AudioScholar Neurology Weekly

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Neurology — a weekly podcast briefing of the most significant peer-reviewed neurology literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

  1. 5d ago

    Thrombectomy at 24-72 h improves function, raises bleeding

    Editor's Pick: Mechanical Thrombectomy 24 to 72 Hours after Large-Vessel Ischemic Stroke (New England Journal of Medicine, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Neurology. This week we're covering 10 notable papers spanning the expanding boundaries of acute stroke treatment and anticoagulation, the benefits and hidden costs of immune therapies in multiple sclerosis and autoimmune ence… This week's papers: 1. Mechanical Thrombectomy 24 to 72 Hours after Large-Vessel Ischemic Stroke. — New England Journal of Medicine 2026 2. Trial of Endovascular Therapy for Mild Stroke with Large-Vessel Occlusion. — New England Journal of Medicine 2026 3. Dual Versus Mono Antiplatelet Therapy in Mild Versus Moderate Ischemic Stroke: A Post Hoc Analysis of the ATAMIS Randomized Trial. — Stroke 2026 4. Anticoagulation in Atrial Fibrillation With Previous Intracranial Bleeding: Competing Adverse Events in a Nationwide Cohort. — Neurology 2026 5. Comparison of DOAC Versus VKA for Cerebral Venous Thrombosis: A Systematic Review and Meta-Analysis. — Stroke 2026 6. Remibrutinib versus teriflunomide in relapsing multiple sclerosis (REMODEL-1 and REMODEL-2): two randomised, phase 3 trials. — The Lancet 2026 7. Risk of Inflammatory Bowel Disease After Anti-CD20 Treatment in Multiple Sclerosis. — JAMA Neurology 2026 8. Short-term outcomes, longer-term disability and relapse risk in LGI1-antibody encephalitis. — Brain 2026 9. Internet Intervention for Functional Seizures: A Randomized Clinical Trial. — JAMA Neurology 2026 10. Global best practice recommendations for genetic counselling and testing in amyotrophic lateral sclerosis. — Brain 2026 Listen at https://audioscholar.cc/episode/u4cdysba45

  2. Oct 22

    DOACs noninferior to warfarin for cerebral venous thrombosis

    Editor's Pick: Initial Direct Oral Anticoagulants Versus Warfarin After Cerebral Venous Thrombosis: A Target Trial Emulation (Stroke, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Neurology. This week we're covering 10 notable papers spanning cerebrovascular treatment and prognosis, the vascular roots of other neurological disease, and the biomarkers and real-world realities shaping how we use our thera… This week's papers: 1. Initial Direct Oral Anticoagulants Versus Warfarin After Cerebral Venous Thrombosis: A Target Trial Emulation. — Stroke 2026 2. Recanalization After Acute Cervical Artery Dissection: A Multicenter International Study. — Neurology 2026 3. Intracerebral Hemorrhage Expansion in Late Presenters: Proposed Target Expansion Criteria. — Neurology 2026 4. Vascular Risk Factors and Late-Onset Epilepsy. — JAMA Neurology 2026 5. A Primer on COL4A1/COL4A2-Related Cerebral Small Vessel Disease for Neurologists. — Neurology 2026 6. Lymphocytosis as a biomarker for natalizumab treatment response in multiple sclerosis: The link with anti-drug antibodies. — Multiple Sclerosis Journal 2026 7. Predictors of Antiamyloid Medication Utilization and Adherence Among People With Alzheimer Disease and Mild Cognitive Impairment. — Neurology 2026 8. Automated Magnetic Resonance Volumetry to Measure Multiple System Atrophy Disease Progression in Clinical Trials. — Movement Disorders 2026 9. Association Between Systemic Fluoroquinolones and Risk of Peripheral Neuropathy. — Neurology 2026 10. Recommendations for the Management of Spontaneous Intracranial Hypotension With Spinal Longitudinal Epidural CSF Collection: A Delphi Study. — Neurology 2026 Listen at https://audioscholar.cc/episode/3z7arrrvyu

  3. Oct 15

    This Week in Neurology — Oct 14, 2026

    Editor's Pick: Effects of Blood Pressure Lowering by Hematoma Location in Acute Intracerebral Hemorrhage (Neurology, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Neurology. This week we're covering 10 notable papers spanning acute cerebrovascular care and small vessel disease, therapeutic trials and medication safety across movement, neuromuscular, headache and epilepsy practice, and t… This week's papers: 1. Thrombolysis in the Delayed Treatment Window for Acute Ischemic Stroke: Updated Systematic Review and Meta-Analysis. — Stroke 2026 2. Cerebral No-Reflow after Thrombectomy: International Delphi Consensus on Definition and Imaging Assessment. — Annals of Neurology 2026 3. Effects of Blood Pressure Lowering by Hematoma Location in Acute Intracerebral Hemorrhage. — Neurology 2026 4. Centrum Semiovale Perivascular Spaces Predict First Hemorrhagic Lesion in Asymptomatic Amyloid-Positive Individuals. — Annals of Neurology 2026 5. Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease: The NOPARK Randomized Clinical Trial. — JAMA 2026 6. Safety and efficacy of delpacibart zotadirsen in Duchenne muscular dystrophy mutations amenable to exon 44 skipping in the USA (EXPLORE44): a randomised, place… — The Lancet Neurology 2026 7. Early Pregnancy Use of Anti-CGRP Monoclonal Antibodies and Propranolol and Spontaneous Abortion Risk. — JAMA Neurology 2026 8. Prognosis of acute symptomatic seizures and impact of prolonged treatment with anti-seizure medication. — Epilepsia 2026 9. Antibody-mediated encephalitides: distinct diseases with transdisciplinary implications. — The Lancet Neurology 2026 10. Degenerative cervical myelopathy: early detection and the potential for preventing disability. — The Lancet Neurology 2026 Listen at https://audioscholar.cc/episode/2j6jms6hhd

  4. Oct 8

    Early p-tau217/NfL results lift certainty, no emotional harm

    Editor's Pick: Earlier Disclosure of Blood-Based Biomarkers, Diagnostic Certainty, and Clinical Management: A Randomized Clinical Trial (JAMA Neurology, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Neurology. This week we're covering 10 notable papers spanning long-term and comparative immunotherapy in demyelinating disease, blood biomarkers for Alzheimer disease, and the timing and technology of deep brain stimulation,… This week's papers: 1. Ten Years of Ocrelizumab in Relapsing Multiple Sclerosis: The OPERA I and II Randomized Clinical Trials. — JAMA Neurology 2026 2. Ofatumumab vs Ocrelizumab in Relapsing-Remitting Multiple Sclerosis: A Nationwide Cohort Study. — Neurology 2026 3. Comparative Effectiveness of Treatments for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. — Neurology 2026 4. Earlier Disclosure of Blood-Based Biomarkers, Diagnostic Certainty, and Clinical Management: A Randomized Clinical Trial. — JAMA Neurology 2026 5. Clinical Factors Associated With Discordant Plasma P-Tau217 and Established Alzheimer Disease Biomarkers. — Neurology 2026 6. Timing of Deep Brain Stimulation and Cognitive Trajectories in GBA1-Associated Parkinson's Disease. — Movement Disorders 2026 7. Directional Adaptive Deep Brain Stimulation: An Initial Report of Safety, Tolerability, and Effectiveness. — Movement Disorders 2026 8. Dual Antiglutamate Therapy in Super-Refractory Status Epilepticus After Cardiac Arrest (SUPER-CAT Study). — Neurology 2026 9. Rapid Whole-Genome Sequencing in Pediatric Neurology Inpatients. — JAMA Neurology 2026 10. Updated Meta-Analysis of Left Atrial Appendage Closure Versus Oral Anticoagulation to Prevent Stroke in Atrial Fibrillation. — Stroke 2026 Listen at https://audioscholar.cc/episode/fsvqcwjwj9

  5. Oct 1

    Hearing aids in MCI: no fewer conversions to dementia

    Editor's Pick: Hearing Intervention for Older Adults With Mild Cognitive Impairment: The CHOICE Randomized Clinical Trial (JAMA Neurology, 2026) This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Neurology. This week we're covering 10 notable papers spanning imaging biomarkers in demyelinating disease, precision diagnosis through genetics and seeding assays, and prevention, prognosis and trial design in cognitive and c… This week's papers: 1. Use of MRI in neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease - MAGNIMS consensus recommendations. — Nature Reviews Neurology 2026 2. MRI Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: A Review. — JAMA Neurology 2026 3. Disentangling Age-Related and Disease-Specific Effects on Upper Cervical Cord Area in Patients With Multiple Sclerosis. — Neurology 2026 4. How should etiology change the classification of the epilepsies? Report from the ILAE 2021-2025 Terminology Commission. — Epilepsia 2026 5. α-Synuclein Seeding Discriminates Between LRRK2 G2019S Variant Carriers with and Without Parkinson's Disease. — Movement Disorders 2026 6. Structural Brain and Spinal Cord Signature of Spinocerebellar Ataxia 27B: A Multisite MRI-Based Study. — Movement Disorders 2026 7. Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability. — Annals of Neurology 2026 8. Hearing Intervention for Older Adults With Mild Cognitive Impairment: The CHOICE Randomized Clinical Trial. — JAMA Neurology 2026 9. Disease Progression in Iatrogenic Cerebral Amyloid Angiopathy. — Neurology 2026 10. Prehospital Stroke Treatment Trials in Conventional EMS Settings: An Expert Consensus Statement on Operational, Ethical, and Technological Priorities. — Stroke 2026 Listen at https://audioscholar.cc/episode/5avvfh34pa

  6. Sep 24

    This Week in Neurology — Sep 23, 2026

    Editor's Pick: Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion: The ATTENTION LATE Randomized Clinical Trial (JAMA, 2026) Welcome to This Week in Neurology. This week we're covering 10 notable papers spanning acute stroke reperfusion and imaging, the long-term cognitive and epidemiologic fallout of cerebrovascular disease, and a cluster of papers on epilepsy, neuroimmun… This week's papers: 1. Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion: The ATTENTION LATE Randomized Clinical Trial. — JAMA 2026 2. Long-Term Risk of Dementia After TIA: A Population-Wide Matched Cohort Study. — Neurology 2026 3. Mechanical Thrombectomy Versus Medical Management for Large Ischemic Core Stroke Identified before Inter-Hospital Transfer: A Post Hoc Analysis of the LASTE Tr… — Annals of Neurology 2026 4. Diagnostic Yield and Therapeutic Impact of Etiologic Investigations After Status Epilepticus: Insights From the ICTAL Registry. — Neurology 2026 5. Diagnostic Utility of Novel and Established Spinal MRI Signs in AQP4-IgG-Seropositive NMOSD Myelitis. — Neurology 2026 6. When to Use the HINTS Examination in Patients With Dizziness: A Review. — JAMA Neurology 2026 7. Stroke in the Young: Incidence, 30-Day Case Fatality Rates, and Risk Factors Over Time in a Population-Based Study. — Neurology 2026 8. Sensitivity of Non-contrast Computed Tomography Net Water Uptake Versus FLAIR-MRI, with MR-DWI Reference Standard, for Early Detection and Physiological Charac… — Annals of Neurology 2026 9. Ursodeoxycholic Acid and Parkinson's Disease Risk: An Emulated Target Trial in UK Electronic Health Records. — Movement Disorders 2026 10. Predicting levetiracetam neuropsychiatric adverse effects using graph-theoretical electroencephalographic network metrics in drug-naive focal epilepsy: A multi… — Epilepsia 2026 Listen at https://audioscholar.cc/episode/62rk4m4qt4

  7. Sep 17

    Factor XIa inhibitors cut recurrent stroke, no bleeding rise

    Editor's Pick: Factor XIa Inhibitors for Secondary Prevention After Noncardioembolic Stroke: A Systematic Review and Meta-Analysis (Neurology, 2026) Welcome to This Week in Neurology. This week we're covering 10 notable papers spanning secondary stroke prevention and the limits of revascularization, the diagnosis and outcomes of treatable cognitive syndromes, and a cluster of trials and cohorts i… This week's papers: 1. Factor XIa Inhibitors for Secondary Prevention After Noncardioembolic Stroke: A Systematic Review and Meta-Analysis. — Neurology 2026 2. Revascularization in Asymptomatic Carotid Artery Stenosis With Hemodynamic Impairment and Cognitive Outcomes: The CREST-H Substudy of the CREST-2 Randomized Cl… — JAMA 2026 3. Idiopathic Normal Pressure Hydrocephalus: A Review. — JAMA 2026 4. Clinical Characteristics, Neuroimaging Findings, and Mortality in Korsakoff Syndrome. — JAMA Neurology 2026 5. VENI, VIDI, VICI: The advantage of early epilepsy surgery in drug-sensitive patients. — Epilepsia 2026 6. Statin use and risk of remote seizure after first new onset status epilepticus. — Epilepsia 2026 7. Longitudinal EEG, Seizure, and Developmental Patterns in Children With CDKL5 Deficiency Disorder in the First 2 Years of Life. — Neurology 2026 8. Intravenous Immunoglobulin Add-On in Newly Diagnosed Idiopathic Inflammatory Myopathies: A Randomized Clinical Trial. — JAMA Neurology 2026 9. Efficacy and Safety of DL-3-n-Butylphthalide in Spinocerebellar Ataxia Type 3. — Movement Disorders 2026 10. The diagnostic biomarker problem in amyotrophic lateral sclerosis. — Brain 2026 Listen at https://audioscholar.cc/episode/ckfjzkmw32

  8. Sep 10

    Plasma p-tau 217 predicts impairment sooner with APOE-ε4

    Editor's Pick: Plasma phosphorylated tau 217 concentrations, APOE genotype, and timing of cognitive impairment in individuals across diverse racial and ethnic groups: a pooled analysis of prospective cohort studies (The Lancet Neurology, 2026) Welcome to This Week in Neurology. This week we're covering 10 notable papers spanning the biomarker-driven remaking of Alzheimer's disease care, two negative or null trials that clear the decks in amyotrophic lateral sclerosis and in seizure rescue,… This week's papers: 1. Safety, tolerability, and efficacy of RIPK1 inhibitor, SAR443820, in amyotrophic lateral sclerosis (HIMALAYA): a multicentre, randomised, double-blind, placebo… — The Lancet Neurology 2026 2. Non-contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor-Associated Intracerebral Hemorrhage: An Analysis from ANNEXa-I Tria… — Annals of Neurology 2026 3. Plasma phosphorylated tau 217 concentrations, APOE genotype, and timing of cognitive impairment in individuals across diverse racial and ethnic groups: a poole… — The Lancet Neurology 2026 4. Fluid biomarkers in the evolving care landscape of Alzheimer's disease and related disorders. — The Lancet Neurology 2026 5. Clinical pathways for cognitively unimpaired individuals with Alzheimer's disease neuropathological change. — The Lancet Neurology 2026 6. Neuroimaging in the era of biologically defined Alzheimer's disease and disease-modifying therapy. — The Lancet Neurology 2026 7. Salovum® reduces mortality in isolated severe traumatic brain injury: a randomized phase II trial. — Brain 2026 8. Intranasal midazolam vs mouth-dissolving clobazam in terminating seizures: A randomized controlled trial. — Epilepsia 2026 9. Common MC1R Variants and Parkinson Disease Progression. — JAMA Neurology 2026 10. Levodopa Use and Characteristics of Freezing-of-Gait in Patients With Parkinson Disease in the NS-Park and PPMI Cohorts. — Neurology 2026 Listen at https://audioscholar.cc/episode/4ey2mx2s9g

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Neurology — a weekly podcast briefing of the most significant peer-reviewed neurology literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

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