Howards Blend

Howard Blend
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Each episode we explore topics that encourage free thought, promote wellness and taking responsibility for one's life.

  1. ١٥‏/٠٣‏/٢٠٢٥

    To Methylate Or Not To Methylate?

    Discuss my thoughts on whether Dimethylglycine or Trimethylglycine is "better" for Homocysteine conversion to Methionine.This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice.Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.Resources: https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/https://cen.acs.org/articles/82/i3/METHYLMERCURY-TOXICOLOGY-PROBED.html#:~:text=%22Glutathione%20can%20be%20pumped%20out,brain%20as%20methylmercury%2Dglutathione.%22https://pmc.ncbi.nlm.nih.gov/articles/PMC4540061/https://www.sciencedirect.com/science/article/pii/S0163725821001182https://www.sciencedirect.com/science/article/pii/S0163725821001182 Image Resource:https://pmc.ncbi.nlm.nih.gov/articles/PMC6635095/ https://www.researchgate.net/figure/Overview-of-de-novo-glutathione-synthesis-Reduced-glutathione-or-GSH-is-a-tripeptide_fig2_5690064 https://lpi.oregonstate.edu/book/export/html/71 https://www.nature.com/articles/hr2011133 https://en.wikipedia.org/wiki/Serine_hydroxymethyltransferase - https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/methylenetetrahydrofolate-reductasehttps://chemtymology.co.uk/2020/11/27/cysteine-and-cystine/ https://fda.report/DailyMed/972f09a7-2aa1-4b1b-a6dc-2c4578a07803 https://www.thoughtco.com/definition-of-precipitate-604612 https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-p-benzoquinone-imine#section=3D-Conformer https://www.semanticscholar.org/paper/DRUG-METABOLISM-IN-THE-LIVER-Nguyen/4a29c6c4d433685a94b94602c012b8731cba5493https://pubchem.ncbi.nlm.nih.gov/compound/S-_Methylmercury_-L-Cysteine#section=2D-Structurehttps://keymerhealth.com/articles/seafood-mercury/https://onlinelibrary.wiley.com/doi/10.1155/2021/6564585 https://www.sciencedirect.com/science/article/abs/pii/S0304416519300133https://www.jbc.org/cms/10.1074/jbc.M111.265348/asset/822df563-eda2-4f48-a333-d01370a79e9c/main.assets/gr5_lrg.jpghttps://www.researchgate.net/figure/Betaine-metabolism-Metabolic-pathways-involving-betaine-BHMT-betaine-homocysteine_fig11_225081065https://www.acs.org/molecule-of-the-week/archive/c/l-cysteine.htmlhttps://biologydictionary.net/glutamic-acid/https://www.researchgate.net/figure/An-overview-of-the-reaction-catalyzed-by-SHMT-and-its-context-in-the-folate-cycle-A-The_fig1_338995871https://pubchem.ncbi.nlm.nih.gov/compound/5-Methyltetrahydrofolate#section=2D-Structurehttps://pubchem.ncbi.nlm.nih.gov/compound/Tetrahydrofolic-acid#section=2D-Structurehttps://pubchem.ncbi.nlm.nih.gov/compound/135398652#section=2D-Structure

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    A Vital Antioxidant

    This episode goes over the compounds of N-acetylcysteine (NAC) and Glycine, and how they are used to make Glutathione. Also, we go over a couple of use cases for Glutathione. This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice.Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.Resources: https://pmc.ncbi.nlm.nih.gov/articles/PMC4684116/https://cen.acs.org/articles/82/i3/METHYLMERCURY-TOXICOLOGY-PROBED.html#:~:text=%22Glutathione%20can%20be%20pumped%20out,brain%20as%20methylmercury%2Dglutathione.%22https://pmc.ncbi.nlm.nih.gov/articles/PMC4540061/https://www.sciencedirect.com/science/article/pii/S0163725821001182https://www.sciencedirect.com/science/article/pii/S0163725821001182 Image Resource:https://pmc.ncbi.nlm.nih.gov/articles/PMC6635095/ https://www.researchgate.net/figure/Overview-of-de-novo-glutathione-synthesis-Reduced-glutathione-or-GSH-is-a-tripeptide_fig2_5690064 https://lpi.oregonstate.edu/book/export/html/71 https://www.nature.com/articles/hr2011133 https://en.wikipedia.org/wiki/Serine_hydroxymethyltransferase - https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/methylenetetrahydrofolate-reductasehttps://chemtymology.co.uk/2020/11/27/cysteine-and-cystine/ https://fda.report/DailyMed/972f09a7-2aa1-4b1b-a6dc-2c4578a07803 https://www.thoughtco.com/definition-of-precipitate-604612 https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-p-benzoquinone-imine#section=3D-Conformer https://www.semanticscholar.org/paper/DRUG-METABOLISM-IN-THE-LIVER-Nguyen/4a29c6c4d433685a94b94602c012b8731cba5493https://pubchem.ncbi.nlm.nih.gov/compound/S-_Methylmercury_-L-Cysteine#section=2D-Structurehttps://keymerhealth.com/articles/seafood-mercury/https://onlinelibrary.wiley.com/doi/10.1155/2021/6564585 https://www.sciencedirect.com/science/article/abs/pii/S0304416519300133

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    It’s Located Where?

    Discussing a question I received asking where the blood brain barrier is located. In addition, we go over information about the blood csf barrier. This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice.Here's a link to the previous video on the blood brain barrier.https://spotifycreators-web.app.link/e/BQceRCwlKRbPlease like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible.Resources:https://www.sciencedirect.com/topics/neuroscience/area-postrema#:~:text=The%20area%20postrema%20refers%20to,actions%20that%20lead%20to%20illness.https://qbi.uq.edu.au/brain/brain-anatomy/what-blood-brain-barrier#:~:text=The%20brain%20is%20precious%2C%20and,of%20the%20blood%E2%80%93brain%20barrier.https://www.cancer.gov/publications/dictionaries/cancer-terms/def/choroid-plexushttps://journals.lww.com/glaucomajournal/fulltext/2013/06001/production_and_circulation_of_cerebrospinal_fluid.5.aspxhttps://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-020-00230-3https://my.clevelandclinic.org/health/articles/22266-meningeshttps://pmc.ncbi.nlm.nih.gov/articles/PMC2821375/https://www.frontiersin.org/journals/neuroanatomy/articles/10.3389/fnana.2021.665803/full#F1https://pmc.ncbi.nlm.nih.gov/articles/PMC1871727/https://pmc.ncbi.nlm.nih.gov/articles/PMC7768803/https://pmc.ncbi.nlm.nih.gov/articles/PMC4120694/Image resources:https://www.cancer.gov/publications/dictionaries/cancer-terms/def/choroid-plexushttps://med.libretexts.org/Bookshelves/Anatomy_and_Physiology/Anatomy_and_Physiology_%28Boundless%29/11%3A_Central_Nervous_System/11.3%3A_Protection_of_the_Brain/11.3C%3A_Ventricleshttps://www.hydroassoc.org/understanding-the-choroid-plexus-function-location-and-its-role-in-hydrocephalus/https://www.researchgate.net/figure/blood-cerebrospinal-fluid-CSF-barrier-The-choroid-plexus-has-fenestrated-capillaries_fig1_325373010https://neuroscientificallychallenged.com/glossary/fourth-ventriclehttps://www.researchgate.net/figure/Area-Postrema-is-Anatomical-Marker-for-the-Subregion-of-NTS-of-Primary-Hypothetical_fig1_259320952https://www.rit.edu/spotlights/blood-brain-barrierhttps://www.cell.com/heliyon/fulltext/S2405-8440%2824%2911593-9https://www.aginganddisease.org/EN/10.14336/AD.2022.0130-1http://epilepsygenetics.net/the-epilepsiome/slc2a1-this-is-what-you-need-to-know/https://www.mdpi.com/2072-6643/16/14/2363https://www.mdpi.com/2072-6643/11/11/2636https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2019.00282/fullhttps://teachmephysiology.com/immune-system/innate-immune-system/phagocytosis/https://oehha.ca.gov/chemicals/methylmercury-and-methylmercury-compoundshttps://www.mdpi.com/2073-4409/11/18/2823https://www.simplypsychology.org/brain-ventricles.htmlhttps://www.frontiersin.org/files/Articles/123479/fnins-09-00032-HTML/image_m/fnins-09-00032-g001.jpghttps://www.researchgate.net/figure/Cerebrospinal-fluid-flow-Cerebrospinal-fluid-is-mainly-produced-in-the-lateral_fig2_370857837https://www.physio-pedia.com/CSF_Cerebrospinal_Fluid

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    BUM Energy Review

    Going 2 Deep (two active ingredients) in this review of BUM Energy Drink, root beer flavor. This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice. Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible. Image References: https://www.mdpi.com/1420-3049/27/12/3679 https://courses.lumenlearning.com/wm-biology2/chapter/neural-stimulation-of-muscle-contraction/ https://link.springer.com/referenceworkentry/10.1007/978-3-030-42634-7_52 https://www.researchgate.net/figure/Tripartite-synapse-Participation-of-the-astrocyte-in-the-regulation-of-synapse-activity_fig3_366464810 https://www.researchgate.net/profile/Francisco-Wandosell/publication/258282849/figure/fig1/AS:203001995239428@1425410855933/The-coordinated-action-of-glial-and-neuronal-purinergic-receptors-and-purines-in-the-CNS.png https://www.researchgate.net/figure/Schematic-drawing-of-ATP-and-adenosine-receptor-localization-on-different-cell-types-in_fig2_284132757 https://www.mdpi.com/1422-0067/22/1/320 https://brainstuff.org/blog/cellular-action-of-adenosine-receptors https://www.osmosis.org/notes/Motor_Nervous_System#page-16 https://www.sciencefacts.net/resting-membrane-potential.html https://www.researchgate.net/figure/Sodium-Potassium-pump-which-uses-ATP-to-pump-sodium-ions-out-of-the-cell-The-hydrolysis_fig2_273751706 https://jackwestin.com/resources/mcat-content/nerve-cell/nodes-of-ranvier-propagation-of-nerve-impulse-along-axon https://old-ib.bioninja.com.au/standard-level/topic-6-human-physiology/65-neurons-and-synapses/synaptic-transfer.html https://www.oist.jp/image/exocytosis-and-endocytosis-are-key-steps-vesicle-recycling-exocytosis-increases-surface-area https://www.sciencelearn.org.nz/images/2456-caffeine-and-adenosine-structure

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  5. ٢٥‏/٠١‏/٢٠٢٥

    Crossing The BBB

    This episode goes over my two cents about a question I received. Does lecithin cross the blood brain barrier more effectively than choline? This is strictly for educational purposes. The information in this video is not meant as a substitute for professional medical advice. Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible. Information References: https://www.sciencedirect.com/science/article/abs/pii/S0197018615300802?via%3Dihub https://pmc.ncbi.nlm.nih.gov/articles/PMC1997116 https://lpi.oregonstate.edu/mic/other-nutrients/choline https://pubmed.ncbi.nlm.nih.gov/14938439/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6835836/ https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/ Image References: https://cordancemedical.com/the-problem/blood-brain-barrier/ https://www.researchgate.net/figure/Molecular-characteristics-of-tight-junction-TJ-protein-complexes-at-the-blood-brain_fig1_363511691 https://www.sciencedirect.com/science/article/abs/pii/S1878818120304357 https://www.ncbi.nlm.nih.gov/books/NBK114308/ https://jissn.biomedcentral.com/articles/10.1186/1550-2783-4-5 https://www.ncbi.nlm.nih.gov/books/NBK594255/ https://pubchem.ncbi.nlm.nih.gov/compound/Choline https://pubchem.ncbi.nlm.nih.gov/compound/L-Tartaric-acid https://www.mdpi.com/2072-6651/8/11/326 https://pmc.ncbi.nlm.nih.gov/articles/PMC8235064/ https://www.examine.com/supplements/alpha-gpc/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10025538/ https://pressbooks.calstate.edu/nutritionandfitness/chapter/6-2-phospholipids-and-sterols/ https://lpi.oregonstate.edu/mic/other-nutrients/choline

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  6. ٢١‏/٠١‏/٢٠٢٥

    Lecithin VS Choline Part 2

    This is the second of a 2 part response to a question about lecithin vs choline. Here's the link to part 1. https://open.spotify.com/episode/2at2pXZQ02Wt9ZmYq3lczz?si=6exmen2-QjWM2fJ6aaItog Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible. Information References: https://www.sciencedirect.com/science/article/abs/pii/S0197018615300802?via%3Dihub https://pmc.ncbi.nlm.nih.gov/articles/PMC1997116 https://lpi.oregonstate.edu/mic/other-nutrients/choline https://pubmed.ncbi.nlm.nih.gov/14938439/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6835836/ https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/ Image References: https://cordancemedical.com/the-problem/blood-brain-barrier/ https://www.researchgate.net/figure/Molecular-characteristics-of-tight-junction-TJ-protein-complexes-at-the-blood-brain_fig1_363511691 https://www.sciencedirect.com/science/article/abs/pii/S1878818120304357 https://www.ncbi.nlm.nih.gov/books/NBK114308/ https://jissn.biomedcentral.com/articles/10.1186/1550-2783-4-5 https://www.ncbi.nlm.nih.gov/books/NBK594255/ https://pubchem.ncbi.nlm.nih.gov/compound/Choline https://pubchem.ncbi.nlm.nih.gov/compound/L-Tartaric-acid https://www.mdpi.com/2072-6651/8/11/326 https://pmc.ncbi.nlm.nih.gov/articles/PMC8235064/ https://www.examine.com/supplements/alpha-gpc/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10025538/ https://pressbooks.calstate.edu/nutritionandfitness/chapter/6-2-phospholipids-and-sterols/ https://lpi.oregonstate.edu/mic/other-nutrients/choline https://www.researchgate.net/figure/molecular-structure-of-the-phosphatidylethanolamine-eluting-at-462-min_fig2_23771336 https://www.nature.com/articles/srep16787 https://www.researchgate.net/figure/Betaine-metabolism-Metabolic-pathways-involving-betaine-BHMT-betaine-homocysteine_fig11_225081065 https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.1109445/full https://ncbi.nlm.nih.gov/books/NBK554408/ https://www.researchgate.net/figure/A-simplified-illustration-of-the-homocysteine-metabolism-pathway-BHMT-betaine_fig1_341362341 https://www.researchgate.net/figure/Fig-2-The-nucleus-basalis-of-Meynert-innervates-the-entire-cerebral-mantle-with_fig1_327756974 https://www.researchgate.net/figure/The-human-cholinergic-system-Cholinergic-nuclei-are-primarily-located-in-numbered-cell_fig1_345346799

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  7. ١٩‏/٠١‏/٢٠٢٥

    Lecithin VS Choline Part 1

    This is the first of a two part response to a question about lecithin vs choline. Stay tuned for part 2. Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible. Information References: https://www.sciencedirect.com/science/article/abs/pii/S0197018615300802?via%3Dihub https://pmc.ncbi.nlm.nih.gov/articles/PMC1997116 https://lpi.oregonstate.edu/mic/other-nutrients/choline https://pubmed.ncbi.nlm.nih.gov/14938439/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6835836/ https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/ Image Resources: https://cordancemedical.com/the-problem/blood-brain-barrier/ https://www.researchgate.net/figure/Molecular-characteristics-of-tight-junction-TJ-protein-complexes-at-the-blood-brain_fig1_363511691 https://www.sciencedirect.com/science/article/abs/pii/S1878818120304357 https://www.ncbi.nlm.nih.gov/books/NBK114308/ https://jissn.biomedcentral.com/articles/10.1186/1550-2783-4-5 https://www.ncbi.nlm.nih.gov/books/NBK594255/ https://pubchem.ncbi.nlm.nih.gov/compound/Choline https://pubchem.ncbi.nlm.nih.gov/compound/L-Tartaric-acid https://www.mdpi.com/2072-6651/8/11/326 https://pmc.ncbi.nlm.nih.gov/articles/PMC8235064/ https://www.examine.com/supplements/alpha-gpc/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10025538/ https://pressbooks.calstate.edu/nutritionandfitness/chapter/6-2-phospholipids-and-sterols/ https://lpi.oregonstate.edu/mic/other-nutrients/choline https://www.researchgate.net/figure/molecular-structure-of-the-phosphatidylethanolamine-eluting-at-462-min_fig2_23771336 https://www.nature.com/articles/srep16787 https://www.researchgate.net/figure/Betaine-metabolism-Metabolic-pathways-involving-betaine-BHMT-betaine-homocysteine_fig11_225081065 https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.1109445/full https://ncbi.nlm.nih.gov/books/NBK554408/ https://www.researchgate.net/figure/A-simplified-illustration-of-the-homocysteine-metabolism-pathway-BHMT-betaine_fig1_341362341 https://www.researchgate.net/figure/Fig-2-The-nucleus-basalis-of-Meynert-innervates-the-entire-cerebral-mantle-with_fig1_327756974 https://www.researchgate.net/figure/The-human-cholinergic-system-Cholinergic-nuclei-are-primarily-located-in-numbered-cell_fig1_345346799

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  8. ٢٥‏/١٢‏/٢٠٢٤

    Increased Absorption?

    Replying to a question about how the absorption of choline be improved. This was a response on a choline bitartrate video, so I used that ingredient to explain. Please like, comment and share if you find value in this video. Also, please ask any questions you have about supplements. I'll do a video reply as soon as possible. Image Resources: https://onlinelibrary.wiley.com/doi/10.1155/2021/6564585 https://socratic.org/questions/how-is-the-structure-of-a-villi-in-the-small-intestine-related-to-its-function

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Each episode we explore topics that encourage free thought, promote wellness and taking responsibility for one's life.

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