In this post: * New evidence on the worrisome, lifelong health effects of sugar in the first 1,000 days * American infant formula promotes obesity and many other diseases * American formula is primarily added sugar: corn syrup is prominent and even most of the lactose is refined * Do formula makers like corn syrup because it gets infants to drink more? * RFK, Jr. needs to make Big Formula back down to fulfill his goal of reforming formula in any meaningful way * The added sugar Mom eats is “secondhand sugar” for the fetus * 2025 Dietary Guidelines: no added sugar up to age 10. Radical? Take a folic acid supplement if you are trying to get pregnant; don’t drink, smoke, or take drugs during pregnancy; hold and love your baby and use breast milk if available. Talk to your infant a lot. These we know. New evidence about the health effects of sugar in the first 1,000 days With the appearance of a new study, the evidence is now very strong for another recommendation that should be on the list already but is not always expressed by an obstetrician, pediatrician, or other relied on sources of pre- or neonatal information. It should be a must-add: don’t feed your fetus, baby, infant, or toddler added sugar. Withholding added sugar from a fetus or child still seems like a bit of a radical idea today, even as we have established the role of refined sugar as a cause of obesity, but there was a time it wasn’t a choice. George Washington did okay without sugar Three hundred years ago sugar was an expensive luxury for the tea cups of the rich. Few kids or adults had much opportunity to enjoy it. The neural pathways of fetuses and babies were not re-shaped by exposure to sugar, because there were very few houses with a sugar bowl on the table and none with highly-processed food in the pantry. That changed during the course of George Washington’s lifetime. Born in 1732, our first President likely ate little sugar as a child. That deprivation didn’t stop him from growing exceptionally tall, very athletic, and into a great leader. But by the 1800s and its industrial innovations in processing, sugar had transformed into a commodity, produced cheaply in massive quantities by enslaved labor on plantations in Haiti, Cuba, Mississippi, Louisiana, Brazil, and Java. Sugar had become part of most people’s diets. Today the pleasure, acceptance, and assumption of refined sugar in the diet is engrained in parents, great-grandparents, obstetricians, pediatricians, politicians, and, unfortunately, nutritionists and public health scientists, including me, around the globe. What’s a baby to do? The evidence brought forward by several papers in the last few years provides compelling reasons for us grownups to do more. Here’s the clever way this evidence has come together. War time rationing in the UK: babies who had sugar and babies who didn’t From the wartime rationing of 1942 all the way until 1953 each person in the United Kingdom, rich or poor, received about 1 cup of sugar a week and 3 ounces of sweets. Children two and under received no ration. Sugar rationing ended throughout the UK on one day in September 1953, and families could suddenly buy as much sugar as they wanted, and they immediately bought a lot. The UK Biobank has medical and biological data for a half-million people. A large number of these spent their first 1,000 days of development just before, just after, or right through the abrupt end of sugar rationing. Those 1,000 days from conception through the second birthday are a critical period for child development. What happens in those first 1,000 days has been tied to obesity, cardiovascular disease, asthma, mental health, diabetes, and cancer. A “natural experiment” The way the Biobank data overlapped with the end of sugar rationing allowed our sugar researchers what is called a natural experiment, a comparison of two groups, one of which was exposed to a real life condition, in this case sugar rationing, and other not exposed. Using the Biobank in this way was such a good idea that several groups did it, each analyzing a group of 60,000 to 65,000 people, the ones that bracketed the end of sugar rationing. Evidence of disease from the data of people born as sugar rationing ended First, Gracner and team found that those who spent their first 1,000 days with restricted sugar had better outcomes later in life for type 2 diabetes and high blood pressure. Two more teams followed with a look at the data for cardiovascular outcomes, finding that heart failure, cardiovascular disease, myocardial infarction, atrial fibrillation, and stroke were all a greater risk for those whose sugar consumption had not been restricted in their first 1,000 days. Cancer and sugar in the first 1,000 days Next, researchers Chen Zhu and Weilong Zhang went back to the same Biobank data and asked if restricting sugar in the first 1,000 days could reduce the risk of cancer? They found that, yes indeed, restricting sugar from womb to 2 years old is very protective. The adults who started life before sugar rationing ended had a reduced chance of cancer for each cancer they looked at: 69% for liver, 40% for rectum, 41% for lung, 52% for prostate, and 36% less chance of breast cancer. What can explain these good results? The authors found that five decades after birth, sugar-restricted people ate less sugar and less food, and their diets were healthier and more diverse. They also had reduced levels of chronic inflammation. They also found that the telomeres of these folks had aged 2.2 years less than the telomeres of the people who came on board life after sugar rationing stopped. Longer chromosome “shoelaces” with less sugar What are telomeres you might ask? Telomeres are the bits at the ends of chromosomes that protect the genetic data when a cell divides. They’re like the plastic tips of a shoelace. The telomeres get shorter every time a cell divides. Eventually the telomere gets too short and the cell dies. Getting an extra 2.2 years of telomere life is a good thing, sort of like when you buy a tire that’s rated for an extra 10,000 miles. Except that tires can be replaced, and some cells, like brain cells, once they’re gone, they’re gone. So, to recap, Zhu and Zhang found that restricting sugar during pregnancy up to the second birthday caused, and they use the word “cause”, a reduction in cancer, chronic inflammation, and cellular aging as those children turn into adults. This, combined with reductions in diabetes, high blood pressure, heart disease and stroke, makes a convincing case for adding a recommendation to restrict, if not eliminate, sugar exposure in the first 1,000 days. Lots of recommendations not to feed added sugar before age two But wait, the American Heart Association recommended no added sugar for children under two in 2016, ten years ago! And the American Academy of Pediatrics followed suit in 2019! And the Dietary Guidelines for Americans said this in 2020! Whew! I guess new moms and dads already know what to do when it comes to sugar. Unfortunately, the FDA does not regulate the carbohydrate content of baby formula or require amounts or types of added sugars to be stated on the label. This is not the case in other parts of civilization or for adult food in America. If knowing added sugar content is helpful for adult nutritional health, surely it’s helpful to make sure infants are getting the best nutrition? Why the FDA needs to act The FDA’s lack of ingredient control and labeling matters a great deal. According to a study published last year, of the 73 infant formula products available in the U.S. across three major brands (Similac, Enfamil, and Gerber/Nestlé), one smaller brand, and some store brands, only a few have naturally occurring lactose as their primary carbohydrate. Lactose is a sugar designed by evolution for mammals at an early stage of life. Almost all of the carbohydrate in human milk is lactose. Natural lactose is bound to fats and proteins in the mother’s milk and is digested somewhat slowly. Added refined lactose is an added sugar and acts like it A little more than half the formula products in the U.S. use added lactose which is refined. Refined lactose is like other refined sugars and isn’t bound to the fat and protein in the formula. It absorbs into the baby’s blood fast, spiking blood sugar and then insulin in response. And lots of formula products use other refined sugars apart from lactose, like glucose, maltose, or sucrose, all with refined lactose’s fast absorption and insulin response. American formula is primarily added sugar With no FDA requirements to use primarily natural lactose and to provide details of the carbohydrate ingredients, American parents and caregivers have no way to know that they are usually giving their babies primarily refined sugar and not natural lactose. I could not tell the proportion of natural to refined lactose from reading any of the formula containers I checked. The Wirecutter doesn’t get it Parents are not getting the info. In June, the Wirecutter section in the New York Times rated the six best infant formulas on the market in the U.S., in their opinion. They claim to have read 20 scientific articles in their research, but five of the six papers they cited were published nine or more years ago. Their seven expert interviews were mostly from 2022 or before, and more than half were with formula makers, none of whose formula sales websites said anything about natural lactose versus refined. In essence, The Wirecutter reported that the FDA had baby needs covered, and all U.S. sold formulas were good. Wirecutter completely missed both that there is an important difference between natural lactose and refined and that FDA-approved formulas contribute to later obesity, and are not adequate for normal growth as The Wirecutter claims, unless obesogenic is the new normal. U.S. baby formula is obesogenic: it promotes obesity A