Genefitletics

Sushant Kumar

This podcast is hosted by biotech entrepreneur Sushant Kumar, Founder & CEO of Genefitletics. Through this exclusive health podcast, he addresses the information asymmetry in the preventive health space. He is currently building Genefitletics, which is a direct-to-customer Biotech company- that studies & analyses activities of single & multicellular microorganisms living on & inside human body to provide precision health interventions in order to eradicate epidemic of chronic diseases, cancer & more.

  1. 13h ago

    The Energetic Physics of Mitochondria- Why Breakdown Here Causes Cancer & Degeneration

    While we are too much focussed on decoding our genome, using wearables to track our health at plasma level & or leveraging DNA-Protein-drug pipeline to manage our post-symptomatic disease conditions, we have missed the key organelle that controls our biology- Mitochondria.Mitochondria is not just a powerhouse of cells as has been thought over decades. Even mitochondria, found in every cell except the red blood cells, is considered to be the motherboard of cells & is a distributed network. It has various receptors which allows it to sense environmental cues, process & integrate information & send signals to nucleus, driving epigenetic modifications & cytokine production that drive cellular adaptations & recalibrations.To understand the energetic processes of mitochondria, we have to understand the application of the laws of physics on human biological systems. Our body has a limited energy budget & is allocated among competing biochemical processes.Cellular stressors could lead to high energy resistance & disrupt the flow of electrons/increase in supply of electrons that could lead to flow back of electrons & production of reactive oxygen species. Mitochondria could also leak out its own DNA that enters the nucleus to communicate stress. This leads to production of cytokines & mitobiokines that drives this communication of stress to other cells as well as body- brain communication. These communication cascades lead to reallocation of energy from expensive growth, maintenance & repair to response to stressors- called as allostatic response, leading to new allostatic state. This persistence allostatic state leads to allostatic overload, systemic dysregulation, breakdown in communication network & onset of disease.From cancer perspective, we need to understand that it is not mutations but disruption in calcium circuits/ion channels & calcium overload that acts as electrostatic barrier to block the gap junction intercellular communication network, making dysfunctional cells detach from the cell collective & pursue its unicellular objectives. Interestingly the ion channels, whose movement drives & controls the biolelectric pattern, the voltage gradient of cells, resides in the mitochondrial inner & outer membrane & is controlled by mitochondrial functions. In effect mitochondria modulates these bioelectric patterns via controlling movement of ion channels, thereby impacting proliferation, differentiation, migration, and apoptosis of cells.In our today’s talk, we discussed how energetic processes of mitochondria drives cellular homeostasis & how breakdown in these processes can lead to organ & systemic dysfunction & onset of degenerative diseases & cancerKnow more at: www.genefitletics.com

    33 min
  2. Why Your Blood Tests & Smartwatch Are LYING to You?

    Jan 30

    Why Your Blood Tests & Smartwatch Are LYING to You?

    Your blood tests are giving you a map of a city that no longer exists.HDL, LDL, HbA1c — these markers tell you nothing about what's actually driving your health or disease. And pairing them with a wearable doesn't fix the problem. It just makes it louder.In this episode, Sushant & Sakshi explore:-Why conventional biomarkers are dangerously outdated- How mitochondria — ancient bacteria — control your entire cell collective- The bioelectric signalling network that governs your hormones, immunity & more- Why the real focus should be: Environment × Microbiome × MitochondriaIf you're serious about transforming your biology — not just managing numbers — this is the conversation you need to hear.🔔 Subscribe for science-backed health insights that go beyond the surface.more at: www.genefitletics.com/orahyg

    37 min
  3. How to personalise your protein intake?

    Jan 2

    How to personalise your protein intake?

    We Indians have got obsessed with protein based on a confusing but dubious marketing narrative- “India is a protein deficient nation”. This has led to launch of numerous startups launching protein supplement- Whey protein, plant based protein, protein bars, protein wafers & moreWe have seen a number of influencers promoting high consumption of protein but if protein deficiency is a reality, is high consumption the solution? How about how each of amino acid is metabolised right now .Let us decode this mystery todayWhat are symptoms of protein deficiency?- Fatigue, skin issues, low muscle mass & more. Are low or marginal income individuals who do not have financial liberty to purchase protein supplements, have protein deficiency? The fact is protein is an essential macromolecule & is required for vital cellular & metabolic processes but marketing as an alternative for every single chronic health condition is a blatant lie.Over the last few years, we have been focussed on personalising our food choices to regulate our blood sugar response but we have not bothered to ask this simple question- Why do not we personalise our amino acids? There are 9 essential amino acids that confer different host benefits or trigger production of signalling molecules & metabolites that could either lead to cellular resilience or cellular inflammation.Just a blanket recommendation of consuming some X gram/KG/day does not translate into biochemical interactions that deliver metabolic health & protein synthesis benefits. Most of the recommendations are based on population studies considering every individual as average healthy while our biology is unique & is neither average nor healthy.Therefore protein deficiency is not a standard deficiency & is a function of your unique biology & how your microbiome interacts with each amino acids.When you fall for these marketing narratives & consume protein in excess, without understanding how each of amino acid interacts with your biology or you lack stomach acid to break protein into constituent amino acids, your microbiome may ferment these amino acids into harmful metabolites that could trigger systemic inflammation. For instance, Imdizole propionate, a microbial byproduct of amino acid histamine leads to glucose intolerance, type 2 diabetes & even an early risk factor independent of cholesterol changes.If you have protein deficiency it is not a function of consumption but how each amino acid interacts with your biology including your microbiome. Personalising amino acids based on your cellular biochemistry is key to better protein synthesis, neurotransmitter production, skin health, metabolic health.Our data shows that 69% of our customers have protein fermentation levels as average with 87% found eggs in minimise list. We at Genefitletics measures your cellular biochemistry to determine how each of amino acid is metabolized & deliver personalised biotherapeutics interventions that promote benefits from amino acid metabolism.Know more here: www.genefitletics.com/orahyg#protein #proteinpowder #proteinshake #proteinsnack #protein #proteinpowder #proteinsnack #proteinshake #supplements #supplementfacts #supplementreview #supplement #wheyprotein #wheyisolate #whey #wheyproteinpowder #wheyconcentrate #arginine #bloating #constipation #constipationawareness #larginine #citrulline

    32 min
  4. The key to healthy aging- Health Discourse Ep-17

    10/29/2025

    The key to healthy aging- Health Discourse Ep-17

    Cellular resilience & homeostasis is the centre piece of longevity. It is the ability of different branches of our biology to work in synchrony to establish & maintain redox equilibrium.The key driving force of our cellular longevity is mitochondria- the furnace that provides energy currency-ATP to our cells, tissues & organs.While mitochondria efficiently produces ATP in the presence of oxygen via oxidative phosphorylation(OXPHOS), as a part of this energy generation process, free radicals/super oxides are also produced. These superoxides are harmful as they have 3 unpaired electrons. However, our body has an inbuilt mechanism wherein interaction between amino acids, microbiome & cellular environment secretes & influences production of specific antioxidants & enzymes-Superoxide dismutase (SOD), Glutathione, Glutathione peroxidase & Catalase that could travel inside the mitochondria to neutralise these super oxides.The mechanism involves multiple biochemical reactions. Your gut microbiome metabolises specific amino acids- Glutamate, Cysteine & glycine to influence their bioavailability. These amino acids are synthesised into glutathione in cytosol( inside the cells) from where it is transported to mitochondria via specific transporters that allows this negatively charged molecule to pass the inner mitochondrial membrane. The activity of these specific transporter proteins are indirectly influenced by Butyrate(gut microbial metabolites) via its metabolic & epigenetic impacts on cells & mitochondrial health.,Gut microbiome also codes for specific proteins that drive production of Superoxide dismutase. Specific gut microbes could increase the production of SOD via nutritional cooperation. It is important to note that only few antioxidants- SOD, Glutathione can pass the inner mitochondrial membraneInside the mitochondria, SOD with the help of co-factor manganese could convert super oxide into Hydrogen Peroxide(H2O2). Glutathione is oxidised by glutathione peroxidase which converts H2O2 into water, thereby neutralising super oxides. However, if you are deficient in manganese, SOD could partner with iron that could have pro-inflammatory effects & even rust mitochondria. However, when we cross the age of 30 years, our body’s ability to produce these antioxidants reduces & therefore we need exogenous consumption of these antioxidants or their precursors. We also have to make sure that our gut microbiome is balanced & performs beneficial functions to drive the synthesis of SOD & glutathione.Understanding your unique biochemistry & interaction between your gut microbiome & mitochondria is key to promote redox homeostasis. Know more at: www.genefitletics.com/agegorithm Citations https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1328324https://pmc.ncbi.nlm.nih.gov/articles/PMC10216031/

    39 min
  5. Can Wearables help you prevent Chronic Disease?

    06/23/2025

    Can Wearables help you prevent Chronic Disease?

    Health is not about reductionist biology, not about treating every body organ separately. Unfortunately this has been practice till now!If we experience particular symptoms, we head to our healthcare practitioner & get a series of labs done! Our healthcare practitioner recommend some synthetic compounds, pharmaceutical drug or generic nutrition recommendations to inhibit or suppress particular biochemical functions.Why? Because we trust our healthcare practitioner. Has it helped? Not really? The same disease management strategy has been adopted by new age healthtech companies. The mode of healthcare delivery data collection has changed, complementing blood works with wearables- be it smartwatch,CGM or smart rings. The data collection is the same- healthcare delivery. Be it blood sugar response, HRV or sleep.Unfortunately, the thousands of biochemical reactions are not linear & outcome to millions of interactions happening inside our body. Our body is a complex ecosystem. These new toys( wearables driven markers are the outcome of these millions of interactions. Until you could measure all of these interactions & what specific pathways or molecules are causing abnormal levels of these markers, you cannot derive actionable interventions to regulate that metric.For instance, if your so called toy ring may tell your HRV is low but it fails to decode what specific pathway or molecule caused it.Is it low Butyrate ? low GABA? Elevated LPS? Low nitric oxide? High Uric Acid? Or histamine overproduction?Just by knowing your HRV is low does not translate into interventions that can modulate your heart rate variability.Similarly for sleep, If you disrupted sleep patterns, is it gut derived neurotoxins disrupting the HPA axis causing stress & obstructing sleep? Or its Fluoride consumption that is entering the pineal gland & disrupting melatonin production?Unfortunately, none of these toys could elucidate the underlying cause of dysregulated wearable metrics be it sleep, HRV or blood pressure?But yes, the healthtech VC will be sold by the phrase “ Oh we are collecting healthcare data for the Indian population” & a lot of money will be poured into developing & marketing such wearables . After few years, they may think “ Oh these investments turned sour”.You need to focus not on healthcare delivery but molecular data- that can be collected & mined by combining multiple scientific disciplines including biology, biochemistry, mathematics, bioinformatics, physics, engineering, computer science & more. Just some piece of toy laden with sensors can never measure these molecular & cellular interactions.

    37 min
  6. Are fats good for your health?

    04/10/2025

    Are fats good for your health?

    We have spent decades avoiding one of the most essential & vital macromolecule-FATS to our own peril.You may hear these fitness folks propagating fats are bad & causing cardiovascular disease referring to an obsolete & obnoxious paper or theory of Ancel keys who claimed in 1958 that it is fat & cholesterol which causes heart disease.Obviously, these folks do not have even an iota of understanding of how human biochemistry works.Years & decades of FAT hate & removing things such butter, ghee or full fat milk( saturated fats) has not helped reduce the incidence of cardiovascular & metabolic diseases. Infact, the incidence of these diseases has increased manifold!What is the reason?We are living under the false assumption that saturated fats are bad & even some folks are even endorsing that seed oils & polyunsaturated fats are not bad!Let us clear this clutter! The number of double bonds in a particular fatty acid determines how it will interact with our cells!While some saturated fats such as C14-myristic acid & C16-Palmitic acid are worst offenders & specifically C16 is said to trigger release of reactive oxygen & nitrogen species & cause cardiovascular disease, it has now been found that some specific odd chain saturated fatty acids such as Pentadecnoic acid(C15) & heptadecanoic acid(C17) as well even chain saturated fatty acid- Stearic Acid(C18) are actually beneficial for our cellular health. Specifically C15 is now called the holy grail of longevity & plays a key role in activating various receptors that reinstates cellular homeostasis, regulates glucose metabolism, reduces cancer cell proliferation, reduces inflammation & even improves cell membrane stability.Just putting all saturated fats in one bucket is a flawed approach & it is important to understand the chemical structure of each saturated fats & interaction with cells, microbiome, receptors & associated biochemical pathways Our today’s talk breaks this myth & discusses, backed by existing research, each of fats in detailKnow more about how you can improve triglyceride levels at:www.genefitletics.com/orahygCitations https://www.nature.com/articles/s41598-020-64960-yhttps://pubmed.ncbi.nlm.nih.gov/33965456/https://pmc.ncbi.nlm.nih.gov/articles/PMC9241382/

    37 min
  7. Discover your Biological Age Story- Health discourse with Sakshi & Sushant Ep 13

    03/26/2025

    Discover your Biological Age Story- Health discourse with Sakshi & Sushant Ep 13

    Aging is the future not because there is a wave of longevity companies measuring your biological age but assessment of biological age at system biology level gives a comprehensive picture of efficiency of your human & microbial cellular functions.Unfortunately, none of the longevity or so-called fitness companies have model & data in place to measure the cellular functions & specific gene expression & molecular pathways that are causing cellular decay.Some may look at telomere testing or DNA methylation while others may look at plasma level of blood investigations to assess the biological ageIt is important to mention that-Telomere testing does not give a comprehensive view of biology at molecular level & is just one aspect of biological age. None of the telomere tests can actually tell how bad your mitochondria is performing or what specific biomarkers is leading to telomere length shortening-DNA methylation just looks at underexpression or no expression of certain genes, lacking a comprehensive view of human biology-Blood tests never focus on human microbiome functions & just look at certain few blood markers, the outcome of that itself suffers from high standard deviation ~ more than 30%. There are multiple structural issues with no focus on the optimality of quantum biomarkers.-None of these biological age clocks are based on Indian specific molecular data.Departure from these flawed models, we measure biological age based on measurement of cellular functions, focussing on -Cellular Proteostasis -Oxidative stress driven DNA damage-Telomere regulation- Systemic Inflammation-Cellular Senescence -Stem Cell Regenerative signalling-Protein Fermentation-Gut & oral microbiome functional pathways-Cellular stress response-including unfolded protein response-Hypoxia induced stress-Metabolic stress-Mitochondrial Biogenesis-Genotoxic Stress-Antioxidant production markersOur model based on deep learning algorithms has been developed from mining 6 billion of molecular & phenotype metadata sets.Our today’s podcast discusses the science behind aging & how we are bringing a data driven revolution in longevity.

    51 min
  8. Metabolic Therapy for Prevention & successful elimination of cancer- Ft. Dr Thomas N Seyfried

    02/11/2025

    Metabolic Therapy for Prevention & successful elimination of cancer- Ft. Dr Thomas N Seyfried

    In the year 2022, 1.46 million Indians developed cancer while over 9,00,000 lost their life.65% cancer mortality rate is the biggest cause of concern given that we have so many companies claiming to detect cancer early & number of therapies- radiation, chemo & immunotherapies to kill the tumours.Have you ever wondered why ?We have been stuck in the Dogma that cancer is a genetic disease caused by random genetic mutations while research & evidence has established that cancer is a mitochondria metabolic disease caused by damaged respiration & genetic mutations are downstream effects. Today at our prevent cancer podcast, we invited a special guest & world’s renowned cancer researcher- Dr. Thomas Seyfried. He holds a Ph.D. in Genetics and Biochemistry from the University of Illinois and has a background in neurology.Dr. Seyfried has received numerous awards and honors from various organizations, and he has over 150 peer-reviewed publications. He is also the author of the book "Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer," published in 2012.We discussed in detail on the following-Cancer as a mitochondrial metabolic disease-Why do we not have any solutions for prevention & successful management of cancer?-Why is the somatic mutation theory flawed?-How do cancer cells survive ? -What is cancer cachexia?-How cancer cells fall back on ancient fermentation pathways to proliferate & grow?-What is the origin of metastasis? Role of macrophages in metastatic cancer?-How does standard of care lead to growth of cancer?-Role of inflammatory oncotaxis in malignant cancer?Worth listening to!You can support Dr. Thomas Seyfried in multiple ways:Buy his summary ebook: https://www.cancer-as-a-metabolic-disease.com/summaryebook-purchase-page/Summary book, paperback: https://www.cancer-as-a-metabolic-disease.com/summaryebook-purchase-page/Buy his scientific bookhttps://www.amazon.com/Cancer-Metabolic-Disease-Management-Prevention/dp/0470584920Donate the research directly: https://foundationformetaboliccancertherapies.com/#cancerawareness #cancermedicine #cancerprevention #cancerresearch #chemotherapy #chemotherapie #chemosideeffects #chemotherapysideeffects #cancersurvivor #cancerpatients #cancerpatient #oncology #oncologia #radiationtherapy #radiationoncology #radiationoncologist #cancergenes #dna #genetesting #dnatest #dnadiet #microbiome #cancertest #earlydetectionsaveslives #earlydetection #oralmicrobiome #gutmicrobiome #gutmicrobiometest #oralmicrobiometest #nutritionfacts #nutritiontips #cancerdiet #geneticmutation #metabolictherapy

    59 min
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About

This podcast is hosted by biotech entrepreneur Sushant Kumar, Founder & CEO of Genefitletics. Through this exclusive health podcast, he addresses the information asymmetry in the preventive health space. He is currently building Genefitletics, which is a direct-to-customer Biotech company- that studies & analyses activities of single & multicellular microorganisms living on & inside human body to provide precision health interventions in order to eradicate epidemic of chronic diseases, cancer & more.

Information

  • Creator
    Sushant Kumar
  • Years Active
    2020 - 2026
  • Episodes
    108
  • Rating
    Explicit
  • Copyright
    © Sushant Kumar
  • Show Website
    Genefitletics