Sepsis remains one of the most consequential medical emergencies facing U.S. hospitals. About 1.7 million U.S. adults develop sepsis each year, and at least 350,000 die during hospitalization or are discharged to hospice, according to the CDC. Awareness is improving—Sepsis Alliance’s 2026 survey found that 78 percent of U.S. adults have heard of sepsis—but only 23 percent could identify all four of the organization’s most common signs and symptoms. Yet recognizing and treating sepsis is only part of the challenge for hospitals. Different clinical criteria and documentation expectations can complicate reimbursement after care is delivered, creating a difficult question for providers: How can clinicians act quickly enough to save a patient with sepsis while documenting the case thoroughly enough to withstand payer scrutiny? On this episode of Deny This, a PayerWatch podcast, host Brian McGraw is joined by Dr. Steven Simpson, Chair of the Board of Directors of Sepsis Alliance, and Dr. Kendall Smith, Chief Medical Officer and Chief Physician Advisor at PayerWatch, for a discussion about sepsis recognition, treatment, documentation, denials, and patient advocacy. Simpson explains that Sepsis Alliance has expanded from its roots in public awareness and patient advocacy to work across professional education, governmental advocacy, and research and innovation. The conversation then examines how competing sepsis criteria can affect clinical documentation and why hospitals may need to capture both the clinical reasoning behind the diagnosis and the evidence payers expect to see. Key Takeaways: Early recognition and treatment remain critical to sepsis outcomes. Simpson explains that some patients can progress from an apparently minor infection to septic shock within hours. Because clinicians cannot reliably predict which patients will deteriorate rapidly, early interventions can include blood cultures, broad-spectrum antibiotics, lactate measurement, and IV fluids when hypotension is present.Competing sepsis criteria create a documentation challenge for hospitals. The discussion contrasts the infection-plus-SIRS framework associated with earlier sepsis definitions and CMS’s SEP-1 reporting requirements with the Sepsis-3 framework centered on infection-related organ dysfunction and SOFA. Simpson argues that payer reviews can focus on whether SIRS, SOFA changes, and the connection between infection and organ dysfunction were explicitly documented. As a result, he recommends documentation approaches that clearly capture relevant SIRS findings, SOFA scores, organ dysfunction, and their relationship to the underlying infection when clinically supported.Denials can ultimately become a patient issue, not simply a hospital revenue issue. Simpson and Smith discuss how denied claims may affect patients financially and emphasize the potential role of patient appeal rights alongside provider appeals. The conversation also explores whether greater patient education around appeals could become another avenue for advocacy, with Simpson saying the discussion had generated ideas for future Sepsis Alliance education on documentation and patient appeals.Dr. Steven Simpson is Chair of the Board of Directors of Sepsis Alliance and a Professor of Medicine at the University of Kansas in the Division of Pulmonary, Critical Care, and Sleep Medicine. His work spans critical care, sepsis education, advocacy, research, and efforts to improve recognition and treatment of the condition. In the episode, Simpson describes Sepsis Alliance’s work across four primary areas: public awareness and patient advocacy, professional education, governmental advocacy, and research and innovation. Dr. Kendall Smith is Chief Medical Officer and Chief Physician Advisor at PayerWatch and a Senior Fellow in Hospital Medicine. Throughout his hospitalist career, he has worked extensively in denial and appeals management, utilization review, case management, clinical documentation improvement, and revenue cycle operations. He has helped design and implement CDI programs at organizations including Cleveland Clinic Florida and MedStar Washington Hospital Center and is an AHIMA ICD-CM/PCS approved trainer/ambassador.