The Preventus Podcast

The Preventus Podcast
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  • Medicine
  • Updated Semiweekly

Husband and Wife Doctors, Dr. Brett Haake and Dr. Felice Haake seek to prevent disease by educating the public about root causes of disease. They do this by translating the process of how diseases start into layman’s terms. Their desire is to stimulate conversation so the listener can apply preventative medicine strategies thereby making themselves more functional and increasing their chances at a longer and healthier life.  They also want to educate the consumer so they can make informed choices about their healthcare delivery.

  1. Aug 26

    Reversing Biological Age: Therapeutic Plasma Exchange & the Future of Longevity

    Doctors Felice and Brett Haake dig into therapeutic plasma exchange — a therapy that's been in medicine since the 1950s under the name plasmapheresis, and is now drawing serious attention for something very different: reversing biological age. Brett walks through the mechanics of the procedure, why it isn't dialysis despite the resemblance, and how less than 1% of blood volume sits outside the body at any point in a session. From there the conversation turns to the research that reframed the therapy — the immunomodulatory signal investigators began noticing decades ago, the Conboy lab work at UC Berkeley, and the 2022 human translation paper on biological age reversal that led the Haakes to partner with Dr. Dobri Kiprov's Global Apheresis team and bring TPE to the Treasure Coast. They close on where this is heading: sequencing TPE with IV Muse cell therapy, the subject of the next episode. Referenced in this episode: "I Don't Feel Like My Body Is Aging," a 33-minute documentary featuring Dr. Kiprov, Dr. Michael Roizen, and patients who've undergone the therapy. It's embedded on the Therapeutic Plasma Exchange page at ikariaconcierge.com, along with more on Dr. Kiprov's work. For the primary literature, search PubMed for the AMBAR study or the Conboy–Kiprov paper.

    Reversing Biological Age: Therapeutic Plasma Exchange & the Future of Longevity

  2. Aug 5

    Alzheimer's as a Metabolic Disease: Diagnosis, APOE4, and the New Anti-Amyloid Therapies — with Dr. Jim Schaefer

    Alzheimer's doesn't begin when you forget a name. It begins ten to twenty years earlier, and much of what drives it shows up in your metabolism long before it shows up in your memory. We sit down with Dr. Jim Schaefer, a neurologist in private practice in Vero Beach since 1997 and an investigator on more than 70 clinical trials across multiple sclerosis, Parkinson's disease, and other neurodegenerative conditions. He walks us through how an Alzheimer's diagnosis is actually made, and why an abnormal blood marker on its own is not a diagnosis. Dementia is a symptom. Alzheimer's is a disease. That distinction changes everything that follows. In this episode: - Why history and cognitive testing still matter more than any single biomarker, and why language loss is often the earliest sign - Amyloid, tau, and what the p-tau 217 and 181 tests can and can't tell you - APOE4 explained, and how Dr. Schaefer actually uses it in clinic - The new anti-amyloid monoclonal antibodies: who qualifies, the ARIA risk, the MRI surveillance protocol, and why he draws a line at age 85 - Why women carry more of this disease, and where estrogen and the menopause transition fit in - Insulin resistance as the upstream driver of Alzheimer's, cardiovascular disease, and most chronic illness - GLP-1 medications, and what a very high dose can cost you in muscle, bone, and receptor sensitivity - Therapeutic plasma exchange, the AMBAR study, and the plasma dilution research behind it - Blue zones, Okinawa, and the lifestyle patterns that keep showing up - Brain health in combat veterans, including repetitive weapons-fire and blast exposure We also talk about the Navy SEAL Museum in Fort Pierce, where Dr. Schaefer serves as chairman of the board, and Hooks of Hope, a local charity serving combat veterans. This conversation is for education. It is not medical advice, and nothing here replaces a relationship with your own physician.

    Alzheimer's as a Metabolic Disease: Diagnosis, APOE4, and the New Anti-Amyloid Therapies — with Dr. Jim Schaefer

  3. Jun 16

    Stem Cells & Regenerative Medicine: What to Ask Before You Inject

    Dr. Brett and Dr. Felice Haake break down one of the most talked-about frontiers in medicine: stem cell therapy. Ahead of their trip to a major regenerative medicine conference in Denver hosted by Regenexx and the International Orthobiologics Foundation, they unpack what stem cells actually are, how they work, who's a real candidate, and what questions every consumer should ask before handing over their money. The conversation moves from the science — autologous vs. embryonic stem cells, mesenchymal cells, PRP, exosomes, and growth factors — into the practical: how Regenexx's twenty-one years of outcome data shape patient selection, why real-time ultrasound guidance is now standard of care, and why leukocyte-poor PRP matters. They close with IKARIA's integrated approach: pairing the Regenexx protocol with functional medicine, hormonal optimization, and hyperbaric oxygen therapy to prepare the "soil" before the seed goes in. What you'll learn: What mesenchymal stem cells actually do — and why they're better understood as master conductors than blank "baby cells"The difference between autologous, embryonic, and adult stem cellsHow PRP, alpha granules, and exosomes work together to drive regenerationWhy patient selection and outcome data matter more than marketingWhy ultrasound or fluoroscopic guidance is now the standard of careHow leukocyte-poor PRP improves regenerative outcomesThe 8-fold increase in stem cell yield seen with hyperbaric oxygen therapyDr. Shai Efrati's research on hypoxic inducible factor and telomere lengthWhy optimizing the patient — insulin resistance, hormones, gut health — changes the outcomeThree things every consumer should demand before getting stem cell therapy: A proven outcomes database and transparent success ratesReal-time image guidance for every injectionA full program — not a one-off injection — that addresses the root causes driving inflammation and joint damage Mentioned in this episode: Regenexx, the International Orthobiologics Foundation (IOF), Dr. Shai Efrati's hyperbaric oxygen research, and IKARIA Concierge and Functional Medicine. Cautious optimism is the right posture. The field is exciting, but discernment matters. Ask the right questions, work with the right team, and demand excellence.

    Stem Cells & Regenerative Medicine: What to Ask Before You Inject

  4. Apr 15

    The Gut: More Than Just a "Hole" in the Middle

    In this episode of Preventus, Dr. Brett Hockey and Dr. Felice Hockey dive deep into the "abyss" of functional medicine: Gut Health. Moving beyond the trendy buzzwords, they break down the complex relationship between the microbiome, metabolic health, and systemic inflammation. From the mechanics of "leaky gut" to the clinical application of the 5R Framework, the doctors discuss how high-level testing (like TMAO and functional stool analysis) can reveal why you might be experiencing fatigue, bloating, or even brain fog despite "normal" lab results. Whether you're curious about the power of Microbiota Accessible Carbohydrates (MACs) or the impact of stress on your intestinal lining, this episode provides a clinical yet accessible roadmap to healing your gut.

    The Gut: More Than Just a "Hole" in the Middle

  5. Mar 31

    Preventing the "Number One Killer": Moving Beyond the Cholesterol Myth

    The "Why" Behind This Episode The Boarded Anesthesiologist: Dr. Brett discusses his journey to becoming one of the few anesthesiologists boarded in lipidology after seeing the stark difference in how heart disease patients react to surgery.The Epidemiology: Understanding the staggering statistics of CHD and why it's on the rise despite modern medicine.Key Technical Deep Dives The Anatomy of Plaque: A step-by-step look at the vascular intima, endothelial cells, and how ApoB particles "rust" (oxidize) to create foam cells.The Four ApoB Particles: Why you need to know about VLDL, IDL, LDL, and the highly genetic LP(little a).The Insulin Connection: How insulin resistance at the fat-cell level drives "small, dense" LDL particles that are more likely to cause damage.The Nitric Oxide Factor: Why your blood vessels need nitric oxide to stay dilated and how insulin resistance shuts that process down.The Prevention Toolkit Advanced Testing: Why the Haakes prefer the Cardio IQ (Quest) and Cardio Zoomer (Vibrant) over standard lipid panels.The "Metabolic Spectrum": Moving away from waiting for an A1C of 5.7 to diagnose a problem.Modifiable Factors: The "Big Four" of longevity: Diet (low insulin-recruiting), Exercise (muscle as an organ of longevity), Sleep, and Stress management.Environmental Toxins: The role of heavy metals and mold in vascular inflammation.

  6. Feb 18

    Beyond the Hype: Using Peptides as a Tool, Not a Crutch

    Dr. Brett and Dr. Felice discuss the rapidly expanding field of peptide therapy. They move beyond the headlines of Ozempic and Mounjaro to explore how peptides interact with cellular receptors to optimize mitochondrial function, gut health, and muscle mass. The central theme: Peptides are only as effective as the lifestyle foundation they are built upon. Key TakeawaysWhat is a Peptide? A sequence of 30-50 amino acids that acts as a "key" to unlock biochemical cascades in the body.The GLP-1 Paradigm: Discussion on Semaglutide and Tirzepatide. Why "microdosing" and maintaining protein intake are essential to prevent muscle loss.The Powerhouse (Mitochondria): Deep dive into MOTS-c and SS-31, peptides that actually enter the cell to "clean" the electron transport chain and boost energy currency (ATP).Body Recomposition: How Dr. Haake utilized a "stack" (Tesamorelin and BAM-15) to lose 13 lbs of fat while gaining muscle.The Wolverine Pack: How BPC-157 and TB-500 aid in systemic healing, from torn tendons to "leaky gut" and inflammation.

  7. Jan 19

    The FDA’s Big Pivot: Estrogen, Breast Cancer, and the Truth About the WHI

    In This Episode, We Discuss:The FDA’s Major Shift: Analyzing Dr. Marty Makary’s recent statements on estrogen and breast cancer risk.The WHI "Genie out of the Bottle": How a flawed media rollout in 2002 led to decades of unnecessary fear and a gap in medical education.Absolute vs. Relative Risk: Why a "26% increase" sounds terrifying but actually represented less than 1 in 1,000 women.The 4 Pillars of BHRT Benefit: How hormones act as a preventative tool for:Osteoporosis: Preventing the "Saturday hip fracture" cycle.Cognitive Health: Why women get Alzheimer’s 2x more than men and how estrogen protects the brain.Cardiovascular Protection: The role of estrogen in keeping arteries healthy.Metabolic Function: Using estrogen to combat insulin resistance and the "menopause belly."The Foundation First: Why hormones work best when paired with the "Big 4": Diet, Exercise, Sleep, and Stress Management.

  8. Jan 13

    Through the Looking Glass: Why Every Disease is a Metabolic Disease

    What if cataracts, glaucoma, and macular degeneration aren't just "signs of aging," but symptoms of a deeper metabolic crisis? In this episode of The Preventus Podcast, Dr. Brett Haake and Dr. Felice Haake sit down with renowned ophthalmologist Dr. Val Zudans to dismantle the "sick care" silos of modern medicine. Dr. Zudans reveals why the eye is the ultimate "canary in the coal mine" for mitochondrial dysfunction. From the biohacking benefits of Methylene Blue and Red Light Therapy to the shocking link between skin tags and insulin resistance, this conversation explores a unified theory of health: that nearly all chronic disease stems from our cells' inability to convert food into energy.

    Through the Looking Glass: Why Every Disease is a Metabolic Disease
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About

Husband and Wife Doctors, Dr. Brett Haake and Dr. Felice Haake seek to prevent disease by educating the public about root causes of disease. They do this by translating the process of how diseases start into layman’s terms. Their desire is to stimulate conversation so the listener can apply preventative medicine strategies thereby making themselves more functional and increasing their chances at a longer and healthier life.  They also want to educate the consumer so they can make informed choices about their healthcare delivery.

Information

  • Creator
    The Preventus Podcast
  • Years Active
    2025 - 2026
  • Episodes
    22
  • Rating
    Clean
  • Copyright
    © The Preventus Podcast
  • Show Website
    The Preventus Podcast

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