JACC Author Interviews

American College of Cardiology
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Interviews with top cardiologists and cardiovascular researchers about breakthrough research, clinical trials, and emerging innovations featured in JACC.

  1. Jun 2

    DCB vs DES in Noncomplex Coronary Bifurcation Lesions: REC CAGEFREE I | JACC: Cardiovascular Interventions

    Dr. Aaysha Cader, Social Media editor for JACC Interventions and Dr. Chao Gao discuss the pre-specified subgroup analysis of the REC-CAGEFREE I trial: Drug-Coated Balloon Angioplasty vs Drug-Eluting Stents in Noncomplex Coronary Bifurcation Lesions.

    13 min

  2. Jun 2

    Side Branch Treatment for Bifurcation Revascularization: KISS Trial | JACC: Cardiovascular Interventions

    Dr. Aaysha Cader, Social Media editor for JACC Interventions and Dr. Antoinette Neylon discuss the randomised KISS trial: Side Branch Additional Treatment for Coronary Bifurcation Lesion Revascularization.

    14 min

  3. May 19

    Behind the Science: NPR-1 Agonist for Resistant Hypertension | JACC Author Interviews

    Join us for the latest Behind the Science discussion, featuring an article published in JACC's May 12 focus issue on hypertension. Adith Arun, MD, joins author William B. White, MD, as they discuss a phase 2 randomized trial of the NPR1 agonist XXB750 in patients with resistant hypertension. The interview highlights the study, a randomized, double-blind, placebo-controlled trial of 4 doses of XXB750, administered once-monthly by subcutaneous injection in 189 patients with resistant hypertension. Dose-related changes in cyclic GMP were observed, supporting target engagement of XXB750 at the NPR-1 receptor. However, there was no dose-response pattern observed with respect to change from baseline in 24-hour systolic BP after 12 weeks; none of the doses of XXB750 had a greater BP lowering effect than placebo. #jacc #jaccjournals #behindthescience

    28 min

  4. May 12

    Global Hypertension 2000 to 2020 | JACC Author Interviews

    In this interview in JACC's May 12 issue focusing on hypertension, JACC Editor-in-Chief Harlan M. Krumholz, MD, SM, MACC speaks with first author Samantha S. O'Connell, MS, MD, as they discuss a comprehensive global analysis of hypertension trends from 2000 to 2020, drawing on data from nearly 300 population-based studies across 119 countries. The findings show that while awareness and treatment have improved modestly—especially in high-income countries—the global burden of hypertension has grown to 1.7 billion adults, with most uncontrolled cases now concentrated in low- and middle-income countries. The conversation emphasizes widening disparities, persistently low control rates, and the urgent need to implement proven strategies worldwide.

    26 min

  5. Apr 21

    Behind the Science: AI in Cardiovascular Clinical Trials | JACC

    Can artificial intelligence really adjudicate heart attacks, strokes, and cardiovascular deaths in clinical trials? Adith Arun sits down with Jonathan W. Cunningham to discuss cutting-edge research using AI to automate major adverse cardiovascular event (MACE) adjudication—one of the most expensive and time‑consuming parts of global clinical trials. They explore how AI models review extensive medical records, assess uncertainty, and work alongside physicians in a hybrid approach that can preserve accuracy while improving efficiency and scalability in large trials.

    16 min

  6. Apr 6

    Automated Alerts for Valvular Heart Disease: Insights From the ALERT Trial | ACC.26 | JACC

    At ACC.26, JACC Editor-in-Chief Dr. Harlan Krumholz speaks with Dr. Wayne Batchelor about the ALERT Trial, published in JACC. Their discussion explores how automated EHR-based clinician alerts can help identify patients with significant valvular heart disease who may otherwise be overlooked, improving timely referral, heart team evaluation, and valve intervention. The conversation also covers the trial's rigorous cluster-randomized design, the promise of low-cost digital interventions at scale, and important considerations around workflow integration, equity, and implementation across health systems.

    23 min

  7. Apr 2

    Panel Discussion: Social Drivers of Health | ACC.26 | JACC

    In a panel at ACC.26, this video features Dr. Clyde Yancy of Northwestern University in conversation with Ambarish Pandey, Lauren Eberly, Jennifer Cluett, and Oluwabunmi Ogugngbe, exploring how social determinants of health can be studied as measurable variables in clinical research. The discussion highlights innovative trials examining "food as medicine," community-based nutrition interventions, and direct financial support for patients with cardiovascular disease. Through examples involving Indigenous, African American, and socioeconomically disadvantaged populations, the speakers emphasize the importance of trust, community engagement, and culturally tailored approaches. The video underscores a shift toward integrating social factors into cardiovascular science to reduce disparities and improve real-world health outcomes.

    15 min

  8. Apr 2

    Panel Discussion: Artificial Intelligence | ACC.26 | JACC

    Recorded on the final day of ACC.26, this video features an unscripted conversation between Dr. Ami Bhatt, Chief Innovation Officer at the American College of Cardiology, and Dr. Harlan Krumholz, Editor-in-Chief of JACC. They reflect on the rapid expansion of artificial intelligence in cardiology, discussing its impact on clinical workflows, research, education, guideline development, and patient empowerment. The discussion explores ethical considerations, trust, human–AI interaction, and the need for clinicians to actively shape AI's role in healthcare. The video highlights both the opportunities and challenges AI presents, emphasizing collaboration, transparency, and clinician leadership as cardiology enters a transformative era.

    18 min
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Interviews with top cardiologists and cardiovascular researchers about breakthrough research, clinical trials, and emerging innovations featured in JACC.

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    American College of Cardiology
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  • Episodes
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    JACC Author Interviews