Endgame with Amanda Cassatt

Serotonin

The world is changing at an accelerating pace—Endgame is here to make sense of it. Hosted by Amanda Cassatt, founder of Serotonin, this podcast brings you conversations with the visionaries driving breakthrough technologies and shaping the future. Join Amanda as she unpacks the trends, innovations, and paradigm shifts defining our time. Where is this all going? Let’s figure it out together. Subscribe now on Apple Podcasts, Spotify, YouTube, and wherever you listen.

  1. How the Financial Elite Rig the Stock Market | Curtis Yarvin

    4D AGO

    How the Financial Elite Rig the Stock Market | Curtis Yarvin

    Most of the people running the world are not evil masterminds; they are sincere operators trapped in an “epistemic maze.” In this episode of Endgame, Amanda Cassatt sits down with Curtis Yarvin to explore why the rules-based international order was always fragile and how elite decision-makers operate on unexamined assumptions. They unpack Yarvin’s “interchangeable baby theory,” the 20th-century belief that human outcomes are largely interchangeable, and how this flawed idea shaped policy without ever being questioned. The conversation shifts to modern finance, where deposit insurance, bailouts, and informal guarantees create a tower of promises barely anchored in reality. From there, they tackle AI, arguing that machines could make most humans economically useless unless society redesigns work, introducing artificial constraints so humans retain meaningful roles. This episode examines the hidden assumptions in power, money, and labor, and what happens when technology exposes the gaps in a system built on faith and untested ideas. Timestamps:  00:00 Intro 01:25 The Fate of the Rules-Based International Order 08:47 Interchangeable Baby Theory and Its Implications 17:58 The Stability of the US Dollar and Financial Systems 29:34 AI, Technology, and the Future of Society 34:07 The Craving for Violence in Media 34:29 Artificial Difficulty in Gaming and Crafting 34:57 Labor Supply and Demand in a Changing World 36:07 The Economic Uselessness of the Majority 36:38 Cultural Reflections on Indigenous Peoples and Welfare 38:11 AI's Impact on Employment Across Professions 38:34 The Dilemma of Meaningful Work vs. Automation 39:41 Autarky and Competing Economies 40:58 The Pursuit of Meaning Over Luxury 43:01 The Role of Technology in Shaping Labor 44:58 Cultural Stagnation and AI's Influence 46:05 The Aesthetic of AI and Over-Optimization Stay Connected: George on X: https://x.com/realGeorgeHotz  Subscribe to Endgame: https://www.youtube.com/@endgamepodcast  Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin_hq  Links to Follow: Endgame on Spotify: https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg    Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

    49 min
  2. MAR 4

    GDP is fake, electricity is real | George Hotz

    "If you are using technology to manipulate other people, you should be ashamed of yourself."In this episode of Endgame, Amanda Cassatt sits down with George Hotz to explore when technology empowers and when it traps. Using the framework of finite and infinite games, they define manipulation as placing someone in a system designed to extract from them without their awareness.They examine algorithmic trading, behavioral betting, and AI agents, asking where the ethical line lies between prediction and deception. The conversation moves from societal measures like GDP to electricity, steel, and Nvidia’s AI chip dominance, highlighting how software moats create real choke points of power.George and Amanda explore whether AI will create a cognitive divide between the upgraded and the monkey class, and whether opting into algorithmic comfort loops is a voluntary surrender of agency.This episode is about the ethics of control in a world where persuasion can be automated and scaled, and whether the games we build are infinite or finite, liberating or extractive.▶️TIMESTAMPS00:00 Intro01:25 The Rise of AI Tools and Productivity03:02 The Evolution of Coding: From Direct Coders to Managers of Agents05:48 Democratization of Coding: Access and Quality08:24 The Impact of AI on Software Production and Value10:56 Cultural Manipulation and the Role of Technology13:48 The Perpetual Underclass: Fears and Realities16:14 The Future of Power Dynamics in AI18:52 The Cost of AI Development and Its Implications21:23 The Role of Culture in Addressing AI Challenges33:29 Cultural Responsibility and Advertising Ethics35:41 The Role of Technology in Manipulation38:40 Ethics of Control and Manipulation43:45 Market Fairness and Regulation46:18 The Future of Capitalism and Financial Products51:28 Electricity Production as a Measure of Progress53:08 NVIDIA and the Future of AI Chips56:30 Cultural Shifts and the Monkey Class01:01:41 The Liminal Space of AI and Culture

    1h 4m
  3. FEB 25

    $40 Billion Deepfake Apocalypse Is Coming | Evin McMullen

    As artificial intelligence agents become the dominant interface to the web, the question is no longer just “Who are you?” but “Who is acting on your behalf?” In this episode of Endgame, Amanda Cassatt sits down with Billions Network CEO Evin McMullen to examine the rapid shift toward agent-mediated internet use. At the end of last year, roughly one in every 31 website visits was conducted by a non-human actor, up sharply from just one in 200 earlier in the year. Increasingly, we are delegating our online activity to digital butlers.But delegation does not eliminate identity. It compounds it. Evin argues that we are moving beyond traditional KYC, Know Your Customer, into a new paradigm called KYA, Know Your Agent. If AI agents are making payments, accessing age-gated services, or interacting with financial and government systems, they must be able to prove who they represent. Identity becomes inheritable, and agents must cryptographically demonstrate the human or organization on whose behalf they act.This reframes the identity debate. The problem is no longer just login friction or platform data extraction. It is the structural need to bind autonomous systems to accountable humans. As armies of specialized sub-agents begin coordinating tasks across domains, payments, compliance, and trust all depend on pairing the person with the agent. Ultimately, identity becomes the backbone of the agentic internet. As humans step back from direct interaction and software takes the wheel, sovereignty shifts from logging in yourself to equipping your agents with portable, provable credentials so they can act and sign on your behalf. Timestamps 00:00 Introduction 01:25 Understanding Identity in the Digital Age 05:15 The Flaws of Current Identity Systems 09:59 Reimagining Identity Workflows 13:00 User Control and Data Ownership 14:30 Incentives and the Future of Identity 18:28 The Role of Crypto in Identity Management 22:27 Proving Human Identity in a Digital World 25:27 The Future of Agents and Identity 30:23 Navigating the New Digital Landscape 33:09 The Intersection of Technology and Regulation

    36 min
  4. FEB 18

    Gen Z is changing the founder game, with Dragonfly's Haseeb Qureshi

    As artificial intelligence becomes the dominant interface for work, creativity, and competition, some people are adapting to it far faster than others. In this episode of Endgame, Amanda Cassatt sits down with Dragonfly Capital’s Haseeb Qureshi to explore a generational shift in technological advantage: the biggest winners of every major tech transition are not the most experienced, but the most “pluripotent.” Younger people, who haven’t yet locked themselves into fixed professional identities, are better positioned to experiment and use new tools as leverage.Haseeb explains how AI intensifies this dynamic. The key emerging skill is no longer traditional engineering or management, but the ability to talk to models. Younger builders are becoming fluent in prompting, cross-agent workflows, and systems where AI agents write, review, and coordinate each other, patterns discovered by people actively building, not by institutions. This reframes what talent and leadership mean. The edge now belongs to those who remain cognitively flexible and let technology reshape how they think and work. In an AI-native world, the most effective founders aren’t the best coders or managers, but the ones who can reason about complex systems and continuously adapt alongside fast-moving tools. Ultimately, AI becomes a generational filter. Those who grow up fluent in these systems will treat them as a natural extension of thought, while older cohorts experience them as something they must translate through. As with every technological shift, the people who adopt the medium as native are the ones who end up defining the future. Chapters: 0:00 Intro 01:23 The Intersection of AI and Crypto 06:13 The Role of AI Agents in Software Development 09:00 Shifting Profiles of Founders in Tech 11:55 The Future of Knowledge Work and AI 14:57 Decentralized AI and Security Concerns 17:57 The Future of AI and Crypto Integration 20:51 The Role of Stablecoins in the Crypto Ecosystem 24:01 The Evolution of Legal Systems in Tech 26:46 The Future of Labor and Capital in AI 30:01 Global Perspectives on AI and Crypto 32:54 The Future of Venture Capital in Tech 35:59 The Intergenerational Wealth Transfer of Crypto 39:01 The Future of AI and Crypto Regulation 42:04 The Role of Innovation in Crypto If this expanded your thinking, don’t forget to Like, Comment & Share. For future cities, global systems & bold ideas, Subscribe now!

    45 min
  5. FEB 11

    When Technology Becomes More Addictive Than Crack

    Technology is the most powerful force in history, and whether it liberates or consumes us depends entirely on how aligned it is with human agency. For Amanda Cassatt, this belief underpins her techno-optimism: the conviction that progress must be actively built, not passively awaited. In this solo episode, she explains how she sees technology as upstream of culture, economics, and politics, and views optimism as a necessary stance for shaping systems that improve the future rather than accepting stagnation. In her view, one of AI’s most powerful use cases will be hyper-addictive entertainment and persuasion, with millions of intelligent agents optimized to capture attention, shape behavior, and extract value. But Cassatt argues that AI also holds the potential to act as a personal ally: an intelligent layer that enforces individual priorities, shields users from exploitative systems, and restores agency in an increasingly manipulative digital environment.As technology progresses, so will the need for “envelope technologies” and personal AI systems that protect users, preserve agency, and give people real control over the tools that mediate their lives. For Cassatt, the future of technology hinges on alignment and ownership, determining whether we build systems that mine human attention or systems that empower humans to shape their own trajectories. Timestamps 00:00 Introduction 01:31 Telling the Story of New Technology 05:13 Innovation or Financial Nihilism? 09:12 Birth of Two Markets 15:38 Key to Successful Startups 18:14 The Role of Brands 27:06 Stories to Understand the World 29:01 The AI Conundrum 39:02 Is AI the Tool or Are We? 44:11 The Case for Techno Optimism Subscribe to Endgame: https://www.youtube.com/@endgamepodcast Edge City on X: https://x.com/JoinEdgeCityTimour Kosters on X: https://x.com/timourxyzAmanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ If this expanded your thinking, don’t forget to Like, Comment & Share. For future cities, global systems & bold ideas, Subscribe now!

    45 min
  6. Can a High IQ Pop-Up City Prevent WW3? | Timour Kosters

    FEB 4

    Can a High IQ Pop-Up City Prevent WW3? | Timour Kosters

    As nation-states double down on borders, nationalism, and readiness for war, some people are choosing not to wait around to see how that ends. Amanda Cassatt sits down with Timour Kosters, who worked alongside Vitalik Buterin on Zuzalu, and co-founder of Edge City, a borderless pop-up society where highly driven builders, thinkers, and creators experiment with life beyond the nation-state. Emerging directly from the Zuzalu experiment in Montenegro, Edge City functions as a live prototype for post-national belonging, a place where identity, culture, and collaboration are designed deliberately rather than inherited by accident. Timour explains how Zuzalu shaped Edge City’s core philosophy: opting out of national identity, rejecting reflexive patriotism, and building high-trust communities that can survive disagreement without collapsing into tribalism. Edge City offers sovereignty within, giving people a way to escape inherited identities, nationalistic pressures, and the growing assumption that global conflict is inevitable. Heterogeneity and multidisciplinarity are intentional. Edge City incubates startups, launches new fields of inquiry, and partners with emerging cities and jurisdictions, turning the community itself into a platform for coordination and long-term impact. The result is a network that produces ideas, companies, and alliances that would be difficult or impossible to form inside traditional state structures. Edge City even tracks an unusual metric of success: children, and conceptions. Including families is not sentimental, it is strategic. It binds people to the community, creates continuity across generations, and embeds the next cohort inside a society actively experimenting with alternatives to nation-states. In a world increasingly organized around borders and conflict, Edge City is betting that opting out early is the real advantage. Timestamps 00:00 Introduction 01:05 Vitalik’s goal: a minimum viable “crazy thing” that’s long enough to become real life 03:00 What Zuzalu was really for (and Timour’s role running the AI track) 08:10 Edge City’s design goal: heterogeneity and multidisciplinarity (and the fault lines) 10:40 AI safety vs accelerationism, crypto skeptics, political diversity—and why debate is hard 16:50 Where Edge City fits in a world of geopolitical blocs 19:40 Timour’s personal relationship to Russia and why he’s not a nationalist 22:10 Can network societies become bridging nodes across spheres of influence? 24:10 Historical parallel: the “International” before WWI—and what’s different now 26:10 Fear as a political tool—and why hope is “really punk” 32:00 The missing step in the Network State: kinship before land 36:10 Startup example: Constellation and the compressed loop from idea → data → investors 41:20 Working with towns and jurisdictions: Esmeralda, Bhutan, and “drop-shipping” talent 47:10 Why kids are a North Star metric—and how families change the entire vibe 49:30 “Conceptions” as an internal joke metric—and what it signals about community health 51:00 Closing: building futures that feel livable, not hollow Subscribe to Endgame: https://www.youtube.com/@endgamepodcast   Edge City on X: https://x.com/JoinEdgeCity Timour on X: https://x.com/timourxyz Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin   Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd    Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

    48 min
  7. Funding Forbidden Science with Crypto | Laura Minquini

    JAN 28

    Funding Forbidden Science with Crypto | Laura Minquini

    What if aging and reproduction were engineering problems, not biological limits? In this episode, Amanda Cassatt sits down with AthenaDAO founder Laura Minquini to unpack how reproductive biotech could transform same-sex reproduction, family structures, and the future of population growth. Laura explains how AthenaDAO and the DeSci movement are using crypto to fund research that has previously not been prioritized by the FDA or mainstream pharma, arguing that reproductive biotech is one of the most consequential frontiers in modern science, from ovarian tissue cryopreservation and in vitro gametogenesis (IVG) to artificial wombs that could radically extend not just fertility, but women’s healthspan. She details how ovarian tissue cryopreservation works, a surgical procedure originally developed for cancer patients where ovarian tissue is removed, frozen, and later reimplanted to restore ovarian function. She describes how this technique is now being offered electively, what it realistically enables, and why it may be the most direct path to delaying menopause. The two dig into why menopause drives systemic aging, why women live longer but spend more years in disease, and how reproductive biology has been sidelined by traditional biotech funding. Timestamps: 00:00 Why the future of biotech isn’t evenly distributed  02:05 Ovarian tissue cryopreservation and extending fertility  06:30 Why menopause affects the entire body—not just reproduction  10:45 Longevity, ovarian function, and why women live longer with more disease  15:10 Why women’s health research is so underfunded  19:40 Clinical trials, fertility risk, and why female data is missing  24:30 Artificial wombs: science fiction or near-term reality?  29:00 In vitro gametogenesis (IVG) and the future of egg creation  34:20 Radical reproductive unlocks and societal implications  39:30 Why controversial technologies need human-first framing  44:50 Decentralized science (DeSci) and crypto-funded research  49:20 Why crypto struggles with long-term scientific timelines  53:40 The AthenaDAO business model and token-equity hybrid approach  58:10 Menopause prediction, HRT, and what Laura uses personally  01:01:30 Moonshots, legacy, and redefining women’s reproductive futures Subscribe to Endgame: https://www.youtube.com/@endgamepodcast   Laura on X: https://x.com/LauraMinquini AthenaDAO on X: https://x.com/athena_DAO_ Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin   Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd    Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

    46 min
  8. How Arbitrum Succeeds Even if Ethereum Scales | Steven Goldfeder

    JAN 22

    How Arbitrum Succeeds Even if Ethereum Scales | Steven Goldfeder

    What is the future of Arbitrum now that L1 Ethereum is becoming scalable? In this episode, Amanda Cassatt sits down with Offchain Labs and Arbitrum co-founder Steven Goldfeder. Arbitrum began as Ethereum’s scaling answer, borrowing its security to add more bandwidth, faster confirmations, and better UX. As Ethereum solves the scalability problem that was Arbitrum's original raison d’être, Steven explains Arbitrum's next frontier: customization and institutional onboarding onto Ethereum, by providing privacy and KYC that won't become available at L1 anytime soon. The two discuss the specific ways and regions Robinhood is already - though invisibly to users - using Arbitrum, the precise path RWAs are taking to gain consumer adoption, and which traditional financial products are poised to come onchain. Steven clarifies where he aligns and departs from Vitalik's articulation of what Ethereum is for, and he tells us what he believes will happen when Ethereum grows beyond its original decentralization-first vision. Times are evolving, and institutions aren’t guaranteed to take on the cypherpunk ideology, but so long as the core system is preserved, Goldfeder believes that there are a lot of benefits to mass onboarding. Timestamps:  00:00 Scaling Ethereum: The Role of Arbitrum 09:29 Customization for Institutions: Arbitrum's Unique Offerings 12:43 Compliance and Privacy: Institutional Needs in DeFi 16:21 The Philosophy of Ethereum: Freedom vs. Compliance 22:39 The Future of Ethereum: KYC and Institutional Adoption 25:03 The Evolution of Use Cases on Arbitrum 31:44 Arbitrum's DAO: Governance and Decision-Making 43:50 Balancing Power: Democracy vs. Monarchy in DAOs 55:24 The Future of Arbitrum: Growth and User Experience Subscribe to Endgame: https://www.youtube.com/@endgamepodcast   Steven on X: https://x.com/sgoldfed Offchain Labs on X: https://x.com/OffchainLabs Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin   Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd    Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

    48 min

Ratings & Reviews

3.7
out of 5
3 Ratings

About

The world is changing at an accelerating pace—Endgame is here to make sense of it. Hosted by Amanda Cassatt, founder of Serotonin, this podcast brings you conversations with the visionaries driving breakthrough technologies and shaping the future. Join Amanda as she unpacks the trends, innovations, and paradigm shifts defining our time. Where is this all going? Let’s figure it out together. Subscribe now on Apple Podcasts, Spotify, YouTube, and wherever you listen.

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