, the cash pay prices are often lower than many people pay, even with insurance, due to copays and deductibles, which are very high for many people." "So once you’ve got an order, you go to your local retail pharmacy to get your blood collected. We’re available in pharmacies in Austin today, on all sides of Austin, and expanding beyond Austin soon. Once you arrive at the pharmacy, you tell them that you’re there for the BetterWay test. They’ll collect a pea-sized blood sample from your fingertip after putting your hand on a hand warmer. And that enables them to collect either one or two tubes of blood, depending on the tests you’ve ordered, instead of large vials of blood from a needle in your vein." #BetterWay #BabsonDiagnostics #BloodTesting #HealthEcosystem #MedicalDeviceDevelopments BetterWay.com Listen to the podcast here

  4. 4 DAYS AGO

    Reimagining Blood Testing with Micro-Sampling and More Access for Collection with Eric Olson BetterWay by Babson Diagnostics

    Eric Olson, COO and Founder of BetterWay™ by Babson Diagnostics™, reports that traditional blood testing is often seen as inconvenient and unpleasant, causing 40% of people to avoid needed blood tests. Babson has developed a more patient-friendly approach to blood collection using a device that fits on the finger and requires a minimum amount of blood. The BetterWay service allows patients or doctors to order tests where blood is drawn at a local pharmacy and samples analyzed at a central lab, providing a quick turnaround with understandable test results.  Eric explains, "Blood testing is something that most people are very familiar with. It’s a routine part of medical care. Every time you go in for your annual visit or if you’re monitoring a disease, maybe a chronic disease, you might get tested more frequently than once a year. The experience is something that a lot of people go through, which consists of having an appointment, going into some sort of patient service center, and getting blood drawn by a professional phlebotomist. They put a needle in your vein and use tubes to pull the blood out of the vein. They fill up multiple tubes of blood that get sent to a high-throughput laboratory that looks a bit like a factory for testing." "If you go to BetterWay.com, you can see the full menu and the prices of all the tests on that menu, so there are no surprise bills. Insurance, FSA, and HSA are accepted. However, the cash pay prices are often lower than many people pay, even with insurance, due to copays and deductibles, which are very high for many people." "So once you’ve got an order, you go to your local retail pharmacy to get your blood collected. We’re available in pharmacies in Austin today, on all sides of Austin, and expanding beyond Austin soon. Once you arrive at the pharmacy, you tell them that you’re there for the BetterWay test. They’ll collect a pea-sized blood sample from your fingertip after putting your hand on a hand warmer. And that enables them to collect either one or two tubes of blood, depending on the tests you’ve ordered, instead of large vials of blood from a needle in your vein." #BetterWay #BabsonDiagnostics #BloodTesting #HealthEcosystem #MedicalDeviceDevelopments BetterWay.com Download the transcript here

    21 min

  5. 5 DAYS AGO

    Improving Women’s Health with Advanced Gynecological Tools with Marylyn Rigby Bioceptive TRANSCRIPT

    Marylyn Rigby, President and CEO of Bioceptive, focuses on improving women's health technologies. Bioceptive has developed a cervical suction retractor as an alternative to the 200-year-old cervical tenaculum device used to insert IUDs and perform biopsies and other intrauterine procedures. While current procedures are extremely painful, there has been a lack of innovation in understanding women's pain because women are often described as hysterical, with little clinical data to get to the source of the pain.   Marylyn explains, "I think that also has to do with what modern medicine is based on, which is a man’s body and not a woman’s body. And because of that, it’s kind of interesting to think that a man could ever possibly understand what it would feel like to have their cervix, which they don’t even have, be pierced, essentially. It is like having your ears pierced and the traumatic experience that it causes because this is done again without any type of anesthetic. So, one of the biggest issues that we see right now, regardless of what your political stance on pro-life or pro-choice, is certainly that women need better options for contraception that are more effective." "Science has indicated that the IUD is the most effective form of contraception and that is because of its efficacy, which is greater than 99%. You’re not looking to remember to take a pill. You’re not looking, you’re not having to have weight gain by having something inserted in your arm. It’s a one-stop shop that is incredibly effective and cost-effective. However, the number one reason that women do not get IUDs more often is because of the trauma and the pain that is associated with the tenaculum, which is required to insert the IUD." #WomensHealth #Gynecology #FemTech #ReproductiveRights #ReproductiveHealth #WomensRights bioceptive.com Listen to the podcast here

  6. 5 DAYS AGO

    Improving Women’s Health with Advanced Gynecological Tools with Marylyn Rigby Bioceptive

    Marylyn Rigby, President and CEO of Bioceptive, focuses on improving women's health technologies. Bioceptive has developed a cervical suction retractor as an alternative to the 200-year-old cervical tenaculum device used to insert IUDs and perform biopsies and other intrauterine procedures. While current procedures are extremely painful, there has been a lack of innovation in understanding women's pain because women are often described as hysterical, with little clinical data to get to the source of the pain.   Marylyn explains, "I think that also has to do with what modern medicine is based on, which is a man’s body and not a woman’s body. And because of that, it’s kind of interesting to think that a man could ever possibly understand what it would feel like to have their cervix, which they don’t even have, be pierced, essentially. It is like having your ears pierced and the traumatic experience that it causes because this is done again without any type of anesthetic. So, one of the biggest issues that we see right now, regardless of what your political stance on pro-life or pro-choice, is certainly that women need better options for contraception that are more effective." "Science has indicated that the IUD is the most effective form of contraception and that is because of its efficacy, which is greater than 99%. You’re not looking to remember to take a pill. You’re not looking, you’re not having to have weight gain by having something inserted in your arm. It’s a one-stop shop that is incredibly effective and cost-effective. However, the number one reason that women do not get IUDs more often is because of the trauma and the pain that is associated with the tenaculum, which is required to insert the IUD." #WomensHealth #Gynecology #FemTech #ReproductiveRights #ReproductiveHealth #WomensRights bioceptive.com Download the transcript here

    17 min

  7. OCT 3

    New Tools to Combat Prescription Opioid Abuse and Synthetic Opioid Overdoses Greg Sturmer Elysium Therapeutics TRANSCRIPT

    Greg Sturmer, Co-Founder and CEO of Elysium Therapeutics, a company with expertise in reducing pain and addressing opioid use disorder and fatal overdose from fentanyl. Elysium has developed O2P, Oral Overdose Protection, a technology that aims to control the impact of opioids and reduce the risk of use disorder or a fatal overdose. SOOPR is a rescue agent designed specifically for overdoses from synthetic opioids, particularly fentanyl, which can last longer and be more potent than traditional opioids. Greg explains, "Anytime there’s an epidemic, you want to control exposure. The tricky bit in the area of pain management and the use of opioids is how do you control exposure without affecting patient care. We’ve come up with a technology that maintains the unmatched efficacy of the opioids. But when somebody takes too many pills, and we’ve actually shown this in our human study, we can reduce the exposure because we use this proprietary molecular delivery system that uses the body’s natural digestive process to control how much of the opioid gets released. That’s how we’re addressing the front end of the issue, where somebody is prescribed an opioid." "But sadly, what happens today is several individuals progress along the road to opioid use disorder, and they end up using illicit drugs. That’s where our second program, SOOPR, comes into play. As you know, our streets in the US have been flooded with fentanyl. Fentanyl is a highly potent opioid. The cartels have gotten very wise in how to expand their market. They introduced fentanyl-laced pills because a lot more people are willing to take pills rather than inject. Well, that changed the game dramatically because when somebody overdoses orally on fentanyl, that puts them at risk of respiratory depression for hours where they stop breathing." "Existing rescue agents like Narcan and Opvee weren’t designed for oral synthetic opioids and overdoses of those drugs. ‎SOOPR, we believe, is the first rescue agent designed specifically for synthetic opioids. What it does is it outlasts that synthetic opioid danger zone, blocking the mu-opioid receptors and preventing that respiratory depression or rescuing somebody who’s already in respiratory depression." #ElysiumTherapeutics #Opioids #OpioidAbuse #SyntheticOpioids #OpioidUseDisorder #PainManagement #SaferMedicines Elysiumrx.com Listen to the podcast here

  8. OCT 3

    New Tools to Combat Prescription Opioid Abuse and Synthetic Opioid Overdoses Greg Sturmer Elysium Therapeutics

    Greg Sturmer, Co-Founder and CEO of Elysium Therapeutics, a company with expertise in reducing pain and addressing opioid use disorder and fatal overdose from fentanyl. Elysium has developed O2P, Oral Overdose Protection, a technology that aims to control the impact of opioids and reduce the risk of use disorder or a fatal overdose. SOOPR is a rescue agent designed specifically for overdoses from synthetic opioids, particularly fentanyl, which can last longer and be more potent than traditional opioids. Greg explains, "Anytime there’s an epidemic, you want to control exposure. The tricky bit in the area of pain management and the use of opioids is how do you control exposure without affecting patient care. We’ve come up with a technology that maintains the unmatched efficacy of the opioids. But when somebody takes too many pills, and we’ve actually shown this in our human study, we can reduce the exposure because we use this proprietary molecular delivery system that uses the body’s natural digestive process to control how much of the opioid gets released. That’s how we’re addressing the front end of the issue, where somebody is prescribed an opioid." "But sadly, what happens today is several individuals progress along the road to opioid use disorder, and they end up using illicit drugs. That’s where our second program, SOOPR, comes into play. As you know, our streets in the US have been flooded with fentanyl. Fentanyl is a highly potent opioid. The cartels have gotten very wise in how to expand their market. They introduced fentanyl-laced pills because a lot more people are willing to take pills rather than inject. Well, that changed the game dramatically because when somebody overdoses orally on fentanyl, that puts them at risk of respiratory depression for hours where they stop breathing." "Existing rescue agents like Narcan and Opvee weren’t designed for oral synthetic opioids and overdoses of those drugs. ‎SOOPR, we believe, is the first rescue agent designed specifically for synthetic opioids. What it does is it outlasts that synthetic opioid danger zone, blocking the mu-opioid receptors and preventing that respiratory depression or rescuing somebody who’s already in respiratory depression." #ElysiumTherapeutics #Opioids #OpioidAbuse #SyntheticOpioids #OpioidUseDisorder #PainManagement #SaferMedicines Elysiumrx.com Download the transcript here

    17 min
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4.9
out of 5
16 Ratings

About

Empowered Patient Podcast with Karen Jagoda is a window into the latest innovations in digital health, the changing dynamic between doctors and patients, and the emergence of precision medicine. The show covers such topics as aging in place, innovative uses for wearables and sensors, advances in clinical research, applied genetics, drug development, and challenges for connected health entrepreneurs.

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