The Derm Vet Podcast

Ashley Bourgeois, DVM, Dip ACVD

Tune in to make veterinary dermatology more fun than frustrating! This podcast features Dr. Ashley Bourgeois, DVM, Dip ACVD sharing practical tips on dermatologic workups you can bring to clinical practice right away. Also, stories about navigating the messy (yet beautiful) journey of being a vet mom while building a career you love.

  1. 4d ago

    326. New JAK Inhibitor for Allergic Dogs? What Vets Need to Know About Numelvi

    Send me a derm question or story through text or voicemail! A new JAK inhibitor has officially entered the veterinary market but where does it fit into managing allergic dogs? In this episode of The Derm Vet Podcast, I sit down with boarded veterinary dermatologist Dr. Christine McKinney from Merck Animal Health to discuss Numelvi, the newest JAK inhibitor approved in the United States for canine allergic dermatitis. We break down what makes this medication unique, how it compares to other allergy therapies, and why having multiple treatment options matters when managing complicated allergic patients. We also dive into practical approaches for itch control, infection management, and building confidence when treating chronic allergy cases in practice. If you manage itchy dogs regularly and want to stay up to date on the latest dermatology treatments, this episode is packed with valuable clinical insights. Watch The Episode: https://www.youtube.com/@thedermvet3932 Follow The Derm Vet Podcast: https://www.instagram.com/thedermvetpod/ Follow Me: https://www.instagram.com/thedermvet/ Timestamps and references: 7:26: At the recommended treatment dose, Numelvi is at least 10X more selective for JAK1 over the other JAK enzymes in in vitro assays. Reference: Kowalski T, Schuette S. The second-generation Janus kinase inhibitor atinvicitinib is a potent and highly selective inhibitor of JAK1. Vet Dermatol. 2026;37(2):179. 8:03: At the recommended treatment dose, Numelvi is at least 10X more selective for JAK1 over the other JAK enzymes in in vitro assays. Reference: Kowalski T, Schuette S. The second-generation Janus kinase inhibitor atinvicitinib is a potent and highly selective inhibitor of JAK1. Vet Dermatol. 2026;37(2):179. 8:07: JAK1 is the primary driver of itch and inflammation. Reference: Huang I, Chung W, Wu P, Chen C. JAK-STAT signaling pathway in the pathogenesis of atopic dermatitis: an updated review. Front Immunol. 2022;13:1068260 10:36: At the recommended treatment dose, Numelvi is at least 10X more selective for JAK1 over the other JAK enzymes in in vitro assays. Reference: Kowalski T, Schuette S. The second-generation Janus kinase inhibitor atinvicitinib is a potent and highly selective inhibitor of JAK1. Vet Dermatol. 2026;37(2):179. 21:52: Numelvi, starts reducing itch within 2-4 hours in a canine interleukin-31 (cIL-31)-induced pruritus model Reference: Kowalski T, Prohaczik A, Locke K, Samson C, Hope K. The second-generation Janus kinase inhibitor atinvicitinib significantly reduces pruritus 2-4 hours after dosing dogs in a canine interleukin-31 model. Vet Dermatol. 2026;37(2):179-180. 23:13: Numelvi, starts reducing itch within 2-4 hours in a canine interleukin-31 (cIL-31)-induced pruritus model Reference: Kowalski T, Prohaczik A, Locke K, Samson C, Hope K. The second-generation Janus kinase inhibitor atinvicitinib significantly reduces pruritus 2-4 hours after dosing dogs in a canine interleukin-31 model. Vet Dermatol. 2026;37(2):179-180. Timestamps 00:00 Intro 02:29 The Complexity of Canine Allergic Dermatitis 06:44 What is Numelvi and How Does it Work? 13:50 Dosing Guidelines and Tablet Specifications 16:57 Candidate Selection and Infection Control 21:37 Onset of Action and Efficacy Timeline 24:08 Final Thoughts This episode is sponsored by Merck Animal Health

    30 min
5
out of 5
135 Ratings

About

Tune in to make veterinary dermatology more fun than frustrating! This podcast features Dr. Ashley Bourgeois, DVM, Dip ACVD sharing practical tips on dermatologic workups you can bring to clinical practice right away. Also, stories about navigating the messy (yet beautiful) journey of being a vet mom while building a career you love.

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