Rotations 2.0

Todd Fredricks DO MSS
  • 5.0 (1)
  • Life Sciences
  • Updated Weekly

A weekly discussion of medicine and science trends between people far too old to be trying something this new.

  1. 3d ago

    Rotations 2.0 Episode 85 Multiple Sclerosis

    Send us Fan Mail Episode 85 Multiple Sclerosis Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Memories in Motion by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Paper for next week: Sophie Waller et al., "The Initial Diagnosis and Management of Parkinson’s Disease," Australian Journal of General Practice 50, no. 11 (November 2021): 793. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

  2. Sep 21

    Rotations 2.0 Episode 84 Epilepsy

    Send us Fan Mail Episode 84 Epilepsy Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Urban Starscape by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS International Leage for Epilepsy.  https://www.ilae.org   Paper for next week: Montague, Turlough, James Drummond, Karl Ng, and John Parratt. "Advancements in Multiple Sclerosis." Internal Medicine Journal 55, no. 7 (2025): 895–904. https://doi.org/10.1111/imj.70023. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency.  Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

  3. Sep 14

    Rotations 2.0 Episode 83 Tension Headache versus Migraine

    Send us Fan Mail Episode 83 Tension Headaches Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Push it to the Extreme by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Paper for next week: Ahmed, Abdullah, Abdul-Habib Rahman, Shimul Williams, Mubeen Toufiq, Eyad Jamileh, Sheema Chaudhry, Khadijah Ahmed, and Munir Ahmed. 2024. “Seizures and Epilepsy: An Overview for UK Medical Students.” Cureus 16 (10): e70654. https://doi.org/10.7759/cureus.70654. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

  4. Sep 7

    Rotations 2.0 Episode 82 Migraines

    Send us Fan Mail Episode 82 Migraines Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Time for Two by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 81  Schizophrenia Question 1 A 28-year-old man with schizophrenia continues to have difficulty maintaining employment despite adequate control of hallucinations and delusions on antipsychotic medication. Which of the following factors most strongly contributes to his impaired functional outcome? C. Cognitive dysfunction Question 2 A researcher is studying quality of life (QOL) in patients with schizophrenia. Which cognitive domain has been shown to have a stronger relationship with subjective quality of life compared to neurocognition? D. Theory of mind Question 3 A clinician is considering treatment strategies to improve cognitive deficits in a patient with schizophrenia. Based on current evidence, which intervention is most likely to produce sustained improvement in multiple cognitive domains? C. Cognitive remediation therapy (CRT) Paper for next week: Onan, Dara, Samara Youns, Wam David Wesgatiñk, Fatemeh Farham, Saulius Andruškevičius, Ana Abashidze, Ase Jusupova, Yury Romanenko, Oxana Grosu, Meermigul Zamirbekovna Modokulova, Ulkar Mursalova, Sada Sadikhodjaeva, Paolo Martelletti, and Sat Ashina. “Debate: Differences and Similarities between Tension-Type Headache and Migraine.” The Journal of Headache and Pain 24, no. 1 (2023): 92. https://doi.org/10.1186/s10194-023-01614-0.   Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions.  Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

  5. Sep 2

    Rotations 2.0 Episode 81.1 Marijuana and Psychosis

    Send us Fan Mail Episode 81.1  Marijuana and Psychosis Shoot me any comments or questions @Rotations2ptoh  on X Intro/Outro: Night Detective by Amaksi Courtesy of Pixabay under Creative Commons for non-Commercial Educational use only. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Paper referenced: Pourebrahim S, Ahmad T, Rottmann E, Schulze J, Scheller B. Does Cannabis Use Contribute to Schizophrenia? A Causation Analysis Based on Epidemiological Evidence. Biomolecules. 2025 Mar 4;15(3):368. doi: 10.3390/biom15030368. PMID: 40149904; PMCID: PMC11940535. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

  6. Aug 31

    Rotations 2.0 Episode 81 Schizophrenia

    Send us Fan Mail Episode 81 Schizophrenia Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Big Guy by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 80  Dementia Question 1 A 74-year-old man presents with gradually worsening memory loss over 5 years. Brain autopsy later reveals extracellular amyloid plaques and intracellular neurofibrillary tangles. Further analysis shows that amyloid deposition began years before symptom onset. Which of the following best describes the earliest stage of Alzheimer’s disease pathogenesis? C. Accumulation of amyloid-beta in the neocortex Question 2 An 82-year-old woman presents with progressive memory loss. She has a history of hypertension and diabetes. MRI reveals multiple small infarcts and white matter changes. At autopsy, she is found to have Alzheimer’s disease pathology, TDP-43 inclusions, and vascular infarcts. Which of the following best explains the underlying cause of her dementia? D. Mixed dementia due to multiple coexisting pathologies Question 3 A 79-year-old patient presents with memory impairment. Amyloid PET imaging is negative, but MRI shows hippocampal atrophy. Neuropathologic examination later reveals TDP-43 protein deposition in the amygdala and hippocampus. Which of the following diagnoses is most consistent with these findings? D. Limbic-predominant age-related TDP-43 encephalopathy (LATE) Paper for next week: Aguilar-Shea, Antonio L., and Javier Diaz-de-Teran. “Migraine Review for General Practice.” Atención Primaria 54 (2021): 102208. https://doi.org/10.1016/j.aprim.2021.102208.  Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

  7. Aug 24

    Rotations 2.0 Episode 80 Dementia

    Send us Fan Mail Episode 80 Dementia Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Inspired to Begin by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS  Answers for Episode 79  Substance Use Disorder  Question 1 A 32-year-old man presents with agitation, tachycardia, and euphoria after using a recreational drug. Laboratory studies show elevated extracellular dopamine levels in the brain. Which of the following mechanisms best explains the primary neurochemical action of cocaine that produces these effects? C. Inhibition of the dopamine transporter leading to increased extracellular dopamine Question 2  A 45-year-old patient with opioid use disorder is found unresponsive with respiratory depression after injecting fentanyl. Emergency medical services administer naloxone, but repeated doses are required to maintain respiration. Which of the following best explains this phenomenon? C. Naloxone has a shorter half-life than fentanyl and may require repeated dosing Question 3  A research study investigates synaptic changes in the brains of individuals with substance use disorder. Investigators find that repeated exposure to cocaine leads to the formation of “silent synapses” characterized by an altered receptor ratio. Which of the following best describes this synaptic adaptation? B. Decreased AMPA/NMDA receptor ratio at glutamatergic synapses Paper for next week: Takeda, Tomoya, Hidehiro Umehara, Yui Matsumoto, Tomohiro Yoshida, Masahito Nakataki, and Shusuke Numata. “Schizophrenia and Cognitive Dysfunction.” Journal of Medical Investigation 71 (August 2024): 205–209. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

  8. Aug 17

    Rotations 2.0 Episode 79 Substance Use Disorder

    Send us Fan Mail Episode 79 Substance Use Disorder Shoot me any comments or questions @Rotation2ptoh  on X  Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Heroic by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 78 ADHD Question 1 A 68-year-old man presents with complaints of lifelong difficulty staying organized, managing finances, and completing tasks. He reports that these issues have been present since childhood but have worsened in impact since retirement. He denies progressive memory loss. Physical exam is unremarkable, and Mini-Mental State Examination (MMSE) score is normal. Which of the following is the most appropriate next step in management? C. Obtain a detailed developmental history focusing on childhood symptoms Question 2 A 72-year-old woman with newly diagnosed ADHD is being considered for pharmacologic treatment. She has a history of hypertension and is currently taking three antihypertensive medications. Which of the following is the most appropriate initial pharmacologic approach? B. Initiate low-dose stimulant therapy with careful titration Question 3 A 66-year-old patient with ADHD reports difficulty adhering to medication regimens for multiple chronic conditions. He frequently forgets doses and misses appointments. His physician decides to incorporate non-pharmacologic strategies. Which of the following interventions is most appropriate? C. Cognitive-behavioral therapy focused on organizational skills Paper for next week: Schneider, Julie A. “Neuropathology of Common Age-Related Dementing Disorders.” Continuum (Minneapolis, Minn.) 28, no. 3 (June 2022): 834–851. https://doi.org/10.1212/CON.0000000000001137. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

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A weekly discussion of medicine and science trends between people far too old to be trying something this new.

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  • Creator
    Todd Fredricks DO MSS
  • Years Active
    2025 - 2026
  • Episodes
    99
  • Rating
    Clean
  • Copyright
    © 2026 Rotations 2.0
  • Show Website
    Rotations 2.0