AudioScholar General Medicine Weekly

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A weekly podcast briefing of the most significant peer-reviewed general medicine literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

  1. 3d ago

    0/1 h vs 0/3 h troponin: no shorter emergency stays

    Editor's Pick: Performance of 0/1 h versus 0/3 h pathways in patients with suspected myocardial infarction: a systematic review and individual participant data meta-analysis of randomised controlled trials (The Lancet, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning acute vascular care from the stroke unit to the emergency department, diagnosis and assessment in everyday clinic medicine, and treatment frontiers in cance… This week's papers: 1. Trial of Endovascular Therapy for Mild Stroke with Large-Vessel Occlusion.. New England Journal of Medicine 2026. 2. Mechanical Thrombectomy 24 to 72 Hours after Large-Vessel Ischemic Stroke.. New England Journal of Medicine 2026. 3. Performance of 0/1 h versus 0/3 h pathways in patients with suspected myocardial infarction: a systematic review and individual participant data meta-analysis…. The Lancet 2026. 4. Left Bundle-Branch Area Pacing vs Right Ventricular Pacing for Atrioventricular Block and Preserved Left Ventricular Function: The LEAP-Block Randomized Clinic…. JAMA 2026. 5. Non-invasive tests in metabolic dysfunction-associated steatotic liver disease: the LITMUS prospective multicentre diagnostic accuracy study.. The Lancet 2026. 6. Preoperative Medicine for the Internal Medicine Clinician: A Review.. JAMA Internal Medicine 2026. 7. Irritable bowel syndrome and related disorders of gut-brain interaction.. The Lancet 2026. 8. Tarlatamab-Durvalumab Maintenance for Extensive-Stage Small-Cell Lung Cancer.. New England Journal of Medicine 2026. 9. Gram-Negative Bacterial Resistance.. New England Journal of Medicine 2026. 10. In Vitro Fertilization or Intrauterine Insemination in Unexplained Infertility.. New England Journal of Medicine 2026. Listen at https://audioscholar.cc/episode/gme92xnesq

  2. Oct 26

    Video decision aid raises ACP in advanced kidney disease

    Editor's Pick: Video Decision Support and Advance Care Planning in Older Adults With Advanced Kidney Disease: The VIDEO-KD Randomized Clinical Trial (JAMA Internal Medicine, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning new evidence in kidney disease, the value of screening and vaccination against chronic infection, and a mix of striking and sobering results in obesity, can… This week's papers: 1. Sibeprenlimab in IgA Nephropathy - Final Phase 3 Trial Analysis.. New England Journal of Medicine 2026. 2. Atacicept in IgA Nephropathy - Phase 3 Trial Final Efficacy Analysis.. New England Journal of Medicine 2026. 3. Sodium-Glucose Cotransporter 2 Inhibitor Use and Levels of Hemoglobin, Markers of Iron Metabolism, and Erythropoiesis: A Systematic Review and Meta-Analysis of…. JAMA 2026. 4. Video Decision Support and Advance Care Planning in Older Adults With Advanced Kidney Disease: The VIDEO-KD Randomized Clinical Trial.. JAMA Internal Medicine 2026. 5. Projected Effect of 2026 Federal Changes to the Childhood Immunization Schedule on Chronic Hepatitis B Virus Infections in the United States.. Annals of Internal Medicine 2026. 6. Cost-Effectiveness of HCV Screening in Emergency Departments Using DETECT Hep C Trial Results.. JAMA Internal Medicine 2026. 7. Helicobacter pylori Infection - Advances, Challenges, and the Road Ahead.. New England Journal of Medicine 2026. 8. Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea.. New England Journal of Medicine 2026. 9. Disease-free survival and overall survival after neoadjuvant immunotherapy in mismatch repair-deficient colon cancer in the Netherlands: results of the single-…. The Lancet 2026. 10. Individualized Cardiac Index-Guided Hemodynamic Therapy in High-Risk Patients Undergoing Elective Major Abdominal Surgery: The PELICAN Randomized Clinical Tria…. JAMA 2026. Listen at https://audioscholar.cc/episode/u4eg2ar2jv

  3. Oct 19

    CGM lowers HbA1c ~0.9 points in T2D not on insulin

    Editor's Pick: Continuous Glucose Monitoring in Non-Insulin-Treated Type 2 Diabetes (New England Journal of Medicine, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning critical care for sepsis and acute kidney injury, the hospital management of sedatives and withdrawal, and primary care questions from diabetes technology t… This week's papers: 1. Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury.. New England Journal of Medicine 2026. 2. Intraoperative Dobutamine Plus Norepinephrine to Prevent Postoperative Acute Kidney Injury in Septic Shock: A Randomized Clinical Trial.. JAMA 2026. 3. Effect of Vasopressin Initiation Threshold on Septic Shock Mortality: The VASSPR Cluster Crossover Randomized Strategy Trial.. JAMA 2026. 4. Isoflurane-Based Inhaled Sedation in Mechanically Ventilated Adults With Acute Hypoxemic Respiratory Failure: The SAVE-ICU Randomized Clinical Trial.. JAMA 2026. 5. Comparative Effectiveness of Phenobarbital vs Diazepam for Alcohol Withdrawal Syndrome.. JAMA Internal Medicine 2026. 6. Benzodiazepine Use Early in Pregnancy and Risk for Congenital Malformations.. Annals of Internal Medicine 2026. 7. Delirium.. Annals of Internal Medicine 2026. 8. Continuous Glucose Monitoring in Non-Insulin-Treated Type 2 Diabetes.. New England Journal of Medicine 2026. 9. How Would You Screen This 26-Year-Old Woman for Cervical Cancer? Grand Rounds Discussion From Beth Israel Deaconess Medical Center.. Annals of Internal Medicine 2026. 10. Adult Attention Deficit-Hyperactivity Disorder.. New England Journal of Medicine 2026. Listen at https://audioscholar.cc/episode/hzdyp7h4s4

  4. Oct 12

    Menopausal hot flashes: ACP backs hormone therapy first line

    Editor's Pick: Pharmacologic Treatments for Females With Menopausal Vasomotor Symptoms: A Clinical Guideline From the American College of Physicians (Annals of Internal Medicine, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning women's health and menopause care, the gap between screening and follow-through in prevention, and a set of therapeutic trials that range from clearly usefu… This week's papers: 1. Pharmacologic Treatments for Females With Menopausal Vasomotor Symptoms: A Clinical Guideline From the American College of Physicians.. Annals of Internal Medicine 2026. 2. Pharmacologic Treatments for Female Menopausal Vasomotor Symptoms: A Systematic Review and Meta-analysis for the American College of Physicians.. Annals of Internal Medicine 2026. 3. Quadrivalent human papillomavirus vaccination before pregnancy and pregnancy outcomes: nationwide, population based case-control study.. BMJ 2026. 4. Smoking Cessation Among Underserved Patients Referred for Lung Cancer Screening: A Randomized Clinical Trial.. JAMA 2026. 5. Evaluation of Intervention Strategies to Improve Follow-Up Colonoscopy After Abnormal FIT/FOBT Result: A Systematic Review and Meta-Analysis.. JAMA Internal Medicine 2026. 6. Temporary Cessation of DMARD Therapy and COVID-19 Supplemental Dose Vaccine Immunogenicity in Patients With Inflammatory Arthritis: The COVER Randomized Clinic…. JAMA Internal Medicine 2026. 7. Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial.. Annals of Internal Medicine 2026. 8. Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease: The NOPARK Randomized Clinical Trial.. JAMA 2026. 9. Oral small-molecule GLP-1RA safiglipron versus dapagliflozin in type 2 diabetes: a randomized, double-blind, active-comparator-controlled phase 3 trial.. Nature Medicine 2026. 10. Advances in Systemic Treatment of Breast Cancer.. New England Journal of Medicine 2026. Listen at https://audioscholar.cc/episode/3ka8u7uxzr

  5. Oct 5

    COPD: ~9 in 10 undiagnosed, tied to ~50% higher mortality

    Editor's Pick: The burden and long-term outcomes of diagnosed and underdiagnosed COPD across diverse communities from high-income, middle-income, and low-income countries: the Prospective Urban Rural Epidemiology (PURE) study (The Lancet Global Health, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning cardiometabolic therapy, the hidden burden of chronic and infectious disease in global health, and new thinking on the gut, cancer detection and treatment r… This week's papers: 1. Survodutide Once Weekly in Adults with Obesity and Type 2 Diabetes.. New England Journal of Medicine 2026. 2. Effects of semaglutide on kidney disease in type 2 diabetes: a randomized placebo-controlled trial.. Nature Medicine 2026. 3. Reframing menopause and menopause hormone therapy as opportunities for healthy aging.. Science 2026. 4. The burden and long-term outcomes of diagnosed and underdiagnosed COPD across diverse communities from high-income, middle-income, and low-income countries: th…. The Lancet Global Health 2026. 5. HIV service delivery after the PEPFAR and USAID HIV funding withdrawal in Uganda and Zimbabwe: an interrupted time-series study.. The Lancet Global Health 2027. 6. Small quantity lipid-based nutritional supplementation and measles vaccination coverage in children aged 6-23 months: a pragmatic cluster-randomized trial.. Nature Medicine 2026. 7. Irritable bowel syndrome.. Nature Reviews Disease Primers 2026. 8. Sugar-rich foods exacerbate antibiotic-induced microbiome disruption.. Nature 2026. 9. Five-year survival with neoadjuvant therapy in melanoma: updated pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC).. Nature Medicine 2026. 10. Urine cell-free RNA for bladder cancer detection and treatment response prediction.. Nature Medicine 2026. Listen at https://audioscholar.cc/episode/8f2y5fskpv

  6. Sep 28

    Oral menopausal HT tied to clots; none seen with transdermal

    Editor's Pick: Contemporary menopausal hormone therapy and thrombotic disease: nationwide nested case-control study (BMJ, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in General Medicine. This week we're covering 7 notable papers spanning sex-specific risk and cardiovascular medicine, randomised trials that either delivered or fell flat, and the newer frontiers of immunotherapy toxicity and gl… This week's papers: 1. Contemporary menopausal hormone therapy and thrombotic disease: nationwide nested case-control study.. BMJ 2026. 2. Redesigning cardiovascular medicine around sex differences.. Nature Medicine 2026. 3. Radiotherapy versus observation following surgical resection of WHO grade 2 atypical meningioma (ROAM/EORTC-1308): an international, multicentre, open-label, p…. The Lancet 2026. 4. Faecal microbiota transplantation in irritable bowel syndrome (REFIT2): a randomised, double-blind, placebo-controlled, phase 3 trial.. The Lancet 2026. 5. Evorpacept plus trastuzumab, ramucirumab and paclitaxel in HER2-positive gastric cancer: a randomized phase 2 trial.. Nature Medicine 2026. 6. Persistence of mucosal CAR-T cells and inflammatory remodeling in enterocolitis associated with BCMA CAR-T cell therapy.. Nature Medicine 2026. 7. Burden of schistosomiasis in Ethiopia following 10 years of preventive chemotherapy: a national cross-sectional geostatistical survey.. The Lancet Global Health 2026. Listen at https://audioscholar.cc/episode/753tpubrax

  7. Sep 21

    Expanded criteria kidneys: no clear survival gain in oldest

    Editor's Pick: Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation (BMJ, 2026) Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning how we weigh benefit against harm in individual patients, a run of novel therapeutics tested in adolescents and in refractory autoimmune disease, and a clus… This week's papers: 1. Survival benefit of deceased donor kidney transplantation versus continued dialysis: international target trial emulation.. BMJ 2026. 2. Intrauterine Mepivacaine Instillation vs Placebo for Pain During IUD Placement: A Randomized Clinical Trial.. JAMA 2026. 3. Switch to injectable cabotegravir-rilpivirine given every 8 weeks in adolescents living with HIV with virological suppression in sub-Saharan Africa (LATA): a r…. The Lancet 2026. 4. Factor IX Padua AAV gene therapy in adolescents with hemophilia B: a phase 1 trial.. Nature Medicine 2026. 5. mRNA-encoding CD19-targeting T cell engager for refractory immune thrombocytopenia.. Cell 2026. 6. Blood test trend versus single threshold abnormality to discriminate cancer from non-cancer in patients with unexpected weight loss: A retrospective cohort stu…. PLOS Medicine 2026. 7. Germline EGFR T790M mutation and lung cancer risk.. Science 2026. 8. Precision prevention and early detection: framework for a new clinical cancer control pathway.. The Lancet 2026. 9. Global inequalities in cardiometabolic care and achievable cardiovascular risk reduction by wealth, region, and sex: a pooled analysis of individual participan…. The Lancet Global Health 2026. 10. Accelerometer-derived real-world sleep stages and risk of incident diseases: A UK Biobank cohort study and phenome-wide association analysis.. PLOS Medicine 2026. Listen at https://audioscholar.cc/episode/sfnnuwgty5

  8. Sep 14

    Prescribing cascades in older adults: 24 high priority

    Editor's Pick: Exploring high priority potentially inappropriate prescribing cascades in older adults: population level retrospective cohort study (BMJ, 2026) Welcome to This Week in General Medicine. This week we're covering 10 notable papers spanning novel targeted therapies in stroke, haematology and lupus, bread-and-butter diagnosis and management in the clinic and emergency department, and a cluster o… This week's papers: 1. Loberamisal for Acute Ischemic Stroke: The LAIS Randomized Clinical Trial.. JAMA 2026. 2. Efficacy and safety of mitapivat in adults with transfusion-dependent α-thalassaemia or β-thalassaemia (ENERGIZE-T): a double-blind, randomised, multicentre, p…. The Lancet 2026. 3. A bispecific CD3×CD19 antibody for systemic lupus erythematosus: a phase 1 trial.. Nature Medicine 2026. 4. Rheumatoid Arthritis in Adults: A Review.. JAMA 2026. 5. Advances in the diagnosis and management of skin and soft tissue infections.. BMJ 2026. 6. Toxidromes.. Nature Reviews Disease Primers 2026. 7. Exploring high priority potentially inappropriate prescribing cascades in older adults: population level retrospective cohort study.. BMJ 2026. 8. Simultaneous derivation, validation, and comparison of predictor hazard ratios for cardiovascular risk prediction equations in patients with diabetes from high…. BMJ 2026. 9. Most-favoured-nation pricing for prescription drugs in US Medicare: a cohort study.. The Lancet 2026. 10. COVID-19 vaccination around immune checkpoint inhibitor start and survival in a nationwide cohort of patients with cancer.. Nature Medicine 2026. Listen at https://audioscholar.cc/episode/h5cjbr5b97

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A weekly podcast briefing of the most significant peer-reviewed general medicine literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

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