The Y in Psychiatry

NguyenInDoubt
  • 5.0 (2)
  • Education
  • Updated Weekly

"The Y in Psychiatry" – a pragmatically endearing podcast talking to the med students, residents, fellows, and attendings of the medicine world about the nuances of psychiatry. Each episode are discussions exploring the intersections of the mental health, medicine, and the human experience. Together, we'll uncover the hidden "Y" – the compelling reasons, profound insights, and groundbreaking discoveries shaping the psychiatric landscape.So grab a seat, warm beverage, tune in, and let's embark on this journey to unlock the mysteries of the human psyche, only on "The Y in Psychiatry." Find articles on our episodes here: https://open.substack.com/pub/nguyenindoubt

  1. Cobenfy Unleashed: Psychiatry's New Frontier

    1d ago

    Cobenfy Unleashed: Psychiatry's New Frontier

    Send us Fan Mail Cobenfy doesn't block dopamine — and that's the whole point. In this special episode, we step away from the bipolar just a bit to unpack the first genuinely new mechanism in schizophrenia treatment in decades. We break down how Cobenfy pairs xanomeline (a brain-penetrant M1/M4 muscarinic agonist) with trospium (a peripheral blocker that curbs the side effects), trace its surprising betel-nut origins, and explain the why behind the how: quieting dopamine in the striatum for positive symptoms and boosting GABA in the prefrontal cortex for cognition — all without the D2 blockade that brings EPS, weight gain, and sedation. https://www.nguyenindoubt.com/theyinpsych https://feeds.buzzsprout.com/2185312.rss

    20 min
  2. The Bipolar Brain on Overdrive: Dopamine, Serotonin & Circuits

    12/03/2025

    The Bipolar Brain on Overdrive: Dopamine, Serotonin & Circuits

    Send us Fan Mail We're now tracing how dopamine and serotonin imbalances map onto psychomotor agitation, depression, and that “too much energy” feel of mania. We also stop by the basal ganglia–thalamus–sensorimotor loop, the ventrolateral and ventromedial prefrontal cortex, the amygdala, and the superior frontal gyrus to show how disrupted circuits drive impulsivity, hyperemotionality, and goal-directed behavior. Say that 10 times. https://www.nguyenindoubt.com/theyinpsych https://feeds.buzzsprout.com/2185312.rss

    16 min
  3. Ticket to Ride: The Bipolar Comorbidity Express Explored

    11/28/2025

    Ticket to Ride: The Bipolar Comorbidity Express Explored

    Send us Fan Mail All aboard the Bipolar Express to unpack one of the messiest puzzles in psych: why diagnosing Bipolar Disorder sometimes feels like trying to solve a Rubik’s cube — when there could also be ADHD, anxiety, personality disorders, substance use, sleep-issues, or even childhood trauma riding shotgun.  https://www.nguyenindoubt.com/theyinpsych https://feeds.buzzsprout.com/2185312.rss

    20 min
  4. The B in Bipolar Stands for ‘Be Careful’: Diagnosing Bipolar Spectrum Disorders

    06/10/2025

    The B in Bipolar Stands for ‘Be Careful’: Diagnosing Bipolar Spectrum Disorders

    Send us Fan Mail We make a tokyo drift to a new topic: bipolarism! Lets jump in and manically (responsibly) get through as much as we can with depression and its interfaces.  Hope you brought your shovel cause we're about to DIGFAST. https://www.nguyenindoubt.com/theyinpsych https://feeds.buzzsprout.com/2185312.rss

    24 min
  5. Late Life Depression: When the Golden Years Turn Grey (and the SSRIs Don't Shine)

    03/28/2025

    Late Life Depression: When the Golden Years Turn Grey (and the SSRIs Don't Shine)

    Send us Fan Mail It never gets old to talk about late-life depression. Lets explore why growing older can sometimes mean growing sadder. We prance through executive dysfunction, vascular woes, inflammatory fires, and amyloid beta blues.  We’ll discuss why SSRIs might not be the golden ticket and what alternatives, like dopamine agonists, rTMS, and even ECT, can brighten those grey years. Plus, we'll ponder if your patient is depressed, or if their brain is just throwing a vascular tantrum. Tune in, turn up your hearing aids, and fluid restrict for the next 20 minutes if you have the worlds smallest bladder. https://www.nguyenindoubt.com/theyinpsych https://feeds.buzzsprout.com/2185312.rss

    19 min
  6. Liver and (Don't) Let Die: Navigating Psychotropic Use in Cirrhosis

    03/21/2025

    Liver and (Don't) Let Die: Navigating Psychotropic Use in Cirrhosis

    Send us Fan Mail Lets do the discussion tango between the liver and psychotrops: today we're focusing on patients with cirrhosis. Discussing 1st-pass metabolism, phase 1 and 2 metabolisms, plasma protein binding, fluid overload, and the implications of these processes on medication efficacy and toxicity. We know you liver this stuff. https://www.nguyenindoubt.com/theyinpsych https://feeds.buzzsprout.com/2185312.rss

    19 min
  7. Kidneys don't Kid Around with Antidepressants

    12/13/2023

    Kidneys don't Kid Around with Antidepressants

    Send us Fan Mail Lets explore the kidneys in psychiatry and discuss the impact of renal disease on medication management. No kidding these kidneys can be curiously be essential to know about for psychiatry. https://www.nguyenindoubt.com/theyinpsych https://feeds.buzzsprout.com/2185312.rss

    14 min
  8. Forgetfully Down: Neurocognitively Impaired Populations and Depression

    12/06/2023

    Forgetfully Down: Neurocognitively Impaired Populations and Depression

    Send us Fan Mail Explore the intersection of depression and neurocognitive disorders in elderly patients. The discussion highlights the challenges in differentiating between depression and apathy, the importance of accurate diagnosis, and the appropriate pharmacological considerations for treatment.  Don't forget to listen to this episode on your geriatrics rotation. https://www.nguyenindoubt.com/theyinpsych https://feeds.buzzsprout.com/2185312.rss

    14 min
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Ratings & Reviews

5
out of 5
2 Ratings

About

"The Y in Psychiatry" – a pragmatically endearing podcast talking to the med students, residents, fellows, and attendings of the medicine world about the nuances of psychiatry. Each episode are discussions exploring the intersections of the mental health, medicine, and the human experience. Together, we'll uncover the hidden "Y" – the compelling reasons, profound insights, and groundbreaking discoveries shaping the psychiatric landscape.So grab a seat, warm beverage, tune in, and let's embark on this journey to unlock the mysteries of the human psyche, only on "The Y in Psychiatry." Find articles on our episodes here: https://open.substack.com/pub/nguyenindoubt

Information

  • Creator
    NguyenInDoubt
  • Years Active
    2023 - 2026
  • Episodes
    21
  • Rating
    Clean
  • Copyright
    © 2026 NguyenInDoubt LLC
  • Show Website
    The Y in Psychiatry