the SPM podcast

Herbert Aberson
  • 5.0 (3)
  • Life Sciences

the SPM podcast is the podcast about Specialized Pro-Resolving Mediators. In this podcast we interview Scientists and Practicioners that work in the SPM field. Subscribe, leave a comment, and share this episode with anyone passionate about cutting-edge science and better health outcomes. Join us next time as we continue exploring the frontiers of human resolution biology.

  1. Sep 16

    Dr Alpdogan Kantarci “SPMs in Oral Inflammation & Periodontal Regeneration: Resolution Biology, Host Modulation & Systemic Links”

    Dr Alpdogan Kantarci Episode 12 Dr. Alpdogan Kantarci “SPMs in Oral Inflammation & Periodontal Regeneration: Resolution Biology, Host Modulation & Systemic Links” In this episode we welcome Professor Dr. Alpdogan Kantarci, a leading voice in inflammation resolution biology and one of the foremost experts exploring how Specialized Pro-resolving Mediators actively resolve inflammation in the oral mucosa and beyond. We discuss his career path from Istanbul University to postdoctoral and specialty training at Boston University, his long-standing work at the Forsyth Institute and Harvard, and his current role as Erwin M. Schaffer Chair and Department Chair at the University of Minnesota. The conversation covers foundational research on SPMs (especially Resolvin E1 and Maresin-1) in periodontitis, tissue and bone protection, reversal of cellular senescence, restoration of immune homeostasis, microbiome rebalancing, pro-resolving nanomedicines, and the translational shift toward host-modulation therapies. Key themes include the unique clinical-translational perspective he brings as both periodontist and researcher, the power of SPMs to regenerate rather than merely suppress damage, challenges and opportunities in moving resolution pharmacology into everyday dentistry, and the growing links between oral inflammation and systemic conditions such as neurodegenerative disease. Key Topics • Career journey from Istanbul to Boston, Forsyth, Harvard, and the University of Minnesota • What SPMs are and how RvE1 & MaR1 protect against local tissue and bone destruction • Reversing senescence-related dysfunction in periodontal ligament cells and stem cells • Failed resolution, T-cell/Th17 imbalance, and restoring homeostasis without immunosuppression • Breaking the inflammatory–dysbiosis vicious cycle and reshaping the oral microbiome • Pioneering pro-resolving nanomedicines with benzo-lipoxin A4 for hard- and soft-tissue regeneration • Preclinical evidence of bone regeneration and restored periodontal ligament stem-cell function • Why host-modulation with nanotechnology represents the future of clinical dentistry • Oral–systemic connections, including links to neurodegenerative disease • Translational outlook for resolution-based therapies in periodontology

    Dr Alpdogan Kantarci “SPMs in Oral Inflammation & Periodontal Regeneration: Resolution Biology, Host Modulation & Systemic Links”

  2. Aug 20

    Episode 12 Dr. Marc Dubourdeau “From Bench to Biotech: SPM Lipidomics, Resolution Biology & Nutritional Innovation"

    Episode 12 Dr. Marc Dubourdeau “From Bench to Biotech: SPM Lipidomics, Resolution Biology & Nutritional Innovation with Dr. Marc Dubourdeau” In this episode we welcome Dr. Marc Dubourdeau, a pioneering scientist and entrepreneur who has been at the forefront of turning SPM research into practical tools for human and animal health. We discuss his journey from immunology and macrophage research in Toulouse and the Institut Pasteur to founding Ambiotis, one of the world’s first contract research organizations dedicated to inflammation resolution and SPM biology. The conversation covers advanced lipidomics platforms, preclinical models across cystic fibrosis, chronic lung disease, cardiovascular conditions, veterinary applications, and skin/aging, his collaborations with Charles Serhan (including contributions to the Atlas of Inflammation Resolution), and the translation of this science into nutritional innovations such as optimized omega-3 blends designed to support endogenous SPM production. Key themes include the shift from classical anti-inflammatory thinking to active resolution biology, the power of precise lipid mediator measurement, and what resolution pharmacology and nutrition can mean for chronic disease and everyday wellness. ─── Key Topics • Early fascination with how the body works and path into immunology • PhD research on monocytes, macrophages, prostaglandins, leukotrienes, and lipid pathways • Work at the Institut Pasteur on macrophage–fungus interactions (Aspergillus) in cystic fibrosis and transplantation • Founding of Ambiotis as a specialized CRO for resolution biology and SPM lipidomics • Development of advanced analytical platforms and disease models • Collaborations with Charles Serhan and contributions to the Atlas of Inflammation Resolution • Applications ranging from lung disease and cardiovascular models to veterinary and skin/aging research • Translation into nutritional products that support the body’s natural SPM production • The broader implications of resolution pharmacology for chronic inflammation and wellness ─── About the Guest Dr. Marc Dubourdeau earned his PhD in immunology from Université Paul Sabatier in Toulouse and conducted research at the Institut Pasteur in Paris. In 2007 he founded Ambiotis, a pioneering contract research organization focused on inflammation resolution and specialized pro-resolving mediator biology. He currently also leads Laboratoire Aloméa, translating SPM science into nutritional innovations.

    Episode 12 Dr. Marc Dubourdeau “From Bench to Biotech: SPM Lipidomics, Resolution Biology & Nutritional Innovation"

  3. Aug 13

    Episode 11 Dr. Joan Clària “SPMs in Liver Disease & Obesity: Resolution Biology from Adipose Tissue to Cirrhosis"

    Episode 11 Dr. Joan Clària In this episode we welcome Professor Dr. Joan Clària, a leading voice in inflammation resolution biology and one of the pioneers exploring how the body actively resolves inflammation through lipid mediators. We discuss his career path from clinical biochemistry at Hospital Clínic Barcelona to postdoctoral work with Charles Serhan, his foundational research on SPMs in liver disease and obesity, the role of resolution deficits in adipose tissue inflammation and metabolic-associated fatty liver disease (MAFLD/MASH), and the translational potential of SPMs, omega-3 precursors, and stable analogs. Key themes include the unique clinical-biochemical perspective he brings to SPM biology, the importance of on-site SPM production in tissues, challenges in reversing established fibrosis, the need for more research on SPMs and adaptive immunity, and the future of resolution pharmacology for chronic metabolic and liver conditions. Key Topics • Early interest in mechanisms and clinical biochemistry training • Postdoctoral work with Charles Serhan (1992–1995) and discovery of aspirin-triggered lipoxins • Establishing a lab focused on lipid mediators in liver disease • First demonstrations of SPM deficits in obese adipose tissue and links to hepatic steatosis • Macrophage polarization, crown-like structures, and unresolved inflammation in obesity • SPMs, efferocytosis (including maresin 1 and Kupffer cells), and infection susceptibility in cirrhosis • Limitations of SPMs for established fibrosis and emphasis on prevention • Adaptive immunity, B-cell responses, and lessons from COVID-era observations • Current supplements vs. future stable analogs and receptor-targeted approaches • Personal life, family farm, and return to acute-on-chronic liver failure research About the Guest Professor Joan Clària is Professor at the University of Barcelona and Group Leader of the Inflammation and Liver Disease research group at IDIBAPS, Hospital Clínic de Barcelona. A clinical biochemist by training with extensive translational experience, he has published widely on pro-resolving mediators in liver disease, obesity, and metabolic inflammation and is a highly cited researcher in the field of inflammation resolution.

    Episode 11 Dr. Joan Clària “SPMs in Liver Disease & Obesity: Resolution Biology from Adipose Tissue to Cirrhosis"

  4. Aug 6

    Episode 10 Dr Mauro Perretti "Immunoresolvents & Resolution Pharmacology: From Annexin A1 to SPMs"

    Episode 10 Dr Mauro Perretti “Immunoresolvents & Resolution Pharmacology: From Annexin A1 to SPMs with Dr. Mauro Perretti” In this episode we welcome Professor Mauro Perretti, a leading pioneer in immunopharmacology and the biology of inflammation resolution. We discuss his career path from Florence to the William Harvey Research Institute, his foundational work on Annexin A1, his collaboration with Charles Serhan, the concept of immunoresolvents, Specialized Pro-resolving Mediators (SPMs), neutrophil microvesicles, and the emerging field of resolution pharmacology. Key themes include why inflammation is not inherently “bad,” what mainstream medicine still overlooks, the therapeutic potential of SPMs and Annexin A1 in arthritis and chronic inflammation, mentorship of prominent researchers (including Jesmond Dalli and Lucy Norling), and the future of treatments that actively promote resolution rather than only suppress inflammation. Key Topics • Early career and entry into inflammation research • Meeting Charles Serhan in Florence and long-term collaboration • Annexin A1 biology and its multiple pro-resolving actions • Convergence of Annexin A1 and SPMs (shared ALX/FPR2 receptor) • Immunoresolvents and active resolution of inflammation • Resolution as a programmed process (apoptosis, efferocytosis, macrophage phenotype switch) • Limitations of drugs that only block the initiation phase of inflammation • Resolution pharmacology and potential in rheumatoid arthritis • Mentorship of key SPM scientists • Biological redundancy and resilience in resolution networks About the Guest Professor Mauro Perretti is a highly cited researcher (over 46,000 citations) whose work bridges Annexin A1, SPMs, neutrophil biology, and translational resolution pharmacology. He has held senior leadership roles at the William Harvey Research Institute and Queen Mary University of London.

    Episode 10 Dr Mauro Perretti "Immunoresolvents & Resolution Pharmacology: From Annexin A1 to SPMs"

  5. Jul 30

    Episode 9 Dr. Thomas E. Van Dyke “SPMs in Periodontal Disease: Neutrophils, Resolution Biology & Oral-Systemic Links"

    Episode 9 Dr. Thomas E. Van Dyke, a world-renowned periodontist, researcher, and leader in inflammation resolution biology. Dr. Van Dyke earned his DDS from Case Western Reserve University in 1973, followed by an MS in Oral Sciences, Certificate in Periodontology, and PhD in Oral Biology from SUNY Buffalo in the early 1980s. He built his early career at Boston University, Rising to Professor and Director of Periodontology Research and Clinical Research programs, before joining the Forsyth Institute in 2010—where he now serves as Senior Vice President for Clinical and Translational Research and holds a professorship at Harvard School of Dental Medicine. Throughout his career, Dr. Van Dyke has focused on the pathogenesis of periodontal disease, with groundbreaking work on neutrophil biology, host responses, and the critical role of failed inflammation resolution in chronic tissue and bone destruction. His long-standing collaboration with Dr. Charles Serhan helped pioneer the application of specialized pro-resolving mediators—or SPMs—such as lipoxins and resolvins to oral health. This research is transforming how we think about treating periodontitis—not just by blocking inflammation, but by actively promoting its natural resolution and tissue regeneration. Dr van Dyke has also mentored many leading scientists in the field, including Drs. Gabrielle Fredman, Alpdogan Kantarci, and Hatice Hasturk, who continue to advance SPM research and its clinical applications.

    Episode 9 Dr. Thomas E. Van Dyke “SPMs in Periodontal Disease: Neutrophils, Resolution Biology & Oral-Systemic Links"

  6. Jul 23

    Dr. Dipak Panigrahy "Battling Cancer Softly: SPMs, Tumor Debris Clearance & Resolution in Cancer Therapy"

    Episode 8 Dr. Dipak Panigrahy " Battling Cancer Softly: SPMs, Tumor Debris Clearance & Resolution in Cancer Therapy" Welcome to the SPM Podcast, the podcastabout Specialized Pro-Resolving Mediators. Subscribe, leave a comment, and share this episode with anyone interested in cancer biology, inflammation resolution, and innovativeapproaches to oncology. Episode Summary: In this eye-opening episode, we welcome Dr.Dipak Panigrahy, a pioneering researcher exploring the role of Specialized Pro-ResolvingMediators (SPMs) in cancer. Dr. Panigrahy explains how conventional cancertreatments like chemotherapy and surgery, while killing tumor cells, can generate tumor debris killing tumor cells, can generate tumor debris that fuels inflammation and promotes cancer recurrence and metastasis. He discusses how SPMs (such as resolvins,maresins, and protectins) actively resolve this inflammation, enhance the clearance of tumor debris by macrophages, reprogram the tumor microenvironment, and suppress cancer progression without immunosuppression. The conversation highlights the paradigm shift from solely destroying cancer cells to also promoting active resolution of the resulting inflammation for better long-term outcomes. Guest Bio: Dr. Dipak Panigrahy, MD, is an Assistant Professor of Pathology at Harvard Medical School and Beth Israel Deaconess Medical Center (BIDMC) in Boston, where he leads a research laboratory in the Center for Vascular Biology Research. His groundbreaking work focuses on the intersection of inflammation, lipid mediators, and cancer. Dr. Panigrahy investigates how Specialized Pro- Resolving Mediators (SPMs) can be harnessed to mitigate cancer-related inflammation, cleartherapy-induced tumor debris, reduce metastasis, and improve the efficacy of conventional cancer treatments. He has collaborated extensively with SPM pioneer Dr. Charles Serhan and is a leading voice in resolution biology applied to oncology. Resources Mentioned: Key Papers: Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases Journal of Clinical Investigation 2019 https://www.jci.org/articles/view/127282 Aspirin-triggered proresolving mediators stimulate resolution in cancer PNAS, 2019 https://www.pnas.org/doi/10.1073/ pnas.1804000116 Exploring the unique role of specialized pro-resolving mediators in cancer therapeutics Prostaglandins & Other Lipid Mediators, 2024 https://pubmed.ncbi.nlm.nih.gov/39722403/ Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation Frontiers in Immunology, 2021 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2021.702785/full Additional Resources: Metagenics Institute Interview: Impact of SPMs on Tumor Size and Growth https://www.metagenicsinstitute.com/video/spms-impact-tumor-growth/ Panigrahy Lab Beth Israel Deaconess Medical Center https://research.bidmc.org/dipak-panigrahy/ research

    Dr. Dipak Panigrahy "Battling Cancer Softly: SPMs, Tumor Debris Clearance & Resolution in Cancer Therapy"

  7. Jul 16

    Episode 7 Dr. Gabrielle Fredman "Resolution biology in the Vascular System:SPMs, Atherosclerosis, Plaque Stability & Cardiovascular Health"

    Episode 7 Dr. Gabrielle Fredman "Resolution biology in the Vascular System:SPMs, Atherosclerosis, Plaque Stability & Cardiovascular Health" Welcome to the SPM Podcast, the podcastabout Specialized Pro-Resolving Mediators. Subscribe, leave a comment, and share thisepisode with anyone interested in heart health, inflammation resolution, and cutting-edgecardiovascular science. Episode Summary: In this compelling episode, we welcome Dr.Gabrielle Fredman, a leading researcher in inflammation resolution and vascular biology. Dr. Fredman explains how Specialized Pro-Resolving Mediators (SPMs) actively resolve. Specialized Pro-Resolving Mediators (SPMs) actively resolve chronic inflammation in blood vessels, promote the clearance of dead cells (efferocytosis), andhelp stabilize atherosclerotic plaques. The conversation dives into why atherosclerosisis fundamentally a disease of failed resolution, the imbalance between pro-inflammatory lipids and SPMs in plaques, and the therapeutic promise of boosting resolution pathways for cardiovascular disease. Guest Bio: Dr. Gabrielle Fredman, PhD, is a Professor in theDepartment of Molecular and Cellular Physiology at Albany Medical College in Albany, New York, where she leads the Fredman Lab. Dr Fredman's research focuses on themechanisms of inflammation resolution in atherosclerosis, vascular inflammation, aging, and plaque stability. She is particularly known for her work on how She is particularly known for her work on how Specialized Pro-Resolving Mediators (SPMs) such as resolvins regulate macrophage function, efferocytosis, and the transition from chronic inflammation to tissue repair in the cardiovascular system. Dr. Fredman has collaborated with SPM pioneers like Dr. Charles Serhan and has received NIH funding for her groundbreaking studies on resolution pharmacology in heart disease. Resources Mentioned: Key Papers: An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques. Nature Communications, 2016 https://www.nature.com/articles/ncomms12859 Boosting inflammation resolution in atherosclerosis: the next frontier for therapy. The American Journal of Pathology, 2017 https://pmc.ncbi.nlm.nih.gov/articles/PMC5455064/ Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease. Nature Reviews Cardiology (with Charles Serhan), 2024 https://pmc.ncbi.nlm.nih.gov/articles/PMC12863063/ Resolvin D1 Enhances Necroptotic Cell Clearance and Promotes Plaque Stability Arteriosclerosis, Thrombosis, and Vascular Biology, 2021 https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.315758 Additional: Metagenics Institute Interview: The Role of Specialized Pro-Resolving Mediators in Atherosclerosis https://www.metagenicsinstitute.com/video/ spms-in-atherosclerosis/ Fredman Profile at Albany Medical College https://www.amc.edu/researcher/gabrielle- fredman-phd/ Lab at Albany Medical College https://fredmanlab.com/

    Episode 7 Dr. Gabrielle Fredman "Resolution biology in the Vascular System:SPMs, Atherosclerosis, Plaque Stability & Cardiovascular Health"

  8. Jul 9

    Episode 6 Dr. Valerio Chiurchiù "Resolution Biology Meets the Brain: SPMs in Neuroinflammation, Multiple Sclerosis & Neurodegenerative Diseases"

    Episode 6 Dr. Valerio Chiurchiù "Resolution Biology Meets the Brain: SPMs in Neuroinflammation, Multiple Sclerosis & Neurodegenerative Diseases" Welcome to the SPM Podcast, the podcast about Specialized Pro-Resolving Mediators. Subscribe, leave a comment, and share this episode with anyone interested in brain health, neuroinflammation, and cutting-edge resolution science. Episode Summary: In this enlightening episode, we welcome Dr. Valerio Chiurchiù, a leading expert in the resolution of neuroinflammation and the role of Specialized Pro-Resolving Mediators (SPMs) in brain health. Guest Bio: Dr Valerio Chiurchiù, PhD, is the Head of the Laboratory of Neuroinflammation and Resolution at the Institute of Translational Pharmacology (CNR) and the European Center for Brain Research at IRCCS Santa Lucia Foundation in Rome, Italy. He is also an Adjunct Professor at Università Campus Bio-Medico di Roma. With over 18 years of research experience, Dr. Chiurchiù has pioneered work on the immunomodulatory functions of bioactive lipids, including endocannabinoids and Specialized Pro-Resolving Mediators (SPMs). His research focuses on how SPMs (such as resolvins, lipoxins, and maresins) regulate innate and adaptive immunity in the brain, with particular emphasis on neuroinflammatory and neurodegenerative diseases. Resources Mentioned: Video's: Oslo resolution conference presentations https://www.mn.uio.no/farmasi/english/research/news-and-events/events/conferences/inflammation-resolution-2026/Recordings%20of%20scientific%20presentations/ Key Papers: SPM's: Specialized Pro-resolving Lipid Mediators and Glial Cells: Emerging Candidates for Brain Homeostasis and Repair Frontiers in Cellular Neuroscience, 2021 https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.673549/full Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation Cell Reports, 2021 https://www.sciencedirect.com/science/article/pii/S2211124721005507 Multiple Sclerosis: Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction Haematologica, 2020 https://haematologica.org/article/view/9980 Parkinson disease: Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease Nature Communications, 2019 https://www.nature.com/articles/s41467-019-11928-w Alzheimer and Parkinson’s disease: Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We? International Journal of Molecular Sciences, 2022 https://www.mdpi.com/1422-0067/23/11/6235 IRCCS Santa Lucia Foundation – Dr. Valerio Chiurchiù Lab https://www.hsantalucia.it/cv/valerio-chiurchi%C3%B9

    Episode 6 Dr. Valerio Chiurchiù "Resolution Biology Meets the Brain: SPMs in Neuroinflammation, Multiple Sclerosis & Neurodegenerative Diseases"
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Ratings & Reviews

5
out of 5
3 Ratings

About

the SPM podcast is the podcast about Specialized Pro-Resolving Mediators. In this podcast we interview Scientists and Practicioners that work in the SPM field. Subscribe, leave a comment, and share this episode with anyone passionate about cutting-edge science and better health outcomes. Join us next time as we continue exploring the frontiers of human resolution biology.

Information

  • Creator
    Herbert Aberson
  • Years Active
    2026
  • Episodes
    13
  • Rating
    Clean
  • Copyright
    © Herbert Aberson
  • Show Website
    the SPM podcast