40 episodes

The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body controls our perceptions, our behaviors, and our health.

We also discuss existing and emerging tools for measuring and changing how our nervous system works.

Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance.

For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology.

He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts.

Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.

Huberman Lab Dr. Andrew Huberman

    • Health & Fitness
    • 4.9 • 4.7K Ratings

The Huberman Lab Podcast discusses neuroscience: how our brain and its connections with the organs of our body controls our perceptions, our behaviors, and our health.

We also discuss existing and emerging tools for measuring and changing how our nervous system works.

Dr. Andrew Huberman is a tenured Professor of Neurobiology and Ophthalmology at Stanford School of Medicine. His laboratory studies neural regeneration, neuroplasticity, and brain states such as stress, focus, fear, and optimal performance.

For more than 20 years, Dr. Huberman has consistently published original research findings and review articles in top-level peer-reviewed journals, including Nature, Science, Cell, Neuron, and Current Biology.

He is a regular member of several National Institutes of Health review panels and a Fellow of the McKnight Foundation and the Pew Charitable Trusts.

Dr. Huberman regularly consults for technology development companies, professional athletic organizations, and various units of U.S. and Canadian Special Operations.

    Controlling Your Dopamine For Motivation, Focus & Satisfaction | Episode 39

    Controlling Your Dopamine For Motivation, Focus & Satisfaction | Episode 39

    This episode serves as a sort of “Dopamine Masterclass”. I discuss the immensely powerful chemical that we all make in our brain and body: dopamine. I describe what it does and the neural circuits involved. I explain dopamine peaks and baselines, and the cell biology of dopamine depletion. I include 14 tools for how to control your dopamine release for sake of motivation, focus, avoiding and combating addiction and depression, and I explain why dopamine stacking with chemicals and behaviors inevitably leads to states of underwhelm and poor performance. I explain how to achieve sustained increases in baseline dopamine, compounds that injure and protect dopamine neurons including caffeine from specific sources. I describe non-prescription supplements for increasing dopamine—both their benefits and risks—and synergy of pro-dopamine supplements with those that increase acetylcholine. 
     
    Thank you to our sponsors:
    ROKA - https://www.roka.com -- code "huberman" InsideTracker - https://www.insidetracker.com/huberman  Headspace - https://www.headspace.com/specialoffer   
    Logitech Event - Rethink Education: The Biology of Learning
    Thursday, Sept. 30 at 12pm PT / 3pm ET Sign up here: https://info.logitech.com/ReThink-Education.html   
    Support Research in Huberman Lab at Stanford:
    https://hubermanlab.stanford.edu/giving  
    Our Patreon page:
    https://www.patreon.com/andrewhuberman   
    Supplements from Thorne:
    http://www.thorne.com/u/huberman   
    Social:
    Instagram - https://www.instagram.com/hubermanlab  Twitter - https://twitter.com/hubermanlab  Facebook - https://www.facebook.com/hubermanlab  Website - https://hubermanlab.com  Newsletter - https://hubermanlab.com/neural-network   
    Links:
    Review on Dopamine - https://doi.org/10.1038/  s41583-021-00455-7  Cold Exposure & Dopamine - https://link.springer.com/article/10.1007%2Fs004210050065   
    Timestamps:
    00:00:00 Introduction & Tool 1 to Induce Lasting Dopamine 00:04:48 Sponsors: Roka, InsideTracker, Headspace 00:09:10 Upcoming (Zero-Cost) Neuroplasticity Seminar for Educators 00:09:58 What Dopamine (Really) Does 00:15:30 Two Main Neural Circuits for Dopamine  00:18:14 How Dopamine Is Released: Locally and Broadly 00:22:03 Fast and Slow Effects of Dopamine 00:25:03 Dopamine Neurons Co-Release Glutamate 00:28:00 Your Dopamine History Really Matters  00:30:30 Parkinson’s & Drugs That Kill Dopamine Neurons. My Dopamine Experience  00:36:58 Tool 3 Controlling Dopamine Peaks & Baselines 00:40:06 Chocolate, Sex (Pursuit & Behavior), Nicotine, Cocaine, Amphetamine, Exercise 00:46:46 Tool 4 Caffeine Increases Dopamine Receptors 00:49:54 Pursuit, Excitement & Your “Dopamine Setpoint” 00:56:46 Your Pleasure-Pain Balance & Defining “Pain” 01:00:00 Addiction, Dopamine Depletion, & Replenishing Dopamine 01:07:50 Tool 5 Ensure Your Best (Healthy) Dopamine Release 01:15:28 Smart Phones: How They Alter Our Dopamine Circuits 01:19:45 Stimulants & Spiking Dopamine: Counterproductive for Work, Exercise & Attention 01:22:20 Caffeine Sources Matter: Yerba Mate & Dopamine Neuron Protection 01:24:20 Caffeine & Neurotoxicity of MDMA 01:26:15 Amphetamine, Cocaine & Detrimental Rewiring of Dopamine Circuits 01:27:57 Ritalin, Adderall, (Ar)Modafinil: ADHD versus non-Prescription Uses 01:28:45 Tool 6 Stimulating Long-Lasting Increases in Baseline Dopamine  01:37:55 Tool 7 Tuning Your Dopamine for Ongoing Motivation 01:47:40 Tool 8 Intermittent Fasting: Effects on Dopamine  01:53:09 Validation of Your Pre-Existing Beliefs Increases Dopamine 01:53:50 Tool 9 Quitting Sugar & Highly Palatable Foods: 48 Hours 01:55:36 Pornography 01:56:50 Wellbutrin & Depression & Anxiety 01:58:30 Tool 10 Mucuna Pruriens, Prolactin, Sperm, Crash Warning 02:01:45 Tool 11 L-Tyrosine: Dosages, Duration of Effects & Specificity 02:05:20 Tool 12 Avoiding Melatonin Supplementation, & Avoiding Light 10pm-4am 02:07:00 Tool 13 Phenylethylamine (with Alpha-GPC) For Dopamine

    • 2 hr 16 min
    Dr. Matthew Johnson: Psychedelics for Treating Mental Disorders | Episode 38

    Dr. Matthew Johnson: Psychedelics for Treating Mental Disorders | Episode 38

    This episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We discuss the biology and medical clinical-trial uses of psilocybin, MDMA, ayahuasca, DMT, and LSD. Dr. Johnson teaches us what the clinical trials in his lab are revealing about the potential these compounds hold for the treatment of depression, addiction, trauma, eating disorders, ADHD, and other disorders of the mind. Dr. Johnson describes a typical psychedelic experiment in his laboratory, start to finish, including the conditions for optimal clinical outcomes. And he explains some of the potential hazards and common misconceptions and pitfalls related to psychedelic medicine. Dr. Johnson explains flashbacks, the heightened risks of certain people and age groups using psychedelics and the ever evolving legal and pharmaceutical industry landscape surrounding psychedelics. Dr. Johnson also explains how the scientific study of psychedelics is likely to set the trajectory of psychiatric medicine in the years to come. Dr. Johnson is among a small handful of researchers who have pioneered the clinical study of these powerful compounds. He has unprecedented insight into how they can be woven into other psychiatric treatments, changing ones sense of self and of reality.
     
    Thank you to our sponsors:
    Athletic Greens - http://www.athleticgreens.com/huberman Belcampo - http://www.belcampo.com/huberman InsideTracker - http://www.insidetracker.com/huberman  
    Dr. Matthew Johnson Social Media: 
    Twitter: https://twitter.com/drug_researcher  Instagram: https://instagram.com/drug_researcher   
    Our Patreon page:
    https://www.patreon.com/andrewhuberman   
    Supplements from Thorne:
    http://www.thorne.com/u/huberman   
    Social:
    Instagram - https://www.instagram.com/hubermanlab  Twitter - https://twitter.com/hubermanlab  Facebook - https://www.facebook.com/hubermanlab  Website - https://hubermanlab.com  Newsletter - https://hubermanlab.com/neural-network   
    Links:
    Dr. Johnson’s Website at Johns Hopkins School of Medicine - https://hopkinspsychedelic.org/johnson Chris Letheby’s forthcoming book - https://amzn.to/3nMTaAs    
    Timestamps:
    00:00:00 Introducing Dr. Matthew Johnson 00:02:10 Supporting Sponsors 00:06:40 ‘Psychedelics’ Defined 00:14:09 Hallucinations, Synesthesia, Altered Space-Time Perception 00:19:56 Serotonin & Dopamine  00:23:50 Ketamine & Glutamate  00:28:00 An Example Psychedelic Experiment 00:37:30 ‘Letting Go’ with Psychedelics 00:44:10 Our Mind’s Eye 00:48:00 Redefining Your Sense of Self  00:58:56 Exporting Psychedelic Learnings to Daily Life 01:04:36 Flashbacks 01:12:10 Ayahuasca, & ASMR, Kundalini Breathing 01:15:54 MDMA, DMT 01:26:00 Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis 01:38:15 Micro-Dosing 01:56:45 Risks for Kids, Adolescents & Teenagers; Future Clinical Trials 02:03:40 Legal Status: Decriminalization vs. Legalization vs. Regulation 02:18:35 Psychedelics for Treating Concussion & Traumatic Brain Injury  02:27:45 Shifting Trends in Psychedelic Research, Academic Culture 02:44:23 Participating in a Clinical Trial, Online Survey Studies, Breathwork  02:50:38 Conclusions, Subscribing & Supporting the HLP, Supplements

    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
     
    Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

    • 2 hr 52 min
    ADHD & How Anyone Can Improve Their Focus | Episode 37

    ADHD & How Anyone Can Improve Their Focus | Episode 37

    In this episode, I discuss ADHD (Attention-Deficit Hyperactivity Disorder): what it is, the common myths, and the biology and psychology of ADHD.
    I discuss both behavioral and pharmacologic treatments for ADHD, and brain-machine interface tools. I also discuss behavioral training protocols that can improve focus in people with ADHD and those without ADHD, and for people of different ages. I discuss the role of dopamine in coordinating 'default-mode' and 'task-related' neural networks, attentional "blinks" (lapses of attention) and how to overcome them, and the role of actual blinks in time perception and attention. Finally, I review some of the prescription and over-the-counter compounds for increasing focus such as Adderall, Ritalin, Modafinil and Armodafinil, the racetams, Alpha-GPC and phosphatidylserine and the role of diet for managing ADHD (and the controversies of diet for ADHD).
    The role of cell phones/technology in ADHD and ADHD-like challenges with focus are also discussed. Throughout, both basic science and clinical scenarios, as well as applicable tools and resources are covered.
    Thank you to our sponsors:
    Roka - https://www.roka.com -- code "huberman" Belcampo - https://www.belcampo.com/huberman Helix Sleep - https://www.helixsleep.com/huberman  
    Our Patreon page:
    https://www.patreon.com/andrewhuberman  
    Supplements from Thorne:
    http://www.thorne.com/u/huberman  
    Support Research in the Huberman Lab at Stanford:
    https://hubermanlab.stanford.edu/giving  
    Social:
    Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab Website - https://hubermanlab.com Email Newsletter - https://hubermanlab.com/neural-network  
    Links:
    Review of Compounds for ADHD, Smart Drugs & Focus - https://www.fbscience.com/Landmark/articles/10.52586/4948 Review of Atypical Compounds for ADHD - https://www.hindawi.com/journals/np/2016/1320423/ Study of Focus Protocol In ADHD & Non-ADHD Children - https://www.mdpi.com/1660-4601/17/13/4780  
    Timestamps:
    00:00:00 Introduction & Note About Diagnosis 00:03:27 Sponsors  00:07:56 ADHD vs. ADD: Genetics, IQ, Rates in Kids & Adults 00:13:00 Attention & Focus, Impulse Control 00:14:57 Hyper-focus  00:16:45 Time Perception 00:18:25 The Pile System 00:20:00 Working Memory 00:24:10 Hyper-Focus & Dopamine  00:26:40 Neural Circuits In ADHD: Default Mode Network & Task-Related Networks  00:32:57 Low Dopamine in ADHD & Stimulant Use & Abuse 00:37:10 Sugar, Ritalin, Adderall, Modafinil & Armodafinil  00:47:00 Non-Prescribed Adderall, Caffeine, Nicotine 00:49:18 How Stimulants “Teach” the Brains of ADHD Children to Focus 00:52:00 When To Medicate: A Highly Informed (Anecdotal) Case Study 00:56:35 Elimination Diets & Allergies In ADHD 01:04:46 Omega-3 Fatty Acids: EPAs & DHAs  01:07:00 Modulation vs Mediation of Biological Processes 01:10:50 Attentional Blinks  01:16:56 Open Monitoring & 17minute Focus Enhancement  01:22:50 Blinking, Dopamine & Time Perception; & Focus Training  01:30:10 Reverberatory Neural & Physical Activity 01:33:40 Adderall, Ritalin & Blink Frequency 01:35:00 Cannabis  01:37:30 Interoceptive Awareness  01:41:15 Ritalin, Adderall, Modafinil, Armodafinil; Smart Drugs & Caffeine: Dangers 01:48:05 DHA Fatty Acids, Phosphatidylserine 0:1:50:54 Ginko Biloba  01:51:45 Modafinil & Armodafanil: Dopamine Action & Orexin 01:56:19 Acetylcholine: Circuits Underlying Focus; Alpha-GPC 01:59:04 L-Tyrosine, (PEA) Phenylethylamine  02:01:23 Racetams, Noopept  02:05:15 Transcranial Magnetic Stimulation; Combining Technology & Pharmacology  02:09:14 Smart Phones & ADHD & Sub-Clinical Focus Issues In Adults & Kids 02:14:30 Synthesis/Summary 02:16:10 Support for Podcast & Research, Supplement Resources  
    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided

    • 2 hr 18 min
    Healthy Eating & Eating Disorders - Anorexia, Bulimia, Binging | Episode 36

    Healthy Eating & Eating Disorders - Anorexia, Bulimia, Binging | Episode 36

    In this episode, I discuss what drives hunger and satiety, and the role our brain, stomach, fat and hormones play in regulating hunger and turning off the desire to eat more. I also address how protein is assimilated better early in the day than it is later in the day, and why those using intermittent fasting might want to shift their feeding window to earlier in the day.  
    Then I delve into the topic of disorders of eating: Anorexia Nervosa, where people starve themselves and Bulimia Nervosa where people binge and purge their food. I discuss some common myths about Anorexia such as the role of media images increasing the rates of anorexia and the myth of the "perfectionist" anorexic. I also review the symptoms, and the brain and chemical systems disrupted in this condition. I explain how anorexics become hyperaware of the fat content of foods and develop reflexive habits of fat-hyperawareness. Then I discuss the most effective treatments ranging from family-based models to those that target the habitual nature of low-fat/calorie food choices. I also discuss new more experimental clinical trials on MDMA, Psilocybin and Ibogaine for Anorexia, and both their promise and risks
     
    I review the latest work on binge eating disorder and brain stimulation, drug treatments and thyroid disruption in Bulimia and why the treatments for Bulimia are so similar to those for ADHD. Finally, I discuss "cheat days," body dysmorphia and the growing list of novel forms of eating disorders start to finish. As always, science and science-based tools are discussed.
     
    Thank you to our sponsors:
    Belcampo - https://www.belcampo.com/huberman -- code "huberman" Headspace - https://www.headspace.com/specialoffer Athletic Greens - https://www.athleticgreens.com/huberman  
    Support Research in Huberman Lab at Stanford:
    https://hubermanlab.stanford.edu/giving  
    Our Patreon page:
    https://www.patreon.com/andrewhuberman  
    Supplements from Thorne:
    http://www.thorne.com/u/huberman  
    Social:
    Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab Website - https://hubermanlab.com Join Newsletter - https://hubermanlab.com/neural-network  
    Links:
    Ingesting Protein in the Morning Supports Muscle Maintenance & Growth: https://bit.ly/3DPlms7  Studies Using Virtual Reality to Explore Eating & Hunger & Body Image: https://bit.ly/3BGaDya  https://bit.ly/2WWGRq8   
    Timestamps:
    00:00:00 Introduction: Fasting, & Defining Healthy Eating 00:08:55 Morning Protein Is Important  00:22:04 Sponsors 00:26:29 Defining & Diagnosing Eating Disorders 00:29:00 Anorexia Nervosa (Overview & Myths) 00:33:44 Bulimia (Overview & Myths) 00:37:35 Binge Eating Disorders, EDNOS, OSFEDS, Pica 00:39:44 What is Hunger? What is Satiety? 00:42:00 Neuronal & Hormonal “Accelerators & Brakes” on Eating 00:46:17 Fat, Leptin & Fertility & Metabolic Dysfunctions in Obesity 00:50:30 Why We Overeat 00:55:30 Homeostasis & Reward Systems/Decisions  00:59:58 Anorexia 01:04:28 The Cholesterol Paradox 01:06:13 Psychological vs. Biological/Genetic Factors in Anorexia 01:09:44 Chemical Imbalances, Serotonergic Treatments 01:12:56 Altered Habits & Rewards in Anorexia: Hyperacuity for Fat Content 01:18:28 Brain Areas for Reward Based Decision Making vs. Habits 01:24:06 Habit-Reward Circuits Are Flipped in Anorexics: Reward for Deprivation 01:28:30 How Do You Break a Habit?  01:33:23 Family Based Models, Cognitive Behavioral Therapy 01:35:39 MDMA, Psilocybin, Clinical Trials, Ibogaine  01:40:35 Anabolic vs. Catabolic Exercise, Spontaneous Movements, NEAT 01:43:23 Distorted Self Image in Anorexia  01:47:54 Bulimia & Binge-Eating, “Cheat Days”, Thyroid Hormone 01:53:05 Inhibitory Control, Impulsivity, Adderall, Wellbutrin 01:58:00 Direct Brain Stimulation: Nucleus Accumbens 02:04:28 Anorexia/Reward. vs Bulimia/Binging   02:05:45 Healthy Eating Revisited 02:10:55 Synthesis, Bo

    • 2 hr 16 min
    Dr. Robert Sapolsky: Science of Stress, Testosterone & Free Will | Episode 35

    Dr. Robert Sapolsky: Science of Stress, Testosterone & Free Will | Episode 35

    In this episode, I interview Dr. Robert Sapolsky, Ph.D., Professor of Biology, Neurology & Neurosurgery at Stanford University. We discuss stress, what defines short-term versus long-term stress, and how stress can be beneficial or detrimental, depending on the context. We also discuss stress mitigation and how our sense of control over stress mitigation techniques, including exercise, determine health outcomes. Dr. Sapolsky explains some of the key effects of the hormone testosterone — how it can amplify pre-existing tendencies for aggression or sexual behavior, but that it does not produce those behaviors per se. He also explains how testosterone impacts our social hierarchies, sense of confidence, and willingness to embrace challenges of different kinds. He also explains how our behaviors and perceptions shape testosterone levels. And we discuss estrogen and the powerful role it plays in brain development, health and longevity. Finally, we discuss free will, what it means to have free will, and if we have any free will, including how knowledge alone might allow us to make better decisions for ourselves and society.   
    Thank you to our sponsors:
    ROKA - https://roka.com - use code "huberman" InsideTracker - https://insidetracker.com/huberman  Belcampo - https://belcampo.com/huberman   
    Our Patreon page:
    https://www.patreon.com/andrewhuberman   
    Supplements from Thorne:
    http://www.thorne.com/u/huberman   
    Social:
    Instagram - https://www.instagram.com/hubermanlab  Twitter - https://twitter.com/hubermanlab  Facebook - https://www.facebook.com/hubermanlab   Website - https://hubermanlab.com  Join Newsletter - https://hubermanlab.com/neural-network   
    Links:
    Dr. Sapolsky's most recent book, "Behave: The Biology of Humans At Our Best & Worst": https://amzn.to/3yrZ6k7  Support Research in the Huberman Lab at Stanford on Stress, Sleep & Human Performance: https://hubermanlab.stanford.edu/giving   
    Timestamps:
    00:00:00 Introduction: Dr. Robert Sapolsky  00:02:26 Sponsors: Roka, Inside Tracker, Belcampo  00:06:30 Stress: Short & Long-Term, Good & Bad  00:09:11 Valence & Amygdala  00:11:00 Testosterone: Common Myths vs. Actual Truths  00:15:15 Behaviors that Affect Testosterone   00:17:20 Mindsets & Contexts that Affect Testosterone 00:20:28 How Finger Length Ratios Reflect Prenatal Hormone Levels   00:22:30 Aggression: Male-Female, Female-Male, & Female-Female  00:24:05 Testosterone: The Challenge Hypothesis  00:29:20 How Dopamine Impacts Testosterone & Motivation  00:32:32 Estrogen: Improves Brain & Longevity BUT TIMING IS KEY  00:39:40 Are Testosterone & Sperm Counts in Males Really Dropping?  00:42:15 Stress Mitigation & Our Sense of Control  00:51:35 How Best to Buffer Stress  00:57:04 Power of Perception, Choice & Individual Differences  01:00:32 Context-Setting, Prefrontal Cortex & Hierarchy  01:11:20 How Dr. Sapolsky Accomplishes Deep Thinking   01:13:17 Do We Have Free Will?  01:20:50 How to Apply Knowledge & Learning   01:23:44 Robert’s New Book: “Determined: The Science of Life Without Free Will”  01:28:27 Reflections, Support of Podcast, & Supporting Stress Research   
    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.

    • 1 hr 29 min
    Understanding & Conquering Depression | Episode 34

    Understanding & Conquering Depression | Episode 34

    This episode, I explain what major depression is at the biological and psychological level and the various treatments that peer-reviewed studies have revealed can help prevent and treat depression. I explain the three major chemical systems that are altered in depression: norepinephrine, serotonin and dopamine. I discuss genetic predispositions to depression and how stress, thyroid hormone and cortisol play a role in many forms of depression. I also discuss inflammation as a common feature of many depression symptoms. I review 8 specific science-supported protocols for treating and avoiding depression, including EPA fatty acids (which have been shown to rival certain prescription treatments), how exercise protects against depression, studies of creatine, adjusting dopamine balance and more. I also discuss the results of ongoing clinical trials for ketamine and psilocybin for depression, how these compounds work and finally, I review how ketogenic diets can help in certain cases of depression, especially treatment-resistant major depression.  
    Thank you to our sponsors:
    InsideTracker - https://www.insidetracker.com/huberman Athletic Greens - https://www.athleticgreens.com/huberman Belcampo - https://www.belcampo.com/huberman -- code "huberman"  
    Our Patreon page:
    https://www.patreon.com/andrewhuberman  
    Supplements from Thorne:
    http://www.thorne.com/u/huberman  
    Social:
    Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab Website - https://hubermanlab.com Join Newsletter - https://hubermanlab.com/neural-network  
    Links:
    Review of EPAs for the Treatment of Depression - https://bit.ly/2Wl15ti  Review of Creatine for the Treatment of Depression - https://www.mdpi.com/520864  Recent Study on the Clinical Use of Psilocybin for Treatment of Depression - https://bit.ly/3sFSGMM   
    Timestamps:
    00:00:00 Mood Disorders & Maintaining Mental Health (Protocol 1) 00:07:10 Sponsors 00:11:15 Major Depression 00:18:40 “Anti-Self” Confabulation 00:21:42 Autonomic (Vegetative) Symptoms of Depression 00:26:58 Norepinephrine, Dopamine & Serotonin 00:31:50 SSRIs (Prozac, Zoloft, etc.): Selective Serotonin Reuptake Inhibitors 00:37:00 Epinephrine/Motor Functions, Dopamine/Motivation & Craving, Serotonin/Emotions 00:39:33 Physical & Emotional Pain are Linked: Substance P 00:41:50 Hormones & Depression: Thyroid & Cortisol  00:46:50 Genetic Susceptibility to Depression: Impact of Stress  00:50:50 Understanding Biological Mechanism Is Key: Recipes versus Skills 00:52:50 Tools for Dealing with Depression: Logic & Implementation (Protocol 2) 00:56:25 Brain Inflammation & Mental State: Cytokines, Prostaglandins, etc. 00:59:20 Protocol 3: Essential Fatty Acids (Omega-3, EPAs: Eicosapentaenoic Acid)* 01:02:50 How EPAs Help Offset Depression: Serotonin Synthesis, Kynurenine, Quinolinic Acid 01:05:25 Protocol 4: How Exercise Offsets Depression  01:11:44 Protocol 5: Creatine Monohydrate, Forebrain Function & NMDA receptors* 01:20:30 Protocol 6*: Ketamine, PCP (*Prescription-Only), & NMDA-Receptor Function 01:33:08 Protocol 7*: Psychedelics (*In Clinical Trials) for Major Depression: Psilocybin* 01:47:00 Protocol 8: Ketogenic Diet, GABA (Gamma-Aminobutyric Acid) 01:54:50 Summary of Protocols Covered 02:00:10 Support & Additional Resources  
    Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
     
    Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

    • 2 hr 1 min

Customer Reviews

4.9 out of 5
4.7K Ratings

4.7K Ratings

Sherri Goldman ,

Science for all!

Thank you to Dr Huberman for thoughtfully delivering science to the masses. He shares mind-blowing content at multiple levels of abstraction, allowing him to reach everyone. No matter what your background, you will get something of value every time you listen.

my fav chord is Gsus ,

Great information and very enjoyable

I like to listen to these podcasts while running, and before bed. Great mission from Andrew to bring zero cost to consumer, science based content. Easy to understand.

Erfan zamani ,

Really appreciated

I have had sleep problems for the past year (probably longer) and i’m amazed to know this show also covers learning process as i’m a student of Mathematics and computer science. Looking forward to the podcast, it was wonderful experience up to now

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