Burnout is chronic for millennials but what does the research say about the medicine we use to help us? Today we deep dive into the real research around CBD and the psychological sabotage of optimisation, wellness routines as another contributor to the burnout cycle and more. Buy the Highly Functional Medicine Journal 10% off with the listener code 'HIGHLYFUNCTIONAL10' SHOW NOTES Curran, T., & Hill, A.P. (2019). "Perfectionism Is Increasing Over Time..." Psychological Bulletin, 145(4), 410–429Maslach, C. — burnout's three-component model (emotional exhaustion, depersonalisation, reduced personal accomplishment) Gundugurti, P.R., Banda, N., Yadlapalli, S.S.R., et al. (2024). "Evaluation of the efficacy, safety, and pharmacokinetics of nanodispersible cannabidiol oral solution (150 mg/mL) versus placebo in mild to moderate anxiety subjects: A double blind multicenter randomized clinical trial." Asian Journal of Psychiatry, 97, 104073. — RCT, n=178, CBD 300–600mg/day vs. placebo over 12 weeks; significant reductions in GAD-7/HAM-A anxiety scores, secondary improvement in PHQ-9 and PSQI sleep scores. Note: industry-funded (Leiutis Pharmaceuticals). Wang, M., Faust, M., Abbott, S., et al. (2025). "Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, crossover study." Journal of Clinical Sleep Medicine, 21(1), 69–80. — RCT, n=125 enrolled/56 completed, CBD isolate (300mg, >99.9% purity) + 8-terpene blend vs. placebo; objective wrist-tracked sleep data; significant increase in SWS+REM sleep, larger effect in low-baseline and day-sleeper subgroups. Note: industry-funded (Defined Research Inc.). You, Z., Li, X., Ye, N., & Zhang, L. (2023). "Understanding the effect of rumination on sleep quality: A mediation model of negative affect and bedtime procrastination." Current Psychology, 42, 136–144. — n=1,103, ages 17–31; rumination predicts poor sleep quality via negative affect and bedtime procrastination as parallel/serial mediators.