Facetime with Scientists

fromthelabbench

This show dives into the world of science (and art!) with behind-the-scenes chats with researchers in their natural habitats. Get ready to hear and see the scientific process in new detail!

  1. Sep 30

    Hunting Deep-Sea Symbioses with the Bald Biologist on the Alvin Sub

    For Min Khant Han, a PhD student at the University of Georgia studying symbiosis, none of us are individuals. We are all living amalgamations of various organisms working together. Take our essential gut microbes, for example! But Min is particularly interested in symbioses—close, long-term biological interactions between two different species—that enable life in the most extreme environments, including the deep sea. He’s currently studying examples of symbiosis between methane-oxidizing bacteria and eukaryotic organisms like mussels and nematodes that thrive near methane seeps in the deep ocean thanks to their bacterial friends!In this FaceTime with Scientists episode, I join Min aboard the RV Atlantis, where he was on a research cruise 70–100 miles off Virginia studying methane cold seeps. He explains how a multidisciplinary team of experts used radar and other measurements to locate bubble plumes so geologists and chemists can sample sediment and water around the seeps. For his part, Min helped process Alvin push-core sediments and used leftover material to extract nematodes from the top ~6 cm for DNA work in the hunt for potential symbiotic relationships with bacteria. Min’s project seeks evidence of a previously unrecorded symbiosis between marine nematodes and methane-using bacteria, analogous to known methane-oxidizing bacterial symbionts in seep mussels’ enlarged gills. Min describes time-sensitive night-ops processing, his first Alvin dive experiences (including seeing bioluminescent animals and deep-sea fauna!), and his early life and immigration from Burma. He talks about how he turned from pre-med to ecology and what his science communication goals look like today. He also shares how he manages his ADHD as a scientist and how creativity is his superpower!00:00 Podcast Intro00:20 Meet Min Onboard the RV Atlantis00:53 Methane Cold Seeps Explained03:05 Nematode Symbiosis Hunt07:36 Giant Deep-Sea Mussels Up Close10:25 Alvin Sediment Cores Workflow12:50 Microscope Worm Picking14:53 Min’s Origin Story and How He Got Into Research 18:44 Life On a Research Cruise20:46 Up Close - First Alvin Dive23:21 Deep-Sea Creatures25:09 From Burma To Science29:43 Science On Social Media32:20 ADHD And Research36:03 Outreach And Creativity40:04 Wrap Up And Next StepsCredits:Funding/program – NSF Chemical Oceanography ALVIN – #WHOI #NDSFChief Scientist – Samantha Joye. Alvin sub footage used with permission from Chief Scientist Dr. Samantha Joye.

  2. Sep 24

    A View Through The Telescope with Astrophysicist Andrea Henderson

    Why is the night sky dark? How and where do stars form in galaxies? What other planets may hold life? These are some of the questions that keep an astrophysicist up at night.On this episode of FaceTime With Scientists, explore star birth, galaxy formation, and space telescope technology with Oxford astrophysics PhD student Andrea Henderson de la Fuente! In her own research, Andrea uses H-alpha light maps to locate star-forming clumps and study where and how new stars form within galaxies over time. But Andrea is a woman of many talents, also working on instrumentation for the William Herschel Telescope and analyzing data from other space telescopes. Watch or listen to learn about spectroscopy and the electromagnetic spectrum, why different wavelengths of light reveal different phenomena occurring in space, and how new tools on space telescopes, including the brand-new Nancy Roman Space Telescope, will power the search for new, potentially habitable exoplanets. Andrea also shares her path into astrophysics, her many “sidequest” hobbies (from dancing to chess to drawing), the value of hands-on experience, the value of an education in astrophysics, and more.00:00 Podcast intro00:21 Meet Andrea01:01 Andrea’s PhD focus and instrumentation02:29 Spectroscopy basics04:09 Mapping star formation06:11 Wavelengths of light and how they reveal different space phenomena07:31 Andrea’s origin story and inspiration08:52 Andrea’s Side quests and hobbies12:00 Roman Space Telescope launch excitement13:24 Roman Space Telescope explained16:27 Hubble, JWST, and Euclid18:33 Euclid involvement and data20:17 Exoplanets and star-forming clump research25:30 Cosmic Curiosity Drivers26:31 Olbers Paradox Explained29:09 What it’s like to be the first one to see this data29:48 Observing Time at Telescopes31:59 Astronomy in Movies33:40 Why Scientists Share Online35:09 Value of Collaboration and Open Data38:35 Survey Telescopes and Archives39:36 Astrophysics Career Paths44:31 COVID Era Remote Learning45:57 Instrumentation and Hands-On Work47:42 Building a Telescope Dream48:35 Closing Reflections and Thanks

  3. Sep 20

    Alaska Marshes, Earthquakes & Mud Cores with Kendall Valentine

    On this episode of FaceTime with Scientists, I go into the field with coastal ecogeomorphologist Kendall Valentine! (Yes, ecogeomorphologist is a mouthful! It’s someone who studies how living organisms and physical earth features shape and change each other over time) Kendall has studied river deltas and coastal regions all over the country, starting in Louisiana. But right now she is examining the marshes of the Copper River Delta near Cordova, Alaska, which have a unique twist – these marshes are growing rapidly when most other marshes are shrinking. That’s partly due to a 1964 magnitude-9 earthquake in Alaska, which uplifted the existing mud flats by several meters. The land suddenly could catch more river sediment and grow vegetation! Valentine explains that she and collaborators Erin Peck and Sophie Wensman are collecting marsh sediment cores to detect earthquake signatures, measure how quickly land is building in this area, and trace exactly where the sediment is coming from. One unexpected finding is marsh sand that seems to be coming from the Eyak River. Valentine explains why existing marsh models based on ice-free, non-tectonic systems fail here and how collecting data in this region helps us better understand what happens when sea level changes drastically and quickly. She discusses how barrier islands and abundant river sediment promote marsh growth in this region, and the value of marshes as vital habitat despite common misconceptions. 00:00 Meet Kendall Valentine 01:02 Alaska Summer Light 01:44 Copper River Delta Tour 03:07 An Earthquake Triggered Marsh 05:25 Sediment Coring And Surveys 07:12 Field Insights And Sand on the Marsh 09:19 Models Meet Tectonics 11:19 Bugs And Bear Safety 15:52 Mapping A Growing Marsh 17:20 Why Marsh Grows Here in Copper River Delta 20:46 Marshes Matter More 22:07 Roots And Winter Plans 23:43 Wrap Up From The Field

  4. Sep 12

    How Drugs Are Formulated and Tested, with Amanda Plunze

    This FaceTime With Scientists episode covers everything you might not know about how drug molecules are formulated into the final products you get from your local pharmacy. You'll learn why formulation is critical to how well a drug works.Dive into a fascinating discussion about how pharmaceutical drugs are formulated into dissolvable tablets, time-release pills, inhalers, and more, with research scientist Amanda Plunze. Amanda works for an organization (a CDMO) that partners with pharma companies to formulate and test drug molecules across stages from early discovery to commercial manufacturing to ensure these drugs are safe, stable, and work as intended.In this episode, watch Amanda perform stability testing and potency/impurity analysis of an intermediate powder drug formulation designed to help poorly water-soluble molecules (more like pepper than sugar) dissolve in the stomach. She uses high-performance liquid chromatography to measure how well drug molecules in powder formuations stay intact once exposed to different temperature and humidity conditions. Amanda explains key formulation priorities—manufacturability, performance in the body (and how she tests how well drugs dissolve in simulated gastric fluids), and shelf-life stability. She also covers what's new and exciting in drug formulation, including efforts to create dry-powder inhaled vaccines. We also talked about why you shouldn't be afraid to ask your doctor and pharmacist questions about your medications, and common misconceptions about what goes into making effective tablets, pills, and inhalers. Watch now to learn more!00:00 Meet Amanda Plunze00:21 What a CDMO Does01:10 The Pipeline of Drug Development02:16 Inside Today’s Lab Test - Testing Drug Stability02:37 Why Drug Water-Solubility Matters03:46 Stability Testing Basics08:58 HPLC Explained: How Amanda Tests Drugs for Degradation11:29 Drug Powder Handling Safety16:39 Traceable Weighing Labels18:10 Food vs Pharma Grade Drug Testing21:05 Sample Prep Bench Skills28:57 How Well Do Drugs Dissolve in the Stomach? In Vitro Dissolution Testing31:49 Designing Inhaled Medicines33:37 Inhaled Vaccine Breakthrough35:00 Why Drug Delivery Methods Matter35:45 Formulation Stability Basics36:57 The Jenga Game Model of How Drugs Dissolve39:08 Partnering With Pharma41:40 Testing Drugs From Lab To Market43:35 Lab Walkthrough44:30 Helping People Better Understand Their Medicines48:41 Why Drug Instructions Get Ignored - Storytelling Matters53:22 Food Effects on Drug Absorption56:46 Overcoming Pharma Mistrust01:02:24 Supplements Versus Medicines01:04:45 Regulation And Better Formulations01:06:22 Big Picture Wrap Up

  5. Sep 5

    What We Breathe Can Impact Asthma Risk Across Generations: Dr. Noel Explains!

    In this episode of Facetime with Scientists, I interview Dr. Alexandra Noel, an inhalation toxicologist at LSU’s vet school. Dr. Noel studies how inhaled pollutants—air pollution, wildfire smoke, cigarette smoke, vaping aerosols, workplace nanoparticles, and microplastics—affect lung health.  Smoke, whether it is cigarette smoke or wildfire smoke, contains particulate matter as well as gases. Noel explains why particle size matters (PM10 vs PM2.5 vs ultrafine) and how smaller particles reach deeper regions of the lungs, worsening conditions like asthma. But she also points out that one of her recent studies found that the gas phase of wildfire smoke is toxic on its own, especially to the lungs, while particulate matter is toxic systemically across the body.  Noel discusses research on vaping, cigarette smoke, microplastics, and occupational nanoparticles, and how findings can inform public health policy. She also outlines in utero mouse studies linking gestational e-cigarette exposure to worsened allergen-triggered asthma via epigenetic methylation changes (in the IL-10 cytokine pathway). She notes transgenerational asthma risk from a smoking grandparent, highlights potential paternal transmission, and shares how you can protect your own health and manage your asthma triggers even if you have an epigenetic predisposition to asthma.  Finally, Noel discusses her career path and offers advice about perseverance in scientific research. 00:00 Asthma Across Generations 00:42 Meet Dr Alexandra Noel 01:54 Inside Inhalation Toxicology 05:37 Wildfire Smoke and PM Sizes 10:46 Teasing Apart Smoke Chemistry 15:19 Surprising Gas Phase Findings 17:17 From Research to Policy 19:53 Staying Hopeful and Finding Treatments 25:00 In Utero Exposure and Epigenetics 31:05 Second Hit Timing and Real Life Exposure 33:29 DOHAD and fetal windows 34:47 Nutrition and lifelong risk 35:55 Transgenerational asthma links 38:26 Wildfire exposure mitigation 40:08 Career path in toxicology 43:53 Microplastics inhalation sources 46:37 Personal exposure choices 50:45 Individual vs public health 52:49 Science setbacks and funding 56:47 Why academia is rewarding 59:13 Closing thanks and outreach

Ratings & Reviews

5
out of 5
3 Ratings

About

This show dives into the world of science (and art!) with behind-the-scenes chats with researchers in their natural habitats. Get ready to hear and see the scientific process in new detail!