Hope Heals w/ Tanvi

Tanvi Mannemala

There's light even during the darkest times. This platform shares stories of those within the cancer community to instill hope and generate a feeling of support within times that feel otherwise. Listen to learn more about different cancer awareness efforts and stories of some of the strongest people, whose stories deserve to be heard. Hosted by Tanvi Mannemala

Episodes

  1. Sep 7

    What I Learned Researching AML Relapse | Hope Heals

    What does it actually look like to do cancer research as a high school student? In this episode of Hope Heals, I share my experience completing my first independent research project through the UCLA Emerging Scientist Program. I explored whether clinical and genomic information collected at diagnosis could be used to predict relapse in acute myeloid leukemia (AML) using machine learning. I explain what AML is, why relapse is so difficult to predict, how I used publicly available TCGA data, the machine-learning models I tested, and what I discovered from my results. I also discuss one of the biggest questions my research raised: could measurable residual disease (MRD) and information collected throughout treatment improve relapse prediction? Most importantly, I share what this project taught me about research—and why sometimes, the most valuable result isn't an answer, but a better question. Here are some resources that guided me during my research, and also for you to learn more: Dataset: https://www.cbioportal.org/study/clinicalData?id=laml_tcga_pub https://www.mdpi.com/2073-4409/15/4/338 https://www.mdpi.com/2072-6694/15/13/3512 https://pmc.ncbi.nlm.nih.gov/articles/PMC11286513/ https://onlinelibrary.wiley.com/doi/10.1002/ajh.27625 https://www.catallyst.com/understanding-mrd/ https://www.sciencedirect.com/science/article/abs/pii/S0268960X25000852?via%3Dihub https://www.insideprecisionmedicine.com/news-and-features/persistent-mutations-throughout-remission-linked-with-poor-survival-in-leukemia/ https://ashpublications.org/blood/article/140/12/1345/485817/Diagnosis-and-management-of-AML-in-adults-2022 https://www.nejm.org/doi/full/10.1056/NEJMoa1516192 https://www.nejm.org/doi/full/10.1056/NEJMoa1301689

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There's light even during the darkest times. This platform shares stories of those within the cancer community to instill hope and generate a feeling of support within times that feel otherwise. Listen to learn more about different cancer awareness efforts and stories of some of the strongest people, whose stories deserve to be heard. Hosted by Tanvi Mannemala