Enrico Mayor Podcast

Enrico Mayor

Conversations with the world’s most exceptional minds 🚀

  1. The Godfather of Ozempic: How a Hormone Could End the Obesity Epidemic | Enrico Mayor Podcast #25

    2d ago

    The Godfather of Ozempic: How a Hormone Could End the Obesity Epidemic | Enrico Mayor Podcast #25

    Jens Juul Holst — Discoverer of GLP-1 & “Godfather of Ozempic” — The scientist behind Ozempic explains why these drugs work so well, what the real risks are, and why they may reshape how the world fights obesity. In this uncut conversation we discuss: • How GLP-1 was discovered and why it first mattered for diabetes, not weight loss • The simple science behind Ozempic, Wegovy, and Mounjaro in plain English • The biggest side effects, long-term risks, and what most people misunderstand • Why stopping GLP-1 drugs often leads to weight regain without lifestyle change • Whether obesity is really about willpower, biology, or the modern food system 00:00 - Meet the Godfather of Ozempic 00:20 - Did anyone expect Ozempic to become this big? 02:01 - The early gut hormone research that led to GLP-1 04:28 - What GLP-1 actually does in the body 07:19 - When scientists realized it could drive weight loss 10:33 - Why early GLP-1 drugs had limited results 14:09 - The breakthrough from Saxenda to Wegovy 17:06 - How Jens discovered GLP-1 and proved it worked 20:20 - Taking GLP-1 from academia to Novo Nordisk 23:59 - Side effects, nausea, gallstones, and muscle loss explained 31:17 - What happens when you stop taking Ozempic or Wegovy 35:23 - Vision loss, safety concerns, and what the data really says 41:19 - Could GLP-1 drugs help people live longer? 44:39 - Ozempic vs Wegovy vs Mounjaro vs the next generation 48:08 - Should people use GLP-1 drugs for smaller weight loss goals? 52:41 - Is obesity a failure of willpower or a broken food system? 📍 Follow Enrico: Instagram – @enricomayor TikTok – @enricomayor 🎧 Also available on Spotify, Apple Podcasts, and more. 💬 Drop your takeaway in the comments & don't forget to Like & Subscribe.

    57 min
  2. MIT Scientist: The Chemical Quietly Contaminating 95% of School Lunches | Enrico Mayor Podcast #24

    Jun 7

    MIT Scientist: The Chemical Quietly Contaminating 95% of School Lunches | Enrico Mayor Podcast #24

    Stephanie Seneff — MIT research scientist — Why a “simple” herbicide may be quietly reshaping our microbiome, metabolism, and chronic disease risk. In this uncut conversation we discuss: • How Stephanie pivoted from early spoken-language AI at MIT to studying autism and environmental toxins • Glyphosate explained simply: a glycine “lookalike” and what that could mean for protein function • Why “non‑GMO” doesn’t guarantee low glyphosate (and which foods tend to be most contaminated) • The gut microbiome link: inflammation, fiber, butyrate, and why so many people struggle with wheat • A surprising obesity/diabetes pathway: Akkermansia, GLP‑1, and what Ozempic reveals about the gut 00:00 - From AI at MIT to human health (and why 2007 changed everything) 02:25 - Building early human-computer dialogue systems (before it was practical) 03:41 - Autism rates rising: the moment she decided to pivot into biology 05:03 - The 2012 glyphosate “aha” moment and why Roundup changed in the US 06:45 - Glyphosate explained like I’m five: glycine mimicry & protein substitution theory 11:23 - GMO “Roundup Ready” crops and the alanine vs glycine clue 12:34 - Why non‑GMO can still be high glyphosate (and how crops are actually sprayed) 18:49 - What to eat: certified organic, minimal processing, fermented foods, fiber 24:09 - The biggest contamination culprits: wheat, oats, barley, legumes (and organic pasta options) 26:01 - Does glyphosate “flush out”? Accumulation, genetics, and the “bullets” idea 31:55 - The disease correlation list: IBD, autism, Alzheimer’s, Parkinson’s, cancers & more 34:03 - Diabetes & obesity mechanism: Akkermansia → butyrate → GLP‑1 (Ozempic connection) 40:01 - Correlation vs causation: what’s known, what’s theory, and how you’d design better studies 44:06 - Supplements, synthetic nutrients, and the deuterium/TMAO rabbit hole 55:52 - The big takeaway: spend more on food, save on health (plus sunlight, movement, basics) 📍 Follow Enrico: Instagram – @enricomayor TikTok – @enricomayor 🎧 Also available on Spotify, Apple Podcasts, and more. 💬 Drop your takeaway in the comments & don't forget to Like & Subscribe.

    59 min
  3. He Meditates Since 1970—Here’s The One Intention Rule That Makes It Stick | Enrico Mayor Podcast #23

    May 24

    He Meditates Since 1970—Here’s The One Intention Rule That Makes It Stick | Enrico Mayor Podcast #23

    Richard Miller — Founder of iRest Yoga Nidra — The surprising shift that changes everything: start your meditation with what’s already “right” in you (indestructible well-being), then use it to meet stress, trauma, pain, and life. In this uncut conversation we discuss: • What iRest is (and why the U.S. military helped popularize it for PTSD) • The 10-step iRest protocol: intention, body sensing, breath, emotions, pure awareness, integration • Why “just come back to the breath” can become emotional repression—and what to do instead • The powerful “opposites” method that can move you into present-centered insight • A practical 7-day iRest starter plan + where to find free guided audios (iRest.org, Insight Timer, Mindfulness Coach) 00:00 - Meditation as a toolkit for modern life 00:42 - What iRest is (Yoga Nidra roots + non-dual traditions) 01:38 - Veterans, PTSD, and why it was renamed “iRest” 03:02 - The 10-step protocol explained (high-level walkthrough) 07:19 - Choosing the right “bucket”: TM vs Zen vs integrative practices 10:40 - Why returning to the breath isn’t always enough (working with difficult emotions) 16:30 - How long should an iRest session be? (30 seconds to 35+ minutes) 21:43 - Guided mini-practice: body sensing + breath + well-being 24:07 - Guided mini-practice: emotions + “opposites” technique 28:18 - Guided mini-practice: accessing “indestructible well-being” (5 inquiries) 38:29 - Can you do iRest without guidance? Memorizing the inquiries 44:16 - A simple 7-day iRest plan + embedding well-being into daily routines 50:51 - Where to get iRest audios, courses, and apps (free + paid) 53:14 - What Richard is still learning after decades of meditation 55:42 - Building an unbreakable meditation habit with tiny intentions 📍 Follow Enrico: Instagram – @enricomayor TikTok – @enricomayor 🎧 Also available on Spotify, Apple Podcasts, and more. 💬 Drop your takeaway in the comments & don't forget to Like & Subscribe.

    59 min
  4. Pregnancy Rewires the Brain: The Shocking Neuroscience of Motherhood | Enrico Mayor Podcast #22

    May 8

    Pregnancy Rewires the Brain: The Shocking Neuroscience of Motherhood | Enrico Mayor Podcast #22

    Sarah McKay — Neuroscientist — The biggest “female brain differences” might come from society, not biology—and pregnancy literally rewires the brain for motherhood. In this uncut conversation we discuss: • Why female brains look *more similar* to male brains in more gender-equal countries • The 2016 pregnancy study showing massive brain reorganization for social cognition • “Baby brain” explained: why tests show normal memory, even when it *feels* worse • The real cause of postpartum struggle: sleep, loneliness, and a broken support system • The #1 thing husbands can do: take the lion’s share of domestic load + protect mom’s sleep 00:00 - The most surprising discoveries about the female brain 00:30 - Gender equality changes brain differences (biology vs biography) 02:31 - Pregnancy rewires the brain for social cognition & motherhood 03:27 - Are baby brains basically the same at birth? 06:09 - What “baby brain” really means (and why it’s not about babies) 07:24 - The study: parents vs non-parents on cognition (and male “confidence”) 11:29 - Baby brain isn’t a brain defect—it’s the ecosystem you’re parenting in 14:11 - What animal mothers teach us about maternal brain plasticity 19:25 - Solo motherhood, sleep loss, and the perfect storm for anxiety/depression 25:05 - Why the solution isn’t “convince women”—it’s policy, partners, and support 32:20 - Practical dad advice: emotional load, tag-teaming nights, and protecting sleep 40:21 - Myth-busting: women aren’t “more emotional” (the data says otherwise) 44:57 - The simplest brain health stack: sleep + strong relationships 📍 Follow Enrico: Instagram – @enricomayor TikTok – @enricomayor 🎧 Also available on Spotify, Apple Podcasts, and more. 💬 Drop your takeaway in the comments & don't forget to Like & Subscribe.

    51 min
  5. I Had Public Speaking Anxiety for 20 Years—This ONE Practice Fixed It | Enrico Mayor Podcast #21

    Apr 26

    I Had Public Speaking Anxiety for 20 Years—This ONE Practice Fixed It | Enrico Mayor Podcast #21

    Christopher Germer — Clinical Psychologist — The fastest way to calm anxiety isn’t “thinking positive”—it’s shifting your body from threat to care with self-compassion. In this uncut conversation we discuss: • How loving-kindness ended Chris’ 20-year public speaking anxiety • Why self-compassion works physiologically (vagus nerve, HRV, cortisol)  • The 3 components of self-compassion: mindfulness, common humanity, self-kindness • A guided “Self-Compassion Break” you can use in 5 minutes (or less) • Burnout, dopamine/drive, and the simple mantra: “You matter too.” 00:00 - Welcome & why self-compassion matters 00:41 - The 20-year public speaking anxiety that mindfulness didn’t fix 02:06 - The surprising turning point: “Just love yourself” (Sharon Salzberg) 03:12 - How self-kindness rewired the fear response before a 500-person talk 05:47 - Meeting Kristin Neff & creating Mindful Self-Compassion (MSC) 08:37 - Why it’s not “logic”—it’s tone, attitude, and physiology 13:33 - The science: threat vs care states, vagus nerve, HRV, cortisol 16:07 - When social threat turns inward: self-criticism, isolation, rumination 20:21 - Daily playbook: 20 seconds of compassionate touch + simple practices 25:52 - Guided Self-Compassion Break (mindfulness, common humanity, self-kindness) 41:18 - What happens in the 8-week MSC program (sessions & outcomes) 46:10 - Burnout for entrepreneurs: permission + reminding + the drive/threat trap 57:21 - The “in-breath is for you” reset in high-stress moments 1:02:35 - The one lesson for future generations: “You matter too.” 📍 Follow Enrico: Instagram – @enricomayor TikTok – @enricomayor 🎧 Also available on Spotify, Apple Podcasts, and more. 💬 Drop your takeaway in the comments & don't forget to Like & Subscribe.

    1h 4m
  6. I Spent 340 Days in Space: Here’s What It Did to My Mind & Body | Enrico Mayor Podcast #20

    Apr 12

    I Spent 340 Days in Space: Here’s What It Did to My Mind & Body | Enrico Mayor Podcast #20

    Scott Kelly — NASA Astronaut — A year in orbit doesn’t just change your body—it rewires how you see Earth, risk, politics, and what actually matters. In this uncut conversation we discuss: • Why the “hardest part of Mars” isn’t rocket science—it’s political science • The real odds of dying on launch (and why astronauts still get on the rocket) • What daily life on the ISS actually feels like: schedules, sleep, food, and isolation • The weirdest realities of microgravity (yes…including the toilet) • The twin study surprises: telomeres, time dilation, and what space does to your biology 00:00 - Intro 01:01 - What a year in space teaches you about Earth (and why Scott is a “big fan of Earth”) 06:31 - Launch prep: Star City, Baikonur quarantine & Russian vs NASA training mindset 12:41 - Superstitions, ceremonies & the reality of quarantine before liftoff 15:43 - “How likely are you to die?” Space Shuttle vs Soyuz risk, escapes & hard truths 22:18 - Why the Space Shuttle was so complex (2,000 switches) vs modern spacecraft 27:05 - Dragon vs Soyuz vs Boeing: which vehicle is “easiest” to fly today? 30:19 - SpaceX landings, Starship scale & why Kelly changed his mind about what’s possible 33:24 - Living with 3–13 people in orbit: toilets, claustrophobia & the gorilla suit story 39:01 - A real day on the ISS: GMT, ground conferences, work weeks & “mental health days” 52:09 - Re-entry: fireball windows, parachutes, “the best ride ever” & why landings feel like a car crash 59:06 - Returning to gravity: dizziness, blood volume changes, skin reactions & losing 20% heart mass 1:08:26 - The twin study: telomeres, radiation, time dilation & being “8 milliseconds younger” 1:15:54 - Mars: radiation, life support, why one-way missions are a bad idea, and the politics problem 1:25:52 - Borders from space, tribalism on Earth & what astronauts learn about cooperation 1:38:09 - The hardest personal moment in orbit: learning Gabby Giffords was shot from space 1:52:11 - Advice to young people: find your spark, embrace failure, and don’t quit 📍 Follow Enrico: Instagram – @enricomayor TikTok – @enricomayor 🎧 Also available on Spotify, Apple Podcasts, and more. 💬 Drop your takeaway in the comments & don't forget to Like & Subscribe.

    1h 55m
  7. How to Sit All Day Without Destroying Your Back | Enrico Mayor Podcast #19

    Mar 29

    How to Sit All Day Without Destroying Your Back | Enrico Mayor Podcast #19

    Esther Gokhale — Posture Coach — Why “sit up straight” may be making your back pain worse, and the simple posture shifts that can reshape your spine and relieve pain. In this uncut conversation we discuss: • Why modern back pain starts with lost posture habits, bad furniture, and even baby seats • The difference between a C-spine, S-spine, and Esther’s pain-saving J-spine • Why sitting isn’t the enemy if you learn to sit well and break it up with movement • How stretch sitting, stretch lying, and glide walking can reduce tension and decompress the spine • Esther’s personal recovery from a severe L5-S1 disc herniation without a second surgery 00:00 - Why Sitting Is Not the New Smoking 00:45 - Why Back Pain Is So Common Today 04:22 - How Bad Posture Becomes the Cultural Norm 05:53 - Why “Sit Up Straight” Can Make Things Worse 09:32 - The J-Spine Explained 14:27 - Why Sitting Well Beats Avoiding Sitting 17:20 - The Everyday Movements That Matter Most 23:23 - Esther’s Practical First Steps for Back Pain Relief 29:00 - How Stretch Sitting Actually Works 32:14 - Stretch Lying, Better Sleep, and Spinal Traction 34:22 - Why Crunches Can Harm Your Back 44:10 - Glide Walking and Using the Glutes Correctly 51:11 - How to Learn Proper Posture Safely 59:16 - Evidence, Results, and Why Esther’s Method Works 1:06:15 - Esther’s Personal Back Pain Story 📍 Follow Enrico: Instagram – @enricomayor TikTok – @enricomayor 🎧 Also available on Spotify, Apple Podcasts, and more. 💬 Drop your takeaway in the comments & don't forget to Like & Subscribe. --- Learn more about Esther Gokhale: Free first chapter of Esther’s bestseller 8 Steps to a Pain-Free Back: https://gokhalemethod.com/free_chapter?utm_medium=podcast&utm_source=enrico_mayor  Free workshop: https://gokhalemethod.com/map/free_workshops?online=1&utm_medium=podcast&utm_source=enrico_mayor gokhalemethod.com facebook.com/GokhaleMethod instagram.com/gokhalemethod linkedin.com/company/gokhale-method youtube.com/user/GokhaleMethod

    1h 10m
  8. How Elites Lost America: The Bargain That Broke Democracy | Enrico Mayor Podcast #18

    Mar 15

    How Elites Lost America: The Bargain That Broke Democracy | Enrico Mayor Podcast #18

    Roger Berkowitz — Political Theory Professor — Why today’s “left vs right” chaos is really a class revolt of the “virtuals” vs the “reals” (and how Arendt helps us rebuild common sense) In this uncut conversation we discuss: • The new political “revolution”: virtual elites vs hands-on “real” life—and why resentment is exploding • How the retreat of everyday citizens from politics helped create today’s moral crisis and cynicism • Why America’s institutions (Congress, federalism, courts) are losing legitimacy—and what that enables • The hidden driver: loneliness, purposelessness, and Arendt’s warning about “metaphysical homelessness” • A practical fix: citizen assemblies as a “jury system for politics” to restore trust and compromise 00:00 - Applying Hannah Arendt to today’s fragile political moment 00:39 - A revolution is underway: “virtuals” vs “reals” 03:28 - The elite bargain failed: why institutions lost credibility 06:52 - Militarized bureaucracy, ICE expansion, and Arendt’s tyranny warning 08:23 - Mafioso politics & cynicism: when power replaces truth 13:08 - Two ways to restrain human nature: leadership vs institutions 15:44 - How federalism eroded and the presidency grew too powerful 18:32 - The leadership crisis in the internet age (and Trump’s charisma) 28:09 - Congress abdicates: bureaucracy, class interests, and why governance got outsourced 37:05 - Gerrymandering & “safe districts”: how incentives push radicalization 55:17 - Rules won’t save you: the Berkowitz axiom & why merit-based arguments matter 1:06:28 - Loneliness, meaning, and Arendt’s path to mass movements 1:11:02 - Citizen assemblies: deliberation as the missing institution 1:22:30 - AI + power politics: why the next decades may be turbulent—and how to prepare 📍 Follow Enrico: Instagram – @enricomayor TikTok – @enricomayor 🎧 Also available on Spotify, Apple Podcasts, and more. 💬 Drop your takeaway in the comments & don't forget to Like & Subscribe.

    1h 30m
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About

Conversations with the world’s most exceptional minds 🚀

Information

  • Creator
    Enrico Mayor
  • Years Active
    2025 - 2026
  • Episodes
    25
  • Rating
    Explicit
  • Copyright
    © 2026 Enrico Mayor Podcast
  • Show Website
    Enrico Mayor Podcast