Signal and Symptoms Podcast

Harvey Castro MD, Junaid Kalia MD, & Edward Marx
  • 5.0 (1)
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Three healthcare AI experts who've watched millions wasted on failed projects. Dr. Harvey Castro, Dr. Junaid Kalia, Edward Marx, and guest experts cover all things healthcare AI - from digital transformation to clinical reality. Every Tuesday, we diagnose real failures, reveal what actually works, and help you avoid the expensive mistakes we've seen repeated everywhere. Because when AI decisions affect patient care, getting it right isn't optional.

  1. 12/30/2025

    15 Healthcare Leaders Predict 2026: AI Will Transform Care (Or Collapse Under Bureaucracy)

    This Holiday Special brings together 15 healthcare leaders, technologists, and innovators to tackle the biggest questions facing medicine in 2026. AI tools are proliferating across hospitals, but can healthcare systems integrate them effectively? Healthcare stands at a crossroads in 2026. AI is everywhere—from radiology to clinical decision support—but critical questions remain. Will it lower costs for patients? Can hospitals keep pace with innovation? And most importantly: who's steering this transformation? Our diverse panel of physicians, educators, consultants, and entrepreneurs shares their frontline perspectives on what's working, what's failing, and what must change. Tune in to discover practical steps for upskilling, embedding AI into workflows, and ensuring the next generation enters the workforce ready to leverage these technologies for better patient outcomes. What You Will Discover: - What's Coming in Healthcare AI 2026 - Breakthrough Technologies & AI in Practice - What's Holding Healthcare Back - What You Can Do Now Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - https://www.marxadvisory.com/ 📹YouTube - https://www.youtube.com/@EdwardMarx Special Guest: Avinash Jayaswal, MD, MS, MSc, 💼LinkedIn - https://www.linkedin.com/in/avinash-jayaswal-md-ms-msc-464a5a2/ Jim Pollock 💼LinkedIn - https://www.linkedin.com/in/jimdpollock/ Dipu Patel, DMSc, MPAS, ABAIM, PA-C 💼LinkedIn - https://www.linkedin.com/in/dipu-patel-dmsc-pa-c-695000b/ Arlen Meyers, MD, MBA 💼LinkedIn - https://www.linkedin.com/in/ameyers/ Kianor Shah DMD, MBA 💼LinkedIn - a...

    24 min

  2. 12/23/2025

    What If Better Patient Care Actually Cost Less? The AI Reality

    The future of AI-enabled care is massive and available, but the question remains: will we be the ones leading it? In this episode, Dr. Robert Pearl – Former CEO of Permanente Medical Group (Kaiser Permanente), Author of "ChatGPT, MD", Forbes Contributor – joins the panel to challenge the core of how we practice medicine today. Medical students are entering training with AI capabilities that their professors don't possess. But beneath this technological evolution lies a clinical crisis: 400,000 deaths annually from misdiagnosis, intermittent care for chronic diseases, and a system that could eliminate up to $2 trillion in wasteful spending. The conversation addresses why AI integration advances rapidly in other countries, yet the US lags, not from lack of technology, but from cultural resistance and misaligned financial incentives. Dr. Pearl reveals the solution he's witnessed work at scale that allows a delivery system to have smarter chronic disease management and better doctor-patient interaction. This discussion connects directly to what matters most in clinical practice: better diagnostic accuracy, continuous disease monitoring that actually works, and care delivery that doesn't burn out physicians while delivering superior results. The paradigm can shift from the traditional trade-off between quality, access, and cost to a model where increasing quality and access genuinely lowers cost. What You Will Discover: - The Era of Smarter Students: AI Skills Professors Don't Have - The Clinical Crisis: 400,000 Deaths From Misdiagnosis - How 24/7 AI Monitoring Reduces Heart Attacks & Strokes by 30-50% - Why Singapore & Dubai Lead While the US Lags - Why Current Incentives Block AI Adoption - The Fee-for-Service Problem: Rewarding Volume Over Outcomes - How AI will Impact Pharmaceutical innovations - Flipping the Paradigm: Lower Cost Through Higher Quality & Access Referenced in the show: 🖇️ "ChatGPT, MD: How-AI Empowered Patients & Doctors Can Take Back Control of American Medicine" – https://www.amazon.com/dp/B0CWCV9DVZ 🖇️ “Mistreated: Why We Think We’re Getting Good Health Care – And Why We’re Usually Wrong” – https://www.amazon.com/Mistreated-Think-Getting-Health-Usually/dp/1610397657/ Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd 🔗Website - https://www.junaidkalia.com/ 📹YouTube - https://www.youtube.com/@junaidkaliamd Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ 🔗Website - https://www.harveycastromd.com/ 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ 🔗Website - a...

    19 min

  3. 12/16/2025

    AI in Healthcare 2025: 3 Insiders Reveal 9 Non-Negotiable Strategies

    If healthcare AI is truly evolving, why are there still gaps between what technology can do and what healthcare organizations are actually doing? These gaps aren't just inefficiencies. They're creating real clinical risks that directly impact patient outcomes. This year-end roundtable brings together three healthcare AI experts—Dr. Harvey Castro, Dr. Junaid Kalia, and Edward Marx—following their appearance at AIMed 2025 to share their key takeaways from deploying AI in the messy reality of hospital systems. They synthesize insights across policy, culture, and implementation: how cost disruption reshapes hospital innovation budgets, what Singapore's mandatory retraining model signals about workforce transformation, and where CMS guidelines create strategic inflection points for health systems. They demonstrate what continuous collaborative learning looks like in practice: completing advanced certifications, testing tools hands-on in their own workflows, and building AI systems for acute care environments. Whether you're a clinician evaluating AI tools for your practice, an executive planning institutional strategy, or a founder building healthcare AI solutions, this episode helps you separate signal from noise and position yourself strategically in this transformation. What You Will Discover: - Introduction & ABIM Course Discussion - Ed's 3 Key Learnings for AI-Driven Transformation - Harvey's 3 Takeaways: Martec's Law & The Culture Problem - Junaid's 3 Lessons from Building AI Solutions - Why Nurses Are Being Left Behind in AI Adoption - Deep Seek Impact: How AI Costs Dropped 99% - Who Should Pay for AI? Government vs. Private Investment - Singapore's Approach: Mandatory AI Retraining Policy Referenced in the show: 🖇️ “2025 Agenda: Advancing Healthcare with Expert-Led AI” – https://aimed.swoogo.com/aimed25/8350420  Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd  🔗Website - https://www.junaidkalia.com/  📹YouTube - https://www.youtube.com/@junaidkaliamd  Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/  🔗Website - https://www.harveycastromd.com/  📷Instagram - https://www.instagram.com/harveycastromd/?hl=en  Edward Marx, CEO, Advisor  💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/  🔗Website - https://www.marxadvisory.com/  📹YouTube - https://www.youtube.com/@EdwardMarx     Visit our website: https://signalandsymptoms.com/ Get advisory insights about...

    17 min

  4. 12/09/2025

    Why Surgeons Can't Measure Brain Temperature Directly (And What's Finally Changing)

    Innovation signals are everywhere, but what matters are those that move from laboratory potential to measurable clinical impact. Joining the conversation are Jim Pollock and Tom Meese from LumenAstra, demonstrating how clinical insight, technical capability, and strategic execution bridge the gap between healthcare innovation and patient outcomes. The discussion explores how their innovative work in developing non-invasive internal body temperature measurement technology will transform the future of AI development, enhance predictive models, and drive the creation of new clinical applications, all while leveraging the interdisciplinary nature of healthcare technology. This isn't promotional & theoretical. Just the evidence of what happens when we measure the right interventions and act on them wisely. What You Will Discover: - Introduction to Lumen Astra & Its Mission - Innovative temperature measurement technology - Why has technology only emerged now - How real-time brain temperature improves clinical decisions  - Dr. Kalia's compassion fatigue story in Neuro-ICU  - Building through customer discovery over assumptions - Closing: AI, evidence, and future Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd  🔗Website - https://www.junaidkalia.com/  📹YouTube - https://www.youtube.com/@junaidkaliamd  Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/  🔗Website - https://www.harveycastromd.com/  📷Instagram - https://www.instagram.com/harveycastromd/?hl=en  Edward Marx, CEO, Advisor  💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/  🔗Website - https://www.marxadvisory.com/  📹YouTube - https://www.youtube.com/@EdwardMarx   Connect With Our Guests: Jim Pollock - Co-founder, LumenAstra 💼LinkedIn - https://www.linkedin.com/in/jipollock/  Tom Meese - Co-founder, LumenAstra 💼LinkedIn - https://www.linkedin.com/in/tom-meese-615ab35/  For clinical collaboration or investment inquiries 📧 - info@lumenastra.io 🔗 - https://www.lumenastra.io/    Visit our website: https://signalandsymptoms.com/ Get advisory insights about Healthcare AI — at zero cost: a href="https://junaidkaliamd.substack.com/" rel="noopener noreferrer"...

    17 min

  5. 12/02/2025

    From Fragmented Silos to Integrated Services: Transforming Cancer Care Delivery

    What if the biggest barrier to better cancer care isn't technology—it's how physicians approach treatment with ego?  In this episode, we sit down with Dr. Talia Baker, a transplant surgeon who walked away from clinical practice to solve a problem she witnessed firsthand: the liver cancer patient journey is fundamentally broken. Dr. Baker introduces the Lori MDT project, a vision for reshaping how patients navigate fragmented cancer care. But the real conversation goes deeper—into the uncomfortable truths about institutional incentives, the care gaps between diagnosis and treatment, and why even the best academic centers are limited by their own biases. Her core argument: fragmented cancer care demands interdisciplinary collaboration and technology-driven process re-engineering. The era of incremental improvements is over. The future belongs to integrated services that cut across specialties—not siloed excellence in labs or imaging alone. What You Will Discover: - How the system's fragmentation and silos fail patients today - Why 75% of cancer patients don't get multidisciplinary care - The hardest problem: physician hubris, not technology implementation - The wisest surgical lesson—knowing when not to operate - Why we lost sight of focusing too much on product quality over service integration - Building mosaics of superpowers before digital twins take over This isn't about replacing clinicians with AI—it's about collaboration across clinicians, technologists, patients, and systems to augment what we can do together. Referenced in the show: 🖇️ "OpenTSLM: Time-Series Language Models for Reasoning over Multivariate Medical Text- and Time-Series Data" – https://arxiv.org/abs/2510.02410  🖇️ “Artificial intelligence should genuinely support clinical reasoning and decision making to bridge the translational gap ” – https://www.nature.com/articles/s41746-025-01725-9  🖇️Chain-of-Influence: Tracing Interdependencies Across Time and Features in Clinical Predictive Modelings – https://arxiv.org/abs/2510.09895  🖇️“Large language models forecast patient health trajectories enabling digital twins” – https://www.nature.com/articles/s41746-025-02004-3  Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd  🔗Website - https://www.junaidkalia.com/  📹YouTube - https://www.youtube.com/@junaidkaliamd  Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/  🔗Website - https://www.harveycastromd.com/  📷Instagram - a href="https://www.instagram.com/harveycastromd/?hl=en" rel="noopener noreferrer"...

    16 min

  6. 11/25/2025

    From Sick Care to True Healthcare: Why AI Demands a New Kind of Leader

    What if we're running a sick care system pretending to be healthcare? AI promises to change that by improving access for patients and reducing burden for providers, but only if we have leaders who know how to guide the transformation. The challenge: healthcare offers no structured pathway for developing these leaders. Joining today's expert panel: Arlen Meyers, MD, MBA, President & CEO of the Society of Physician Entrepreneurs, and Muhammad Siddiqui, Chief Digital & Information Officer at Reid Health. Together, they reveal why this leadership gap exists across four levels (personal, organizational, systemic, and societal) and what's actually working on the front lines. The conversation moves beyond theory into practical realities: why the traditional triple threat model (clinician-researcher-educator) must evolve into something new, how real implementation success shows up in physician quality of life before ROI spreadsheets, and why sustainable AI adoption ultimately requires changing the rules that shape our current healthcare system. The missing piece isn't just technology. It's a culture of continuous learning that prepares physicians to bridge clinical expertise, technological fluency, and entrepreneurial thinking. What You Will Discover: - Introduction & Episode Overview - The Four Barriers to AI Adoption - Why Physicians Aren't Becoming Tech Entrepreneurs - The New Triple Threat in Medical Career - Building AI IQ of Healthcare Through Education - The Leadership Development Gap - Bridging Clinical Innovation and Business Value - The Complexity of Healthcare Sales - Actionable Advice for Healthcare Leaders - Reframing the Problem: Changing the Rules Referenced in the show: 🖇️ "There is no Chief Healthcare AI Officer School" – https://arlenmeyersmdmba.substack.com/p/there-is-no-chief-healthcare-ai-officer  📚 Digital Health Entrepreneurship (Health Informatics) by Arlen Meyers - https://www.amazon.com/Digital-Health-Entrepreneurship-Informatics-dp-3031339010/dp/3031339010/ref=dp_ob_title_bk  Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd  🔗Website - https://www.junaidkalia.com/  📹YouTube - https://www.youtube.com/@junaidkaliamd  Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/  🔗Website - https://www.harveycastromd.com/  📷Instagram - https://www.instagram.com/harveycastromd/?hl=en  Edward Marx, CEO, Advisor  💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/  🔗Website - a href="https://www.marxadvisory.com/about-ed-marx" rel="noopener noreferrer"...

    16 min

  7. 11/18/2025

    Mindset, Audits, & Equity: What’s REALLY Slowing Down Healthcare AI?

    If AI is the future of healthcare, why is its adoption moving at a glacial speed? In this episode, Sherri Douville, CEO of Medigram and Chair of the Trustworthy Technology and Innovation Consortium (TTIC), argues the true bottleneck is not technology, but a crisis of accountability. She explains that systems—even those that are FDA-approved and cyber-secure —stall because hospital leadership lacks robust governance frameworks to properly evaluate solutions and grant final approval for patient care.  The panel reveals how to establish trust infrastructure and why elevating AI governance to the same rigorous level as finance and clinical quality is the only path to scalability. This structural shift from treating AI as an "innovation experiment" to a reliable "system of record" is the only way to manage risk, ensure accountability, and accelerate safe, effective deployment. What You Will Discover: - Deploying AI Safely and Effectively: Her Mission - Why the C-Suite Cannot Evaluate AI - The CIO's Dilemma: Clinical Risk Approval - Founder's Advice: Investor-Client Compatibility - Govern AI Like Finance and Clinical Quality - Mindset is the Biggest Limiting Factor - Hospitals Face Audits Q2 Next Year - Human Resilience Gives the Most Hope Tune in for an actionable roadmap to accelerate your AI transformation, complete with frameworks for executive oversight, ethical deployment, and securing your future investments. Books Mentioned: 📚Mobile Medicine by Sherri Douville – https://www.amazon.com/Mobile-Medicine-Overcoming-Culture-Governance/dp/0367651505 📚Advanced Health Technology by Sherri Douville – https://www.amazon.com/Advanced-Health-Technology-Managing-Acceleration/dp/1032391480  Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd  🔗Website - https://www.junaidkalia.com/  📹YouTube - https://www.youtube.com/@junaidkaliamd  Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/  🔗Website - https://www.harveycastromd.com/  📷Instagram - https://www.instagram.com/harveycastromd/?hl=en  Edward Marx, CEO, Advisor  💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/  🔗Website - https://www.marxadvisory.com/about-ed-marx 📹YouTube - https://www.youtube.com/@EdwardMarx   Special Guest: Sherri Douville 💼LinkedIn -...

    17 min

  8. 11/09/2025

    What Keeps a Pediatric AI Pioneer Up at Night (It's Not What You Think)

    What if the biggest threat to the future of medicine isn't AI—but our refusal to use it? That's exactly what keeps Dr. Anthony Chang up at night. As founder of Intelligence-Based Medicine (AIMed) and a pioneering pediatric cardiologist, he's dedicated his career to a singular mission: ensuring clinicians aren't left out of healthcare's AI revolution. In this episode, Dr. Chang joins us to outline the new paradigm where AI serves as the great equalizer—amplifying the reach of elite institutions while empowering rural hospitals with the same capabilities. He shares his vision for a future driven by clinical leadership, data science, and the most revolutionary tool in modern medicine: the Digital Twin, which will soon become routine for personalized care. What You Will Discover: - Introduction & AIMed Conference preview - Digital Twins: The end of "1x research" in medicine - The real barriers to AI adoption - Why AI is the great equalizer for rural hospitals & developing countries - The bilingual clinician imperative - How physicians’ critical thinking and judgment will remain essential Learn the practical skills and strategic knowledge to lead the AI revolution at the premier event for Artificial Intelligence in Medicine. 🔗Register for AIMed25 Global Summit: https://aimed.swoogo.com/AIMed25 🔗Explore the American Board of AI in Medicine: https://abaim.org/  🔗Catch Dr. Harvey Castro's upcoming TEDx talk on AI in healthcare at TEDxSouthlake 2025 🔗Discover cutting-edge AI applications at the AI for Healthcare Leaders Conference Article reference: 🖇️ "If A.I. Can Diagnose Patients, What Are Doctors For?" – https://www.newyorker.com/magazine/2025/09/29/if-ai-can-diagnose-patients-what-are-doctors-for  Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd  🔗Website - https://www.junaidkalia.com/  📹YouTube - https://www.youtube.com/@junaidkaliamd  Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/  🔗Website - https://www.harveycastromd.com/  📷Instagram - https://www.instagram.com/harveycastromd/?hl=en  Edward Marx, CEO, Advisor  💼LinkedIn -  https://www.linkedin.com/in/edwardmarx/  🔗Website - a href="https://www.marxadvisory.com/about-ed-marx" rel="noopener noreferrer"...

    19 min
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Three healthcare AI experts who've watched millions wasted on failed projects. Dr. Harvey Castro, Dr. Junaid Kalia, Edward Marx, and guest experts cover all things healthcare AI - from digital transformation to clinical reality. Every Tuesday, we diagnose real failures, reveal what actually works, and help you avoid the expensive mistakes we've seen repeated everywhere. Because when AI decisions affect patient care, getting it right isn't optional.

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  • Creator
    Harvey Castro MD, Junaid Kalia MD, & Edward Marx
  • Years Active
    2K
  • Episodes
    23
  • Rating
    Explicit
  • Copyright
    © Copyright 2025 Harvey Castro MD, Junaid Kalia MD, & Edward Marx
  • Show Website
    Signal and Symptoms Podcast