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Programs from the University of California, San Diego.

  1. قبل ٣ أيام

    Early Roles of SYNGAP1 in Neurodevelopment: Insights from a Top Autism Risk Gene

    Human brain organoids help researchers study neurodevelopmental disorders that are difficult to examine directly in developing brain tissue. Giorgia Quadrato, USC, uses cortical organoids derived from human pluripotent stem cells to examine SYNGAP1, an autism risk gene associated in the transcript with intellectual disability, epilepsy, and global developmental delay. Quadrato describes how SYNGAP1 appears in progenitor cells as well as neurons, and how SYNGAP1 haploinsufficiency is linked to disrupted radial glia organization, altered cell division, and faster maturation of cortical projection neurons. She also discusses newer work focused on enteric neurons, gastrointestinal symptoms, and gut motility. By connecting brain development, autism genetics, and the enteric nervous system, this research points to models that may help test therapies and better understand symptoms that affect families. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Show ID: 41174]

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  2. ١ يوليو

    The 2000-Year History of Rome and Its Lessons Today

    Rome survived for 2,000 years. Edward Watts explores the long history of the Roman state and the lessons it offers for the modern world. From its beginnings as a small Italian city-state to its transformation into a Christian empire centered in Constantinople, Rome maintained a remarkable sense of political continuity across centuries of cultural and religious change. Watts examines how Roman institutions adapted over time and how the Fourth Crusade and capture of Constantinople ultimately destroyed the foundations that sustained the state for generations. Watts highlights the importance of resilient institutions and the dangers of disrupting the systems that preserve political stability and continuity. Series: "Osher UC San Diego Distinguished Lecture Series" [Public Affairs] [Humanities] [Show ID: 41602]

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  3. ٢٨ يونيو

    How Machine Learning Improves Algorithms with Ellen Vitercik

    Hard optimization problems often look impossible through worst-case analysis, but real-world problems can contain structure that helps algorithms work faster. Ellen Vitercik, Ph.D., of Stanford University explains how machine learning can improve algorithm design for NP-hard optimization problems while preserving the formal guarantees that make solvers useful. She discusses beyond worst-case analysis, problem-specific heuristics, and the gap between tools that perform well in practice and methods that prove optimality. Vitercik also describes research on LLM reasoning using data structure tasks, where answers can be checked programmatically and failures reveal when models rely on pattern matching rather than true generalization. Her work helps clarify how AI may support stronger algorithms, more useful benchmarks, and more reliable reasoning systems. Series: "Data Science Channel" [Science] [Show ID: 41179]

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  4. ٢٦ يونيو

    Heart Regeneration in Humans: Are We There Yet?

    Heart regeneration faces two connected challenges: replacing lost muscle and keeping transplanted cells safe and accepted by the body. Charles Murry, M.D., Ph.D., of USC explains why the adult heart heals major cardiomyocyte loss with scar tissue rather than new muscle, leading to progressive heart failure. Murry describes how stem cell derived cardiomyocytes can be manufactured at scale, transplanted into injured hearts, and tested for function in animal models. He also examines major barriers, including graft related arrhythmias, calcium handling stress, immune rejection, and the need for practical immunosuppression or immune edited cells. By connecting cell manufacturing, electrophysiology, immunology, and clinical trial planning, this research shows why heart regeneration is difficult and why careful translation matters for patients with severe heart injury. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40853]

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  5. ٢٣ يونيو

    How to Not Know with Simone Stolzoff

    In an age obsessed with expertise, certainty, and endless self-optimization, author and journalist Simone Stolzoff invites audiences to rediscover the power of curiosity, humility, and not having all the answers. His new book, How to Not Know, challenges the cultural pressure to define ourselves by what we do or what we know—and instead celebrates the richness of uncertainty as a pathway to creativity, empathy, and authentic connection. [Public Affairs] [Humanities] [Show ID: 41267]

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  6. ١٩ يونيو

    Inflammatory Memory in Human Hematopoietic Stem Cells as a Driver of Clonal Selection in Aging and Cancer

    Hematopoietic stem cells make blood across the lifespan, but they do not all behave the same way. Stephanie Xie, Ph.D., Scientist at Princess Margaret Cancer Centre, University of Toronto, examines how these rare cells self-renew, differentiate, and respond to inflammatory stress, asking whether differences in the stem cell pool help explain why aging affects people so differently. Xie identifies two hematopoietic stem cell subsets, including one that retains inflammatory memory after stress recovery, and connects this state to aging, clonal hematopoiesis, sickle cell disease, post-COVID recovery, and mortality risk markers in blood. Her research also raises questions about whether targeting the inflammatory environment, including through GLP-1 receptor agonists or metformin, could help mitigate clonal hematopoiesis. Understanding these patterns could clarify how inflammation shapes blood production, cancer risk, and immune health over time. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41406]

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  7. ١٢ يونيو

    Gene Therapies and Rare Disease - Medicine Informing Novel Discoveries (MIND)

    Rare disease research is creating new paths for diagnosis, treatment, and broader medical discovery. Gene therapy can repair or replace faulty genes, and work on cystinosis has led to a stem cell platform now being applied to Danon disease, Sanfilippo syndrome C, Friedreich’s ataxia, and Alzheimer’s research. Funding programs support gene therapy, clinical trials, and new platform approaches for rare diseases. CAR-T cell research is also advancing treatment possibilities for pediatric brain tumors, including early results in children with DIPG and diffuse midline glioma. A patient advocate shares her daughter’s diagnostic odyssey and treatment for TUBB4A leukodystrophy. Together, these stories show why rare disease research matters beyond rarity. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 41402]

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  8. ٨ يونيو

    Ethical Sourcing in Health Data Supply Chains: Considerations for ML/AI Training

    Health data affects artificial intelligence in important ways. Camille Nebeker, Ed.D., M.S., UC San Diego, explains why ethically sourced data is foundational to building trustworthy, AI-ready health data repositories. Nebeker examines how ethical sourcing applies across the full data lifecycle, including consent, governance, transparency, data quality, privacy, stewardship, and community engagement. She also shows how ideas from supply chain management and value sensitive design help teams identify ethical tensions and improve decision-making. This work helps explain why ethics cannot be added at the end of AI development and points toward more accountable data practices that support public trust and stronger downstream performance. Series: "Exploring Ethics" [Science] [Show ID: 41368]

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Programs from the University of California, San Diego.

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