The Longevity Pharmacist Podcast

Ciarán O'Connor MPSI
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  • Health & Fitness
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I'm Ciaran — a pharmacist based in Kinsale, Co. Cork, and I'm 51 years old. For most of my career I've helped people manage illness. Now I'm obsessed with a different question: what does it actually take to live longer and feel extraordinary while doing it? The Longevity Pharmacist Podcast cuts through the noise on supplements, sleep, muscle, gut health, biomarkers and the science of ageing. No fads. No shortcuts. Just evidence-based longevity from a pharmacist who's doing the work himself. New episodes every fortnight. From Kinsale, Ireland — to wherever you are.

Episodes

  1. Jun 8

    It's Not Anxiety It's Biology-Sleep Hormones and the 3am Wake.

    In this episode I cover: Why estrogen and progesterone are your two most underappreciated sleep hormones — and what happens to your sleep architecture when they declineAllopregnanolone — the natural sedative built into your own hormonal cycle that most people have never heard ofThe cortisol-melatonin seesaw — why these two hormones directly antagonise each other, and why the cortisol morning surge arrives at 3am in perimenopause and menopauseThe SWAN study — what 40–60% of women actually experience during the menopausal transition, and why most of them minimise itCognitive hyperarousal — how the bed becomes an anxiety cue, and what CBT-I does about itSleep environment — the evidence behind consistent wake time, bedroom temperature, blue light, and alcoholCaffeine — half-life, the adenosine mechanism, the CYP1A2 genetic variation, and why 2pm is your cutoffExercise — zone two as your sleep best friend, why HIIT belongs in the morning, and the 2023 circadian rhythm dataSupplements — magnesium glycinate (Abbasi et al. 2012), melatonin (prescription-only in Ireland), ashwagandha KSM-66 (Salve et al. 2019), and L-theanineSleep teas and lavender — honest about the evidence, honest about what they're actually useful forMenopausal hormone therapy — why for the right woman, nothing else comes closeSauna — the thermoregulation mechanism, cortisol reduction data, and why I've started using it myselfMy own sleep protocol — what I actually do at 51, including the stuff that doesn't always work

  2. Apr 1

    Trailer-Welcome to the Longevity Pharmacist Podcast

    A short introduction to the podcast and what's coming. I'm Ciaran, a pharmacist in Kinsale, Co. Cork — and this is where we talk longevity.

  • 2 Episodes

About

I'm Ciaran — a pharmacist based in Kinsale, Co. Cork, and I'm 51 years old. For most of my career I've helped people manage illness. Now I'm obsessed with a different question: what does it actually take to live longer and feel extraordinary while doing it? The Longevity Pharmacist Podcast cuts through the noise on supplements, sleep, muscle, gut health, biomarkers and the science of ageing. No fads. No shortcuts. Just evidence-based longevity from a pharmacist who's doing the work himself. New episodes every fortnight. From Kinsale, Ireland — to wherever you are.

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