AudioScholar Pathology Weekly

AudioScholar

Pathology — a weekly podcast briefing of the most significant peer-reviewed pathology literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.

  1. 3d ago

    This Week in Pathology — Oct 3, 2026

    This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning predictive biomarker scori… This week's papers: 1. Claudin 18.2 Immunohistochemistry in Gastroesophageal Adenocarcinomas: A Study of Interobserver Variability Among Gastrointestinal Pathologists. — Human Pathology 2026 2. Spatial and Interlesional Heterogeneity of FGFR2b Expression in Paired Primary and Metastatic Gastric and Gastroesophageal Junction Adenocarcinomas. — Human Pathology 2026 3. Tumour deposits are associated with increased metastatic risk in colorectal cancer: a population-based analysis of metastatic patterns and burden. — Histopathology 2026 4. Does Positive Margin in Secondary Tumors at Radical Prostatectomy Predict Biochemical Recurrence in Multifocal Prostate Cancer? — The American Journal of Surgical Pathology 2026 5. Histologic Features and Clinical Outcomes of Lean Metabolic Dysfunction-Associated Steatotic Liver Disease. — JAMA 2026 6. Expanding the clinicopathological spectrum of BAP1 mutated ccRCC: a study of 84 cases in multi-center cohort. — Human Pathology 2026 7. Immunohistochemical profile of molecularly verified clear cell renal cell carcinomas. — Histopathology 2026 8. Clinicopathologic, immunohistochemical, and molecular correlates in resected primary adrenocortical carcinoma: a single-institution cohort study. — Virchows Archiv 2026 9. Mixed neuroendocrine-non-neuroendocrine neoplasms, amphicrine-like carcinoma and related lesions: a review of changes in classification and current concepts. — Histopathology 2026 10. Papillary Endothelial Hyperplasia in Late Post-Radiation or Late Post-Operative Breast Hematomas Mimicking Angiosarcoma. — Human Pathology 2026 Listen at https://audioscholar.cc/episode/2qxk9gduft

  2. Sep 26

    This Week in Pathology — Sep 26, 2026

    This AudioScholar briefing is generated by artificial intelligence for healthcare professionals and trainees. It is not medical advice. Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning reproducibility and gradin… This week's papers: 1. Inter-rater reliability of frozen donor liver macrovesicular steatosis assessment applying the Banff consensus method: a real-world, multi-specialty validation… — Histopathology 2026 2. A modified CAP-based grading system incorporating non-tubular components for prognostic stratification in pancreatic ductal adenocarcinoma. — Virchows Archiv 2026 3. Immunohistochemical expression of p53 is a helpful surrogate marker in the differential diagnosis of primary ovarian mucinous tumors: a large study of 181 case… — Virchows Archiv 2026 4. Western versus Asian utilization of molecular testing for indeterminate thyroid nodules: A meta-analysis of divergent clinical impact. — Cancer Cytopathology 2026 5. Artificial intelligence-assisted digital thyroid FNA cytology: Improved agreement and sensitivity for higher-risk Bethesda categories with enhanced screening e… — Cancer Cytopathology 2026 6. Immunohistochemistry Resolves Indeterminate MTAP Deletion Calls from Exome Sequencing: A Pan-Cancer Concordance Study. — Modern Pathology 2026 7. Immunoglobulin Light Chain mRNA In Situ Hybridization Refines Classification Across the NLPHL-cHL Spectrum. — Modern Pathology 2026 8. In-frame variants in TP53 gene identified in adult leukemia samples are predominantly deleterious: a study of the TP53 Network of Education and Research Initia… — The Journal of Pathology 2026 9. Heterogeneity of breast and nodal response to neoadjuvant pembrolizumab-based chemoimmunotherapy in early triple-negative breast cancer and its clinical signif… — Histopathology 2026 10. RAS/RAF/MAPK alterations in prostatic adenocarcinoma: A multi-institutional study. — Human Pathology 2026 Listen at https://audioscholar.cc/episode/grnc2bvj94

  3. Sep 19

    This Week in Pathology — Sep 19, 2026

    Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning three broad themes: the unglamorous but decisive questions of which stain and which block we choose, transcription-factor and copy-number subtyping of aggressive t… This week's papers: 1. Orcein is a more sensitive stain than EVG for detecting large vessel (venous) invasion in colorectal cancer. — Histopathology 2026 2. Ki67 proliferation indices in advanced jejunoileal well-differentiated neuroendocrine tumours are most prognostic when evaluated in mesenteric tumour deposits. — Histopathology 2026 3. Clinicopathologic Spectrum and Intraprostatic Heterogeneity of Primary Mismatch Repair-Deficient Prostate Cancer. — The American Journal of Surgical Pathology 2026 4. Immunohistochemical stratification of bladder small cell carcinoma reveals two major phenotypes with distinct therapeutic biomarker profiles. — Histopathology 2026 5. Molecular Subtyping of Biliary Tract Neuroendocrine Carcinomas: Clinicopathological Features and Prognostic Implications. — The American Journal of Surgical Pathology 2026 6. Acute Myeloid Leukemia With KMT2A Amplification: A TP53-Alteration-Enriched Subgroup Associated With Chromoanagenesis and Poor Prognosis. — Modern Pathology 2026 7. sWGS Identifies a Copy-Number-High Subset of TP53-mutated Multiple-Classifier Endometrial Carcinomas With Adverse Clinicopathological Features. — Modern Pathology 2026 8. Hepatocellular Carcinoma With JAK1 Mutations Harbors Distinct Histologic Features and Specific Mutational Hotspots in an Asian Cohort. — The American Journal of Surgical Pathology 2026 9. Clinicopathological and Molecular Insights into ERBB2-altered S100/SOX10-positive Uterine Sarcoma: A Report of 6 Cases. — Modern Pathology 2026 10. Germline Cancer Predisposition Gene Mutations and Upgrade Rate to Breast Cancer Among Patients with Pleomorphic and Florid Lobular Carcinoma in Situ. — Human Pathology 2026 Listen at https://audioscholar.cc/episode/5wmf94fykw

  4. Sep 12

    This Week in Pathology — Sep 12, 2026

    Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning classification and molecular taxonomy, new immunohistochemical markers that solve everyday diagnostic problems, and the recurring challenge of cutaneous and soft t… This week's papers: 1. Gastric carcinoma classification in the WHO 6th edition (2026): Updated framework and emerging entities. — Virchows Archiv 2026 2. Methylation profiling in CNS tumor diagnostics: a single-centre real-world experience from Central Europe. — Virchows Archiv 2026 3. An Agreement Study of Stromal Cellularity, Stromal Cell Atypia, and Tumor Border of Phyllodes Tumors of the Breast. — Modern Pathology 2026 4. Sarcomatoid malignancies with strong PD-L1 expression often represent dedifferentiated or undifferentiated melanomas. — Human Pathology 2026 5. FOG1: A Highly Sensitive and Specific Diagnostic Marker for Gastroesophageal Adenocarcinoma. — The American Journal of Surgical Pathology 2026 6. Cribriform tumors of the skin: CD38 expression distinguishes from histologic mimics in a multi-institutional series. — Virchows Archiv 2026 7. C-Cell Lesions and Medullary Thyroid Carcinoma: A Review. — Modern Pathology 2026 8. Uterine Sarcomas With KDM2B Fusion: Clinicopathological Analysis of Three Cases Supporting a Novel BCOR-Altered Entity. — The American Journal of Surgical Pathology 2026 9. Primary Cutaneous Apocrine Carcinoma: Clinicopathologic, Immunohistochemical, and Molecular Characterization of Twenty-Seven Cases. — Modern Pathology 2026 10. Histopathologic, Genomic, and Clinical Characteristics of Primary Cutaneous Melanocytic Tumors With Concomitant NRAS Q61 and IDH1 R132C Mutations. — Modern Pathology 2026 Listen at https://audioscholar.cc/episode/ubw7m4shx8

  5. Sep 5

    This Week in Pathology — Sep 5, 2026

    Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning three broad themes: artificial intelligence and quantification in the laboratory, consensus and standardization efforts that shape how we report, and the molecular… This week's papers: 1. International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cance… — The American Journal of Surgical Pathology 2026 2. Guidance for laboratory implementation, governance and continuous assurance of artificial intelligence in histopathology. — Virchows Archiv 2026 3. Inflammatory bowel disease-associated colorectal dysplasia: the expanding morphologic landscape and diagnostic challenges. — Virchows Archiv 2026 4. Preanalytical variables in surgical pathology: practical sources of diagnostic error before microscopic interpretation. — American Journal of Clinical Pathology 2026 5. Visual steatosis assessment: method-dependent variation and systematically higher estimates compared with AI measurement. — Histopathology 2026 6. Punctate nuclear low-risk HPV chromogenic in situ hybridization in digital papillary adenocarcinoma: a practical tool for identifying HPV42 in routine patholog… — Histopathology 2026 7. Folate Receptor Alpha Expression Across the Spectrum of Serous Tubal Lesions: An Adjunct Biomarker for Distinguishing Serous Tubal Intraepithelial Carcinoma Fr… — The American Journal of Surgical Pathology 2026 8. Deep learning in breast cancer histopathology: predicting and detecting axillary lymph node metastasis. — Virchows Archiv 2026 9. Expanding the Morphologic, Clinical, and Molecular Spectrum of Succinate Dehydrogenase A (SDHA)-Deficient Renal Cell Carcinoma: A Case Series With Review of Li… — The American Journal of Surgical Pathology 2026 10. Aggressive high-grade papillary-patterned renal cell carcinomas harboring FLCN mutations: expanding the clinicopathological spectrum in Birt-Hogg-Dubé syndrome… — Virchows Archiv 2026 Listen at https://audioscholar.cc/episode/28mnr2n7xw

  6. Aug 30

    This Week in Pathology — Aug 30, 2026

    Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning molecular biomarker interpretation and its reproducibility, classification updates in soft tissue, skin and gastrointestinal pathology, and the recurring theme of… This week's papers: 1. Liquid biopsy in solid tumours: expert opinion paper of the European society of pathology — Virchows Archiv 2026 2. Cutaneous lymphomas - an update — Histopathology 2026 3. Morphologic correlates of genetic subtypes of acute myeloid leukemia — Human Pathology 2026 4. Diagnostic reproducibility, spatial heterogeneity, and survival outcomes of HER2-Null, HER2-Ultralow, and HER2-Low categories in invasive breast carcinoma — Virchows Archiv 2026 5. Tumours of the duodenum and the ampulla of Vater: An overview of the key criteria for their classification, pathogenesis, and molecular assessment — Virchows Archiv 2026 6. Toward Improved Classification of Vulvar Smooth Muscle Tumors: A Clinicopathologic Study of 35 Cases — The American Journal of Surgical Pathology 2026 7. Diversion-Associated Rectal Pathology in Patients With and Without Inflammatory Bowel Disease: A Rectum-Exclusive, Blinded Histologic Comparison and Practical… — The American Journal of Surgical Pathology 2026 8. HER2 Intratumoral Heterogeneity in Salivary Duct Carcinoma: Association With Treatment Response and Comparison Between Primary and Metastatic Lesions — Modern Pathology 2026 9. Bile Duct-Narrowing Neuroendocrine Tumors Show a PDX1+/CDX2+ Phenotype Resembling Duodenal Rather Than Pancreatic Neuroendocrine Tumors — Modern Pathology 2026 10. Comparison of Albumin In-Situ Hybridization in Genetically Characterized Cholangiocarcinoma and Tumors of Other Origins — Modern Pathology 2026 Listen at https://audioscholar.cc/episode/agcsv7gpqb

  7. Aug 23

    This Week in Pathology — Aug 23, 2026

    Welcome to This Week in Pathology. This week we're covering ten notable papers spanning predictive biomarker testing in gastrointestinal and gynaecological cancers, the diagnostic pitfalls of immunohistochemistry when a single stain is asked to do to… This week's papers: 1. Pancreatic ductal adenocarcinoma and its subtypes: clinical relevance of histopathology and molecular characterization, integrating the key updates of the 2026… — Virchows Archiv 2026 2. Comprehensive Profiling of Claudin 18.2 Immunohistochemical Expression in 564 Surgically Resected Gastric and Gastroesophageal Junction Adenocarcinomas — Modern Pathology 2026 3. Pathologist-Recommended Molecular Testing in Endometrial Cancer: A Single-Institution Experience — Human Pathology 2026 4. Thyroid nodules of uncertain malignant potential non-conforming to World Health Organization diagnostic criteria - clinicopathologic and molecular characteriza… — Human Pathology 2026 5. Nondiffuse p16 Expression in HPV-Associated and HPV-Independent Cervical Squamous Cell Carcinomas — The American Journal of Surgical Pathology 2026 6. Inflammatory and Nested Testicular Sex Cord Tumor: Clinicopathologic and Molecular Features — Modern Pathology 2026 7. SMARCA4-deficient undifferentiated malignancies in the digestive system: clinicopathological features and prognostic significance with genomic insights from th… — The Journal of Pathology 2026 8. SRF fusion genes in myoid soft tissue tumors — The Journal of Pathology 2026 9. Assessment of isochromosome 12p supports that pagetoid involvement of the rete testis represents spread of germ cell neoplasia in-situ — Human Pathology 2026 10. Pattern-based interpretation of SOX2 expression in ovarian teratomas: avoiding diagnostic pitfalls in the distinction between immature and mature neuroectoderm… — Histopathology 2026 Listen at https://audioscholar.cc/episode/2thxxsntgs

  8. Aug 16

    This Week in Pathology — Aug 16, 2026

    Welcome to This Week in Pathology. This week we're covering 10 notable papers spanning smarter test-triage strategies that replace expensive downstream assays, the persistent problem of interobserver variability and what artificial intelligence is ac… This week's papers: 1. Real-World Experience With TRBC1 Immunohistochemistry Across Cutaneous T-Cell Lymphoma Subtypes: A Large Cohort Study — Modern Pathology 2026 2. Duct Quest: An International Survey of Genitourinary and Community Pathologists Reveals Diagnostic Uncertainties in Separating Atypical Intraductal Proliferati… — Human Pathology 2026 3. Additional sectioning and AI-assisted diagnosis reveal underdiagnosis of serous (pre)malignancies in fallopian tube specimen from BRCA1/2 carriers — Histopathology 2026 4. HER2 status in extrahepatic cholangiocarcinoma and gallbladder carcinoma: concordance between immunohistochemistry and chromogenic in situ hybridization in 140… — Human Pathology 2026 5. Leveraging large language models to enhance cytopathology: Opportunities, challenges, and future directions; a practical review from the ASC Clinical Practice… — Cancer Cytopathology 2026 6. Experience of the United States-Canadian Mesothelioma Reference Panel 1985-2026: Historical Review and New Developments in Mesothelial Pathology — Archives of Pathology & Laboratory Medicine 2026 7. Panel of Methylation-based PCRs for Separating Mucinous Lung Adenocarcinomas from Gastrointestinal Metastases Involving the Lung — Modern Pathology 2026 8. Intratumoral IDH1 mutation status in intrahepatic cholangiocarcinoma is homogeneous — Histopathology 2026 9. Comprehensive and reproducible grading of the Updated Sydney System in gastric biopsies using artificial intelligence: multi-pathologist validation and a reade… — Histopathology 2026 10. Streamlining Urinary Tract Infection Evaluation in a Large Pediatric Hospital System: Feasibility of Reflex Urine Culture After Urinalysis With Microscopy — Archives of Pathology & Laboratory Medicine 2026 Listen at https://audioscholar.cc/episode/quzfrq6zh3

About

Pathology — a weekly podcast briefing of the most significant peer-reviewed pathology literature, synthesized from PubMed and delivered as ~10-minute audio. For practicing physicians. Generated by AudioScholar at audioscholar.cc.