Tales of the Resistance

iAMResponsible

Antimicrobial-resistant (AMR) infections have been recognized globally as a significant threat to public health. In this podcast series, we're going to be talking to folks who are working to address the AMR crisis, we'll hear how they got started working with AMR and why they care about it so much...all that and more in Tales of the Resistance.Ready to learn more about AMR? Check in with the iAMResponsible team: https://iamrproject.unl.edu/

Episodes

  1. Aug 6

    Unlocking the Chemical Mysteries of Antibiotics in the Environment: An Expert Deep Dive with Diana Aga

    What happens after antibiotics leave the body? Do they simply disappear—or do they continue changing in the environment? In this episode, analytical chemist Dr. Diana Aga explains how scientists detect antibiotics in water and soil at incredibly small concentrations, why antibiotics transform into new compounds after entering the environment, and why those changes matter for antimicrobial resistance. From chromatography and mass spectrometry to unknown chemical "suspects" that researchers haven't identified yet, this conversation explores how chemistry helps connect environmental science, microbiology, and public health. Dr. Diana Aga is SUNY Distinguished Professor and Henry M. Woodburn Chair in the Department of Chemistry at the University at Buffalo. Her research focuses on analytical chemistry, environmental contaminants, pharmaceuticals, PFAS, wastewater, and emerging pollutants. She has spent more than three decades developing methods to detect chemicals at extremely low concentrations and studying how they behave in environmental systems.  University of Buffalo Profile Key Concepts Explained Liquid Chromatography (LC): A technique used to separate complex mixtures into individual chemicals before they are analyzed.Mass Spectrometry (MS): Measures molecules based on their mass and chemical fragmentation patterns, allowing scientists to identify compounds present at extremely low concentrations.Target Analysis: Searching specifically for chemicals you already know may be present.Non-target Analysis: Looking broadly for unknown compounds that may not have been anticipated before the analysis began.Transformation Products: New chemicals formed when antibiotics break down in sunlight, water, or through microbial activity.Related Episodes with the CAMRADES team Michelle Soupir — Agricultural pathways of antimicrobial resistanceAdina Howe — How bacteria share resistance genesBing Wang and Jaber Ghorbani— Predicting human exposure through environmental modelsMoriah Brown — Modeling contaminants across watershedsThis show is produced by the iAMResponsible project, a nationwide university outreach team led by Amy Schmidt at the University of Nebraska-Lincoln. Find out more about the project here. Funding for the iAMResponsbile Project was provided by USDA-NIFA Award Nos. 2017-68003-26497, 2018-68003-27467 and 2018-68003-27545. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the U.S. Department of Agriculture.

  2. Jul 23

    How Bacteria Outsmart Antibiotics: A Conversation with Dr. Adina Howe

    Bacteria are constantly adapting. They exchange genes, respond to their environment, and evolve in ways that can make antibiotics less effective over time. But understanding antimicrobial resistance requires much more than studying bacteria alone. In this episode, microbiologist Dr. Adina Howe explains how environmental microbiology helps scientists understand where antibiotic resistance develops, how it spreads, and why agricultural environments are an important part of the story. Drawing from her work on the multidisciplinary CAMRADES project, she discusses why manure can become a hotspot for antimicrobial resistance, how bacteria share resistance genes, and why researchers combine microbiology, genetics, chemistry, hydrology, and predictive modeling to understand these complex environmental systems.   Whether you're curious about microbiology, environmental science, or the future of antibiotics, this conversation offers an accessible look inside the invisible microbial world that surrounds us every day.  This show is produced by the iAMResponsible project, a nationwide university outreach team led by Amy Schmidt at the University of Nebraska-Lincoln. Find out more about the project here. Funding for the iAMResponsbile Project was provided by USDA-NIFA Award Nos. 2017-68003-26497, 2018-68003-27467 and 2018-68003-27545. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the U.S. Department of Agriculture.

About

Antimicrobial-resistant (AMR) infections have been recognized globally as a significant threat to public health. In this podcast series, we're going to be talking to folks who are working to address the AMR crisis, we'll hear how they got started working with AMR and why they care about it so much...all that and more in Tales of the Resistance.Ready to learn more about AMR? Check in with the iAMResponsible team: https://iamrproject.unl.edu/