Genetics in Your World

Genetics Society of America

The Genetics in Your World podcast spotlights noteworthy studies published in GSA Journals GENETICS and G3: Genes|Genomes|Genetics. Through conversations with the authors, you’ll hear about their research and its significance for the fields of genetics and genomics. The podcast is produced by the GSA Early Career Scientist Multimedia Subcommittee. Hosted on Acast. See acast.com/privacy for more information.

  1. EPISODE 2

    Functions of Blm Helicase N-terminal IDR — A Conversation with Dr. Evan B. Dewey

    In this episode of Genetics in Your World, GSA Early Career Scientist Multimedia Subcommittee member Allie Hutchings interviews Dr. Evan Dewey of Winthrop University about the functions of Blm helicase N-terminal IDR. Read Dr. Dewey's paper titled, “Functions of the Bloom syndrome helicase N-terminal intrinsically disordered region,” published in the March 2025 issue of GENETICS: https://doi.org/10.1093/genetics/iyaf005. Music: Loopster Kevin MacLeod (incompetech.com). Licensed under Creative Commons: By Attribution 3.0 License, http://creativecommons.org/licenses/by/3.0/   Podcast Notes: Bloom syndrome helicase (Blm) has important roles in maintaining genome stability. About half the protein is predicted to be intrinsically disordered (IDR), and its functions are poorly understood. The authors of this study identified regions that are locally conserved in closely related Drosophila species, then deleted these and assayed various functions. They find that each region is required for a subset of Blm functions. The authors’ modeling suggests these regions adopt structure in complex with Top2alpha and the results provide novel insights into Blm IDR functions.   Dr. Evan Dewey would like to acknowledge the following colleagues: Colleen C. Bereda, Dr. Jeff Sekelsky, Dr. Christopher A Johnston, Denise Soroka, Dr. Mitch McVey, Carolyn Turcotte, Dr. Nila Pazhayam, Mohamed A. Nasr, Priscila Santa Rosa, Susan McMahan, Dr. Robert J. Duronio, Dr. Gregory Matera, Dr. Dan McKay, and Dr. Richard Cripps. Thank you to the GSA Early Career Scientist Multimedia Subcommittee, in particular the production team who worked on this episode: Allie Hutchings, Interviewer; Sarah Shahba and Laetitia Chauve, Researchers. Hosted on Acast. See acast.com/privacy for more information.

    28 min

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5
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7 Ratings

About

The Genetics in Your World podcast spotlights noteworthy studies published in GSA Journals GENETICS and G3: Genes|Genomes|Genetics. Through conversations with the authors, you’ll hear about their research and its significance for the fields of genetics and genomics. The podcast is produced by the GSA Early Career Scientist Multimedia Subcommittee. Hosted on Acast. See acast.com/privacy for more information.

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