Endgame with Amanda Cassatt

Serotonin

The world is changing at an accelerating pace—Endgame is here to make sense of it. Hosted by Amanda Cassatt, founder of Serotonin, this podcast brings you conversations with the visionaries driving breakthrough technologies and shaping the future. Join Amanda as she unpacks the trends, innovations, and paradigm shifts defining our time. Where is this all going? Let’s figure it out together. Subscribe now on Apple Podcasts, Spotify, YouTube, and wherever you listen.

  1. 5D AGO

    When Technology Becomes More Addictive Than Crack

    Technology is the most powerful force in history, and whether it liberates or consumes us depends entirely on how aligned it is with human agency. For Amanda Cassatt, this belief underpins her techno-optimism: the conviction that progress must be actively built, not passively awaited. In this solo episode, she explains how she sees technology as upstream of culture, economics, and politics, and views optimism as a necessary stance for shaping systems that improve the future rather than accepting stagnation. In her view, one of AI’s most powerful use cases will be hyper-addictive entertainment and persuasion, with millions of intelligent agents optimized to capture attention, shape behavior, and extract value. But Cassatt argues that AI also holds the potential to act as a personal ally: an intelligent layer that enforces individual priorities, shields users from exploitative systems, and restores agency in an increasingly manipulative digital environment.As technology progresses, so will the need for “envelope technologies” and personal AI systems that protect users, preserve agency, and give people real control over the tools that mediate their lives. For Cassatt, the future of technology hinges on alignment and ownership, determining whether we build systems that mine human attention or systems that empower humans to shape their own trajectories. Timestamps 00:00 Introduction 01:31 Telling the Story of New Technology 05:13 Innovation or Financial Nihilism? 09:12 Birth of Two Markets 15:38 Key to Successful Startups 18:14 The Role of Brands 27:06 Stories to Understand the World 29:01 The AI Conundrum 39:02 Is AI the Tool or Are We? 44:11 The Case for Techno Optimism Subscribe to Endgame: https://www.youtube.com/@endgamepodcast Edge City on X: https://x.com/JoinEdgeCityTimour Kosters on X: https://x.com/timourxyzAmanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ If this expanded your thinking, don’t forget to Like, Comment & Share. For future cities, global systems & bold ideas, Subscribe now!

    45 min
  2. Can a High IQ Pop-Up City Prevent WW3? | Timour Kosters

    FEB 4

    Can a High IQ Pop-Up City Prevent WW3? | Timour Kosters

    As nation-states double down on borders, nationalism, and readiness for war, some people are choosing not to wait around to see how that ends. Amanda Cassatt sits down with Timour Kosters, who worked alongside Vitalik Buterin on Zuzalu, and co-founder of Edge City, a borderless pop-up society where highly driven builders, thinkers, and creators experiment with life beyond the nation-state. Emerging directly from the Zuzalu experiment in Montenegro, Edge City functions as a live prototype for post-national belonging, a place where identity, culture, and collaboration are designed deliberately rather than inherited by accident. Timour explains how Zuzalu shaped Edge City’s core philosophy: opting out of national identity, rejecting reflexive patriotism, and building high-trust communities that can survive disagreement without collapsing into tribalism. Edge City offers sovereignty within, giving people a way to escape inherited identities, nationalistic pressures, and the growing assumption that global conflict is inevitable. Heterogeneity and multidisciplinarity are intentional. Edge City incubates startups, launches new fields of inquiry, and partners with emerging cities and jurisdictions, turning the community itself into a platform for coordination and long-term impact. The result is a network that produces ideas, companies, and alliances that would be difficult or impossible to form inside traditional state structures. Edge City even tracks an unusual metric of success: children, and conceptions. Including families is not sentimental, it is strategic. It binds people to the community, creates continuity across generations, and embeds the next cohort inside a society actively experimenting with alternatives to nation-states. In a world increasingly organized around borders and conflict, Edge City is betting that opting out early is the real advantage. Timestamps 00:00 Introduction 01:05 Vitalik’s goal: a minimum viable “crazy thing” that’s long enough to become real life 03:00 What Zuzalu was really for (and Timour’s role running the AI track) 08:10 Edge City’s design goal: heterogeneity and multidisciplinarity (and the fault lines) 10:40 AI safety vs accelerationism, crypto skeptics, political diversity—and why debate is hard 16:50 Where Edge City fits in a world of geopolitical blocs 19:40 Timour’s personal relationship to Russia and why he’s not a nationalist 22:10 Can network societies become bridging nodes across spheres of influence? 24:10 Historical parallel: the “International” before WWI—and what’s different now 26:10 Fear as a political tool—and why hope is “really punk” 32:00 The missing step in the Network State: kinship before land 36:10 Startup example: Constellation and the compressed loop from idea → data → investors 41:20 Working with towns and jurisdictions: Esmeralda, Bhutan, and “drop-shipping” talent 47:10 Why kids are a North Star metric—and how families change the entire vibe 49:30 “Conceptions” as an internal joke metric—and what it signals about community health 51:00 Closing: building futures that feel livable, not hollow Subscribe to Endgame: https://www.youtube.com/@endgamepodcast   Edge City on X: https://x.com/JoinEdgeCity Timour on X: https://x.com/timourxyz Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin   Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd    Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

    48 min
  3. Funding Forbidden Science with Crypto | Laura Minquini

    JAN 28

    Funding Forbidden Science with Crypto | Laura Minquini

    What if aging and reproduction were engineering problems, not biological limits? In this episode, Amanda Cassatt sits down with AthenaDAO founder Laura Minquini to unpack how reproductive biotech could transform same-sex reproduction, family structures, and the future of population growth. Laura explains how AthenaDAO and the DeSci movement are using crypto to fund research that has previously not been prioritized by the FDA or mainstream pharma, arguing that reproductive biotech is one of the most consequential frontiers in modern science, from ovarian tissue cryopreservation and in vitro gametogenesis (IVG) to artificial wombs that could radically extend not just fertility, but women’s healthspan. She details how ovarian tissue cryopreservation works, a surgical procedure originally developed for cancer patients where ovarian tissue is removed, frozen, and later reimplanted to restore ovarian function. She describes how this technique is now being offered electively, what it realistically enables, and why it may be the most direct path to delaying menopause. The two dig into why menopause drives systemic aging, why women live longer but spend more years in disease, and how reproductive biology has been sidelined by traditional biotech funding. Timestamps: 00:00 Why the future of biotech isn’t evenly distributed  02:05 Ovarian tissue cryopreservation and extending fertility  06:30 Why menopause affects the entire body—not just reproduction  10:45 Longevity, ovarian function, and why women live longer with more disease  15:10 Why women’s health research is so underfunded  19:40 Clinical trials, fertility risk, and why female data is missing  24:30 Artificial wombs: science fiction or near-term reality?  29:00 In vitro gametogenesis (IVG) and the future of egg creation  34:20 Radical reproductive unlocks and societal implications  39:30 Why controversial technologies need human-first framing  44:50 Decentralized science (DeSci) and crypto-funded research  49:20 Why crypto struggles with long-term scientific timelines  53:40 The AthenaDAO business model and token-equity hybrid approach  58:10 Menopause prediction, HRT, and what Laura uses personally  01:01:30 Moonshots, legacy, and redefining women’s reproductive futures Subscribe to Endgame: https://www.youtube.com/@endgamepodcast   Laura on X: https://x.com/LauraMinquini AthenaDAO on X: https://x.com/athena_DAO_ Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin   Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd    Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

    46 min
  4. How Arbitrum Succeeds Even if Ethereum Scales | Steven Goldfeder

    JAN 22

    How Arbitrum Succeeds Even if Ethereum Scales | Steven Goldfeder

    What is the future of Arbitrum now that L1 Ethereum is becoming scalable? In this episode, Amanda Cassatt sits down with Offchain Labs and Arbitrum co-founder Steven Goldfeder. Arbitrum began as Ethereum’s scaling answer, borrowing its security to add more bandwidth, faster confirmations, and better UX. As Ethereum solves the scalability problem that was Arbitrum's original raison d’être, Steven explains Arbitrum's next frontier: customization and institutional onboarding onto Ethereum, by providing privacy and KYC that won't become available at L1 anytime soon. The two discuss the specific ways and regions Robinhood is already - though invisibly to users - using Arbitrum, the precise path RWAs are taking to gain consumer adoption, and which traditional financial products are poised to come onchain. Steven clarifies where he aligns and departs from Vitalik's articulation of what Ethereum is for, and he tells us what he believes will happen when Ethereum grows beyond its original decentralization-first vision. Times are evolving, and institutions aren’t guaranteed to take on the cypherpunk ideology, but so long as the core system is preserved, Goldfeder believes that there are a lot of benefits to mass onboarding. Timestamps:  00:00 Scaling Ethereum: The Role of Arbitrum 09:29 Customization for Institutions: Arbitrum's Unique Offerings 12:43 Compliance and Privacy: Institutional Needs in DeFi 16:21 The Philosophy of Ethereum: Freedom vs. Compliance 22:39 The Future of Ethereum: KYC and Institutional Adoption 25:03 The Evolution of Use Cases on Arbitrum 31:44 Arbitrum's DAO: Governance and Decision-Making 43:50 Balancing Power: Democracy vs. Monarchy in DAOs 55:24 The Future of Arbitrum: Growth and User Experience Subscribe to Endgame: https://www.youtube.com/@endgamepodcast   Steven on X: https://x.com/sgoldfed Offchain Labs on X: https://x.com/OffchainLabs Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin   Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd    Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

    48 min
  5. Against the Crypto Casino | Kevin Owocki

    JAN 14

    Against the Crypto Casino | Kevin Owocki

    What happens when crypto stops optimizing purely for profit and starts optimizing for people, planet, and long-term coordination? In this episode, Amanda Cassatt sits down with Gitcoin founder Kevin Owocki to discuss Ethereum’s public goods, swallowing the Green Pill, and what onchain coordination will look like in the future. Owocki maps the cultural fault lines inside Ethereum: the libertarian and cypherpunk roots, the rise of hyper-financialized degen culture, and the parallel effort to build something different: a regenerative ecosystem that funds public goods, sustains open source, and solves coordination failures instead of reproducing them. The two unpack what Green Pill really means and the choice it asks of builders, how Gitcoin funded $70 million in public goods and why grants and vibes aren’t enough anymore.  Timestamps: 00:00 Introduction to Regen and Degen 02:57 The Green Pill Movement 06:13 Public Goods in Ethereum 09:10 Funding Challenges in the Ethereum Ecosystem 12:07 Comparing Ethereum to Traditional Governments 15:00 The Evolution of Public Goods Funding 17:48 Incentive Alignment and the Tragedy of the Commons 21:04 Building Proofs for Public Goods 24:11 Ethereum's Unique Approach to Public Goods 26:48 Meditations on Moloch and Coordination Failures 29:39 Exploring Moloch and Ginsberg's Influence 30:04 Addressing Coordination Failures in Ethereum 34:48 The Future of Capitalism and Its Alternatives 39:40 Balancing Different Forms of Capital 45:03 Navigating Financial Nihilism Among Youth 47:41 Success Stories in Building Parallel Institutions Subscribe to Endgame: https://www.youtube.com/@endgamepodcast   Kevin on X: https://x.com/owocki Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin   Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd    Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

    46 min
  6. Has Crypto Become TradFi Rebranded? | Gabriel Shapiro

    JAN 7

    Has Crypto Become TradFi Rebranded? | Gabriel Shapiro

    Crypto was supposed to be the escape hatch. So why does it increasingly feel like it’s being absorbed by the very systems it set out to challenge? In this candid conversation, Amanda Cassatt sits down with cyberpunk crypto lawyer Gabriel Shapiro about the “fintech-ization” of crypto, where the industry stands in the post-Gary Gensler era and the fading relevance of the four-year cycle. Is crypto a tool for resisting power, or just a more efficient version of traditional finance waiting to be regulated into submission?  Regulation isn’t a complete negative for the space; Gabriel believes that certain aspects, such as antitrust law, are beneficial. But while some laws age like a fine wine, others aren’t as relevant as technology evolves. Amanda and Gabriel also discussed KYC and how it’s evolving, zero-knowledge proofs, and what Tornado Cash did wrong.  Timestamps:  00:00 Current State of Crypto and Market Cycles 02:53 The Debate on Decentralization vs. Centralization 05:47 The Role of Government and Regulation in Crypto 08:43 Crypto as an Alternative to Traditional Legal Systems 11:49 The Impact of Incumbent Protection on Innovation 15:03 The Future of Crypto in a Regulated Environment 17:51 The Importance of Privacy and Programmability in Crypto 26:18 The Imperative of Privacy in Crypto 34:52 Navigating Legal Compliance and Privacy 39:41 The Dilemma of Civil Disobedience 46:24 The Future of KYC in Crypto 48:40 Zero Knowledge Technology and Its Potential

    41 min
  7. Why AI Is Crypto’s Biggest ‘Competitive’ Threat | Aaron Wright

    12/18/2025

    Why AI Is Crypto’s Biggest ‘Competitive’ Threat | Aaron Wright

    Is crypto’s biggest rival artificial intelligence?  As AI absorbs talent and capital, it’s not clear yet if crypto and AI are competing or converging but crypto’s focus on human agency may matter more than ever in an automated world. Amanda Cassatt is joined by Aaron Wright, crypto lawyer, former Wikia general counsel and CEO of Tribute Labs, to unpack the battle between crypto and AI and what the explosive growth of stablecoins actually means for the U.S. dollar as both institutions and corporations look to gain exposure to crypto.  Outside of the technological battle we’re seeing, Aaron believes we’re also undergoing a structural shift that’ll see the separation of the U.S. dollar from U.S. banks. He discusses the slow erosion of smaller national currencies, and the rise of open, permissionless financial infrastructure that anyone can access. What looks incremental today may ultimately reshape who controls money and how power flows in a dollar-dominated world. The conversation spans across artificial intelligence, dollar hegemony, central bank authority, as well as the growing divide between institutional crypto and the onchain “trenches.” Timestamps:  00:00 – Cold Open: Stablecoins and the End of Dollar Hegemony 05:00 – Splitting the Dollar from the Banks 10:00 – Do Stablecoins Weaken Central Banks? 15:00 – Should Local Currencies Even Exist? 20:00 – The Paradox of American Decline 25:00 – Regulation, Law, and Crypto’s Lost Years 30:00 – Institutional Crypto vs. the Trenches 35:00 – Is Crypto Still About Technology? 40:00 – AI vs. Crypto 45:00 – Open Systems, Wikipedia, and Internet Decay 50:00 – KYC, Surveillance, and Enshittification 55:00 – Identity, Reputation, and ZK Proofs 1:00:00 – Crypto’s Endgame: Human Agency Resources:  Follow Aaron Wright @awrigh01 https://x.com/awrigh01 Learn more about Aaron's work: https://papers.ssrn.com/sol3/cf_dev/AbsByAuth.cfm?per_id=2373233 Subscribe to Endgame: https://www.youtube.com/@endgamepodcast   Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin   Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd    Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

    45 min
  8. Inside China: Crypto's Largest Hidden Market | Mable Jiang

    12/10/2025

    Inside China: Crypto's Largest Hidden Market | Mable Jiang

    What if the biggest forces shaping crypto today are hidden behind VPNs? In this episode of Endgame, host Amanda Cassatt sits down with Mable Jiang, Trends co-founder, former Multicoin partner and founding member of the Solana Foundation Council,for a rare, unfiltered look at the Chinese and Asian crypto markets — the traders, the memes, the exchanges, and the invisible liquidity that moves the entire ecosystem. From the rise of Bybit and Binance to the cultural phenomenon of Chinese tickers and global “trenchers,” Jiang dives into the real size of the Chinese crypto market and why so much of that activity is “concealed” and never shows up in Western reports. Cassatt and Jiang explore Hong Kong’s resurgence and what’s led to it in comparison to the “Westworld effect” Singapore has. The two also touch on Solana’s “Lala” moment, creator-coin culture and what Western builders don’t understand about Asia. The US may have claimed the crypto capital for now, but Asia, and China, may dominate crypto’s next chapter. Timecodes:  00:00 The Evolution of Dance and Technology 05:01 The Chinese Crypto Market Landscape 11:18 Centralized Exchanges and Their Impact 17:06 Institutional Participation in Crypto 22:43 The Role of Education in Innovation 27:23 The Gaokao System and Its Implications 34:39 Stereotypes of Chinese Tech Culture 39:02 Government Perspectives on Crypto 43:09 Opportunities and Risks in Crypto Adoption 50:44 Navigating the Chinese Market for Crypto Projects Subscribe to Endgame: https://www.youtube.com/@endgamepodcast   Amanda on X:  https://x.com/amandacassatt   Serotonin on X: https://x.com/serotonin   Endgame on Spotify: https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd    Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440   Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ

    1 hr

Ratings & Reviews

3.7
out of 5
3 Ratings

About

The world is changing at an accelerating pace—Endgame is here to make sense of it. Hosted by Amanda Cassatt, founder of Serotonin, this podcast brings you conversations with the visionaries driving breakthrough technologies and shaping the future. Join Amanda as she unpacks the trends, innovations, and paradigm shifts defining our time. Where is this all going? Let’s figure it out together. Subscribe now on Apple Podcasts, Spotify, YouTube, and wherever you listen.