Metabolic Mindset

Shara Perry

Metabolic Mindset is a science-backed podcast that breaks down metabolic physiology into simple, practical strategies you can actually live by. Hosted by dietitian Shara Perry, each episode cuts through nutrition dogma and teaches you how to fuel, train, and live for better energy, hormones, and long-term health.

  1. 6d ago

    Brian Sanders - Nutrient Energy Quotient (NEQ) and Intake Regulation Model (IRM)

    In this episode of Metabolic Mindset, I’m joined by Brian Sanders @food.lies for a wide-ranging conversation about metabolism, food quality, satiety, ancestral nutrition, and his new work challenging some of the assumptions underlying conventional nutrition advice. Brian has spent nearly a decade interviewing hundreds of doctors and scientists through Food Lies and Peak Human, trying to answer one deceptively simple question: What should humans actually eat? We dive into his new Nutrient Energy Quotient (NEQ) framework, which looks at the relationship between the nutrients a food provides and the energy it contains. We discuss why all calories may not be physiologically equivalent, how nutrient density and food structure could influence appetite regulation, and why whole foods may allow the body to regulate intake differently than highly processed foods. We also get into: • Why “just eat fewer calories” may be an incomplete approach to fat loss • Brian’s Intake Regulation Model (IRM) and his theory of why processed foods can disrupt appetite regulation • Why protein, vitamins, and minerals may need to be thought about differently from dietary energy • Fiber: essential target or accidental byproduct of eating whole foods? • Whole fruit vs. dried fruit and the role of food structure and water content • GLP-1, satiety, gastric emptying, and the gut-brain connection • Ancestral diets, the Hadza, and what hunter-gatherer populations can—and cannot—teach us • Why “processed” doesn’t necessarily mean unhealthy • Traditional foods like sourdough, fermented foods, cheese, and sausage • Why high-fat + high-carb combinations can make it easier to overconsume energy • Whether we can actually get to a place where our appetite regulates itself without obsessively tracking calories And, of course, we challenge each other along the way. This is not a conversation about finding the one perfect diet. It’s about stepping outside of nutrition camps, questioning assumptions, and trying to understand the physiology underneath them. Because we don’t do dogma. We do physiology. Follow Brian: @food.lies Learn more about Food Lies: https://www.sapien.org/ This podcast is for educational and informational purposes only and is not intended to provide individualized medical or nutrition advice. Send us Fan Mail Support the show Work with me at Nourish (covered by insurance, often $0): https://signup.nourish.com/providers/shara-perry?referralSource=Nourish+dietitian&referralName=Shara+Perry&utm_source=Nourish_dietitian&utm_term=Shara_Perry

  2. Sep 12

    Aspirin, Brain, and Cancer: A Deep Review of Ray Peat’s Article

    Aspirin is having a moment. From inflammation and pain to cancer prevention, brain health, metabolism, and even thyroid function, you’ve probably heard some pretty impressive claims about what this little drug can do. But how much of it is actually supported by science? In this episode of Metabolic Mindset, we take a deep dive into Ray Peat’s article “Aspirin, Brain, and Cancer” and unpack the physiology behind his ideas. We’ll explore aspirin’s effects on prostaglandins, inflammation, polyunsaturated fatty acids, mitochondrial function, glucose metabolism, estrogen, cancer biology, the brain, and more. More importantly, we’ll separate interesting mechanisms from actual clinical evidence. What did Peat get right? Where was his reasoning ahead of the research? And where does a plausible physiological mechanism become an unsupported leap? This is not an episode telling you to take aspirin. It’s an exploration of how to critically evaluate physiological theories, understand what the research actually shows, and recognize the difference between a fascinating hypothesis and a clinical recommendation. Because we don’t do dogma—we do physiology. Send us Fan Mail Support the show Work with me at Nourish (covered by insurance, often $0): https://signup.nourish.com/providers/shara-perry?referralSource=Nourish+dietitian&referralName=Shara+Perry&utm_source=Nourish_dietitian&utm_term=Shara_Perry

  3. Aug 31

    Building a Nutrition Strategy for an Elite Endurance Athlete

    In this episode, we explore how a dedicated endurance athlete builds a nutrition plan from scratch. We cover calculating calorie and macro requirements, fasting, hydration, and fueling strategies to optimize performance and recovery. In this episode, Shara Perry, RDN and endurance athlete Brance Baca-White discuss optimal nutrition, hydration, and training strategies, emphasizing personalized approaches and scientific insights to improve performance and health. Use these calculations as starting points, then adjust based on body-weight trends, performance, hunger, recovery, sleep, and training quality. 1. Estimate BMR Mifflin-St Jeor Men: BMR = (10 × kg) + (6.25 × cm) − (5 × age) + 5 Women: BMR = (10 × kg) + (6.25 × cm) − (5 × age) − 161 Conversions: lb ÷ 2.205 = kg inches × 2.54 = cm 2. Estimate TDEE TDEE = BMR × Activity Factor 1.2 = Sedentary  1.375 = Lightly active  1.55 = Moderately active  1.725 = Very active  1.9 = Extremely active For high-volume endurance athletes, approximately 1.725–1.9 may be an appropriate starting range. 3. Set Protein ~1 g protein per lb of desired body weight Example: 185 lb goal = 185 g protein/day Protein = 4 calories/g 4. Set Fat ~0.25–0.4 g fat per lb body weight Fat = 9 calories/g Example: 196 lb = approximately 49–78 g/day 5. Calculate Carbohydrates Carb calories = Total calories − protein calories − fat calories Carb grams = Carb calories ÷ 4 Example at 3,400 calories: 185 g protein = 740 calories  55 g fat = 495 calories  Remaining = 2,165 calories  Carbohydrate = ~541 g/day 6. Pre-Workout Fuel For easy/short sessions, some athletes may tolerate minimal fueling. For long or hard sessions, prioritize carbohydrate. A simple starting point: 20–40 g carbohydrate before an early workout Choose foods that are high-carb, relatively low-fat, relatively low-fiber, and easy to digest. 7. During the Run For sessions lasting more than ~1 hour: 30–60 g carbohydrate/hour For longer marathon-specific sessions: 60–90 g/hour may be appropriate for highly trained athletes who have practiced and can tolerate it. 8. Post-Workout 25–40 g protein + substantial carbohydrate Prioritize recovery nutrition after long or demanding sessions, particularly when another hard workout is coming soon. 9. Baseline Hydration A practical starting estimate for baseline daily fluid intake is: Body weight (lb) × 0.5–0.67 = ounces of fluid/day This is your baseline before accounting for significant exercise losses. 10. Calculate Sweat Rate Record: Pre-exercise body weightPost-exercise body weightFluid consumedUrine producedExercise duration  Fluid loss = weight loss + fluid consumed − urine produced Sweat rate = fluid loss ÷ exercise duration Repeat under different training and environmental conditions for a better estimate. 11. Post-Exercise Fluid Replacement For more rapid recovery: ~16–24 oz fluid per pound of body weight lost This is particularly useful when another significant workout is coming soon. 12. Sodium There isn't a well-established evidence-based body-weight formula for baseline sodium needs in healthy adults. The National Academies specifically set an adult sodium Adequate Intake at 1,500 mg/day, but they also note that this does not adequately address people with large sweat losses, such as competitive athletes. They could not establish a higher universal requirement for high-intensity athletes. During endurance training: ~300–600+ mg sodium/hour Individual sodium needs vary. Sweat sodium testing can provide a more personalized target. The Takeaway These calculations are starting points, not magic numbers. Calculate, implement, monitor your response, and adjust based on body weight, performance, hunger, recovery, sleep, and training quality. Send us Fan Mail Support the show Work with me at Nourish (covered by insurance, often $0): https://signup.nourish.com/providers/shara-perry?referralSource=Nourish+dietitian&referralName=Shara+Perry&utm_source=Nourish_dietitian&utm_term=Shara_Perry

  4. Jul 16

    Understanding Energy Availability and Metabolic Health

    Many people believe metabolism is simply a matter of calories in versus calories out. But if that's true, why can two people eat the same amount of food, weigh the same, and exercise the same amount, yet experience completely different levels of energy, recovery, hunger, hormone health, and body composition? In this episode, we're diving into one of the most overlooked concepts in nutrition and metabolism: energy availability. You'll learn why your body doesn't just track calories—it continuously evaluates whether enough energy is available to support essential functions like hormone production, thyroid health, recovery, immune function, and daily activity.  We'll discuss:  What energy availability actually means  Why calories alone don't tell the whole story  The role of ATP, glycogen, and stored energy  How the brain gathers information about your energy status  Why chronic dieting can lead to fatigue, stalled progress, and metabolic adaptation  The connection between carbohydrate intake, recovery, and energy expenditure  What NEAT (non-exercise activity thermogenesis) is and why it matters  Why some people feel and perform better when they start eating more If you've ever wondered why your body seems to resist your efforts despite eating less and exercising more, this episode will help you understand the metabolic signals happening behind the scenes. This is Part 1 of a two-part series on energy availability and metabolism. Send us Fan Mail Support the show Work with me at Nourish (covered by insurance, often $0): https://signup.nourish.com/providers/shara-perry?referralSource=Nourish+dietitian&referralName=Shara+Perry&utm_source=Nourish_dietitian&utm_term=Shara_Perry

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Metabolic Mindset is a science-backed podcast that breaks down metabolic physiology into simple, practical strategies you can actually live by. Hosted by dietitian Shara Perry, each episode cuts through nutrition dogma and teaches you how to fuel, train, and live for better energy, hormones, and long-term health.