AudioScholar General Medicine Weekly

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General Medicine — a weekly podcast briefing of the most significant peer-reviewed general medicine literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

  1. 23h ago

    This Week in General Medicine — Aug 31, 2026

    Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning cardiology's ongoing habit of questioning its own long-standing practices, prevention and adherence at the system level, and a review of where psychiatry is… This week's papers: 1. Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis — New England Journal of Medicine 2026 2. Anticoagulation for Atrial Fibrillation with Intermediate Stroke Risk — New England Journal of Medicine 2026 3. Discontinuation of β-blockers in stable patients with previous myocardial infarction, preserved left ventricular ejection fraction, and no heart failure: a poo… — The Lancet 2026 4. Catheter ablation for symptomatic atrial fibrillation (PVI-SHAM-AF): a randomised, double-blind, sham-controlled, multicentre trial — The Lancet 2026 5. Safety and efficacy of the 0/1 h pathway for myocardial infarction in the emergency department: an international, pragmatic, stepped-wedge, cluster-randomised,… — The Lancet 2026 6. Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy — New England Journal of Medicine 2026 7. Eplontersen for Transthyretin Amyloid Cardiomyopathy — New England Journal of Medicine 2026 8. Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer: A Randomized Clinical Trial — JAMA Internal Medicine 2026 9. Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence: The ADHERE-ASCVD Randomized Clinical Trial — JAMA 2026 10. Schizophrenia: advances in pathophysiology, management, and precision medicine — BMJ 2026 Listen at https://audioscholar.cc/episode/9mekmrkz4m

  2. 6d ago

    This Week in General Medicine — Aug 25, 2026

    Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning three broad themes: interventions that turned out not to work as hoped, transfusion safety signals that could change how we think about blood products, and… This week's papers: 1. Adult Overweight and Obesity Management: Updates From the 2025 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guidelines — Annals of Internal Medicine 2026 2. Diagnosis and management of acute hyperkalaemia — BMJ 2026 3. Postural Orthostatic Tachycardia Syndrome (POTS): A Review — JAMA 2026 4. Head positioning after endovascular therapy for acute stroke due to large vessel occlusion (HeadSOAR): multicentre randomised controlled trial — BMJ 2026 5. Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome — JAMA Internal Medicine 2026 6. Cancer pain — Nature Reviews Disease Primers 2026 7. Risk of transmission of amyloid β pathology via transfused blood products — The Lancet 2026 8. Effect of a digital intervention on mental health symptoms in adults with chronic conditions: A three-arm randomized controlled trial — PLOS Medicine 2026 9. Robotic-arm-assisted versus conventional total knee replacement (RACER-Knee): a pragmatic, multicentre, participant-masked and assessor-masked, superiority, ra… — The Lancet 2026 10. Rezpegaldesleukin treatment of moderate-to-severe atopic dermatitis (REZOLVE-AD): final results from the 16-week induction period of an international, double-b… — The Lancet 2026 Listen at https://audioscholar.cc/episode/htwuk3rmga

  3. Aug 17

    This Week in General Medicine — Aug 17, 2026

    Welcome to This Week in General Medicine. This week we're covering 8 notable papers spanning oncology treatment and biomarkers, immune-mediated disease and infection, and the social and biological determinants of ageing and child health. Let's dive i… This week's papers: 1. Stereotactic Body Radiotherapy vs Moderately Hypofractionated IMRT for Localized Intermediate-Risk Prostate Cancer: A Randomized Clinical Trial — JAMA 2026 2. Efficacy and safety of upadacitinib in adults and adolescents for treatment of non-segmental vitiligo (Viti-Up): results of two phase 3 randomised controlled s… — The Lancet 2026 3. Methicillin-resistant Staphylococcus aureus — Nature Reviews Disease Primers 2026 4. Biomarkers of nivolumab benefit in resectable non-small cell lung cancer — Nature 2026 5. First-line PD-1/VEGF bispecific antibody plus chemotherapy in triple-negative breast cancer: a phase 2 trial — Nature Medicine 2026 6. Socioeconomic inequalities in functional ageing trajectories in England and Canada: A comparative longitudinal cohort study — PLOS Medicine 2026 7. Sustainability and adherence to behaviour change: a cross-sectional 3-year follow-up survey of the CoMIC trial for child health in rural Pakistan — The Lancet Global Health 2026 8. Histological aging signatures for monitoring tissue-specific aging and disease — Nature Medicine 2026 Listen at https://audioscholar.cc/episode/rwwy97t2a2

  4. Aug 10

    This Week in General Medicine — Aug 10, 2026

    Welcome to This Week in General Medicine. This week we're covering seven notable papers spanning psychiatric drug trials with controlled substances, global health and adherence interventions, and population-level trends in stroke and infectious disea… This week's papers: 1. [Lu]Lu-PSMA-617 in patients with PSMA-positive metastatic androgen pathway modulator-naive/sensitive prostate cancer (PSMAddition): a phase 3 randomised, contr… — The Lancet 2026 2. Dronabinol for nightmares in post-traumatic stress disorder: a randomized controlled trial — Nature Medicine 2026 3. Evaluation of patient centred digital adherence technology for tuberculosis treatment outcomes: pragmatic randomised controlled trial — BMJ 2026 4. Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial — Nature Medicine 2026 5. Time trends in stroke incidence and modifiable risk factor prevalence in England (2018-2024): A record linkage population-based study — PLOS Medicine 2026 6. Iron or Multiple Micronutrient Powder Supplements With Malaria Chemoprevention in Rural Malawian Children: The IRMA Randomized Clinical Trial — JAMA 2026 7. Influenza — Nature Reviews Disease Primers 2026 Listen at https://audioscholar.cc/episode/yc7xdf2h7f

  5. Aug 3

    This Week in General Medicine — Aug 3, 2026

    Welcome to This Week in General Medicine. This week we're covering nine notable papers spanning perioperative and cardiac surgical care, randomised trials that push drugs into unfamiliar territory, and a cluster of papers on chronic disease managemen… This week's papers: 1. Multivessel coronary artery bypass grafting via small thoracotomy versus sternotomy (MIST): an investigator-initiated, international, open-label, randomised co… — The Lancet 2026 2. Deramiocel heart-derived cellular therapy in advanced Duchenne muscular dystrophy (HOPE-3): a phase 3, randomised, double-blind, placebo-controlled trial — The Lancet 2026 3. Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial — JAMA 2026 4. Antithrombotic treatment for migraine in patients with patent foramen ovale: multicentre, randomised, active controlled, open label trial — BMJ 2026 5. Initial HIV Therapy for Adults and Treatment-Associated Weight Gain: The Opti-DOR Randomized Clinical Trial — JAMA 2026 6. Psoriasis — The Lancet 2026 7. Antihistamines for atopic dermatitis (eczema): systematic review and network meta-analysis of randomised trials — BMJ 2026 8. Nicotine E-Cigarettes for Cigarette Smoking Cessation: Recommendations to US-Based Clinicians — JAMA 2026 9. Expanding the Developmental Origins of Health and Disease beyond maternal behaviors — PLoS Medicine 2026 Listen at https://audioscholar.cc/episode/q3p6tfs3tk

  6. Jul 31

    This Week in General Medicine — Jul 31, 2026

    Welcome to This Week in General Medicine. This week we're covering 3 notable papers spanning novel therapeutic approaches for glycemic control in type 2 diabetes and updated clinical management strategies for bulimia nervosa. Let's dive in. We begin… This week's papers: 1. Efficacy and safety of once-weekly subcutaneous zenagamtide, a novel unimolecular GLP-1 and amylin receptor agonist, in type 2 diabetes: a multicentre, randomi… — Lancet (London, England) 2026 2. Efficacy and safety of once-daily oral zenagamtide, a novel unimolecular GLP-1 and amylin receptor agonist, in adults with type 2 diabetes: a multicentre, rand… — Lancet (London, England) 2026 3. Bulimia nervosa. — Nature reviews. Disease primers 2026 Listen at https://audioscholar.cc/episode/kbrgq5b5g3

  7. Jul 20

    This Week in General Medicine — Jul 20, 2026

    Welcome to This Week in General Medicine. This week we're covering 9 notable papers spanning cardiovascular and metabolic health, maternal and pediatric outcomes, and lifestyle factors influencing long-term well-being. Let's dive in. We begin with a… This week's papers: 1. What to Know About the First CKM Syndrome Guidelines. — JAMA 2026 2. Global Cardiology Groups Issue New Universal Definition of Heart Failure. — JAMA 2026 3. Work-family conflict and mental health: A systematic review and meta-analysis. — PLoS medicine 2026 4. Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort. — BMJ (Clinical research ed.) 2026 5. FDA Approves Hypertriglyceridemia Drug That May Reduce Pancreatitis Risk. — JAMA 2026 6. Meningitis B: All 15 year olds should be offered vaccine on NHS, say expert advisers. — BMJ (Clinical research ed.) 2026 7. Alzheimer's drug lecanemab: FDA approves easier initial use, with "huge implications" for UK. — BMJ (Clinical research ed.) 2026 8. Empirical treatment with valganciclovir in infants living with HIV and hospitalised with severe pneumonia in Africa: a multicentre, open-label, factorial, rand… — Lancet (London, England) 2026 9. Long-term neurodevelopmental outcomes after vacuum-assisted delivery: A population-based cohort study. — PLoS medicine 2026 Listen at https://audioscholar.cc/episode/chaawshbx3

  8. Jul 13

    This Week in General Medicine — Jul 13, 2026

    Welcome to This Week in General Medicine. This week we are covering seven notable papers spanning venous thromboembolism management, wound care optimization, and the latest updates in clinical pharmacology and preventive health. Let's dive in. Diagn… This week's papers: 1. YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism in Patients With Cancer: A Randomized Clinical Trial — JAMA 2026 2. Rivaroxaban Then Aspirin vs. Aspirin Alone after Total Hip or Knee Arthroplasty — The New England Journal of Medicine 2026 3. Compression therapies for venous leg ulcers: The VENous Ulcer Study 6 (VenUS 6), an open, multicentre, randomised clinical trial — PLoS Medicine 2026 4. FDA Approves First Oral Carbapenem for Complicated UTIs — JAMA 2026 5. Testosterone Therapy: Does New Evidence Warrant Broader Prescribing? — JAMA 2026 6. Physical activity guidance update: Top UK doctors highlight small boosts of regular movement and special advice for people taking GLP-1s — BMJ (Clinical research ed.) 2026 7. Acetaminophen Use During Pregnancy Is Unlikely to Cause Autism or ADHD, New Study Reaffirms — JAMA 2026 Listen at https://audioscholar.cc/episode/fuscgccgjh

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General Medicine — a weekly podcast briefing of the most significant peer-reviewed general medicine literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

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