High Signal: Data Science | Career | AI

Delphina

Welcome to High Signal, the podcast for data science, AI, and machine learning professionals. High Signal brings you the best from the best in data science, machine learning, and AI. Hosted by Hugo Bowne-Anderson and produced by Delphina, each episode features deep conversations with leading experts, such as Michael Jordan (UC Berkeley), Andrew Gelman (Columbia) and Chiara Farranato (HBS). Join us for practical insights from the best to help you advance your career and make an impact in these rapidly evolving fields. More on our website: https://high-signal.delphina.ai/

  1. 5d ago

    Episode 40: The Economic Reality of AI: Friction, Talent, and the Future of the Firm

    Steve Tadelis, Professor of Economics at UC Berkeley and former senior economist at eBay and Amazon, joins High Signal to bridge the gap between economic theory and the high-stakes reality of data science and AI. Drawing on his experience at the forefront of the world’s largest marketplaces, Steve discusses the "invisible friction" that prevents organizations from acting on data: a combination of misaligned incentives, organizational inertia, and the "Upton Sinclair problem," where leaders are effectively paid not to understand new paradigms. The conversation moves from the "frustratingly obvious" opportunities left on the floor during eBay’s early years to the relentlessly scientific culture of Amazon. Steve explains why surface-level metrics like conversion rates often mask underlying rot in user retention and how rigorous experimentation, such as his famous $20 million search-ad experiment, can expose the difference between genuine growth and mere navigational intent. We also explore the structural shifts of the AI era, where Steve offers an important counter-narrative: rather than leveling the playing field, AI may act as an "unequalizer" that exponentially rewards those with the deepest critical thinking skills. LINKS Steve on LinkedIn Consumer Heterogeneity and Paid Search Effectiveness by Blake, Nosko, and Tadelis (Econometrica, 2015) The Limits of Reputation in Platform Markets by Nosko and Tadelis (NBER, 2015) Information Disclosure as a Matching Mechanism by Tadelis and Zettelmeyer (AER, 2015) The Anatomy of a Large-Scale Hypertextual Web Search Engine by Brin and Page (with Appendix A: Advertising and Mixed Motives) Freakonomics Radio Ep 441: Does Advertising Actually Work? (Part 2: Digital) High Signal podcast Watch the podcast episode on YouTube Delphina's Newsletter

    59 min
  2. May 12

    Episode 39: The 100-Year Lead: What Baseball Teaches Us About the Future of AI

    Chris Fonnesbeck, veteran analyst for the Yankees and Mets and creator of the open-source Bayesian modeling library PyMC, joins to unpack why baseball has been a leading indicator for data science and analytics for over a century, and why builders and AI leaders need to pay attention now. The reason it has led is simple: huge incentives and a culture that treats decisions as quantifiable. With wins worth about eight to ten million dollars apiece and front offices built around probabilistic reasoning, baseball has had every reason to push the methods further and faster than industry. The skillset and culture that built this lead is what AI teams now need to adopt more of: probabilistic thinking, hierarchical models, integrating expert judgment, reasoning carefully under uncertainty, and increasingly causal inference. The conversation traces the throughline from those early statistical innovations to the decisions driving multi-million dollar contracts today, with concrete patterns AI builders can take back to their own work: how to handle small samples and high stakes, why outcomes are the wrong thing to measure, what changes when you push uncertainty all the way through your model, and why robust causal inference needs to be the next frontier. LINKS Chris on LinkedIn The Signal and the Noise: Why So Many Predictions Fail--But Some Don't by Nate Silver Superforecasting: The Art and Science of Prediction by Tetlock and Gardner The Book: Playing the Percentages in Baseball by Tango, Lichtman, and Dolpin High Signal podcast Watch the podcast episode on YouTube Delphina's Newsletter

    56 min
  3. Apr 16

    Episode 38: Why AI Won’t Fix Your Data Culture, It Will Only Amplify It (And What To Do About It)

    Noah Bruegmann, President of Data CRT, joins High Signal to discuss how to move your data function from a cost center to a strategic "value center". He explains how AI amplifies your existing data culture, the importance of "no-assistance" reporting, and how rebranding documentation as "Context" can finally secure executive buy-in. Drawing on 15 years of experience spanning trading floors and Silicon Valley startups, Noah argues that for too long, data teams have been submerged under an "iceberg" of invisible data preparation. He details how the arrival of LLMs and agentic tools is fundamentally shifting this landscape, automating technical drudgery and allowing data professionals to transition into what he calls "Jack Ryan" mode: acting as high-level intelligence analysts rather than mere number crunchers. We dig into the architectural and psychological shifts required to navigate this new era and why the most valuable skill in an AI-augmented world is no longer mastering SQL syntax, but "problem framing": the ability to reduce business ambiguity into high-leverage insights. Noah cautions that while AI offers a dopamine hit of instant answers, it demands a new discipline of rigorous verification to avoid automated hallucinations. The conversation provides a clear directive for executives: move past the "ticket-taker" model and start treating the data team as the essential "left-side brain" for organizational decision-making. LINKS Noah on LinkedIn High Signal podcast Watch the podcast episode on YouTube Delphina's Newsletter

    46 min
  4. Mar 5

    Episode 35: Beyond Online Experimentation: Generative Software That Optimizes Itself

    Martin Tingley, Head of Windows Experimentation at Microsoft and former Head of the Experimentation Platform Analysis Team at Netflix, talks about why humans are the bottleneck in experimentation, and how a five-level maturity framework points the way toward self-optimizing software. Our conversation traces the path from basic hypothesis testing to a frontier where Generative AI creates, evaluates, and refines product variants in a closed loop. We explore the architectural shift required to move from testing single variants to optimizing entire parameter spaces, and how startups are already using AI to generate production-ready landing pages for Fortune 500 companies in hours rather than weeks. Tingley also shares a strategic lens on "experimentation programs," explaining how plotting the distribution of treatment effects across different product areas can serve as a powerful tool for capital allocation and high-level strategy. LINKS Martin on LinkedIn Want Your Company to Get Better at Experimentation? by Iavor Bojinov, David Holtz, Ramesh Johari, Sven Schmit and Martin Tingley (Harvard Business Review) Avoid the Pitfalls of A/B Testing by Iavor Bojinov, Guillaume Saint-Jacques and Martin Tingley (Harvard Business Review) Martin & Co.'s Seven Part Blog Series on Experimentation at Netflix Roberto Medri (Meta) on High Signal: The Incentive Problem in Shipping AI Products — and How to Change It Tim O’Reilly on High Signal: The End of Programming As We Know It Watch the podcast episode on YouTube Delphina's Newsletter

    55 min
  5. Jan 27

    Episode 33: Why Your AI Product Will Be Obsolete in Six Months (And What To Do About It)

    Benn Stancil, writer and co-founder of Mode, joins High Signal to ask some uncomfortable questions about the current AI moment. Is now actually a terrible time to start a company? If the tools you build on today are obsolete in six months, at what point does the head start stop mattering? Is all that context engineering you're doing a waste of time, destined to go the way of Boolean search syntax in the 90s? Benn argues that AI is turning us all into Steve Jobs, not the visionary who delegated, but the one who berated people over pixel placement. As AI takes over the doing, our job becomes obsessing over the polish. He makes the case that technical debt may be self-healing: if future models can untangle the mess today's models made, then messy code isn't debt…it's a spec for a clean rewrite. We also dig into why Claude Cowork can't work. AI has these uncanny ticks you can't beat out, so anything it writes "as you" will smell like AI. The solution isn't better AI writing—it's to stop pretending we write to each other at all. Benn envisions a future where communication is radically intermediated: I dump facts into a shared repository, your AI reads them, and nobody bothers with the social decoration in between. LINKS Benn’s blog on Substack Benn.website, with links to all everything else Benn related Will there ever be a worse time to start a startup? Today's frontier is tomorrow's tech debt. Why Cowork can’t work: The future isn’t collaborative. Producer theory: Platforms are overrated. Tim O’Reilly on High Signal: The End of Programming As We Know It Watch the podcast episode on YouTube Delphina's Newsletter

    1 hr
5
out of 5
19 Ratings

About

Welcome to High Signal, the podcast for data science, AI, and machine learning professionals. High Signal brings you the best from the best in data science, machine learning, and AI. Hosted by Hugo Bowne-Anderson and produced by Delphina, each episode features deep conversations with leading experts, such as Michael Jordan (UC Berkeley), Andrew Gelman (Columbia) and Chiara Farranato (HBS). Join us for practical insights from the best to help you advance your career and make an impact in these rapidly evolving fields. More on our website: https://high-signal.delphina.ai/

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