Let's start with the good parts:
-Audio quality is excellent. You'll never have to deal with condensor mics or room noise.
-Music is used well, though they sometimes linger on the music too long without any dialogue.
-They are respectful of the Fallout setting and make good use of it.
Unfortunately, there's plenty of bad.
-Most episodes open with a prewritten flashback, and they are bad. They're badly written, and they have the worst kind of ham-fisted, forced attempts at drama. It's like they're screaming "FEEL THE PATHOS". It doesn't work. This also happens during gameplay, especially in the early episodes, when the players try to amplify the drama, but it falls flat. Emotional stakes must be slowly earned over time.
-There are some weird word choices from time to time that show that these people are not accustomed to speaking for an audience. That's understandable, since English is a second language for some of them. This isn't a live show, though. They can correct the misspoken or misused word by simply rerecording the line. The audience doesn't have to know they flubbed it.
-The story is super linear. If the GM wants the players to encounter a danger, their successful rolls won't stop it from happening. An NPC will screw up to make sure it happens. Some folks don't mind this. Personally I prefer a story in which the players have more choices that matter.
-They don't tell us the die rolls! They can clearly all see them at the table, but we have to infer from their reactions what happened, and sometimes that is difficult. I can appreciate not wanting to focus too much on mechanics, but this is an actual-play podcast. You're playing the game. Let us hear the game.
-Terrible pre-game banter. If you're not capable of Glass Cannon Podcast-level pre-game banter, just get into the game! This is another problem that arises due to their awkward conversational and speaking abilities.
If you really want to listen to a Fallout actual-play podcast, this is the best one I've found. You could do worse, but there is a lot of room for improvement.
