AudioScholar General Medicine Weekly

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General Medicine — a weekly podcast briefing of the most significant peer-reviewed general medicine literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

Episodes

  1. 1d ago

    This Week in General Medicine — Jul 13, 2026

    Welcome to This Week in General Medicine. This week we are covering seven notable papers spanning venous thromboembolism management, wound care optimization, and the latest updates in clinical pharmacology and preventive health. Let's dive in. Diagn… This week's papers: 1. YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism in Patients With Cancer: A Randomized Clinical Trial — JAMA 2026 2. Rivaroxaban Then Aspirin vs. Aspirin Alone after Total Hip or Knee Arthroplasty — The New England Journal of Medicine 2026 3. Compression therapies for venous leg ulcers: The VENous Ulcer Study 6 (VenUS 6), an open, multicentre, randomised clinical trial — PLoS Medicine 2026 4. FDA Approves First Oral Carbapenem for Complicated UTIs — JAMA 2026 5. Testosterone Therapy: Does New Evidence Warrant Broader Prescribing? — JAMA 2026 6. Physical activity guidance update: Top UK doctors highlight small boosts of regular movement and special advice for people taking GLP-1s — BMJ (Clinical research ed.) 2026 7. Acetaminophen Use During Pregnancy Is Unlikely to Cause Autism or ADHD, New Study Reaffirms — JAMA 2026 Listen at https://audioscholar.cc/episode/fuscgccgjh

  2. 5d ago

    This Week in General Medicine — Jul 9, 2026

    Welcome to This Week in General Medicine. This week we're covering four notable papers spanning the clinical efficacy and access barriers of modern pharmacotherapy, and the critical need for personalized standards in risk assessment. Let's dive in.… This week's papers: 1. Comparative effects of drugs for adults with overweight or obesity: systematic review and network meta-analysis — BMJ (Clinical research ed.) 2026 2. Advances in systemic therapies for advanced prostate cancer — BMJ (Clinical research ed.) 2026 3. Formulary-Related Insurance Denials of Single-Source Branded Drugs in the United States — JAMA 2026 4. Designation of small for gestational age according to seven fetal growth charts in England's National Health Service: population based cohort study of 3.2 mill… — BMJ (Clinical research ed.) 2026 Listen at https://audioscholar.cc/episode/8jk4x6enpc

  3. Jun 30

    This Week in General Medicine — Jun 30, 2026

    Welcome to This Week in General Medicine. This week we are focusing on a critical clinical update in outpatient infectious disease management, specifically reviewing the latest evidence-based guidelines for antiviral therapies in adults with mild-to-… This week's papers: 1. Antiviral Therapies for Adults With Mild to Moderate COVID-19 Infection — JAMA 2026 Listen at https://audioscholar.cc/episode/vjdhprr3h5

  4. Jun 24

    This Week in General Medicine — Jun 23, 2026

    Welcome to This Week in General Medicine. This week we're covering 9 notable papers spanning acute care protocols, chronic disease management, and digital innovations. Let's dive in. We begin with new evidence that challenges traditional practice in… This week's papers: 1. Expanding Technology-Enabled, Nurse-Delivered Chronic Disease Care : A Pragmatic, Randomized, Effectiveness-Implementation Trial. — Annals of internal medicine 2026 2. Towards autonomous medical artificial intelligence agents. — Nature 2026 3. Management of Differentiated Thyroid Cancer. — The New England journal of medicine 2026 4. Bispecific Antibody Ivonescimab Added to Chemotherapy in EGFR-Variant Non-Small Cell Lung Cancer: The HARMONi-A Randomized Clinical Trial. — JAMA 2026 5. Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage. — The New England journal of medicine 2026 6. Symptom-Based Dosing for Neonatal Opioid Withdrawal: The OPTimize NOW Randomized Clinical Trial. — JAMA 2026 7. Endovascular Therapy for Post-Thrombotic Syndrome - A Randomized Trial. — The New England journal of medicine 2026 8. Amylin and the renin-angiotensin system: risk or opportunity in amylin-based therapy? — Lancet 2025 Listen at https://audioscholar.cc/episode/dc575d2p8k

  5. Jun 17

    This Week in General Medicine — Jun 16, 2026

    Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning advances in oncology, new frontiers in diabetes care, and a critical look at when more technology or treatment isn't better. Let's dive in. We begin this w… This week's papers: 1. Lonvoguran Ziclumeran - In Vivo CRISPR Gene Editing in Hereditary Angioedema. — The New England journal of medicine 2026 2. Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, r… — Lancet (London, England) 2025 3. An AI-Based OCT System to Detect Diabetic Macular Edema: A Prospective Validation and Noninferiority Randomized Clinical Trial. — JAMA 2026 4. General-purpose large language models outperform specialized clinical AI tools on medical benchmarks. — Nature medicine 2026 5. Screening Children for Early-Stage Type 1 Diabetes. — JAMA 2026 6. High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury: The VICTORY Randomized Clinical Trial. — JAMA 2026 7. IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease. — The New England journal of medicine 2026 8. Mezigdomide, carfilzomib, and dexamethasone versus carfilzomib and dexamethasone in patients with relapsed or refractory multiple myeloma (SUCCESSOR-2): a phas… — Lancet (London, England) 2026 9. Preoperative mFOLFIRINOX versus PAXG for stage I-III resectable and borderline resectable pancreatic ductal adenocarcinoma (PACT-21 CASSANDRA): results of the… — Lancet (London, England) 2025 10. Diagnosis and treatment of postpartum haemorrhage: a race against time. — Lancet (London, England) 2026 Listen at https://audioscholar.cc/episode/mesgy2kgr2

  6. Jun 10

    This Week in General Medicine — Jun 9, 2026

    Welcome to This Week in General Medicine. This week we're covering 7 notable papers spanning major advances in cardiovascular and renal care, new considerations for hospitalized older adults, a powerful new diabetes therapy, and a crucial interventio… This week's papers: 1. Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation. — The New England journal of medicine 2026 2. Efficacy and safety of finerenone in patients with chronic kidney disease: an individual participant data pooled analysis (INFINITY). — Lancet (London, England) 2026 3. Effects of SGLT2 inhibition on incident heart failure in carriers of cardiomyopathy-associated genetic variants. — Nature medicine 2026 4. Estimating the Effect of Hospital Admission on Health Care Outcomes and Spending Among Persons With Dementia : A Quasi-experimental Study. — Annals of internal medicine 2026 5. Rehospitalization and the Association of Postoperative Delirium With Cognitive Decline in Older Adults. — JAMA internal medicine 2026 6. Cagrilintide-semaglutide (CagriSema) as an add-on to basal insulin in adults with type 2 diabetes (REIMAGINE 3): a randomised, double-blind, placebo-controlled… — Lancet (London, England) 2026 7. Pragmatic Parental Support to Mitigate Burnout Among Pregnant and Postpartum Trainees: A Randomized Clinical Trial. — JAMA 2026 Listen at https://audioscholar.cc/episode/8r25kw9psq

  7. Jun 6

    This Week in General Medicine — Jun 5, 2026

    Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning major advances in chronic kidney disease, new targeted therapies and treatment intensification in oncology, and important findings in low back pain manageme… This week's papers: 1. Finerenone in Persons with Chronic Kidney Disease without Diabetes. — The New England journal of medicine 2026 2. Atrasentan in patients with IgA nephropathy (ALIGN): final 2.5-year results from a randomised, double-blind, placebo-controlled, phase 3 trial. — Lancet (London, England) 2026 3. Low-Dose Rivaroxaban and Cardiovascular Events in Advanced Kidney Disease: The TRACK Randomized Clinical Trial. — JAMA 2026 4. Chronic kidney disease, complex conditions, and advancing therapeutics: new hope and challenges. — Lancet (London, England) 2026 5. All-Oral Treatment of Newly Diagnosed Acute Myeloid Leukemia. — The New England journal of medicine 2026 6. Obexelimab for the Treatment of IgG4-Related Disease. — The New England journal of medicine 2026 7. Savolitinib in MET-amplified gastric or gastroesophageal junction adenocarcinoma: a phase 2 trial. — Nature medicine 2026 8. Spinal Manipulation and Clinician-Supported Self-Management for Preventing Chronic Low Back Pain Impact: The PACBACK Randomized Clinical Trial. — JAMA internal medicine 2026 9. Perioperative Apalutamide in High-Risk Localized Prostate Cancer. — The New England journal of medicine 2026 10. PARP and Androgen-Signaling Inhibition plus ADT in Metastatic Prostate Cancer. — The New England journal of medicine 2026 Listen at https://audioscholar.cc/episode/pjuba4wnjw

  8. May 28

    This Week in General Medicine — May 28, 2026

    Welcome to This Week in General Medicine. This week we're covering 8 notable papers spanning major therapeutic updates in oncology, endocrinology, and pulmonology; new strategies in diagnostics and screening; and a look at the future of health system… This week's papers: 1. The Lancet Commission on precision health: equitable, data-driven health outcomes for all. — Lancet (London, England) 2026 2. Updated trends in the global prevalence and burden of mental disorders, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023. — Lancet (London, England) 2026 3. Screening Children for Early-Stage Type 1 Diabetes. — JAMA 2026 4. Primary Care as a Public Utility: The Case for a Common Fund. — JAMA 2026 5. Safety and efficacy of astegolimab for COPD with frequent exacerbations regardless of baseline blood eosinophil counts (ALIENTO and ARNASA): randomised, double… — Lancet (London, England) 2026 6. Fast Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia: The FAST Randomized Clinical Trial. — JAMA 2026 7. Preoperative mFOLFIRINOX versus PAXG for stage I-III resectable and borderline resectable pancreatic ductal adenocarcinoma (PACT-21 CASSANDRA): results of the… — Lancet (London, England) 2026 8. Orforglipron, an oral small-molecule GLP-1 receptor agonist, for the treatment of obesity in people with type 2 diabetes (ATTAIN-2): a phase 3, double-blind, r… — Lancet (London, England) 2026 Listen at https://audioscholar.cc/episode/76mdujhzm8

  9. May 21

    This Week in General Medicine — May 21, 2026

    Welcome to This Week in General Medicine. This week we're covering 9 notable papers spanning chronic disease management in COPD, diabetes, and cancer; innovations in emergency care for hemorrhage and cardiac arrest; and the growing role of artificial… This week's papers: 1. Reprogrammed apoptotic platelets drive rapid hemostasis through phosphatidylserine and prostaglandin E2 signaling in preclinical models. — Science translational medicine 2026 2. Screening Children for Early-Stage Type 1 Diabetes. — JAMA 2026 3. Accelerating scientific discovery with Co-Scientist. — Nature 2026 4. Safety and efficacy of astegolimab for COPD with frequent exacerbations regardless of baseline blood eosinophil counts (ALIENTO and ARNASA): randomised, double… — Lancet (London, England) 2026 5. Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage. — The New England journal of medicine 2026 6. Biomarker-Based Eligibility for Lung Cancer Screening: Validation of the Protein-Based INTEGRAL-Risk Model. — JAMA 2026 7. An Artificial Intelligence-Enabled Cardiopulmonary Resuscitation Instructor. — JAMA internal medicine 2026 8. Life Expectancy in Chronic Obstructive Pulmonary Disease. — JAMA internal medicine 2026 9. Tucidinostat Plus R-CHOP vs R-CHOP in MYC/BCL2 Double-Expressor Diffuse Large B-Cell Lymphoma: A Randomized Clinical Trial. — JAMA 2026 Listen at https://audioscholar.cc/episode/43x4x7qh6a

  10. May 14

    This Week in General Medicine — May 14, 2026

    Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning cardiovascular updates, advances in immunology, and new data on prevention and screening. Let's dive in. [PAUSE] Cardiovascular Updates [PAUSE] First, in… This week's papers: 1. Abatacept versus hydroxychloroquine for prevention of rheumatoid arthritis in individuals with palindromic rheumatism: a randomized open-label trial. — Nature medicine 2026 2. Prophylactic tranexamic acid for the prevention of postpartum haemorrhage in women with placenta praevia: multicentre, double blind, randomised, placebo contro… — BMJ (Clinical research ed.) 2026 3. Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts. — The New England journal of medicine 2026 4. Natural killer cell immunotherapy reverses lung fibrosis by eliminating senescent fibroblasts. — Science translational medicine 2026 5. Efficacy of dual antiplatelet therapy for three months versus 12 months after coronary artery bypass grafting: multicentre, double blinded, randomised controll… — BMJ (Clinical research ed.) 2026 6. Integrating Planetary Health in Health Guidelines (GRADE Guidance 46). — Annals of internal medicine 2026 7. Low-dose digoxin in patients with heart failure with reduced or mildly reduced ejection fraction: a randomized controlled trial. — Nature medicine 2026 8. Long-term effects of colonoscopy screening on colorectal cancer incidence and mortality: a multicountry, population-based randomised controlled trial. — Lancet (London, England) 2026 9. A convergent uPAR-positive tumor ecosystem creates broad vulnerability to CAR T cell therapy. — Cell 2026 10. A Phase 3 Trial of Brepocitinib in Dermatomyositis. — The New England journal of medicine 2026 Listen at https://audioscholar.cc/episode/q9tk8cu8wq

  • 10 Episodes

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General Medicine — a weekly podcast briefing of the most significant peer-reviewed general medicine literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

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