The Clinical Research Podcast Research & Innovation

You’d think that clinical researchers would welcome surprises - but they don’t. Even if the results are new and groundbreaking, they want their trials and studies to run in a predictable, controlled way,.

And that ability to deliver a total lack of surprise is one of the reasons that cancer research at Nottingham University Hospitals NHS Trust has made it into the top flight in the UK working with major pharmaceutical companies. 

As well as clinical and scientific excellence, it’s about building up relationships with our partners so that we know we can deliver on recruiting patients, managing the pharmacy needs, and study set up. 

The focus is particularly on chemo-free approach to lymphoma treatment, immunotherapy such as CAR T therapy, bispecific antibodies and using data analysis to target treatments.

I talked to Professor Mark Bishton, who’s a consultant haemotologist and the divisional co-lead for research and innovation into cancer and associated. As well as his own research, he’s responsible for delivering the trust’s studies in the specialty.

More information at https://www.nuh.nhs.uk/research-in-cancer

This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&Icomms@nuh.nhs.uk.

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Staff at the NIHR Nottingham Clinical Research Facility talk about the UCAB trial.

The facility worked with Swedish pharmaceutical Umecrime Cognition to study using a new molecule as a treatment for Primary Biliary Cholangitis (PBC) for patients with severe symptoms of fatigue and cognitive impairment.

Quick takeaways - 

    • one of only two UK locations for first stage drug trial

    • kept to tight, complex timelines

    • exceeded recruitment targets by building on existing relationships

    • patients praised care and treatment

The NIHR Nottingham Clinical Research Facility (CRF)  was one of just two centres worldwide – and the only UK facility – to conduct the first part of a clinical study.

We were picked because of our expertise in liver disease.

We hosted five patients on a purpose-built inpatient ward within the CRF, to confirm the correct dose of the molecule. During their seven-day stay, our team of research nurses and physicians assessed and cared for the patients around the clock.

Nottingham CRF has 18 adult and five paediatric inpatient beds dedicated for research, alongside our dedicated outpatient and specialist clinics. In total, there is over 3,400m² of clinical space at our CRF. The PBC study was a randomised, double-blinded and placebo controlled two-part study to evaluate the pharmacokinetics, safety and tolerability, and preliminary efficacy of two dose levels of the new drug.

There’s more about it at https://nottinghamcrf.nihr.ac.uk/facilities/case-studies

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Watch a video explainer about clinical trials: https://youtu.be/SWS4FCSMWAQ 

Read more at https://www.nottinghamresearch.org/get-involved and https://www.nuh.nhs.uk/take-part-in-a-trial and https://www.nuh.nhs.uk/researchvolunteers

Email us at  getinvolved@nuh.nhs.uk

Contacts for his episode:




COACH trial for hearing aids vs cochlear implants - More information from coachtrial.ac.uk or email coach@nottingham.ac.uk
Ultrasound probe for people with trauma injuries - contact Georgia Melia at georgia.melia@nuh.nhs.uk
The studies in Norfolk and Leicester into communities and genomics - www.eastgenomics.nhs.uk or email the East Genomic Medicine Service Alliance (GMSA) at egmsa@nnuh.nhs.uk
The Healthcare Scientists Research Showcase tickets are at  https://www.eventbrite.co.uk/e/healthcare-scientists-research-showcase-tickets-835899837917

Bulletin 9 - developing treatments for cystic fibrosis, depression, alcoholic liver disease and eczema

In this episode:

We pick up on presentations from the NIHR Nottingham BRC conference, from:


Dr Helen Barr, on matching medicines to gene for CF patients
Prof Richard Morriss on treating depression and anxiety with transcranial magnetic stimulation - https://www.mindtech.org.uk/news-events/latest-news/brightmind-trial-improves-the-lasting-effects-of-treatment-for-severe-depression
A Q and A on alcoholic liver disease - https://youtu.be/orJBGWAo8fM
Finding out how often should you shower if you eczema - rapideczematrials.org/eczema-bathing-study

Our YouTube channel: @NottinghamClinicalResearch

This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&Icomms@nuh.nhs.uk.

If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially. It's For Science.

In this bulletin:


Testing the Respirasense breathing monitor from PMD Solutions - https://www.pmd-solutions.com - https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3944-respirasense-trial
Bone graft augmentation and gene therapy research with Theragenix - https://theragenix.health/
https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3942-nearly-1m-for-pioneering-gene-therapy-formulation-for-bone-graft-augmentation

Rib fracture pain relief - https://orif.octru.ox.ac.uk/
https://nottinghambrc.nihr.ac.uk/about-nottingham-brc/news/3949-can-innovative-surgery-cut-mortality-after-major-trauma-injuries



Medicine showcases


Clinical Academie Research Partnership awards - https://www.nihr.ac.uk/documents/clinical-academic-research-partnership-carp/30439
Robot urology surgery to lessen erectile dysfunction - https://www.theurologyfoundation.org/get-involved/urology-awareness-month

In this bulletin:


Secure Data Environments - ⁠https://transform.england.nhs.uk/key-tools-and-info/data-saves-lives/secure-data-environments/⁠
Prof Guru Aithal appointed new medical lead for the Eastern Genomic Medicine Service Alliance - ⁠https://www.eastgenomics.nhs.uk
Showcase of gastro intestinal research at Nottingham⁠
Meet the respiratory research team - with pizzas
Networking for early career imaging researchers

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This Podcast is brought to you by the Research & Innovation team at Nottingham University Hospitals NHS Trust. Follow us on @ResearchNUH and @NottmBRC, or email R&Icomms@nuh.nhs.uk, or visit nuh.nhs.uk/research for more information.

If you haven't already, please subscribe to the podcast where-ever you get your podcasts, and like/review us on Apple Podcasts especially.