In this episode of Lead with Balance, host Jessie Li sits down with Dr. med. Jan Stritzke, MaHM—Specialist in Cardiology & Internal Medicine, expert in precision prevention, longevity, and medical wellness, and Medical Director at Lanserhof Sylt. Drawing on decades of clinical experience at the intersection of cardiovascular health, healthy ageing, and functional diagnostics, Dr. Stritzke breaks down why the conventional playbook for performance fails high-performing women—and what actually works instead. Dr. Stritzke demystifies the distinction between lifespan and healthspan, exposing why blindly following viral wellness trends, NAD supplements, or extreme biohacks often backfires. Together, they walk through evidence-based, actionable protocols tailored for busy corporate leaders and entrepreneurs navigating chronic stress, perimenopause, travel, and high-pressure environments. In this episode, we cover: The Longevity Pyramid: Why standard preventive diagnostics (cancer screenings, cardiovascular checks, annual blood panels) must precede high-end longevity protocols.Hallmarks of Ageing: Identifying your unique personal ageing drivers—from gut dysbiosis to mitochondrial health—rather than copying generic routines.Movement & Key Longevity Biomarkers: Why hand grip strength and body impedance matter more than basic scale weight, and how spirometry/lactate testing identifies your true fat-burning zone.Fueling & Muscle Preservation: The truth about protein intake, the danger of constant mTOR overactivation, and why post-workout timing matters.Female-Specific Fasting Protocols: Why zero-calorie or aggressive fasting backfires for women (especially in the luteal phase), and how to align fasting with your hormonal cycle.Weight Gain, Stress & Bioidentical Hormones: Why elevated stress prevents weight loss regardless of caloric deficit, and how bioidentical hormone replacement therapy (HRT) protects muscle mass, bone density, and arterial health. If you’ve done everything right on paper and still feel exhausted, overcommitted, or frustrated by shifting metabolism, this conversation offers you science-based tools you can implement in your daily life! Chapters: 00:00 - 03:00 Introduction to Dr. Jan Stritzke & Redefining Longevity03:00 - 07:22 Lifespan vs. Healthspan & The Longevity Pyramid07:22 - 11:08 Personalizing Longevity: Hallmarks of Ageing & Peptides11:08 - 13:28 Key Physical Biomarkers: Hand Grip Strength & Body Impedance13:28 - 18:58 Cardio, Spirometry & Finding Your Optimal Fat-Burning Zone18:58 - 21:52 Strength Training, Protein Intake & Avoiding mTOR Overactivation21:52 - 28:11 Female Fasting Protocols & Cycle-Synced Nutrition28:11 - 33:00 Stress, Perimenopause Weight Gain & Bioidentical Hormone Replacement Follow Dr. Jan Stritzke: LinkedIn: https://www.linkedin.com/in/docstritzke/ Website: https://lanserhof.com/en/ Follow Jessie Li: Instagram: https://www.instagram.com/jessieli LinkedIn: https://www.linkedin.com/in/jessie-li-cfa/ Website: https://www.jessieli.co/ Lead With Balance: Linkedin: https://www.linkedin.com/company/lead-with-balance/ Youtube: https://www.linkedin.com/company/lead-with-balance/ Newsletter: https://open.substack.com/pub/leadwithbalance Instagram: https://www.instagram.com/lead_with_balance Hosted on Acast. See acast.com/privacy for more information.