Dose of Alpha

Bryan Colligan

Real-time intel from the DeFi front lines. Bryan Colligan and Eric Waisanen share unfiltered perspectives exploring decentralized finance, market maneuvers, TradFi convergence, and the enduring importance of crypto in today's political and economic landscape. Bring RWAs onchain in 2026 with alphagrowth.io.

  1. Sep 23 ·  Video

    Can You Actually Insure DeFi | Nate Minton | Dose of Alpha - Ep. 17

    Can You Actually Insure DeFi? | Nate Minton, Flux Point Studios | Dose of Alpha - Ep. 17 Most insurance is a promise backed by a shared pot of money. Aegis is not. The moment you buy cover, your payout is set aside in its own box on chain with your name on it — and as Nate Minton puts it, even if the main vault were empty the next day, you would still get paid in full. Nate is CEO and co-founder of Flux Point Studios, a studio that came out of two things he loves: gaming and building. He played World of Warcraft professionally, got frustrated with how the big studios treated their players, and went looking for what blockchain could fix. Flux Point now runs a games arm and an AI and blockchain arm, and owns Aegis, a parametric insurance protocol on Cardano, alongside Materios, their own data verifiability layer. Parametric is the part worth understanding. With ordinary insurance somebody has to agree you were harmed before you get paid. With parametric cover, it pays when a number crosses a line that was agreed up front. No claims adjuster, no waiting weeks for a call. The event triggers and the payout lands — on Cardano, in the same block it happened in. Bryan Colligan and Eric Waisanen push on what actually needs insuring: stablecoin depeg, which Aegis already has live on mainnet; collateral that quietly falls below its mapped value; risk curators accruing bad debt; and the question nobody answers cleanly, which is who watches the oracles. When a protocol breaks, the primitive, the curator and the oracle all point at each other, and the oracle almost never takes the hit. From there it gets into the engineering. Why Aegis runs several oracle providers rather than one point of failure, and the zero-oracle product they are building on neural network models. How rehypothecation — making the same money do two jobs — is exactly what broke in 2008 and again with crypto lenders in 2022, and why a written claim can never be touched by it. Why liquidations settling in the same block would let money markets run more risk on without bad debt, and why a third party purchase agreement for liquidations is, in Bryan's view, the number one blocker to serious RWA volume on chain. Then a round of fad, here to stay, or kill it, on AI and crypto, RWAs and the DeFi mullet. Nate's answers are not the safe ones, and the RWA conversation that follows — about how much yield issuers quietly keep for themselves, and the time someone pitched unmined gold in a mountain as a stablecoin — is the most pointed stretch of the episode. Guest: Nate Minton, CEO and co-founder, Flux Point Studios — @realdecimalist on X Hosts: Bryan Colligan and Eric Waisanen, AlphaGrowth Chapters 00:00 Cold open 00:10 Flux Point Studios, from pro gaming to building on chain 03:44 Why Cardano 05:14 Materios, and connecting Bitcoin to Cardano 05:47 Intents, and what AI routing already solved 09:13 What Aegis is 10:17 What parametric insurance actually means 10:49 Paying out in the same block 11:32 What DeFi actually needs insured 13:11 Stablecoin depeg cover, live on mainnet 16:42 Who watches the oracles 18:15 Underwriters, and where the yield comes from 20:14 Rehypothecation, and ring-fencing a claim 21:00 OEV and oracle extractable value 23:20 Liquidations, bad debt and RWAs 25:32 Risk added after the fact — the Curve example 27:02 Settling on Indigo's own liquidation feed 27:59 Fad, here to stay, or kill it 30:17 Unmined gold in a mountain 32:19 What RWA issuers keep for themselves 34:38 Sovereign cover tranches 35:55 Outro AlphaGrowth works on risk curation, structured products and the lending infrastructure behind them. If you are building something that needs cover, or capital, reach out.

  2. Sep 4 ·  Video

    Why Real Stablecoins Don't Pay Yield | Interview w James & Marco at USDM | Dose of Alpha - Ep. 16

    What if the killer app for stablecoins isn't DeFi yield, but a closed-loop payment network for multinational airlines? James and Marco join Bryan Colligan and Eric Waisanen to break down how Cardano's fiat-backed stablecoin is bringing traditional finance onchain. Marco brings decades of traditional finance and board advisory experience, while James operates deep in the trenches of Cardano's ecosystem. Together, they sit in a rare seat: bridging the regulatory rigor of a true 1:1 fiat-backed stablecoin with the permissionless flexibility of Cardano native assets. USDM isn't a yield coin or a disguised business deal—it's a payments stablecoin. While other protocols chase mercenary liquidity with unsustainable APRs, Moneta builds real-world utility. By leveraging Cardano's native architecture and the upcoming CIP 113 for regulatory programmability, USDM provides a secure, non-volatile settlement layer. They are already structuring closed-loop stablecoin solutions for an airline services company operating across 13 countries, completely bypassing localized currency friction like the Nigerian Naira. The kicker: Tokenizing private, illiquid markets was the wrong first step for RWAs. The real unlock is keeping treasury capital in yield-bearing tokenized money market funds, then seamlessly sweeping it into a payment stablecoin like USDM the second a corporate card is swiped. It transforms stablecoins from a speculative holding into an invisible, instant settlement rail. This is the alpha. Chapters: 0:00 Cold Open & Welcome: James and Marco 1:16 Marco's TradFi Background & the Need for Fiat-Backed Stables 4:07 From Cardano over Coffee to Building a Stablecoin 7:08 CIP 113 & Regulatory Programmability on Cardano 10:07 Payment Stables vs. Yield Stables 11:55 The Airline Industry Use Case: Closed-Loop Corporate Stablecoins 14:12 The Liquidity Problem: Why Cardano Needs Deep Onchain Utility 21:32 F/Marry/Kill: AI, Tokenized RWAs, and the DeFi Mullet 30:38 Interoperability, VLabs, and the Visa Flex Partnership More alpha drops soon. Follow on X: Alpha Growth: @alphagrowth1 | Bryan Colligan: @bryancolligan | Eric Waisanen: @EricWaisanen | James: @blockjack2017 & Moneta: @USDMOfficial The Alpha Growth team is excited to bring you real-time intel from the DeFi front lines. Catch every episode of Dose of Alpha on YouTube, Spotify, and X. Learn more at alphagrowth.io. Subscribe, like, and drop a comment to let us know what alpha you want next. #DoseOfAlpha #USDM #Cardano #Stablecoins #DeFi #RWAs #Tokenization

  3. Aug 18 ·  Video

    We Speed-Ran 200 Years of Finance in 15 | Crypto From Zero — 5 Questions with Alpha Growth's CEO | Dose of Alpha - Bonus Ep.

    What if you could protect your wealth with your brain instead of an army? In this bonus episode, Alpha Growth's own Nic Rowen steps in front of the camera for the first time and puts five beginner questions straight to Bryan Colligan, CEO of Alpha Growth — the questions this show usually skips past. What is crypto, actually? Why do layer twos exist? And how does a contract enforce itself with no lawyer in the room? Bryan has been in crypto since 2013, and he answers the way he pitches: in analogies. Blockchains solve digital ownership — the thing Web2 platforms quietly kept for themselves. Protocols are email for money. A layer one is the wholesaler; a layer two is the retail shop. RWAs tear down the old $300,000 gate that kept most of the world out of US markets — now a farmer with a phone buys a tenth of a SpaceX share. And a smart contract bakes the cost of adjudication into the code itself. The kicker: cattle ranchers in Brazil face a 50–60% cost of capital at home. Onchain, that same operation prints at 28–29% APR — the rancher borrows cheaper, the lender earns more, and both sides win the rate game. That's the arbitrage crypto opens when 200 years of finance gets speed-run in 15. This is the alpha. Chapters: 0:00 Cold Open: Armies, Brains & Goat Farmers 0:15 Meet Nic: The Editor Steps in Front of the Camera 0:43 Question 1: What Is Crypto, a Blockchain & a Protocol? 4:48 Question 2: Crypto's Effect on the World — From Granaries to Cryptography 8:06 Question 3: Layer 1 vs. Layer 2 — Wholesale vs. Retail 9:34 Question 4: RWAs — Gold, SpaceX Shares & the $300K Gate 13:33 Question 5: Smart Contracts — Adjudication Baked Into Code 14:58 Wrap: More Questions Coming More alpha drops soon. Follow on X: Alpha Growth: @alphagrowth1 | Bryan Colligan: @bryancolligan | Eric Waisanen: @EricWaisanen The Alpha Growth team is excited to bring you real-time intel from the DeFi front lines. Catch every episode of Dose of Alpha on YouTube, Spotify, and X. Learn more at alphagrowth.io. Subscribe, like, and drop a comment to let us know what alpha you want next. #DoseOfAlpha #Crypto101 #DeFi #Blockchain #RWA #SmartContracts

  4. Aug 4 ·  Video

    How Indigo Survived the Flash Crash with Zero Bad Debt | Dose of Alpha - Ep. 14

    What if the most resilient financial primitive in crypto actually gets stronger every time the market crashes? Eric Coley, CEO of Indigo, joins Bryan Colligan and Eric Waisanen to break down how collateralized debt positions (CDPs) absorb panic and why real-world assets are the next massive unlock for onchain liquidity. Eric builds in crypto and leads one of Cardano's original DeFi mainstays—launching a "hello world" before smart contracts even existed on the chain. He sits in a rare seat: overseeing a protocol that survived the brutal October flash crash without taking on a single dollar of bad debt. While centralized market makers hide losses on their balance sheets after a crash, properly structured CDPs do the opposite. By heavily collateralizing positions and aggressively rewarding stability pool depositors, Indigo stays entirely solvent. As Nassim Taleb's "Black Swan" theory outlines, the leverage stack eventually breaks. But a CDP acts as an anti-fragile primitive—using liquidation hunting to maintain the peg and protect the ecosystem. Now, Indigo pushes this model into Real World Assets (RWAs), building out a multi-collateral suite that allows tokenized T-Bills or equities to mint stable liquidity without paying Wall Street's 16% hurdle rates. The kicker: Superior technology means nothing if big liquidity providers can't find basic composability. That's why building siloed chains no longer works, and why continuous infrastructure upgrades are the only true way to capture institutional capital when the macro cycle flips. Eric closes by ranking the narratives—killing the "DeFi mullet," charting the RWA pump, and betting long-term on agentic AI. This is the alpha. Chapters: 0:00 Cold Open & Welcome: Eric Coley from Indigo 1:13 Paying for Past Sins: Crypto's Necessary Purge 2:44 The October Flash Crash: Surviving With Zero Bad Debt 4:41 Taleb's Black Swan & The Anti-Fragile CDP 8:41 Information Cascades: How Hype Actually Moves Markets 10:36 Tokenize Everything: RWAs & Cheaper Crypto Loans 16:02 Solving Cardano's Composability Gaps 22:39 Why Indigo Partnered With AlphaGrowth 23:35 F/Marry/Kill: Agentic AI, RWAs & The DeFi Mullet More alpha drops soon. Follow on X: Alpha Growth: @alphagrowth1 | Bryan Colligan: @bryancolligan | Eric Waisanen: @EricWaisanen | Eric Coley: @ecatxvc & Indigo: @Indigo_protocol The Alpha Growth team is excited to bring you real-time intel from the DeFi front lines. Catch every episode of Dose of Alpha on YouTube, Spotify, and X. Learn more at alphagrowth.io. Subscribe, like, and drop a comment to let us know what alpha you want next. #DoseOfAlpha #Indigo #Cardano #DeFi #RWAs #Stablecoins

  5. Jul 26 ·  Video

    Turning Cardano into a DeFi Juggernaut w/ Charles Hoskinson | Dose of Alpha - Ep. 13

    What if the next trillion-dollar market isn't driven by institutions, but by non-custodial AI agents trading 24/7 on your behalf? Charles Hoskinson, founder of Cardano and CEO of Input Output, joins Bryan Colligan and Eric Waisanen to break down the unification of Web2 and Web3. Charles is a 15-year crypto OG who created the first algorithmic stablecoin, co-founded Ethereum, and now pioneers synthetic biology at Colossal. He sits in a rare seat: he understands the philosophical roots of decentralized consensus better than almost anyone, and actively applies them to everything from genetic engineering to privacy-enhancing network layers. True mainstream adoption requires four pillars: abstraction, smart compliance, privacy-enhancing tech (PET), and agents. Right now, DeFi is too complex and unforgiving. By pairing zero-knowledge proofs with trusted execution environments, your agent navigates the markets, reads 10-Ks, and executes complex trades without ever leaking your proprietary alpha. Charles calls tokenization and smart contracts the "financial stem cell"—a primitive that grows into any financial instrument imaginable, completely outside the legacy broker-dealer structure.  The kicker: Cardano is adding its "executive branch," transforming from an insular research project into an industry-wide juggernaut. With Input Output operating as a venture studio, the chain with eight years of perfect uptime is aiming to capture billions in TVL through novel, non-adversarial ecosystems like Midnight City. In the rapid-fire F/Marry/Kill segment, Charles kills RWA 1.0 (tokenized Microsoft stock) but marries agentic finance. This is the alpha.  Chapters: 0:00 Cold Open & Welcome: Charles Hoskinson 2:08 Resurrecting the Direwolf: Synthetic Biology & Decentralized Science 10:54 Metcalfe's Law, AI Deepfakes & The Veracity Layer 15:30 Cardano's Constitution & Building an Executive Branch 21:58 Input Output's Pivot to a Venture Studio 29:18 The DeFi Mullet & Unifying Web2 and Web3 35:41 F/Marry/Kill: RWAs, Agentic Finance & The DeFi Mullet 41:48 Non-Custodial Agents & The "Financial Stem Cell" 52:20 Turning the "Ghost Chain" into a TVL Juggernaut More alpha drops soon. Follow on X: Alpha Growth: @alphagrowth1 | Bryan Colligan: @bryancolligan | Eric Waisanen: @EricWaisanen | Charles Hoskinson: @IOHK_Charles & @IOGroup The Alpha Growth team is excited to bring you real-time intel from the DeFi front lines. Catch every episode of Dose of Alpha on YouTube, Spotify, and X. Learn more at alphagrowth.io.  Subscribe, like, and drop a comment to let us know what alpha you want next.  #DoseOfAlpha #Cardano #DeFi #AgenticFinance #CharlesHoskinson #InputOutput

  6. Jul 9 ·  Bonus Video

    Designing a Coherent Growth Strategy for Cardano DeFi | Bonus Episode

    What if the chain everyone calls a "ghost chain" or "a cult" is quietly becoming the closest thing crypto has to an actual working government? Dave (@Dave__Dionisio) joins Bryan Colligan and Eric Waisanen straight from the Cardano ecosystem — years auditing banks at the CFPB in D.C., then in deep with Input Output (formerly IOG), now working alongside Midgard, the Cardano layer-2 built by Anastasia Labs founder Philip DiSarro. Dave breaks down why Cardano's UTXO model isn't just a technical footnote: it's why the chain hasn't gone down since launching in 2017, why Midgard can inherit that security instead of bootstrapping a new trust model, and why Vitalik Buterin quietly agreeing with ideas Charles Hoskinson mapped out eight years ago isn't a coincidence. Then governance. Cardano runs on a tri-cameral system — SPOs keeping the network running, DReps voting with delegated ADA, a constitutional committee acting as the Supreme Court — sitting on top of a 1.5 billion ADA treasury. Dave calls it a mini-government, complete with the same growing pains: expertise gaps, emerging political factions, and the hard problem of asking one ADA holder to be an expert in security, tokenomics, and go-to-market all at once. The kicker: Alpha Growth's own proposal to bring a coherent DeFi strategy to Cardano goes on-chain around this very episode — not because Bryan and Eric claimed to know every protocol, but because they didn't. Dave tells the Tether Gold story to explain why: great tech with zero marketing or BD still fails. Alpha Growth won the RFP by offering to curate and connect, not compete. This is the alpha. Chapters: 0:00 Intro: Welcoming Dave from Midgard 1:28 Dave's Path: D.C. Bank Regulator to Cardano & IOG 6:22 Vitalik Validates Hoskinson: Cardano's Long Game 9:41 UTXO & Real Decentralization, Explained 12:52 Bitcoin's Upgrade Problem vs. Cardano's Built-to-Evolve Design 17:02 Plutus & Math-Provable Smart Contracts 18:57 What Midgard Actually Is (and Why Philip DiSarro Built It) 23:49 Inside Cardano's Tri-Cameral Governance 28:18 The D-Rep Expertise Problem 33:27 Political Factions Emerging in Cardano Governance 37:53 Why Alpha Growth Won the Cardano DeFi RFP 43:35 The Tether Gold Story: Tech Isn't Enough 51:44 What Winning Looks Like for Cardano in 1, 5, 10 Years 54:24 F/Marry/Kill: AI, RWAs & the DeFi Mullet 1:00:08 Money, Privacy & the Surveillance Question 1:04:13 AI Tangent: Claude's Fable & the Ceramics Parable 1:14:50 Wrap & Where to Find the Cardano Proposal More alpha drops soon. Follow on X: Alpha Growth: @alphagrowth1 | Bryan Colligan: @bryancolligan | Eric Waisanen: @EricWaisanen | Dave: @Dave__Dionisio & Midgard: @midgardprotocol | Cardano: @Cardano The Alpha Growth team is excited to bring you real-time intel from the DeFi front lines. Catch every episode of Dose of Alpha on YouTube, Spotify, and X. Learn more at alphagrowth.io. Subscribe, like, and drop a comment to let us know what alpha you want next. #DoseOfAlpha #Cardano #Midgard #DeFi #Governance #UTXO #ADA

  7. Jul 2

    Solving RWA's Liquidity Problem

    What if the only thing keeping hundreds of millions in real-world assets off-chain is a four-day wait for a bank wire to clear? Mike Massari, Head of Partnerships at RedStone, joins Bryan Colligan and Eric Waisanen to break down what it takes to make RWAs work onchain — and why the fix has to live in the oracle. RedStone started as a price-feed oracle with a spotless track record, but secure feeds aren't enough once institutions and tokenized assets show up. So the team built the RedStone Stack, including OEV (Oracle Extractable Value): instead of letting MEV bots pocket the bonus on every liquidation, an off-chain auction fires the instant a price update would trigger one, and the recaptured value goes back to the protocol. Their acquisition of Credora added independent risk ratings on top. Then the centerpiece: RedStone Settle, built with Symbiotic. RWAs have a redemption problem — a gold token might promise $100M of borrow capacity while holding just $5M of real onchain liquidity, and redeeming to cash can take four days. Settle fixes it with a reverse auction: solvers bid a discount to liquidate closest to 100%, the position settles instantly at T-zero, and the solver eats the multi-day wait. Instant liquidity on an asset that normally can't offer it. The kicker: Mike ranks RWAs as the single most bullish narrative in crypto — above the DeFi mullet, above AI — not because he's cheerleading, but because "it's just happening." The endgame is no "TradFi" and no "DeFi," just finance, with the chain as the rails underneath. This is the alpha. Chapters: 0:00 Cold Open & Welcoming Mike from RedStone 1:53 Beyond Price Feeds: The Evolution of RedStone 2:53 Inside the RedStone Stack 3:49 What Institutions Actually Want in DeFi 6:20 Oracle Extractable Value (OEV), Explained 9:15 Is a Protocol a Business? The Liquidation Debate 11:12 The Ugly Truth About Risk Curation 14:35 F/Marry/Kill: Ranking RWAs, the DeFi Mullet & AI 18:08 The RWA Liquidity Problem (The Gold Token Story) 20:11 Introducing RedStone Settle with Symbiotic 24:07 Winners & Losers in the On-Chain Transition 29:02 The Need for Speed: RedStone Bolt & Fast Oracles 32:29 Partnership Reflections & Where to Find RedStone More alpha drops soon. Follow on X: Alpha Growth: @alphagrowth1 | Bryan Colligan: @bryancolligan | Eric Waisanen: @EricWaisanen | Mike Massari: @mkmassari & RedStone: @redstone_defi The Alpha Growth team is excited to bring you real-time intel from the DeFi front lines. Catch every episode of Dose of Alpha on YouTube, Spotify, and X. Learn more at alphagrowth.io. Subscribe, like, and drop a comment to let us know what alpha you want next. #DoseOfAlpha #RedStone #RWA #DeFi #Oracles #OEV #Symbiotic

  8. Jul 2

    Bringing MicroStrategy's STRC Onchain

    What if the most reliable 11% yield in crypto exists only because Wall Street still scores Bitcoin as negative capital? Kevin Li, co-founder and CEO of Saturn Credit, joins Bryan Colligan and Eric Waisanen to break down how MicroStrategy's digital credit is becoming the benchmark rate for onchain finance — and where it could break. Kevin ran the Digital Asset Treasury initiative at Artemis and has held MicroStrategy since 2023, so he sits in a rare seat: he understands Strategy better than most people in DeFi, and DeFi better than most people who follow Strategy. Stretch (STRC) is a perpetual preferred equity — no maturity, no redemption to par, a dividend the board can skip. So it all rests on Strategy's willingness to pay, backed by ~800K BTC at a 25% LTV. The catch that unlocks the yield: S&P scored that Bitcoin as negative capital. TradFi can't price Bitcoin as collateral yet — and that mispricing is the entire ~11% spread. Saturn brings that credit onchain through USDAT and sUSDAT, plus a simple DeFi stack — Pendle, looping, and tranching — that splits Stretch into a safe senior tranche and a leveraged junior one. Launched a month ago, already at $167M TVL. The kicker: Stretch grew from $2.7B to $8.5B in months — through a Bitcoin drawdown — because unlike Ethena, every dollar in ultimately buys more Bitcoin, giving Strategy room to issue even more. It's a reflexive flywheel, and it's still leverage: it only really breaks under massive contagion. Kevin closes by ranking the narratives — AI, the DeFi mullet, and RWAs. This is the alpha. Chapters: 0:00 Cold Open & Welcome: Kevin from Saturn 1:18 Kevin's Background: Artemis, a VC Fund & the STEPN Craze 3:51 Is Stretch an Infinite Money Glitch? Preferred-Equity Risk 6:15 Will Strategy Sell Its Bitcoin? The "Trust Me, Bro" Problem 9:55 The Three Stages of MicroStrategy's Evolution 11:19 Saturn's Edge & Stretch as the New Benchmark Rate 12:50 Taking the Leap: The Saturn Founding Story 14:08 Launch, $167M TVL & Yield Compression 17:35 TradFi's Big Mispricing: Bitcoin as "Negative Capital" 21:00 The Saturn Stack: USDAT, Pendle, Looping & Tranches 25:00 Oracle Pricing, Liquidations & Saturn's Business Model 28:35 The Sailor Lesson: Focus & Distribution 29:40 Rate Compression, the Bitcoin Flywheel & Dynamic Reserve 36:12 F/Marry/Kill: AI, the DeFi Mullet & RWAs   More alpha drops soon.   Follow on X: Alpha Growth: @alphagrowth1 | Bryan Colligan: @bryancolligan | Eric Waisanen: @EricWaisanen | Kevin Li: @kevinlhr88 & Saturn: @saturn_credit   The Alpha Growth team is excited to bring you real-time intel from the DeFi front lines. Catch every episode of Dose of Alpha on YouTube, Spotify, and X. Learn more at alphagrowth.io.   Subscribe, like, and drop a comment to let us know what alpha you want next.   #DoseOfAlpha #Saturn #MicroStrategy #Bitcoin #DeFi #Stablecoins #STRC

About

Real-time intel from the DeFi front lines. Bryan Colligan and Eric Waisanen share unfiltered perspectives exploring decentralized finance, market maneuvers, TradFi convergence, and the enduring importance of crypto in today's political and economic landscape. Bring RWAs onchain in 2026 with alphagrowth.io.