In this episode, we review nasal polyps, benign inflammatory growths of the sinonasal mucosa commonly associated with chronic rhinosinusitis, asthma, allergic rhinitis, and aspirin-exacerbated respiratory disease (AERD). We discuss the underlying inflammatory mechanisms, including Type 2 inflammation and Samter's triad, along with the classic presentation of progressive nasal obstruction, congestion, rhinorrhea, and decreased or absent sense of smell (anosmia). The segment also covers the diagnostic approach, emphasizing the characteristic pale, translucent, "peeled grape" appearance on nasal examination, along with the role of nasal endoscopy and sinus CT. We finish with treatment strategies involving saline irrigation, intranasal corticosteroids, biologic therapies such as dupilumab, and functional endoscopic sinus surgery (FESS), highlighting key clinical pearls including evaluation of unilateral nasal masses for possible malignancy and screening children with nasal polyps for cystic fibrosis. References Bushardt RL, Colomb-Lippa DM, Klinger AM, Reed H. The JAAPA QRS Review for PAs: Study Plan and Guide for PANCE and PANRE. 1st ed. LWW; 2021. ISBN: 9781975143817 Esmaeilzadeh, H., Zare, M., Alyasin, S., Nabavizadeh, H., Mortazavi, N., & Kanannejad, Z. (2022). A Review of Aspirin-exacerbated Respiratory Diseases and Immunological Efficacy of Aspirin Desensitization. Iran J Allergy Asthma Immunol, 21(5), 512-523. Kariyawasam, H. H., et al. (2023). Biologic treatment for severe chronic rhinosinusitis with nasal polyps: a systematic review and meta-analysis. Rhinology, 61(2): 98-107. del Toro, E., Hardin, F. M. L., & Portela, J. (2025). Nasal Polyps. StatPearls [Internet] (Accessed 4/29/26).