Runtime by UpWest

Gil Ben-Artzy and Shuly Galili

Runtime is where the people building the future of technology share what really happens behind the scenes. ⠀ Hosted by Gil Ben-Artzy and Shuly Galili, founding partners at Silicon Valley venture firm UpWest, it brings founders, operators, and investors together to unpack the decisions, breakthroughs, and failures that shape technology companies and the markets around them. ⠀ For over a decade, Gil and Shuly have backed Israeli founders. On Runtime, they share what worked, what broke, and what today’s builders wish they’d known earlier. ⠀ New episodes every other Wednesday. Produced by POLDHU.

Episodes

  1. Sep 23

    Inside the Black Box: How CIOs Really Buy

    Yousuf Khan has bought enterprise software as CIO at companies including Pure Storage, Moveworks, and Qualys. He funded enterprise startups as a partner at Ridge Ventures. And now, as founder and CEO of Clario, he’s building one himself. He joins Shuly Galili on Runtime to unpack what he learned from each seat: why a CIO decides in the first five minutes whether a startup is building something of consequence, why the security team belongs in the second meeting, and why he became an early Zoom customer in 2015—even when people laughed at the idea. For years, Yousuf was, in his words, “the weirdo in the Bay Area.” Now he’s the one pitching. Clario—which he calls “the Marie Kondo of enterprise data”—raised a $6 million seed round, and Yousuf is now selling to the same CIOs he still brings together for “group therapy” dinners three times a month. A candid conversation about enterprise buying, selling, investing, and what founders often misunderstand about the CIO on the other side of the table. New episodes every other Wednesday. Produced by POLDHU. CHAPTERS 00:00 - Meet Yousuf Khan of Clario 04:17 - Why CIOs Need Group Therapy 05:17 - What AI Changed About the CIO's Job 10:03 - Build or Buy 12:56 - Buying Zoom Before Anyone Else 18:24 - The First Five Minutes 22:06 - A Rollback, and the Apology That Followed 24:46 - From Operator to Investor 34:42 - Leaving Venture to Build Clario 39:53 - Is Silicon Valley Detached?

    Inside the Black Box: How CIOs Really Buy
  2. Aug 12

    Building Before Consensus: Securing the AI Frontier

    Michael Bargury on building Zenity and securing the agentic AI frontier. Zenity just raised $125 million to secure the era of agentic AI in the enterprise. The rapid adoption of AI agents brings a new set of security challenges for organizations eager to innovate but concerned about how these new systems and AI tools might act inside the enterprise. Three years ago, Zenity co-founders Ben Kliger (CEO) and Michael Bargury (CTO) were already working with some of the largest Fortune 50 companies on securing low-code and citizen development when generative AI changed the trajectory of the industry—and the company. They made a bold decision: to follow what they were seeing with customers and refocus Zenity's mission on securing agentic AI. That decision required immense conviction in their instincts. It also came down to a moment of clarity. During a visit to Microsoft, while Microsoft was shipping its first AI agent product, Michael flew to New York and spent the day walking around Central Park with Ben—five times. By the end of the day, they had decided to leave the old product behind and build for the future they were seeing. UpWest co-led Zenity's seed round. Today, the company has more than 230 employees and protects Fortune 500 banks, hospitals, and pharmaceutical companies. In this episode of Runtime, Shuly Galili sits down with Michael to unpack how Zenity went from that pivotal reset to securing what AI agents actually do inside the enterprise. They discuss where conviction comes from, why "security of AI" is the wrong frame—and "security from AI" is the right one, how sharing a document can plant a false memory in someone's ChatGPT, why agent identity is table stakes and intent is the real problem, how enterprises can roll out new AI tools across an entire fleet in seven days, and why the security stack needs to move from build time to… runtime. New episodes every other Wednesday. Produced by POLDHU. CHAPTERS 00:00   Intro: securing AI agents in the enterprise03:26   SQL injection at 15, and the years at Microsoft06:26   Starting Zenity on the unpaved road07:39   2023: burning what they built11:10   Security from AI, not security of AI15:31   The Black Hat demo that hijacks ChatGPT17:02   What CISOs are measuring wrong20:58   How fast enterprises are actually moving27:12   The hacker community, culture, and the team36:34   Runtime, not build time40:58   Advice to founders

    Building Before Consensus: Securing the AI Frontier
  3. Jul 29

    The Outsider's Advantage: What an Engineer Saw in Cancer Care

    What happens when the obviously right idea is also the one nobody believes? Gil Ben-Artzy sits down with Lavi Kwiatkowsky, founder and CEO of Canopy, the company building enterprise AI for oncology. Canopy helps cancer centers care for patients between visits, from monitoring symptoms and flagging emergencies to fielding millions of patient calls and messages, and today works with about 10 percent of oncology patients and providers in the US. Lavi did not come from healthcare. A bad accident at 23, a missed infection, and years in and out of hospitals showed him how much of care still runs on paper and archaic software. In 2018, he founded Canopy. They talk about why investors and oncologists alike refused to believe very sick patients would engage with an app, what a satirical BMJ study about parachutes reveals about evidence and medicine, how a flagged headache gave a young patient her remission back, why a finite market means hiring deep experience instead of big sales teams, and how cutting a few years off the decade it takes new therapies to reach patients could mean thousands, maybe tens of thousands of lives. New episodes every other Wednesday. Produced by POLDHU. 00:00 Intro: Canopy and enterprise AI for oncology02:38 The accident that started everything07:07 Meeting the US market10:26 The truth no one believed about cancer care12:58 The parachute problem16:15 The first customer and the patient who got more time22:01 Adopting AI without going zero to hero24:49 Hiring deep, staying lean31:47 Cutting years off adoption37:00 Advice to founders and the road ahead

    The Outsider's Advantage: What an Engineer Saw in Cancer Care

Ratings & Reviews

5
out of 5
6 Ratings

About

Runtime is where the people building the future of technology share what really happens behind the scenes. ⠀ Hosted by Gil Ben-Artzy and Shuly Galili, founding partners at Silicon Valley venture firm UpWest, it brings founders, operators, and investors together to unpack the decisions, breakthroughs, and failures that shape technology companies and the markets around them. ⠀ For over a decade, Gil and Shuly have backed Israeli founders. On Runtime, they share what worked, what broke, and what today’s builders wish they’d known earlier. ⠀ New episodes every other Wednesday. Produced by POLDHU.