Oncology Insights with Petros Grivas

Petros Grivas
  • 5.0 (5)
  • Medicine
  • Updated Biweekly

Cancer experts and scientists "Meet the Greek" – Fred Hutch Cancer Center's Dr. Petros Grivas – to discuss their work. This biweekly podcast explores the latest developments in cancer care and research. Dr. Grivas emphasizes the importance of learning from colleagues, engaging with patients, and fostering community partnerships. The podcast will feature diverse guests and cover a range of topics, including innovative treatments, clinical trials, and educational initiatives in oncology.

  1. Jun 30

    Inside Sarcoma Care: New Therapies, Clinical Trials & Team-Based Treatment

    In this episode of the Oncology Insights Podcast, host Petros Grivas MD, PhD, FASCO, sits down with Lara Davis, MD, head of the Sarcoma Program at Fred Hutch Cancer Center, to discuss the latest treatment advances for sarcomas, ongoing clinical trials, multidisciplinary care and the importance of working with community oncologists to improve patient outcomes. Timestamps: 00:07 - Introduction to Dr. Lara Davis and her role at Fred Hutch 05:58 - Overview of the diverse sarcoma types and diagnostic challenges 06:27 - The rarity of individual sarcoma subtypes despite their collective importance 08:41 - The value of multidisciplinary teams in sarcoma care 11:33 - Germline mutations associated with sarcoma risk, including Li-Fraumeni syndrome 13:27 - Outpatient vs inpatient chemotherapy management 16:56 - Exciting clinical trials at Fred Hutch, including the ASCO sarcoma plenary  17:54 - Innovative trial combining CDK4/6 inhibitors with radiation for liposarcoma 21:36 - Collaboration with community practices to ensure patient access 25:57 - Future vision: biomarkers, targeted therapies, and advancing sarcoma care 28:48 - The potential of immunotherapy and CAR T-cell approaches in sarcoma 32:07 - Closing remarks and future prospects for sarcoma research Resources & Links: Dr. Lara Davis: https://www.fredhutch.org/en/provider-directory/lara-davis.html Dr. Petros Grivas: https://www.fredhutch.org/en/provider-directory/petros-grivas.html

    Inside Sarcoma Care: New Therapies, Clinical Trials & Team-Based Treatment

  2. Jun 16

    The Evolution of Stem Cell Transplantation – Insights from Dr. Marco Mielcarek

    Join us as we explore the incredible advancements in stem cell transplantation with Marco Mielcarek, MD, PhD, director of the Blood and Marrow Transplantation Program at Fred Hutch. Discover the journey from the early days of transplantation to cutting-edge techniques that are transforming patient outcomes worldwide. In this episode, you will learn about: Dr. Mielcarek's personal journey from Berlin to Seattle and his long-standing contributions since 1994 The historical evolution of the Fred Hutch Cancer Center's infrastructure and comprehensive cancer care services Key progress in stem cell transplantation, including the role of Nobel laureate Don Thomas Strategies to manage and reduce graft-versus-host disease (GVHD) over the decades The impact of post-transplant cyclophosphamide technology in expanding donor pools and reducing complications How outpatient care models are revolutionizing patient recovery and follow-up after transplantation The future of transplantation: safer, less toxic regimens and targeted therapies like CAR T-cells The importance of becoming a donor through the National Marrow Donor Program and how donors help save lives Timestamps: 00:00 - Introduction 00:36 - Dr. Mielcarek's story and early career in Berlin 01:52 - Transition to Seattle and research focus on bone marrow microenvironment 03:10 - Infrastructure evolution at Fred Hutch and historical context of transplantation 04:33 - Progress in cancer treatment and transplant outcomes 05:34 - Focus on managing toxicity and improving survival rates 05:55 - Advancements in GVHD prevention and treatment strategies 08:10 - Patient access and logistics of transplantation, including international patients 09:53 - The donor selection process and international collaboration 12:48 - Coordinating outpatient and inpatient transplant care 15:43 - Cutting-edge research: post-transplant cyclophosphamide and its impact 19:05 - How to become a donor and expand the donor pool 23:38 - Future predictions for transplantation physics and methodology 27:58 - Innovative approaches and ongoing studies to improve safety and efficacy Resources & Links: Marco Mielcarek Petros Grivas Be The Match - National Marrow Donor Program

    The Evolution of Stem Cell Transplantation – Insights from Dr. Marco Mielcarek

  3. Jun 2

    Exploring Neuro-Oncology Leadership and Innovation with Dr. Vyshak Venur

    Join Dr. Petros Grivas in this episode of the Oncology Insights Podcast as he hosts Dr. Vyshak Venur, a leader in neuro-oncology and Deputy Chief Medical Officer at Fred Hutch. Discover insights into career development, groundbreaking neuro-oncology research and the future of precision medicine in cancer care. Main Topics: Dr. Vyshak Venur's journey from India to leadership at Fred Hutch Advances and ongoing clinical trials in neuro-oncology The importance of multidisciplinary care in neuro-oncology Use of AI and precision medicine in future cancer treatments Strategies to improve patient access and community outreach Mentorship, education, and leadership in oncology Future trends in neuro-oncology and immunotherapy Timestamps: 00:07 - Introduction to Dr. Vyshak Venur and his role at Fred Hutch 01:01 - Vyshak's journey from India, Singapore, Cleveland Clinic to Fred Hutch 04:15 - Advances in neuro-oncology with new drug approvals and trials 04:49 - Challenges and future opportunities in neuro-oncology 06:56 - Multidisciplinary approach to neuro-oncology care at Fred Hutch 07:55 - The unique Brain Metastasis Clinic and clinical trials landscape 09:04 - Exciting ongoing trials including IDH inhibitors and CAR-T therapy 11:04 - Importance of rapid patient access initiatives 12:45 - Mentorship, education, and nurturing future oncologists 14:20 - Leadership roles and organizational vision, including collaboration with Dr. Shadman and Dr. Purcell 16:49 - Engaging community practices and improving communication channels 19:39 - Inpatient care teams and innovative therapies like CAR-T 21:20 - Future of oncology: AI, big data, and personalized medicine 22:43 - Translational research at Fred Hutch and integration of lab and clinical advancements 24:07 - The legacy of immunotherapy and future directions

    Exploring Neuro-Oncology Leadership and Innovation with Dr. Vyshak Venur

  4. May 19

    Dr. Sara Hurvitz: Leadership, Innovation and Compassion in Oncology

    In this episode of the Oncology Insights Podcast, host Petros Grivas, MD, PhD, FASCO, speaks with Sara Hurvitz, MD, FACP, senior vice president of Fred Hutch's Clinical Research Division and head of the Division of Hematology and Oncology at the University of Washington School of Medicine. Hurvitz reflects on her journey from California to leading-edge oncology research and shares insights on clinical trials, multidisciplinary care, community outreach and the importance of diverse perspectives in leadership. In this episode: Dr. Hurvitz's personal and professional journey from Northern California to Seattle The significance of patient-oncologist relationships and clinical research impact The importance of interdisciplinary teamwork and rapid access in patient care Strategies for successful multi-site trials and community engagement Leadership lessons: listening, decisiveness and collaboration The role of women and underrepresented groups in medical leadership Personal stories, including memorable moments in Greece and family life   Timestamps: 00:00 - Welcome and introduction to Dr. Hurvitz's leadership journey 03:34 - Inspiration from AIDS-related lymphoma research at USC 06:28 - The significance and challenges of clinical trials in oncology 09:31 - The collaboration between lab research and patient care 11:50 - The role and impact of neoadjuvant trials in breast and bladder cancer 14:01 - Expanding trials through multi-site collaborations in the Pacific Northwest 17:11 - Multidisciplinary care and rapid patient access initiatives 20:10 - Building community relationships and outreach strategies 24:13 - Key leadership qualities: listening, decisiveness, humility 26:46 - Promoting women and varied perspectives in leadership roles

    Dr. Sara Hurvitz: Leadership, Innovation and Compassion in Oncology

  5. May 5

    Bladder Cancer: Symptoms, Risk Factors, Early Detection and Emerging Treatments with Dr. Jonathan Wright

    Bladder Cancer Awareness Month is observed each May to raise awareness of bladder cancer, including its symptoms, risk factors and the importance of early detection. In recognition of the month, Petros Grivas, MD, PhD, FASCO sits down with colleague Jonathan Wright, MD, MS, FACS, a urologic oncologist at Fred Hutch Cancer Center and the University of Washington. They discuss epidemiology, risk factors, emerging research and the critical role of multidisciplinary care and advocacy. The conversation highlights ongoing innovation and the future of bladder cancer treatment and management. Key topics: Dr. Wright's path to urology and bladder cancer research Epidemiology and risk factors, including smoking, occupational exposures and genetics The importance of early detection and delays in diagnosis, particularly among women Advances in diagnostics, including artificial intelligence and machine learning Translational research, from bench to bedside including autopsy programs and DNA sequencing Multidisciplinary clinics and collaborative care models The Bladder Cancer Advocacy Network (BCAN) and community engagement Mentorship and leadership in academic medicine and research   Timestamps: 00:00 – Introduction: The importance of bladder cancer awareness and Dr. Wright's background 03:59 – Epidemiology: How common is bladder cancer and risk factors like smoking and occupational exposures 07:08 – Genetic factors and family history considerations 09:05 – The impact of environmental and occupational exposures, including in veterans 11:14 – Challenges in diagnosis, especially in women, and signs to watch for 12:23 – Variants of bladder cancer and the importance of targeted research 13:55 – AI in pathology: Improving diagnosis and treatment prediction 17:04 – The power of translational research and the rapid autopsy program 20:21 – The significance of tissue banks and understanding tumor resistance 23:27 – Multiprofessional clinics and integrated care models 28:21 – The bladder cancer advocacy community and BCAN's role in education and support 31:36 – Community and survivor engagement in awareness events and walks 32:52 – Mentorship, leadership, and shaping the future of bladder cancer research and care

    Bladder Cancer: Symptoms, Risk Factors, Early Detection and Emerging Treatments with Dr. Jonathan Wright

  6. Apr 21

    How CAR T Cells are Transforming Cancer Care | Dr. Stanley Riddell on Immunotherapy

    In this episode of the Oncology Insights Podcast, host Dr. Petros Grivas is joined by Dr. Stanley Riddell, one of the world's leading pioneers of cancer immunotherapy and a longtime physician-scientist at Fred Hutch. Dr. Riddell's career traces the remarkable evolution of immunotherapy, from the early days of bone marrow transplantation to the development of genetically engineered T-cell therapies that are transforming cancer care today. Main Topics: Dr. Riddell's career path and contributions to immunotherapy Development and clinical success of CAR T cell therapy Challenges of translating immunotherapy from lab to clinic Future of cancer treatment and possibilities for solid tumors Collaboration between academia, industry, and global health equity The importance of perseverance and impactful research   Timestamps: 00:00 - Introduction to Dr. Stanley Riddell and his contributions to immunotherapy 02:00 - Early career: Stem cell transplant and immunology breakthroughs 05:00 - Overcoming infectious complications in transplant patients 08:00 - Development of CMV-specific T cells and initial cancer applications 11:00 - The birth and growth of CAR T cell therapy at Fred Hutch 12:50 - Clinical successes and ongoing challenges in CAR T treatments 15:00 - Industry collaborations and commercialization efforts 16:00 - Implementing CAR T therapies in community settings and future innovations 18:00 - Addressing healthcare disparities globally 20:00 - The infrastructure at Fred Hutch supporting cutting-edge research 23:00 - The promising future of biomedical science and immunology 25:00 - Role of funding and federal support in sustaining innovation 26:00 - Potential of immunotherapy in solid tumors and personalized medicine 28:00 - Final thoughts: hope for curing more patients and improving quality of life   Resources & Links: Stan Riddell Faculty Bio: https://www.fredhutch.org/en/faculty-lab-directory/riddell-stanley.html

    How CAR T Cells are Transforming Cancer Care | Dr. Stanley Riddell on Immunotherapy

  7. Apr 7

    Inside the Science Changing Lung Cancer Treatment

    In this episode of the Oncology Insights Podcast, host Petros Grivas, MD, PhD, FASCO, speaks with Lei Deng, MD, a thoracic oncologist at Fred Hutch Cancer Center and the University of Washington, about advances in lung cancer research and patient care. Deng discusses how precision medicine, immunotherapy and rapid molecular testing are improving outcomes for patients with lung cancer. The conversation also highlights the importance of early detection, team-based care and delivering treatment that reflects patients' values and priorities. Key topics include: Deng's path into lung cancer research and thoracic oncology Advances in targeted therapies and precision oncology for key lung cancer mutations The role of biomarkers and immunotherapy in treatment decision-making Innovative clinical trials at Fred Hutch and the University of Washington Early detection, rapid molecular testing and multidisciplinary care Patient-centered care, including communication, emotional support and shared decision-making Timestamps: 00:07 - Introduction to Dr. Lei Deng and her work in thoracic oncology 01:21 - Dr. Deng's pathway into lung cancer research and joining Fred Hutch 02:57 - Exploring current research focus areas and promising trials in precision medicine 07:35 - The significance of MTAP loss and targeted therapy development 10:20 - Rapid access to care and multidisciplinary team collaboration 14:44 - Molecular testing timing and its role in personalized lung cancer treatment 16:46 - Trends in young patients with lung cancer and multifactorial etiology 18:25 - Impact and future of lung cancer screening programs 22:54 - Genetic predisposition and familial risk assessments 24:28 - The importance of patient communication and listening to patient voices Resources & Links: Fred Hutch Cancer Center: fredhutch.org Lei Deng, MD, provider profile: https://www.fredhutch.org/en/provider-directory/lei-deng.html Petros Grivas, MD, PhD, FASCO, provider profile: https://www.fredhutch.org/en/provider-directory/petros-grivas.html

    Inside the Science Changing Lung Cancer Treatment

  8. Mar 24

    Inside the World of Immunotherapy: Innovations and Access Strategies with Dr. Mazyar Shadman

    Join us as we explore the latest advancements in immunotherapy at Fred Hutch, including CAR T-cell therapy, novel agents, strategies to expand access, and collaboration between research and community care. Dr. Mazyar Shadman, Medical Director of Cellular Immunotherapy and Deputy Chief Medical Officer at Fred Hutch, shares insights on the future of cancer treatment and the importance of teamwork in oncology.   Chapters: 00:00 Intro 00:48 The Journey to Fred Hutch and Immunotherapy Innovations 07:24 Building Bridges: Community and Access to Care 14:25 Advancements in Clinical Trials and Future Directions 20:18 Vision for the Future: Leadership and Teamwork Links: Mazyar Shadman: Provider Profile, X Petros Grivas: Provider profile, X Subscribe to Oncology Insights

    Inside the World of Immunotherapy: Innovations and Access Strategies with Dr. Mazyar Shadman
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Cancer experts and scientists "Meet the Greek" – Fred Hutch Cancer Center's Dr. Petros Grivas – to discuss their work. This biweekly podcast explores the latest developments in cancer care and research. Dr. Grivas emphasizes the importance of learning from colleagues, engaging with patients, and fostering community partnerships. The podcast will feature diverse guests and cover a range of topics, including innovative treatments, clinical trials, and educational initiatives in oncology.

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